Atorvastatin으로 유도된 근위축 세포모델에서 상황-오미자박 고상발효물 열수추출물의 보호효과

김영숙,황수진,박광일,임종민,천다미,정유진,전병엽,곽경태,오태우,Kim, Young-Suk,Hwang, Su-Jin,Park, Kwang-Il,Lim, Jong-Min,Cheon, Da-Mi,Jung, Yu Jin,Jeon, Byeong Yeob,Kwak, Kyeung Tae,Oh, Tae Woo 대한한의학방제학회 2021 大韓韓醫學方劑學會誌 Vol.29 No.4

Objectives : This study is to effect of improving muscle atrophy through water extract on the solid-phase fermentation extraction with Phellinus linteus of discarded Schisandra chinensis in an atorvastatin-induced atrophy C2C12 cell. Methods : C2C12 myoblast were differentiated into myotube by 2% horse serum medium for 6 days, and then treated solid-phase fermentation(S-P) extract at different concentrations for 24h. To investigate the effect of S-P extract on the induction of muscle atrophy and expression of atrophy-related genes and apoptosis in differentiated C2C12 myotubes using a GSH, ROS, real-time PCR, western blots analysis. Results : As a result of treatment with atorvastatin at concentrations of 5, 10, and 20 uM on the 6th day of differentiation in C2C12 myotube cells, it was confirmed that the cell morphology was damaged in a concentration-dependent manner, and the length and thickness of the myotube also decreased in a concentration-dependent manner. Treatment with S-P extract (50, 100 and 200 ㎍/㎖) increased of GSH and inhibited ROS in the atorvastatin-induced muscle atrophy cell model at a concentration that did not induce toxicity. In addition, it was confirmed that it has an effect on muscle reduction by inhibiting apoptosis of muscle cells as well as being involved in protein production and degradation of muscle cells. Conclusions : Atorvastatin-induced atrophy C2C12 cell, S-P extract activates related to differentiation/generation and proteolysis, and inhibits cell death of atrophy in C2C12 cell. Based on this, it is necessary to prove its effectiveness through animal models and human application test, but it is considered to be discarded Schisandra chinensis can present the potential for development as a recycling industrial material.

부산지역 방문간호사업 실태에 관한 연구

김영숙,박정란,박형숙,이윤미,Kim, Young-Suk,Park, Jung-Ran,Park, Hyoung-Sook,Lee, Yun-Mi 한국가정간호학회 2004 가정간호학회지 Vol.11 No.1

Purpose: The purpose of this research is to give basic data about a way of connection to individual centers and vitalization of visiting nursing program on Busan. Method: The research is done with survey for eight hospitals. sixteen public heath centers, forty-six social welfare centers to be practised visiting nursing program on Busan for actual condition of that. Results: 1. The average nursing career is below 5-10 years. But visiting nursing career is below 3 years(70%) in hospital. public, public heath center, and heath center. 2. Hospitals coverage of visiting nursing service is city as a whole. Whereas public heath center and social welfare center covered some local area. 3. Client of visiting nursing service possess in order of alone lived elderly, person in uncomplete movement, a disabled person, and a chronic disease person. 4. The main service in visiting is patient assessment, basic nursing activity, and treatment nursing activity with medication care, B.P check, dressing, bedsore care, catheter care and exchange, fluid therapy. Particularly, the hospital runs parallel to basic care and treat care in 100%. The social service center has 65.0% in a patient assessment and basic nursing activity. 5. The concern about services connecting with other center is very high. Conclusion: Actual conditions of visiting nursing program on Busan, which is presented in this study. The results of this study will become the pillar of visiting nursing program planning and application.

간호대학생의 행복지수 영향요인

김영숙(Young Suk Kim),한미영(Mi Young Han) 한국간호행정학회 2015 간호행정학회지 Vol.21 No.5

The purposes of this study were to identify the effects of social support, resilience, stress and satisfaction in major on the happiness index of nursing students. Methods: Data were collected from March 16 to April 10, 2015 through a self-report questionnaire survey. Participants were 205 students in three different nursing colleges located in Busan and Yangsan. Measured variables were social support, resilience, stress, satisfaction in major and Happiness index. Results: Social support, resilience, satisfaction in major, and personal relationships had significant positive effects on the happiness index, while stress had a negative effect on the happiness index. Explained variance for the happiness index was 46% and social support was the most significant factor in the happiness index of nursing students. Conclusion: The results from this study suggest that resilience, social support, stress, satisfaction in major, and personal relationships should be considered as the main influential factors when developing intervention strategies to increase of the happiness index of nursing students.

웹툰 〈은밀하게 위대하게〉의 스토리텔링에 나타난 일상성

김영숙(Kim, Young-Suk) 한국애니메이션학회 2017 애니메이션연구 Vol.13 No.3

최근 디지털의 발달과 함께 등장한 웹툰은 대중문화로서 현대인들에게 일상생활 속의 친숙한 콘텐츠 역할을 하고 있다. 온라인을 통해 범위를 넓혀 가며 영역을 확장하고 있는 웹툰은 영화나 TV드라마, 뮤지컬 등을 통해 많은 다른 매체로 변환되어 향유자들에게 전달되고 있다. 웹툰의 문화적 파급력이 확장되고 지속적인 활성화를 성취하려면, 인터넷 환경에 따른 변화와 사용자들의 변화된 특성을 고려한 웹툰 제작이 중요한 관점이 될 것이다. 본 연구는 웹툰에 함축되어 표현된 스토리의 핵심요소인 일상성을 논의하기 위해 웹툰의 장르적 특징과 일상성의 특징을 분석하여 향유자의 이해를 돕고 웹툰의 문화적 위상을 높이는 데에 목적이 있다. 연구 방법으로는 웹툰의 특징과 일상성, 웹툰 장르 자체가 가진 매체의 환경적 특성, 그로 인한 향유 패턴의 변화에 대해 분석하고, 웹툰 〈은밀하게 위대하게〉에 나타난 서사구조, 캐릭터 구도, 공간의 성격화, 인물구성과 상황의 딜레마, 사실적인 공간 배치와 상징적인 셔레이드 유형을 통하여 웹툰에 표현된 일상성 분석에 접근하였다. 연구 결과, 웹툰의 일상성의 특징은 개인화 추세, 편의성과 접근성, 일상적인 소재 등으로 볼 수 있다. 웹툰만의 특징인 세로읽기를 통해 매체환경과 공간의 여백을 적극적으로 활용하여 심미적 아름다움과 자유로운 공간 구성과 서사를 펼치고, 불연속적인 연재 방식은 예고편이나 셔레이드를 통해 극복하였다. 또한, 셔레이드의 유형을 통해 주제의 암시, 캐릭터의 형상, 관계 상징, 상황의 암시, 이미지의 대사화 등을 연출함으로써 향유자의 적극적인 향유를 가능하게 했다. 최종훈만의 상징적 대사 구현, 강렬한 색감과 독특한 조형미로 스토리텔링을 이끌어 내고, 섬세한 캐릭터의 묘사를 통해 일상성에 대한 적극적이고 확장된 향유를 가능하게 하였으며 ‘일상성’의 개념과 중요성을 부각시킨 것으로 분석된다. 오늘날 계속 새롭고 다양해지고 있는 매체환경과 문화 콘텐츠뿐만 아니라 미디어가 나날이 최적화되는 방향으로 전환되는 시점에서 웹툰은 일상성에 대한 깊이 있는 표현으로 이루어져야 한다. 다양한 모습의 캐릭터 연출로 향유자들에게 일상성의 다양하고 진한 감동과 정보가 향유되도록 해야 한다. 또한 웹툰이 향유자들의 쉼터역할을 해 주며 삭막해져 가는 현대인들의 마음을 순화할 수 있는 장르로서의 역할을 하기를 기대한다. With the development of digital system, the recent webcomic has played a role of familiar contents in modern people’s everyday life as public culture, Webtoon, which has been expanded through online service, has been provided to readers by being transferred to another type of media such as movies, Tv dramas or musicals. For continuous revitalization and cultural ripple effect of Webtoon, webcomic artists have to take account into user’s changed characteristics, which Internet environment caused. This study aims to analyze features of genre of webtoon and features of dailiness in this webtoon to discuss dailiness which is the core implied stories in webtoon. First of all, I will do analysis of the environmental features which webtoon itself has and the changes of the enjoyment patterns. And then, I will also analyze the dailiness expressed in webtoon 〈Secretly, Greatly〉through narrative structure, character composition, characterization of space, characters` duplicity and dilemma, realistic space arrangement and type of a symbolical charade, According to the research result, webtoon shows aesthetic beauty and free narration with space constraints, utilizing media environment and blank space through vertical reading, which is webtoon’s unique feature. Also, webtoon is overcoming discontinuous serial publication method in the way of a preview and charade and it encourages readers` enjoyment to strongly last, creating suggestion of theme from the type of charade, characters` shape, implication of events and dialogue of images. Webtoon generates storytelling through unique beauty of a structure and outstanding colors, therefore it has a signification that users can enjoy the theme actively and deeply through delicate descriptions of characters. Today, the media environment and the cultural contents are constantly diversifying. Thus, webtoon should provide modern people with enjoyment of feeling moved by analyzing dailiness in depth and describing various daily lives of ordinary people at this point of time, I expect webtoon to play a role not only as shelter in which users relieve their stress but also as genre which purifies user’s heartless mind.

학습자의 모어를 고려한 일본어 문법교육에 관한 고찰 -「で」의 문법지도와 번역전략의 관계를 중심으로-

김영숙 ( Young Suk Kim ) 한국일어교육학회 2009 일본어교육연구 Vol.17 No.-

井上(2005)에서는 학습자의 모어(母語)를 배려한 일본어교육문법이 필요하다고 주장하고 있다. 여기서 학습자의 母語를 배려한다는 것은 학습자의 모어의 관점에서 생각했을 때 학습자가 이해하기 쉬운 일본어문법을 제공하는 것을 말하는데, 그 구체적인 내용 중 한가지로, 일본어와 유사한 언어체계를 갖는 한국어 모어 학습자에게는, 초급 학습항목의 경우, 문법요소라 할지라도 어휘요소로서 지도한다는 것이다. 예를 들어, 「で」는 격조사로서 다양한 용법을 갖고 있으나 초급과정에서는 한국어의 「에서(eseo)」「로(lo)」와 대응관계를 중심으로 지도한다는 것이다. 이러한 지도법은 한국어의 관점에서 일본어를 이해한다는 점에서 학습자의 모어를 일본어학습에 적극적으로 활용할 수 있는 장점이 있고, 실제로 한국어모어화자를 대상으로 한 초급 교과서에서도 이와 같은 설명이 이루어지고 있다. 그러나 다른 한편으로, 한국어 「로(lo)」의 용법이 일본어의 「で」와 완전히 일치하는 것은 아니기 때문에, 「で」와「로(lo)」의 대응관계에만 의존한 문법지도의 문제도 있을 것이 예상된다. 이 논문에서는 이러한 문제의식에서 출발하여, 위와 같은 「で」의 문법지도가 한국어모어학습자의 번역전략에 미치는 영향을 조사했다. 다양한 수준의 일본어 학습자 97명을 대상으로 한국어를 일본어로 번역하는 과제를 시행한 결과, 많은 학습자들이 한국어文이 나타내는 의미나 「로(lo)」의 기능이 아닌, 「로(lo)」의 형태를 「で」로 번역하는 것을 알 수 있었다. 또한, 학습자들은 수업 등의 의식적인 학습이나 의식하지 않는 사이에 이루어지는 학습과정을 통해서 「で」와「로(lo)」의 대응관계를 습득하고 있었으며 번역할 때에는 이러한 지식을 이용하는 것을 알 수 있었다. 井上(2005)では學習者の母語を考慮した日本語敎育文法の必要性について述べられているが、具體的に、日本語と類似した言語體系をもつ韓國語話者の場合、初級の學習項目は文法形式であっても語彙項目として扱うという內容が示されている。このような文法敎育の觀點から韓國語話者を對象とした初級敎科書の「で」の文法說明に注目すると、實際、「で」に關しては「에서(esyo)」「로(lo)」との對應關係に基づいた說明が多く、語彙項目として扱われる傾向が見られる。このような文法指導は學習者の母語を文法敎育に生かすというメリットもあるが、しかし、他方で、韓國語の「로(lo)」の用法は必ずしも「で」のそれと一致するわけではなく、「で」と「로(lo)」の關係を語彙的な關係として捉えた學習者の誤りが予想される。本稿では、このような問題に著目して「で」の文法指導が韓國語話者の飜譯に及ぼす影響を調べた。樣樣なレベルの韓國語話者の學習者97人の飜譯ストラテジ―を調べた結果、多くの學習者が韓國語の「로(lo)」を「で」に飜譯するという形態ストラテジ―を用いることが分かった。なお、學習者は授業などの意識的な學習、あるいは意識しない學習プロセスを通じて「で」と「로(lo)」の形態を關連づけていることが分かった。

보건계열과 비보건계열 대학생의 심폐소생술에 대한 지식, 태도 및 자기효능감

김영숙(Young-Sook KIM),김지숙(Ji-Suk KIM),박정언(Jeong-Eon PARK) 한국수산해양교육학회 2018 水産海洋敎育硏究 Vol.30 No.3

인공 초기우식병소에 대한 나노크기 탄산인회석의 재광화 효과

김영숙 ( Young Sook Kim ),민지현 ( Ji Hyun Min ),김영석 ( Young Seok Kim ),홍석진 ( Suk Jin Hong ),권호근 ( Ho Keun Kwon ),김백일 ( Baek Il Kim ) 대한예방치과·구강보건학회 2009 大韓口腔保健學會誌 Vol.33 No.1

항암성과 향미가 개선된 재래식 버섯균사체메주의 제조

김영숙(Young-Suk Kim),박철우(Cherl-Woo Park),김석종(Seck-Jong Kim),박숙자(Sook-Jahr Park),류충호(Chung-Ho Ryu),조현종(Hyun-Jong Cho),김정옥(Jeong-Ok Kim),임동길(Dong-Kil Lim),하영래(Yeong-Lae Ha) 한국식품영양과학회 2002 한국식품영양과학회지 Vol.31 No.6

항암성과 향미가 개선된 기능성 재래식 버섯균사체메주는 버섯균을 액체배양하여 재래식메주의 각 면에 5개씩 만든 구멍(1×3 cm)에 버섯균배양액을 메주 무게의 10%를 접종한 후 25℃에서 4주간 배양하여 제조하였다. 제조한 버섯균사체 메주 중 상황, 영지, 또는 신령버섯균사체메주가 항암성과 향미완화능이 우수하였다. Mushroom mycelia-cultured traditional meju (MTM) was prepared by inoculating 10% submerged-liquid culture of mushroom strains to five holes (1×3 cm) per side of the traditionally-fermented meju (10×10×10 cm), followed by incubating additional 4 weeks at 25℃. Mushroom strains used were Neutari (Pleurotus ostreatus, PO), Yeongji (Ganoderma lucidum, GL), Synryeong (Agaricus blazei, AB), Ypsae (Grifola frondosa, GF), Pyogo (Lentinus edodes, PE), Dongchunghacho (Paecilomyces japonicus, PJ) and Sanghwang (Phellinus linteus, PL). All MTMs showed an enhanced anticarcinogenicity against S-180 cell-induced mouse ascites cancer, antimutagenicity against aflatoxin B₁ (AFB₁) and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), and sensory qualities, relative to control meju. Such positive effects of MTM prepared with Sanghwang, Yeongji, or Synryeong were superior to those of MTM with Ypsae, Pyogo, Dongchunghacho, or Neutari.

여자 높이뛰기에서 경기력 간 도움닫기와 발구름 동작의 운동역학적 분석

김영숙 ( Young Suk Kim ),류재균 ( Jae Kyun Ryu ),장재관 ( Jae Kwan Jang ) 한국운동역학회 2015 한국운동역학회지 Vol.25 No.1

Objective : The purpose of this study was to find some kinetic variable`s relationships between personal records and low records in female high jump· Methods : Collected data of the subjects(N=8, ages: 25·5±1·85, height: 173±5·83, mass: 54·75±6·36 personal record: 1·71±0·04, low record: 162·±0·03)were used for the last three strides and take-off phase· Five video cameras set in 30frames/s were used for recording· After digitizing motion, theDirect Linear Transformation(DLT) technique was employed to obtain 3-D position coordinates· The kinematic and kinetic factors of distance, velocity,angle, impulse, jerk variables were calculated· A paired t-test was applied for the difference of variables between personal records and lower recordsand for correlation with performances and variables· The significance level was accepted at p<·05· Results : There was no relationship between pattern of stride and performance· However, rate of change of velocity was related with cental of massheight(CMH) at peak point(PP)· Knee, hip, backward lean, foot plant, approach and take off angle showed no difference between best record and lowrecord· Vertical impulse momentum also showed no difference between performances· Conclusion : According to a t-test result, there were significant differences in CMH at PP and jerk at touch down between best record and low record·

고신대학교 간호대학생의 선교소명의식과 선교훈련 경험 현황 조사

김영숙(Kim Young Suk) 고신대학교 전인간호과학연구소 2016 전인간호과학학술지 Vol.9 No.-

Purpose : The purpose of this study is to identify the awareness of the calling of mission and mission training experiences of nursing students in Kosin University. Method : Data were collected from December 1 to 14, 2015. participants were 402 nursing students those who agreed to be part of the research, among entire nursing students in Kosin University. Result : Those students who received calling of mission were 18.2% and among these students those who found it while attending to university were 50%, and those who are interested in were 63.6%. The percentage of students those who received domestic mission training were about 40%, and those who have experienced overseas short term mission training were 30.1%. The programs that affected content of calling of mission were lectures about nursing and mission, chapel, overseas short term mission training, extracurricular activities, spiritual nursing practice, and the missionary’s testimony. Conclusion : The results from this study suggest that to develop the nursing mission, there is a need to develop specific programs for awareness of the calling of mission of nursing and nursing mission volunteers.