瞿秋白體制와 左傾盲動路線 : 土地革命의 展開와 관련하여

김원규 부산대학교 사학회 2000 釜大史學 Vol.24 No.-

初期 中國共産黨과 코민테른 : 農民ㆍ土地問題를 중심으로

김원규 부산대학교 사학회 1998 釜大史學 Vol.22 No.-

Cyclosporin-A가 흰쥐 자궁선상피세포의 미세구조에 미치는 영향

김훈기,정호삼,김원규 漢陽大學校 環境科學硏究所 1994 環境科學論文集 Vol.15 No.-

Cyclosporin은 11개의 아미노산을 가지고 있는 cyclic oligopeptide로서 면역억제작용으로 인하여 오늘날 장기 이식후 나타나는 거부작용의 억제제로서 혹은 자가면역질환의 치료제로서 사용되고 있으나 신독성, 간독성, 암발생, 임파조직의 종대 및 신경독성 등의 여러 부작용을 유발한다고 알려져 있다. 또한 cyclosporin은 세포내 핵산 및 단백질 합성을 억제하므로 cyclosporin을 흰쥐에 투여하면 흰쥐의 자궁선상피제포가 손상을 받을 것으로 사료되어 저자는 흰쥐에 cyclosporin을 투여하여 자궁선 상피세포내 소기관에서 일어나는 형태적인 변화를 관찰하기 위하여 본 실험을 시도하였다. 실험동물로는 체중 200gm 내외의 Sprague-Dawley계 자성흰쥐을 사용하였으며 체중 ㎏당 500㎎의 cyclosporin-A를 생리적 식염수 0.2cc에 희석하여 1일 1회씩 2주간 복강내로 투여하고 최종 주사후 6시간, 12시간, 24시간 및 72시간 후에 경동맥사혈로 희생시키고 개복하여 자궁을 적출한 후 일반적인 전자현미경 표본제작법에 따라 두께 600∼800Å의 초박절편을 제작한 후 uranyl acetate와 lead citrate로 이중 염색하고 Hitachi H-600 투과형 전자현미경으로 관찰하여 다음과 같은 결과를 얻었다. 1. Cyclosporin 투여군 흰쥐의 발정전기 자궁선상피세포에서는 자궁선 내강으로 돌출한 미융모가 대조군 흰쥐의 미융모에 비하여 다소 파괴된 양상을 보였고, 핵의 형태가 불규칙해졌으며, 일부 사립체에서 사립체막과 사립체릉이 파괴되었고, 조면내형질세망의 일부 소조가 낭상화, 확장 및 단절되었으며, 막부착 ribosome도 탈락되었고, Golgi 복합체는 위축되었으며, 또한 자식공포, 다소포체 및 식소체 등이 다수 관찰되었다. 2. Cyclosporin 투여군 흰쥐의 발정기 자궁선상피세포에서는 자궁선 내강으로 돌출한 미융모가 파괴되고 단절 및 위축된 양상을 보였고, 핵의 형태가 불규칙해졌고, 일부의 사립체에서 사립체막과 사립체릉이 파괴되었으며, 특히 12시간 및 24시간 경과군의 흰쥐 자궁선상피세포에서 조면내형질세망의 소조가 심하게 낭상화, 확장 및 단절되었고, 막부착 ribosome도 탈락되었으며, Golgi 복합체는 위축되었고, 다수의 자식공포 및 식소체가 관찰되었다. 3. Cyclosporin 투여군 흰쥐의 발정후기 자궁선상피세포에서는 자궁선 내강으로 돌출한 미융모가 파괴 및 단절된 양상을 보였고, 핵의 형태가 불규칙해졌으며, 일부 사립체의 사립체막과 사립체릉이 파괴되었고, 조면내형질세망의 일부 소조가 낭상화, 확장 및 단절되었으며, 막부착 ribosome이 탈락되었고, Golgi 복합체는 위축되었으며, 식소체, 다소포체 및 자식공포가 다수 관찰되었다. 4. Cyclosporin 투여군 흰쥐의 발정간기 자궁선상세포에서는 자궁선 내강으로 돌출한 미융모가 단절 및 위축된 양상을 보였고, 핵의 형태가 불규칙해졌고, 일부 사립체의 사립체막과 사립체릉이 파괴되었으며, 조면내형질세망의 일부 소조는 낭상화, 확장 및 단절되었고 막부착 ribosome도 탈락되었으며, Golgi 복합체는 위축되었고, 식소체, 다소포체 및 자식공포가 다수 관찰되었다. 이상의 결과를 종합 검토한 바 cyclosporin은 흰쥐 자궁선상피세포의 세포내 소기관에 손상을 일으키는 것으로 사료된다. Cyclosporin, a potent immunosuppressive agent, is produced from culture broth of soil fungus, Tolypocladium Gams or Gylindrocarpon ludidium Booth. It is used for immunosuppressive drugs in organ transplantation or therapeutic agent in autoimmune diseases such as Hashimoto's thyroiditis, type I diabetes mellitus, rheumatoid arthritis, etc. Though the mechanism of immunosuppression of this drug is not exactly known, it may inhibit the proliferation and activation of cytotoxic T lymphocytes, the response of precusor cytotoxic T lymphocytes to interleukin-2 and inactivation of calmodulin to mitogen stimulation. Cyclosporin is very effective agent to graft recipient patients, many adverse effects including nephrotoxicity, hepatotoxicity and neurotoxicity, however, may be occured. So the morphological changes of uterine glandular cells by cyclosporin that the author has taken this study to investigate the effects of cyclosporin on the fine structure of cytoplasmic organelles in the uterine glandular epithelial cells of the albino rats at different stages of the estrous cycle according to time course. Cyclosporin-A(Sandimmun : 50㎎/㎏) was given intraperitoneally once for a day to the animals of the experimental group and normal saline to those of the control group for 14 days. All the animals were sacrificed on the 6, 12, 24 and 72 hours after initial injection, and specimens were obtained from the corpus uteri. Ultrathin section(600∼800Å in thick) made from each specimens were stined with uranyl acetate and lead citrate and observed with electron microscope(Hitachi 600). In the uterine glandular cells of cyclosporin treated rats at the proestrous stage, the following changes were observed : destruction or segmentation or atrophy of microvilli, disorganization of mitochondrial cristae and disruption of the mitochondrial membrane, sacculation, dilatation or fragmentation of the cisternae of the rough endoplasmic reticulum associated with detachment of the membrane-bound ribosomes, and appearance of numerous secondary lysosomes such as autophagic vacuoles, multivesicular body, phagosomes. Similar changes in ultrastructure of the uterine glandular cells were identified in the cyclosporin treated animals at the estrous stage. All the changes induced by cyclosporin in the fine structure of organelles of these cells at the metestrous and diestrous stages were not much different from those produced at the estrous stage. It is demonstrated that cyclosporin causes degenerative changes in the uterine glandular cells of rats in all stages of the estrous cycle.

韓國의 地區計劃 制度에 關한 硏究

金元珪 건국대학교 행정대학원 1983 建國大學校 行政大學院 硏究論叢 Vol.11 No.-

명사초대석-나의 건강비결

김원규,Kim, Won-Gyu 한국건강관리협회 1985 건강소식 Vol.9 No.10

A TOPOLOGICAL MINIMAX INEQUALITY WITH γ-DCQCV AND ITS APPLICATIONS

김원규 충청수학회 2012 충청수학회지 Vol.25 No.2

In this paper, using the γ-diagonally C-quasiconcave condition, we will prove a new minimax inequality in a non-convex subset of a topological space which generalizes Fan's minimax in-equality and its generalizations in several aspects.

2 자유도 구륜 이동 로보트의 모델링과 경로추적

김원규,박종국,문종우,정용욱 慶熙大學校 1995 論文集 Vol.24 No.-

In this paper are presented kinematic and dynamic modeling and path-tracking of four-wheeled mobile robot with 2 d.o.f having the limited drive-torques. Controllability of mobile robot is revealed by using the kinematic model which analyzes motion of wheeled-mobile robot from the viewpoint of geometry. Instantaneously Coincident Coordinate System (ICCS), force/torque propagation and Newton's equilibrium law are used to induce the dynamic model. When drive-torques generated by inverse dynamics exceed the limitation, we make wheeled-mobile robots follow the reference path by modifying the planned reference trajectory with time-scaling. The controller is introduced to compensate for error owing to modeling uncertainty and measurement noise. And simulation results prove that method proposed by this paper is efficient.

Existence of Nash equilibrium in a non-compact acyclic strategic game with infinite players

김원규 충청수학회 2011 충청수학회지 Vol.24 No.2

In this paper, we will prove an equilibrium existence theorem of a non-compact acyclic strategic game with affine constraint correspondences which is comparable with equilibrium existence theorems due to Debreu, Nash, Kim-Kum, and Lu in several aspects.

공정거래법상 경쟁제한적 기업결합에 관한 연구

김원규 한국상사법학회 2006 商事法硏究 Vol.25 No.2

A Study on Integration to limit competition in Antitrust Law Antitrust Law is controlling Integration to limit competition. Integration means phenomenon that corporation more than two is admited inside one control system. Each corporation is integrated to the company which corporation’s decisive power is combined as well as lose perfectly economical independence by Integration. That is, Integration is phenomenon that is compose one corporation by legal and economical by union between corporation. Integration will be promoted actively and may have to be fenced in this point. But, corporations do not Integration for economic of scale simply. That is, corporations control market and seek monopolistic profit through Integration. When Integration has this purpose, distort market’s competition order necessarily or do unfair transaction action. Antitrust Law is controlling this action of corporation justly. Integration is divided by Horizontal Integration, Vertical Integration and mixing Integration. The most Integration are mixing union in the South Korea. In fact, it is monopoly that become an issue in each Integration. The Fair Trade Commission made standard to judge Integration in 1999. The Fair Trade Commission should be little more fair and reasonable in use of system including this standard. Antitrust Law, drawing that control integration that is to limit competition must be thing which the country controls to make agreeable environment that all corporations can be active wholeheartedly in market. Specific and realistic standard of judgment for Antitrust law article 7 the first clause each trench should be made, and the third clauses and the fourth clauses are erased or must ease the important matter. Because Antitrust Law is prohibiting that integration is forced or consists by unfair method.

에너지 절감을 위한 배전설비 개선에 대한 조사연구

김원규 경희대학교 산학협력기술연구원 1996 산학협력기술연구논문집 Vol.2 No.-

An investigation was conducted at a factory where a great deal of electric power is consumed. As a result of that investigation several suggestions were made concerning how to improve the efficiency of electric energy distribution. Those suggestions were as follow: 1.to improve the power factor 2.to reform load distribution 3.to charge the choke 4.to provide a method of safety control to prevent current leakage 5.to check the oil in the transformer