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Molecular Epidemiological Trend of Tuberculosis in Korea, 2000`s
김경종,양정성,최홍조,박미선,김성한,박상희,이길수,전세미,김창기 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-
Background: Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the second major cause of death from infectious diseases worldwide. To understand the status of transmission Of Mycobacterium tuberculosis in Korea after 2000. We analysed genotype of 443 clinical isolates. Methods and Results: A total of 443 clinical isolates collected throughout Korea were genotyped by using the IS6110-RFLP, and then analysed for the number of VNTR copies from 24 locus MIRU-VNTR. IS6110-RFLP identified 392 different profiles, of which 367 were unique and 76 isolates were in 25 clusters, giving a strain-clustering rate of 11.5%. Whereas, 24 locus MIRU-VNTR identified 358 different profiles, of which 319 were unique and 124 isolates were in 39 clusters, giving a strain-clustering rate of 19.2%. The discriminatory indexes were very close at 0.9986 and 0.9975, respectively. We confirmed 6 cases of outbreak, and 3 cases of outbreak were matched genotype, respectively. Furthermore, We found that suspected index case associated with the outbreak in high school in Busan, 2010. Conculosion: We found that clustering rate was 11.5%, 19.2% by using IS6110-RFLP and MIRU-VNTR, respectively. It means that tuberculosis occurring in KOREA seems to be due to relapse rather than transmission. We found that index case associated with the outbreak. However, For more accurate and comprehensive epidemiologic investigation, there is a need for epidemiological survey of the entire tuberculosis occurring annually in Korea.