Synthesis of Acylthiocholine and its kinetic study with Acetylcholineesterase (I)

정대일,권수천,신은화,이용균,박유미 한국생명과학회 2000 한국생명과학회 학술발표회 Vol.27 No.-

Choline esters are used as substrate of BuChE-catalyzed hydrolysis. It was synthesized by two methods. First, 2-chloroethyl hexanoate and 2-chloroethyl octanoate were synthesized by the treatment for hexanoyl chloride and octanoyl chloride with ethylene surfide. Hexanoylthiocholine and octanoylthiocholine were synthesized by using 2-chloroethyl hexanoate and 2-chloroethyl octanoate with trimethylamine. Second, after reaction of ethylene surfide and dimethylamine and acylation with acid anhydride, heptanoylthiocholine and decanoylthiocholine were synthesized by the treatment of methyl iodide. The synthesized choline esters are to study for its reactivity and strength of ES complex according to increase in number of carbon. The reaction mechanism of BuChE-catalyzed hydrolysis of choline esters (HexTCh, HepTCh, OcTCh, and DoTCh) have been surmised from kinetic parameter, pH-rate profile, and solvent isotope effects.

Pyrrole유도체와 Diethyl Azodicarboxylate의 부가반응

정대일,장두옥,한치선 연세대학교 자연과학연구소 1986 學術論文集 Vol.17 No.-

N-substituted pyrrole들, 즉 1-(p-acetylphenyl)-(6a), 1-(m-acetylphenyl)-(6b), 1-(p-bromophenyl)-(6c),1-(p-nitrophenyl)-(6d), 1-(m-nitrophenyl)-(6e), 그리고 1-(p-methoxyphenyl) pyrrole(6f)을 합성하여 이들과 diethyl azodicarboxylate와의 부가반응을 논하였다. 또한 이들 치환체에 의한 감응효과에 다른 반응상의 차이점을 논하였으며, 모든 반응이 1:1 및 1:2 Michael 형태를 부가반응으로 진행됨을 생성물의 IR, UV, NMR spectra로 확인하였다. The following N-substituted pyrroles, that is, 1-(p-acetylphenyl)-(6a), 1-(m-acetylphenyl)-(6b), 1-(p-bromophenyl)-(6c), 1-(p-nitorphenyl)-(6d), 1-(m-nitrophenyl)-(6e) and 1-(p-methoxyphenyl)pyrrole(6f) were prepared by the known methods, and the addition reactions of these compounds with diethyl azodicarboxylate were examined. The difference in reactivities was discussed in terms of inductive effects of the pyrrole derivatives. Both of the 1:1 and 1:2 Michael-type adducts were synthesized by these reactions and identified by IR, UV and NMR spectra.

Pyrrole 誘導體와 Dimethyl Acetylene Dicarboxylate 및 Diethyl Azodicarboxylate의 反應

鄭大一 東亞大學校附設基礎科學硏究所 1987 基礎科學硏究論文集 Vol.4 No.1

N-substituted pyrrole들, 즉 1-(p-fluorophenyl)-(6a), 1-(p-nitrophenyl)-(6b), 1-(m-nitrophenyl)-(6c), 1-(m-acetophenyl)-(6d), 1-(p-methylphenyl)-(6e), phenyl(6f), 그리고 1-(p-bromophenyl) pyrrole(6g)을 합성하여 이들과 diethyl azodicarboxylate 및 dimethyl acetylene dicarboxylate의 반응을 논하였다. 또한 이들 치환체에 의한 감응효과에 따른 반응상의 차이점을 논하였으며, 이들 반응이 1:1 및 1:2 Michael 형태의 부가반응, 그리고 1:1 및 1:2[4+2]환 부가반응으로 진행됨을 생성물의 IR, UV, NMR spectra로 확인하였다. The following N-substituted pyrroles, that is, 1-(p-fluorophenyl)-(6a), 1-(p-nitrophenyl)-(6b), 1-(m-nitrophenyl)-(6c), 1-(m-acetophenyl)-(6d), 1-(p-methylphenyl)-(6e), phenyl(6f), and 1-(p-bromophenyl) pyrrole(6g) were prepared by the knwon methods, and the addition reactions of these compounds with diethyl azodicarboxylate and dimethyl acetylene dicarboxylate were exaimned. The difference in reactivities was discussed in terms of inductive effects of the pyrrole derivatives. Both of the 1:1, 1:2 Michael-type adducts and 1:1, 1:2[4+2]cycloadducts were synthesized by these reactions and identified by IR, UV and NMR spectra.

3,7-Dihydroxy-3,7-dioxoperhydro-1,5,3,7-diazadiphosphocine-1,5-diacetic acid 유도체의 합성과 구조분석

정대일,이도훈 東亞大學校 附設 環境問題硏究所 2007 硏究報告 Vol.29 No.1

In the last few tears, great efforts have been devoted to the development of efficient ligands for transition metal ions, in order to obtain complexes whose stability, physical properties and biodistribution could make them suitable for application as contrast agents for magnetic resonance imaging(MRI), diagnostic- therapeutic radiopharmaceuticals, or f1uorescent bioassays To the best of our knowledge, there are few reports involving the reation of hypophosphorous acid with formaldehyde and primary amines. Our interest in α-aminoalkylphosphinic and bis(α-aminoalky) phosphinic acids lies in their coordination ability towards metal ions, thereby providing useful structure motifs for the preparation of multi-sited ligands. πle reaction was then perfOI1Tl<:화 adopting glycine, aspartic acid, or glutamic acid as a model arninoacid in aq. HCl. The heterαyclic ligand synthesised by glycine is 3,7-dihydroxy-3,7-dioxoperhy dro-l,5,3,7-diazadiphosphocine-l,5-diacetic acid, and product synthesized by Lglutamic acid is 2- [5-(1,3-Di-carboxypropy])-3,7-dihydroxy-3,7-dioxo-315,715-[1,5,3,7l d경adiphosphocan-l-yll-pentan어ioic acid. Synthesis of acid compound by trearment of L -aspartic acid is in progress.

TiO₂를 이용한 아세틸렌, 프로필렌, 프로판 가스의 광촉매 산화반응

정대일,변석인,이도훈,이용균,박유미,최순규,김동현 동아대학교 환경문제연구소 2002 硏究報告 Vol.25 No.1

Photocatalyzed degradation of acetylene, propylene, and propane gases were carried out over precoated titanium dioxide(anatase) illuminated UV light in a flow reactor. photocatalytic oxidation of acetylene, propylene, and propane gases respectively indicated high conversion rates (78.0%) to CO₂gas. And photocatalytic oxidation of three gases according to a fold, twofold, and threefold of titanium dioxide(anatase) respectively gave high conversion rate. The longer reaction time was, the higher conversion rate to CO₂gas showed.

달걀껍질(생, 삶은)의 수처리에 관한 연구

정대일,정선주,김인식,최영하,류정숙,이용균,최순규 동아대학교 환경문제연구소 1999 硏究報告 Vol.22 No.2

The selective absorption ability of low density heavy metal(Pb(Ⅱ) ion or Cu(Ⅱ) ion) of eggshell(raw or boiled) is better than one of existing absorption materials in treatment ability and experimental condition. The elimination ability of chlorine of eggshell(raw or soiled) is worse than one of active carbon. In elimination of trihalomethane, the effect of treatment of eggshell is almost the same as one of pine cones. And surface of eggshell(raw or boiled) after absorption of heavy metal ion was observed by Scanning Electron Microscope(SEM). Application and availability of eggshell(raw or boiled) as absorption material need lots of experiments. The experiment on baked eggshell is proceeding.

증발량 관련 기후인자와 팬증발량의 변화 분석

정대일,강재원,Jeong, Dae-Il,Kang, Jae-Won 한국수자원학회 2009 한국수자원학회논문집 Vol.42 No.2

전지구적 기온상승으로 인해 증발량이 증가할 것으로 예견되었으나, 다양한 지역에서 관측된 팬증발량은 지난 수십 년간 뚜렷한 감소추세를 나타내고 있다. 본 연구에서는 1960년부터 2007년까지 관측된 국내 18개 기상관측소의 팬증발량과, 증발에 관련된 강수량, 온도, 상대습도, 풍속, 일조시간, 일조율에 대한 변화를 분석하였다. 분석결과 팬증발량은 뚜렷한 감소현상을 나타내었으며, 강수량과 온도는 증가추세를, 상대습도, 풍속, 일조시간, 일조율은 감소추세를 나타내었다. 특히, 일조시간과 일조율의 감소추세는 팬증발량과 지역적으로 상당히 일치하고 있음을 확인하였다. 산점도를 그려 상관관계를 확인해본 결과, 일조시간과 일조율은 팬증발량과 양의 상관관계를 강하게 나타내고 있으며, 강수량의 경우는 팬증발량과는 음의 상관관계가 존재하였다. 강릉관측소 사례연구에서 Penman공식에 의해 추정된 개방된 수면에서의 증발량은 팬증발량에서 보인 것 같은 뚜렷한 하향추세가 검증되지 않아, 기존에 팬증발량 관측값으로부터 증발량을 추정하는 것은 장기적인 증발량 변화를 검토하기 위해서는 부적절함을 확인하였다. 마지막으로 팬증발량이 실제증발량과 서로 상호보완적 관계를 갖기 때문에, 팬증발량이 감소하더라도 실제증발량은 증가할 수 있음을 설명하였다. Evaporation over the world is expected to increase owing to increase in temperature by global warming. However, pan evaporation around the world has decreased in the past few decades. This study, which has been conducted in 18 meteorological gauging stations in Korean peninsula, investigates the changes in pan evaporation and climate variables such as precipitation, temperature, relative humidity, wind speed, sunshine hours, and percentage of sunshine, which can affect evaporation processes; the changes in these variables have been recorded between 1960 and 2007. At most gauging stations, pan evaporation shows statistically significant downward trends. The relative humidity, wind speed, sunshine hours, and percentage of sunshine also show downward trends. On the other hand, precipitation and temperature show upward trends. The spatial distribution of the downward trend in sunshine hours and percentage of sunshine correspond to that of the downward trend in pan evaporation. Scatter plots imply that pan evaporation has a strong positive correlation with the sunshine hours and percentage of sunshine, while it has a negative correlation with precipitation. At the Gangneung gauging station, the open water evaporation estimated using the Penman equation does not show the significant downward trend shown by pan evaporation. This result implies that pan evaporation is not a good indicator of potential or open water evaporations during the investigation of their long-term variability. Finally, this study explains the complementary relationship between pan and actual evaporations. Decreases in the pan evaporation can act as an evidence for the ever-increasing actual evaporation.

Benzodiazepinone들과 Pyridobenzodiazepinone의 합성에 관한 연구

정대일,최순규,박유미,이용균,김윤영,김인식,최태원 東亞大學校附設基礎科學硏究所 1996 基礎科學硏究論文集 Vol.13 No.1

?? 존재하에서 o-phenylenediamine 5와 acrylic acid 11의 반응은 benzodiazepinone 13과 pyridobenzodiazepinone 17을 생성한다. PPA 또는 SiO₂존재하에서의 o-phenylenediamine 5와 acrylic acid 11의 반응은 오직 benzodiazepinone 13만을 생성한다. 100∼110 ℃에서 PPA 또는 ?? 또는 SiO₂존재 하에서 o-phenylenediamine 5와 crotonic acid 19의 반응은 각각 1:1 cycloadduct인 4-methylbenzodiazepinone 20을 얻었다. The reaction of o-phenylenediamine 5 with acrylic acid 11 in the presence of ?? afforded benzodiazepinone 13 and pyridobenzodiazepinone 17. The reactions of o-phenylenediamine 5 with acrylic acid 11 in the presence of PPA or SiO₂afforded only benzodiazepinone 13. The reactions of o-phenylenediamine 5 with crotonic acid 19 in the presence of PPA or ?? or SiO₂at 100∼110℃ afforded respectively 4-methylbenzodiazepinone 20 as 1:1 cycloadduct.

TiO₂를 이용한 프로필렌 가스의 광촉매 산화반응

정대일,이동희,김용환,김현숙,이용균,박유미,최순규,김동현 동아대학교 환경문제연구소 2001 硏究報告 Vol.24 No.1

Photocatalyzed degradation of propylene gas was carried out over precoated titanium dioxide(anatase) illuminated W light in a flow reactor. photocatalytic oxidation of propylene gas indicated high conversion rates (78.0%) to CO₂ gas. And photocatalytic oxidation of gas according to a fold, twofold, and threefold of titanium dioxide(anatase) respectively gave high conversion rate. The longer reaction time was, the higher conversion rate to CO₂ gas showed.

흥미로운 구조를 가진 Dipyrrolylbenzene들의 합성에 관한 연구

정대일,김인식,정두희,박철우,김윤영 東亞大學校 大學院 1996 大學院論文集 Vol.21 No.-

1-(2-Aminophenyl)pyrrole 20a and 1,2-dipyrrolylbenzene 17a were synthesized by using 1,2-phenylenediamine 16a with 2,5-dimethoxytetrahydrofuran 12 in glacial acid. 1-(3-Aminophenyl)pyrrole 20b and 1,3-dipyrrolylbenzene 17b were obtained by using 1,3-phenylenediamine 16b with 2,5-dimethoxytetrahydrofuran 12 in glacial acetic acid. 1,4-Dipyrrolybenzene 17c was synthesized by using 1,4-phenylenediamine 16c with 2,5-dimethoxytetrahydrofuran 12 in glacial acetic acid. Aminophenylpyrroles 20 and dipyrrolylbenzenes 17 were respectively synthesized by the treatment of 1,2-phenylenediamine 16a, 13-phenylenediamine 16b, 1,4-phenylenediamine 16c and 2,5-dimethoxytetrahydrofuran 12 in no solvent, acrylic acid, silica-gel, acrylic acid + silica-gel + acetic acid instead of glacial acetic acid. In case of silica-gel + acetic acid among various methods reactivity about synthesis of dipyrrolylbenzene 17 was best. 9-Phenylcarbazole 15 was synthesized by treatment of 1-phenylpyrrole 13 with 2,5-dimethoxytetrahydrofuran 12 in glacial acetic acid.