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Immunomodulatory effect of captopril and local irradiation on myeloid-derived suppressor cells
조원경,신성원,김신영,홍장원,최창훈,박원,노재명 대한방사선종양학회 2016 Radiation Oncology Journal Vol.34 No.3
Purpose This study is to investigate the effect of captopril when combined with irradiation. Materials and Methods 4T1 (mouse mammary carcinoma) cells were injected in the right hind leg of Balb/c mice. Mice were randomized to four groups; control (group 1), captopril-treated (group 2), irradiated (group 3), irradiated and captopril-treated concurrently (group 4). Captopril was administered by intraperitoneal injection (10 mg/kg) daily and irradiation was delivered on the tumor-bearing leg for 15 Gy in 3 fractions. Surface markers of splenic neutrophils (G-MDSCs) and intratumoral neutrophils (tumor-associated neutrophils [TANs]) were assessed using flow cytometry and expression of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 alpha (HIF-1α) of tumor was evaluated by immunohistochemical (IHC) staining. Results The mean tumor volumes (±standard error) at the 15th day after randomization were 1,382.0 (±201.2) mm3 (group 1), 559.9 (±67.8) mm3 (group 3), and 370.5 (± 48.1) mm3 (group 4), respectively. For G-MDSCs, irradiation reversed decreased expression of CD101 from tumor-bearing mice, and additional increase of CD101 expression was induced by captopril administration. Similar tendency was observed in TANs. The expression of tumor-necrosis factor-associated molecules, CD120 and CD137, are increased by irradiation in both G-MDSCs and TANs. Further increment was observed by captopril except CD120 in TANs. For IHC staining, VEGF and HIF-1α positivity in tumor cells were decreased when treated with captopril. Conclusion Captopril is suggested to have additional effect when combined to irradiation in a murine tumor model by modulation of MDSCs and angiogenesis.
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조원경,조상욱,김두인,김대업,정명영,Cho, Won Kyoung,Cho, Sang Uk,Kim, Doo-In,Kim, Dae-Up,Jeong, Myung Yung 한국마이크로전자및패키징학회 2016 마이크로전자 및 패키징학회지 Vol.23 No.1
본 연구에서는 소수성 구현을 위한 표면 거칠기가 접촉각과 접촉각 이력에 미치는 영향을 평가하였다. 초발수 특성을 극대화하기 위해, 액적이 이동하기 위해 필요한 구름저항력을 제안하였으며, 이에 대한 평가를 통하여 표면에 형성한 패턴이 접촉각 이력 및 구름저항력에 큰 영향을 주는 것을 확인하였다. 초발수 특성이 요구되는 실제 응용을 위해서는 액적의 이동에 필요한 에너지를 최소화하기 위하여 접촉각을 극대화하고 동시에 접촉각 이력을 최소화하기 위한 표면 패턴 형상의 최적화가 요구됨을 확인하였다. In this study, the effects of the contact angle (CA) and contact angle hyteresis (CAH) of planar and nano-patterned surfaces on rolling resistance of water droplet were studied. Based on the investigation on the CAH of water droplet on surfaces with various static wettability, it was found that the rolling resistance coefficient of water droplet is highly influenced by the surface pattern as well as CAH. The observed results suggest that the optimal surface patterns should be designed in order to minimize the rolling resistance of water droplet for the practical applications where superhydrophocitiy is required.
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재래종 쌀보리의 형태적 특성 및 RAPD에 의한 유연 관계 분석
조원경,이정민,권무식,정태영,Cho, Won-Kyong,Lee, Jeong-Min,Kwon, Moo-Sik,Chung, Tae-Young 한국식물생명공학회 2002 식물생명공학회지 Vol.29 No.4
재래종 쌀보리 들은 추파형이며 내한성이 약하고 장간이면서 밀수, 장망으로 출수가 늦은 품종이 많았다. 그러나 파성, 내한성, 출수기, 간장, 수장의 변이가 컸으며, 내한성이 강한 품종, uzu 유전자, 찰성, 자색종피 등 다양한 유용 돌연변이를 보였다. 재래종들의 유연관계를 형태적 특성과 RAPD분석 결과, 112품종 모두 다른 품종으로 밝혀졌으며, 재래종 쌀보리와 겉보리의 유전적 특성을 비교한 결과, 일양성이 인정되어 쌀보리 품종들이 겉보리 재래종으로부터 돌연변이 되었던 것으로 추정할 수 있었다. Barley varieties collected from 1940 to 1951 allover the Korean peninsula by Dr. Takahashi Ryuhei were reintroduced from the Research Institute for Bioresouces in Okayama University, Japan, and the evaluation of morphological characteristics and RAPD analysis were performed. Totally, 493 varieties of Korean barley landraces were planted in the green house, from which seeds of 491 varieties were harvested and conserved in the seedbank of the Rural Development Administration. Majority of the naked barley varieties showed dense spikes with long awn, late heading, winter habits, and long plant height. However, variants having various phenotypes such as short awn, blue aleurone color, brachytic type and waxyness were also identified. Plant height, spike length, and cold-tolerance in the varieties were also highly variable among them. Homogeneity tests on the variation of growth habits, spike density, anthocyanin pigmentation on the seed coat, and hairiness on leaf sheath between naked and covered barley showed that the variations of naked barley were similar to those of covered barley. It maybe indicate that the most of naked barley landraces were mutated from the covered barley landraces. Korean landraces of naked barley were broadly divided into 4 groups by the dendrogram produced by morphological characteristics; however, the identities of the group were rather indistinct. Many varieties, belonged to the same group, were showed different band patterns in RAPD analysis using 5 different primer sets. These results indicate that the 112 varieties of naked barley landraces were different genotypes.
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중년기 직장 남성의 직업에 대한 태도 - 공무원과 일반기업 종사자를 대상으로 -
조원경,한정란 한국직업교육학회 2009 職業 敎育 硏究 Vol.28 No.1
본 연구의 목적은 공무원과 일반기업 종사자를 대상으로 중년기 직장 남성의 사회인구학적 변인에 따른 직업에 대한 태도의 차이를 분석하고, 직업만족도에 영향을 미치는 변인을 분석하는 데 있다. 이 연구의 목적을 달성하기 위하여 충남 및 경기지역 일반기업 근로자 222명과 공무원 150명 등 중년기 직장 남성 372명을 대상으로 직업만족도, 직업안정성, 직업스트레스, 직업지향성 등에 관한 설문조사를 실시하였다. 본 연구의 결과 첫째, 연구 대상자들의 직업에 대한 태도는 영역별로 다소 차이가 있긴 했지만 대체로 중립범위 안에 있었다. 둘째, 사회인구학적 변인에 따른 직업태도의 차이에서 직업만족도는 50대, 배우자가 있는 경우, 자녀가 있는 경우, 경력이 많은 경우에 더 높게 나타났으며, 직업안정성은 일반기업체 종사자보다 공무원들에게 더 높은 것으로 나타났다. 직업스트레스는 50대, 250만원 이하 소득자, 자녀가 없는 경우, 6~10년 경력자들에게 더 낮은 것으로 나타났다. 직업지향성은 50대, 251~350만원 소득자, 자녀가 있는 경우, 21년 이상 경력자에게서 더 높은 것으로 나타났다. 셋째, 직업태도들간의 관계에서는 직업안정성이 높을수록, 직업스트레스가 낮을수록, 직업지향성이 높을수록 직업만족도가 높은 것으로 나타났다. 넷째, 직업만족도에 대한 영향요인을 알아보기 위하여 회귀분석을 실시한 결과 사회인구학적 변인보다는 직업에 대한 태도 변인들 그 중에서도 특히 직업지향성이 직업만족도에 중요한 영향력을 갖는 것으로 나타났다. The purpose of this study was to investigate middle-aged male workers' attitudes to their job. The subjects were 372 employed males(222 company employees and 150 civil servants) of at least 30 years old in Chungnam and Gyeonggi areas. The Findings were as follows: First, most respondents had neutral attitudes toward their job. Second, higher job satisfaction was observed from those who were in 50s, with a spouse, with children, with more career than others. Third, higher job security was observed from civil servants than company employees. Fourth, less job stress was observed from those who were in 50s, with low income, without children, with career of 6 to 10 years than others. Fifth, higher job orientation was observed from those who were in 50s, with income less than 2,500,000 won, with children, with career more than 21 years than others. Sixth, respondents with higher job security, lower job stress, and higher job orientation had higher job satisfaction. Seventh, attitudes toward job such as job security, job stress, and job orientation showed stronger impact than socio-democratic variables such as age, children, and occupation on job satisfaction. Finally, we suggested several implications for future research on the limitations of this study.
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Which Patients with Left Breast Cancer Should be Candidates for Heart-Sparing Radiotherapy?
조원경,박원,최두호,차혜정,남석진,김석원,이정언,유종한,임영혁,안진석,박연희,김지연 한국유방암학회 2018 Journal of breast cancer Vol.21 No.2
Purpose: This study aimed to identify risk factors that have significant interaction with radiation exposure to the heart, and thus to determine candidates for heart-sparing radiotherapy (RT) among women with left breast cancer. Methods: We identified 4,333 patients who received adjuvant RT following breast-conserving surgery for ductal carcinoma in situ or invasive breast cancer from 1996 to 2010. Incidence rates of cardiovascular disease were compared between left-sided and right-sided RT, and stratified by age and risk factors such as body mass index (BMI), smoking, hyperlipidemia, hypertension, diabetes, administration of anthracycline, and trastuzumab. Results: In all patients, the cumulative incidence of cardiovascular disease was greater in patients treated with left-sided RT than in those treated with right-sided RT, but the difference was not significant (p=0.428). Smoking (hazard ratio [HR], 5.991; 95% confidence interval [CI], 2.109–17.022; p=0.002) and hyperlipidemia (HR, 5.567; 95% CI, 3.235–9.580; p<0.001) were the most powerful risk factors for cardiovascular disease. There was no significant factor that further increased the risk of cardiovascular disease after left breast RT compared to right breast RT. Conclusion: Although hyperlipidemia and smoking are risk factors for cardiovascular disease, they have not been proven to increase the risk of RT-related cardiovascular disease in Korean women.
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