Mianserin에 의한 불안정 하지 증후군 4례

박원명,김용찬,백인호 大韓神經精神醫學會 1986 신경정신의학 Vol.25 No.2

This is a clinical report of 4 cases of restless legs syndrome developed in patients diagnosed as major depressive disorder by DSM-III criteria, who were treated with "Mianserin" which is known as one of the new generation tetracyclic antidepressants. With the duration of the average of 1 or 2 weeks following the administration of mianserin, all of these patients showed characteristic symptoms of restless legs syndrome which included unpleasant creeping sensation and vague discomfort on the both legs at rest typically in the evening and during the night. For the prevention of exacerbation of these symptoms, hotbag, diazepam, lowering or discontinuation of mianserin, and shifting to another antidepressants including tricyclic antidepressants had concurrently been tried and proved effective.

우울증 환자에서 Cortisol 일일변화 검사의 의의

채영래,한상익,백인호 大韓神經精神醫學會 1988 신경정신의학 Vol.27 No.4

This study was designed to investigate whether depressed patient showed increased plasma contisol level compared with nondepressed patients and to examine whether diurnal variation is preserved or flattened in depressed patients and whether diurnal variation itself could be a useful diagnostic procedure in depression. We studied also the possible relationship between the diurnal variation of cortisol secretion and the degree of symptomatic improvement with antidepressant administration in major depression patients. The results were as follows : 1) The value of serum cortisol levels checked before antidepressant administration were 8.44±4.89㎍/dl, 5.74±3.19㎍/dl, 3.18±3.54㎍/dl, 10.75±5.23㎍/dl at 12AM, 4PM, 11PM and 8AM respectively in endogenous depression group, and 6.39±3.29㎍/dl, 6.25±3.75㎍/dl, 2.74±1.85㎍/dl, 10.79±4.77㎍/dl respectively in control group. There were no significant differences in serum cortisol levels between both groups(Table 2). 2) In 31 endogenous depressives, 18(58.1%) maintained diurnal variation of cortisol level and 13(41.9%) showed flattened variation. However, of 16 control group(schizophrenics and dysthymic disorder patients), 11(68.8%) maintained diurnal variation of cortisol secretion and5(31.2%) showed flattened variation. As a result, the sensitivity, specificity and predictive value of diurnal cortisol test for endogenous depression were 42%, 67%, and 72% respectively 3) In 26 major depression patients, 11 patients who showed flattened diurnal variation of cortisol secretion had significantly high "agitative depression" factors of Hamiltion Rating Scale for Depression compared with 15 patients who maintained diurnal variation. 4) Among 15 major depression patients whose diurnal variation was preserved, 12(80.0%) showed marked improvement of depressive symptoms with antidepressant administration and 3(20.0%) did not. Among 11 major depression patients whose diurnal variation was disturbed, 6(54.5%) improved and 5(45.5%) did not. There were no significant differences in symptomatic improvement between two groups.

[행복일기] 꿀벌에게 배운다

백인호 샘터사 2010 월간 샘터 Vol.485 No.-

만성정신분열증 환자에서 우측 전두엽 전부 백질의 양성자 대사물질 변화

신경섭,최보영,이철,이창욱,이수정,백인호 대한신경정신의학회 1994 신경정신의학 Vol.33 No.3

Objects : Magnetic resonance spectroscopy is being used to survey functional activity throughout the brain and thus bring together the disparate lines of neurochemical, neuroanatomical approaches to various psychiatric illness. The most frequently reported morphometric changes in schizophrenia are in ventricle and temporolimbic tissue. Other abnormalitis reported are sulcal enlargement and alterations in whole-brain gray matter frontal lobes, subcortical structures, corpus callosum, and cerebellum. With these aspects in mind, this study was designed to test the so-called ‘hypofrontality’hypothesis, one of pathophysiology in schizophrenia in terms of neurochemical aspects. Mechods : The subjects consisted of 16 hospitalized patients who fulfilled criteria for chronic schizophrenia by DSM-IIIR-R. All subjects were further interviewed to rate the severity of clinical symptoms on Brief Psychiatric Rating Scale(BPRS), and Positive and Negative Syndrome Scale(PANESS). All were examined with localized in vivo ¹H MR spectroscopy in right prefronal white matter to measure proton metabolites and their change possibly associated with treatment. Results : The results were as follows : 1) The spectral features of some distinct proton metabolites such as NAA, Cr, Cho, Glu, GABA were clearly identified in both schizophrenics and healthy controls. 2) The mean signal intensity ratios of proton metabolites were 1.17±0.23 for Cr/Cho, 1.48±0.24, for NAA/Cho, 1.29±0.19 for NAA/Cr, 0.32±0.18 for Glu/NAA, 0.63±0.20 for GABA/NAA, 0.94±0.32 for GABA/Cho, and 0.78±0.21 for GABA/Cr, respectively in schizophrenics. The schizophrenics had significantly higher ratios of Cr/Cho, GABA/NAA, GABA/Cho, and GABA/Cr compared to controls(P=0.002, P=0.0022, P=0.001, P=0.033). Those were 0.89±0.14, 0.38±0.14, 0.53±0.21, 0.60±0.21, respectively in normal controls. However, a significant decrease in NAA/Cr ratio was found in schizophrenics(P=0.017). 3) The correlation between the signal intensity ratio of proton metabolites and symptom severity rated by BPRS showed that the higher were the BPRS scores, the higher was the ratio of GABA/Cho(P=0.05, P=0.027). However increased ratio of NAA/Cr was correlated with decrease of BPRS scores(P=-0.68, P=0.004). 4) The increase of NAA/Cr ratio was correlated with the decrease of negative symptoms assessed by PANSS(P=-0.55, P=0.029). Conclusion : In light of our results, it seems likely that the decrease of NAA/Cho ratio which would be closely associated with neuronal damage supports the hypofrontality hypothesis, and clinical symptoms would be related to the change of GABA.

땅은 팔지 마라

백인호 샘터사 2010 월간 샘터 Vol.489 No.-

청소년의 부모에 대한 기대와 만족도 : Normal Population 정상집단

백인호 大韓神經精神醫學會 1976 신경정신의학 Vol.15 No.1

Psychiatric theories suggest that child rearing practice and parent-child relationship are main clue to the development of personality. Having this kind of view in mind, this study aimed to evaluate perceived parental attitude and children's expectancy toward parents and to identify what kind of parental attitudes are more influencing on the locus of control such as internal control or external control. Perceived parental attitudes was estimated by MacDonald's Perceived Parental Attitude Scale which is revised in Korean. And in order to evaluate the expectancy toward parents the auther make up another rating scale according to the MacDonald's perceived parental Attitude Scale. Subjects are consited of 200 adolescent, 15-16 years old boys and girls. The results were as follow; 1. Eventhough there are some differences between child's perception and expectancy to parents, it seems grossly to be satisfactory. But compared with the result of MacDonald's research, principal discipline and instrumental companionship are more less than its expectancy, both sexes, in this sample. 2. Fater, compared with Mother, seems to be significantly less nurturance than expectation in male. 3. Low Locus of Control seems to be more influenced by mother's attitudes such as instrumental companionship, principal discipline, and emotional punishment. This kind of results suggest that instrumental companionship and principal discipline in concordance with achievement pressure must be considered for the desirable parent-child relationship as well as healthy personal adjustment.

[행복일기] 도둑방귀, 물럿거라!

백인호 샘터사 2011 월간 샘터 Vol.492 No.-

[행복일기] 농부의 병상일기

백인호 샘터사 2010 월간 샘터 Vol.488 No.-

恭愍王 20년의 改革과 그 性格

白仁鎬 東亞大學校 博物館 1991 考古歷史學志 Vol.7 No.-

정신분열증 환자의 음성증상과 혈청 Prolactin 값

홍승철,이철,백인호 大韓神經精神醫學會 1988 신경정신의학 Vol.27 No.5

With the development of radioimmunoassay method, one of the improved investigative laboratory tools available today, many investigators have begun to examine relationship of prolactin(PRL) to clinical features in schizophrenia. However, the reports of relating PRL to negative symptoms in schizophrenia have been scarce. This study was designed to find whether serum PRL levels measured before antipsychotics administration are related to negative symptoms. The subjects were consisted of 36 male schizophrenia by Diagnostic and Statistical Manual of Mental Disorder-Ⅲ, who were admitted to the Department of Neuropsychiatry, Dae-Gu Catholic Hospital from Sep. 1, 1986 to Mar. 31. 1987 and 17 normal men (control group). The results were as follow ; 1) Before antipsychotics administration, the serum PRL levels of a high negative symptom group(9.18±6.46ng/ml) were significantly lower than a low negative symptom group(21.81±16.22ng/ml) and control group (16.01±5.49ng/ml) (p<0.005). 2) The reciprocal correlation between serum PRL levels and negative symptoms was statistically significant(r=-0.50, p<0.001). In the light of these results, it seems that the measurement of serum PRL as a biological marker could be used in evaluating negative symptoms of schizophrenia.