유핵타원적혈구(有核楕圓赤血球)의 Hemolysis와 Fragility에 관(關)하여

신현찬 대한피부과학회 1954 대한피부과학회 학술발표대회집 Vol.6 No.-

個體發生에 있어서의 Rana nigro maculata 赤血球의 形態的變化에 關하여

申鉉鑽 慶北大學校 1966 論文集 Vol.10 No.-

By means of drawing eccentricity distribution curve, the distribution curve of the ratio of the short diameter to the long diameter and the distribution curve of the area of surface of the red blood cells under the microscope in each stage of the development of Rananigro-maclata follow sesults are obtained. In each stage of the development of Rana nigromaculata mountain shape above mantioned three kind distribution curves have been drawn. But the locations of those curves move as the development of individual goes. In the stage of tadploe most of red blood cells are round or nearly round, but the number of those red blood cells decreases and the number of the red blood cells the eccentricity of which are greater increases as the development of individual goes. On the area of surface of the red blood cell under the microscope, the number of the red blood cells the area of surface of which are greater decreases and the number the red blood cells the area of surface of which are smaller increases as the development goes in the stage of tadpole, but in the stage of frog the number of the red blood cells the area of surfaca of which are greater increases and the number of the red blood cells the area of surface of which are smaller decreases as the develoment of individual goes.

75Se-Selenomethionine을 이용한 췌장주사에 관한 연구

신현찬,도상희,나우연,서철성 대한핵의학회 1968 핵의학 분자영상 Vol.2 No.1

췌장질환의 진단상 췌주사의 의의를 알기 위하여 23예에서 췌주사를 행하고 이 성적을 종합하면 다음과 같다. 1) 19예에서 사용한 방사성 75Se-Selenomethionine이 충분히 췌내에 농축되어 췌영상이 잘 나타났고, 1예에서 섭취가 저하되었었고 2예에서 섭취가 저하됨과 동시에 췌조직의 충만결손을 보였고 1예에서 췌체부위가 상부로 환상으로 이동되어 있었고, 1예에서 묘사가 되지 않았다. 2) 방사성 물질의 섭취가 낮았던 1예에서 담관 및 담낭의 병변이 있음이 증명되어 췌장과 밀접한 관계가 있음을 알 수 있다. 3) 2예에서 췌조직이 충만결손을 보였으나 1예는 췌낭종이 증명되었지만 1예는 환자의 수술 거절로 확인되지 않았다. 4) 1예에서 췌장의 묘사가 되지 않아서 기능성 췌실질이 없음을 알았고 췌암이 확인되었다. 5) 2예에서 십이지장환의 광대가 위장 검사상에서 나타나 췌장주사를 행했으나 정상 영상을 얻어 췌질환을 배제할 수 있었다. 6) 1예에서는 췌체부위가 상부로 환상으로 이동되어 췌조직에 대한 방사성 물질의 충만결손같이 보였으나 그 부위에 상부 장문막동맥증후군이 증명됨으로서 췌묘사가 완전한 경우에는 충만결손과 췌암에 대해서는 감별진단에 주의가 요함으로 사료 Radiographic visualization of the pancreas is a difficult problem, but the direct visualization of the pancreas is possible by the injection of the amino-acid methionine tagged with selenium^(75) (Se^(75)). In order to know the diagnostic value of pancreas scanning, scans were performed on 23 cases using selenium^(75)-Selenomethionine. These cases were also given egg white, probanthine and morphine. 1) Good visualization of the pancreas scanning was observed on 19 cases, presumably with normal pancreas. 2) A case which showed diffusely decreased uptake on pancreas scanning was proven to have lesions in the bile duct and the gall bladder. 3) Of those two cases which showed localized cold area, ond had pancreas cyst and the other one was not explored. 4) A case which showed no visualization of the pacreas was proven to have pancreatic carcinoma. 5) Two cases which showed widened duodenal loop by upper gastro-intestinal series revealed normal pancreas scanning, and no pancreatic disease was found in both cases. $quot;

Ether 全身麻醉와 Barbital Sodium 및 Thiopental Sodium의 In Vitro 添加가 家兎 赤血球의 酸素消費量에 미치는 影響

申鉉鑽 慶北大學校 1975 論文集 Vol.20 No.-

It has been reported that the addition of some barbiturate derivatives enhances potassium transport through the red cell membrane and inorganic phosphate level of the red cell. However, little has been known of the effect of barbiturate derivatives on the oxygen consumption rate (QO_2) of the red cell. In the present study, the changes in the QO_2 of the rabbit red cells were measured by the standard Warburg manometric methods following subjecting the rabbits to the general ether anesthesia, and adding barbital sodium or thiopental sodium to the blood of the rabbit. A comparision was made with the normal group where the QO_2 of the normal rabbit blood was measured, and with the control group where the red cells were mixed with saline only. The results thus obtained are as follows: 1) QO_2 of the normal group showed a tendency of a gradual decrease as the experiment proceeded, the values being 1.01± 0.32×10 exp (-9) ㎕ O_2/RBC/10 min in the first 10 min, and 0.43±0.17×10 exp (-9) ㎕ O_2/RBC/10 min in the last 10 min. 2) QO_2 of the control group were less than the normal as 0.70±0.22×10 exp (-9) ㎕ O_2/RBC/10 min in the first 10 min and 0.33± 0.14×10 exp (-9) ㎕ O_2/RBC/10 min in the last 10 min. 3) The general ether anesthesia produced a significantly lower values of QO_2 comparing with the normal regardless of the degree and time after the anesthesia. 4) The addition of barbital sodium in the concentratration of 1 : 1600 resulted in the lower QO_2 than the control. 5) The QO_2 were found to be increased with the addition of barbital sodium in the concentration of 1 : 2400. 6) Generally elevated QO_2 levels were observed with the addition of thiopental sodium in the concentration of 1 : 800. 7) A tendency of the decreased QO_2 levels were observed with the addition of thiopental sodium in the concentration of 1 : 1200.

X―線照射가 사람, 家兎및 닭의 赤血球의 酸素消費量에 미치는 影響

申鉉鑽 慶北大學校 文理科大學 1974 文理學叢 Vol.2 No.-

The oxygen consumption rates (QO_2) of the normal erythrocytes of the man, rabbit and hen were measured with the Warburg manometric method and compared each other. The mean corpuscular hemoglobin contents (MCHC) and the mean corpuscular volumes (MCV) of the normal erythrocytes of the man, rabbit and hen were also measured and compared each other. The QO_2 of 1000r. X-irradiated erythocyte of the man, 1000r, 12000r and 1500r X-irradiated erythrocytes of the rabbit and hen were measured and compared with the control. The results obtained are summarized as follows: 1) The QO_2 of the normal erythrocytes of the man and rabbit which are anucleate erythroyctes were generally similar, and the QO_2 of the normal erythrocytes of the hen which is nucleate erythrocyte was about four times greater than the QO_2 of the normal erythocytes of the man and rabbit. 2) The MCHC and MCV of the normal erythrocyte of the rabbit were generally smaller than those of the normal erythrocytes of the man and hen, and the MCHC and the MCV of the normal erythrocytes of the man and hen were almost similar. 3) The QO_2 of 1200r and 1500r X-irradiated erythrocytes of the hen were decreased comparing with the control. 4) The QO_2 of 1000r X-irradiated erythrocyte of the man and 1000r, 1200r and 1500r X-irradiated erythrocytes of the rabbit decreased comparing with the control but they were statistically not significant from the controi.

원발성 난관상피내암

신현찬 ( Sin Hyeon Chan ),정철권 ( Jeong Cheol Gwon ),주장오 ( Ju Jang O ),김창운 ( Kim Chang Un ),엄상탁 ( Eom Sang Tag ),박경도 ( Park Gyeong Do ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.10

Primary carcinoma of the fallopian tube is the rarest cancer of the female genital tract with an incidence of 1% all gynecologic tumors Moreover, adenocarcinoma in situ of fallopian tube accounts for approximately 1% of primary fallopian tube cancer. Ovar

최소자승법을 적용한 도어 개폐 험 데이터의 보정 및예측 알고리즘

신현찬(Hyun-Chan Shin),양학진(Hac-Jin Yang),김성근(Seong - Kun Kim) 호서대학교 공업기술연구소 2016 공업기술연구 논문집 Vol.35 No.1

차량이 위치하고 있는 다양한 경사조건에 따라 사용자가 도어에 가하는 개폐 힘을 평지와 같도록 하기 위해 개폐보조 힘을 예측하는 모델을 제안하였다 . 학습에 앞서 모의실험장치로부터의 데이터는 외부 요인에 의한 오차를 가질 수 있다고 판단하였다 . 이러한 문제를 해결하기 위해 최소제곱법을 이용하여 구간마다 최댓값을 보정하였고 , 예측 값의 정확도를 높이는 방안을 제안하였다 . 그에 따른 결과를 인공신경망 모델을 통하여 검증하였고 예측 신뢰 도를 높였다 . 이와 같은 알고리즘 검증을 통하여 사용자가 평지와 유사한 힘으로 도어를 효과적으로 제어하도록 돕는 방안을 제시하였다 . \Ve proposed prediction model of assistance force for the user when use the automobile door to assist the deviation of required door force in the slope condition as needed in the plane condition. Before the training of data we supposed the data can have some error by external factors. So we used Least Squares Method(LSM) to resolve it and proposed the plan can improve accuracy of the prediction force data by revising maximum value. We validated the result Artificial Neural Network(ANN) and improved confidence of prediction force. As a result we proposed to control the door as a similar force regardless of a slope condition.

The Study on the Hypotonic Fragility of the Nucleate Elliptical Erythrocytes

Shin, Hyun-Chan 慶北大學校 1962 論文集 Vol.6 No.-

본연구 제일부에 있어서 유핵타원적혈구를 가진 각종 동물들의 적혈구의 점감적 저장식염농도에 있어서의 용혈도로서 취약분포곡선을 그리고, 제이부에 있어서 제일부의 결과의 원인을 밝히고자 타원적혈구의 이심률과 경하표면적을 구함으로써 다음과 같은 결론을 얻었다. 1. 적혈구취약분포곡선을 작도함으로써 유핵타원적혈구의 저장취약성을 더 명료히 했다. 2. 유핵타원적혈구에 있어서도 무핵원형적혈구와 같이 산형인 부약분포곡선이 그려졌다. 3. 유핵타원적혈구의 저장저항성은 무핵원형적혈구의 그에 비하여 높다. 즉 각종 동물의 적혈구의 최고취약빈도가 위구하는 식염농도는 양서류, 파충류, 조류, 조류 급 포유류의 순으로 낮았다. 4. 유핵타원적혈구에 있어서는 기 이심률과 경하표면적이 클수록 저장저항성도 길다. 5. 이종동물의 혈액에도 존재하는 저장저항성이 상등한 적혈구들의 백분비를 선명하게 했다. 6. 유핵타원적혈구를 가진 동물들의 혈액에는 무핵원형적혈구를 가친 동물에 비하여 저장저항성이 상리한 더 많은 종류의 적혈구들이 있었다.

개구리(Rana nigromaculata)肝細胞內 Phosphoenolpyruvate Carboxykinase의 分布에 關하여

曺準承,申鉉鑽 慶北大學校 1975 論文集 Vol.20 No.-

In the present study the existence and subcellular diststribution of the phosphoenolpyruvate (PEP) carboxykinase in the liver of the frog were investigated and compared with those in the livers of the several animals. The results thus obtained are as follows. 1. The considerable amount of PEP carboxykinase was detected from the liver of the frog, the activity of this enzyme was 50.100 cpm/min /g liver, and this enzyme was contained in the mitochondria and the cytoplasm of the liver cell of the frog. 2. About 74% of PEP carboxykinase in the frog liver cell was contained in the mitochondria, and 26% was in the cytoplasm. The mitochondria in the frog liver cell contained three times as much enzyme as the cytoplasm. 3. The activity of PEP carboxykinase was highest in the liver of the chicken and became lower in the order of the rabbit, dog, cattle, frog and mouse. In the liver cells of the chicken and frog the mitochondria contained more enzyme than cytoplasm. However, in the liver cell of mouse the cytoplasm contained more enzyme than the mitocondria. In the case of the rabbit, dog and cattle, the amount of this enzyme in the mitochondria and cytoplasm was similar.

韓國在來 雜種成犬의 數種 生理値에 關하여

崔瓊淑,申鉉鑽,金亨洙,李在福 경북대학교 의학연구소 1969 慶北醫大誌 Vol.10 No.1

Mongrel dog is one of the commonly using experimental animal and particularly is favorable for cardio-pulmonary research study. However, control laboratory data in Korean mongrel dogs are variable with papers reported. Present study attempted to prescribe the normal range of some laboratory data in anesthetized Korean mongrel dog. 25mg/kg of sodium thiopental was used as intravenous anesthetics. Respiratory rate and minute ventilation were measured on pneumogram recorded by means of Krog's spirometer, oxygen consumption was measured using Krog's spirmeter installed with sodalime and oxygen bag. Oxygen capacity and saturation of arterial blood were analysed according to the methods of VanSlyke and Neill. Heart rate was counted on electrocaridiogram, arterial pressure was monitored by mercury manometer and cardiac out put was measured according to the Fick principle. Blood volume was measured by dulution method using redioactive chromium tagged red cells. The number of red blood cells and white blood cells were counted by means of Thoma-Zeiss homocytometer and hematocrit was measured using microhematocrit centrifuge and it's reader. Mean value and range(parenthesis) of measured laboratory data are as follows: Respiratory rate; 19.92(11-34)/min., minute ventilation: 336.87(93-638) ml/kg. oxygen consumption; 7.95(4-10.22) ml/min/kg, arterial O_2 capacity and saturation; 18,69 (13.5-23.0) vol. % and 82.3(69-93.5%), heart rate; 183 (100-250)/min, mean arterial pressure; 155.5 (125-190)mmHg, circulating blood volume; 87.79(66.4-119.1) ml/kg, number of red cells and white cells; 773.44(568-1000)×10 exp (4)/㎣ and 14.55(7-27)×10 exp (3)/㎣, hematocrit; 45.36(31-62.8)%, ratio of arterial hematocrit versus venous hamatocrit; 1: 0.98, resectively.