http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
박창현,김수영,김만수 대한안과학회 2014 Korean Journal of Ophthalmology Vol.28 No.5
Purpose: To determine effectiveness of laser-assisted in situ keratomileusis (LASIK) in the treatment of astigmatismfollowing penetrating keratoplasty (PK). Methods: We performed a retrospective review of medical records of patients who underwent LASIK followingPK and had over 1 year of follow-up data. Results: Twenty-six patients (26 pairs of eyes) underwent LASIK following PK. Mean age of the patients at thetime of LASIK was 40.7 years (range, 26 to 72 years). Following LASIK, the mean cylinder was reduced by2.4 diopters and mean reduction of cylinder after LASIK was 65.4% from the preoperative values at the lastfollow-up visit. Uncorrected visual acuity became 20 / 50 or better in 69.2% of the eyes after LASIK. Best-correctedvisual acuity became 20 / 50 or better in 73.1% of the eyes after LASIK. All of them were intolerableto contact lenses before LASIK. After LASIK, 6 pairs (23.1%) did not need to use contact lenses and 18 pairs(69.2%) were tolerable to using contact lenses or spectacles. There were no significant endothelial cell densitychanges 12 months after LASIK (p = 0.239). Conclusions: LASIK is effective in the treatment of astigmatism following PK and increases contact lens andspectacle tolerance.
박창현,김현승,김미금,김은철,김재용,김태임,김홍균,송종석,윤경철,이도형,이형근,정태영,최철영 대한안과학회 2019 Korean Journal of Ophthalmology Vol.33 No.4
Purpose: To evaluate the efficacy and safety of cyclosporine nanoemulsion 0.05% compared to cyclosporine emulsion0.05% and diquafosol sodium 3%. Methods: This was a multicenter, randomized, evaluator-masked, active control, parallel, phase IV study. A total of227 patients were randomly allocated to instill cyclosporine nanoemulsion 0.05% (CN) twice daily, cyclosporineemulsion 0.05% (CE) twice daily, or diquafosol sodium 3% (DQ) six times daily. Non-inferiority of CN was analyzedby primary endpoint (cornea and conjunctival staining scores at week 12). The secondary endpoints were scoresof corneal staining, conjunctival staining, tear break-up time, Schirmer test, and Ocular Surface Disease Index atweeks 4 and 12. Results: Primary endpoints showed statistically significant improvements in all groups. Primary endpoints were -6.60for the CN group, -5.28 for the CE group, and -6.63 for the DQ group (National Eye Institute scale from 0 to 33), verifyingthe non-inferiority of CN compared to CE (95% confidence interval, -0.15 to 2.80, Δ>-2.88). In intergroup comparisonbetween CN and CE groups, the CN group had significantly more decreased conjunctival staining score atweek 12. Intergroup comparison between CN and DQ groups showed consistent statistically significant improvementsin TBUT and Schirmer test in the CN group. In the DQ group, TBUT showed late statistically significant improvementat week 12 and Schirmer test showed relatively short-term statistically significant improvement at week 4. Conclusions: Cyclosporine nanoemulsion 0.05% was equivalently efficient compared to cyclosporine emulsion 0.05%and diquafosol sodium 3%. In addition, CN showed significant improvements in several parameters for treatment ofdry eyes.