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      • 抗-histamine劑로 因한 흰쥐 腸間膜 肥滿細胞의 Degraunlation에 關하여

        姜浩錫,文炳烈,方爀,朴滿洙,朴秀淵 최신의학사 1968 最新醫學 Vol.11 No.7

        The tissue mast cells, which contain metachromatic or orthochromatic granules in the cytoplasm, have baen described in the literature as a source of heparin, histamine, hyaluronic acid, serotonin and certain mucopolysaccharides. The metachromatic granules of the mast cells in the connective tissue were readily diffused or degranulated from the cells by certain chemical administration. It is well known that the histamine was liberated by the administration of histamine liberators, such-as compound 48/80 and others associated with degranulation of the mast cells. Additionally it was reported that the concentration of histamine in blood was increased after the administration of various antihistamines. However, the accompanying histological feature of mast cells due to administration of various antihistamines was controversial according to the authors. The present experiment was undertaken to find out whether antihistamine releases the metachromatic granules from the mesenteric mast cells in albino rats after administration of the antihistamine. Chlorpheniramine(0.6 mg. /kg.) in normal saline solution and Tyrode solution was intravenously and intraperitoneally given in a single dose. The mesenteric mast cells were stained in Pugh's solution containing toludine blue which was applied by Lee (1968). The results were as follows: 1. In the experimental group of chlorpheniramine giN en intravenously, slight or moderate degranulation of the mast cells shoved with the incidence of the normal mast cells occurring about (90.21-5%) compared with an incidence of 98.20.2% in the control group. 2. In the experimental group of chlorpheniramine given intraperitoneally, slight degranulation of the mast cells occurred with the incidence of the normal mast cells counting about 92.74-1.2% compared with an incidence of 95.7.12.0 % in the control group. Consequently~it is deduced that the experimental dosage of . antihistamine, chlorpheniramine maleate applied by Lee et al. (1960) caused an evident degranulation of the mesenteric mast ceIIs of the albino rats associated with the probable histamine liberation.

      • 韓國人에 있어서 反回神經과 下甲狀動脈과의 局所解剖學的 關係에 對한 觀察 -第2報-

        李圭植,文炳烈,朴萬洙,方爀,朴秀淵 최신의학사 1969 最新醫學 Vol.12 No.2

        The topographical relationships between the recurrent laryngeal nerve and the inferior thyroid artery in 54 Korean cadavers, which were used for dissection in Yonsei University from 1964 to I 1968, were studied. { 1. The most f requent type of the relationship, in which the recurrent laryngeal nerve passed behind the inferior thyroid artery, was Type 11 and found in an incidence of 43.4% in the right sides and 47.6% in the left sides. 2. The Type, 2, which was secondly found and in which the recurrent laryngeal nerve passed between the terminal twings_,of :the inferior hyroid artery, was found in an incidence of 37.7% in the right sides and 33.3% in the left sides. 3. The Type 1, which was thirdly found and in which the recurrent laryngeal nerve passed in front of the inferior thyroid artery, was occurred in an incidence of 13.2% in the right sides and j 11.9% in the left ones.

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