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최성준,오소희,윤현선 대한피부과학회 2022 Annals of Dermatology Vol.34 No.3
Background: With accumulating evidence that achieving a 90% improvement in the Pso- riasis Area and Severity Index score (PASI90) has better correlation with improved health- related quality of life as compared to PASI75 achievement, there has been demand for estab- lishing new treatment goals for psoriasis. Objective: We investigated whether the short-term PASI90 achievement would predict lon- ger drug survival as compared to PASI75 achievement. Methods: This single-center retrospective cohort study reviewed 180 treatment series in 128 patients with plaque psoriasis, who were treated with tumor necrosis factor-alpha inhibitors (n=12), ustekinumab (n=88), secukinumab (n=23), guselkumab (n=45), and ixekizumab (n=12). The first effectiveness assessment, usually performed within 12 to 20 weeks, was considered a short-term treatment response to biologics. Results: After adjustment for covariates, time-dependent Cox proportional hazards re- gression analysis showed that moderate responders (short-term achievement of ≥PASI75 but <PASI90) were more likely to discontinue therapy than the excellent responders (short-term achievement of PASI90; adjusted hazard ratio, 3.159; 95% confidence interval, 1.180~8.457; =0.0220). Conclusion: The short-term PASI90 achievement is a better predictor of longer drug sur- vival as compared to PASI75 achievement.
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최성준,지차호,나기정 한국동물위생학회 2011 韓國家畜衛生學會誌 Vol.34 No.3
Wildlife has been recognized that has important role as reservoir hosts of disease affecting both people and livestocks. However, information intestinal helminths of Korean water deer were limited. We obtained 20 feces from Korean water deers that were transferred to veterinary hospital in Chungbuk National University from May 2010 to June 2011. Parasite ova were collected using saturated zinc sulfate floatation method. Parasite eggs were examined and measured using light microscope. The identification of parasitic eggs was done by morphological characters. The overall infection rate of parasite was 85%(n=17). The eggs were observed as being Nematodirus spp.(n=14), strongyles egg(n=11), Capillaria spp.(n=9), Trichuris spp.(n=7), Eimeria spp.(n=4), Ogmocotyle spp.(n=3), and Strongyloides(n=1). Mixed infection rate was observed as being single 15%(n=3), double 20%(n=3), triple 15%(n=3), quadruple 30%(n=6), and quintuple 5%(n=1). The Ogmocotyle spp. was first reported in Korea.
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최성준,이동호 대한노인병학회 2012 Annals of geriatric medicine and research Vol.16 No.3
Oral antibiotics are usually prescribed for geriatric patients for the treatment of infectious diarrhea and management of hepatic encephalopathy. But oral antibiotics have systemic adverse events, so many doctors face the issue of choosing the right antibiotics. Rifaximin, an intestinal topical antibiotic that exhibits a wide antimicrobial activity against both aerobic and anaerobic bacteria, has various indications, such as acute bacterial diarrhea caused by Gram positive and negative bacteria, traveler’s diarrhea, small intestine bacterial overgrowth, prevention of infection after gastrointestinal surgery, and the management of hepatic encephalopathy with hyperammoniemia. But there are few clinical trial data on the geriatric population. Hence we reviewed the clinical study data that included geriatric patients in their clinical trials. Based on our literature searches, only one clinical trial on acute bacterial diarrhea was performed only for geriatric patients. Other clinical trials for various indications usually recruited elderly patients, but the number of elderly patients was limited. However, generally speaking, rifaximin showed good efficacy and safety profile in acute bacterial diarrhea caused by Gram positive and negative bacteria, traveler’s diarrhea, small intestine bacterial overgrowth, prevention of infection after gastrointestinal surgery, and the management of hepatic encephalopathy with hyperammoniemia; and there were no differences in efficacy and safety, compared to the nongeriatric population. We concluded that rifaximin is a good therapeutic option for various gastrointestinal indications, and shows good efficacy and an excellent safety profile, compared to other oral agents. For more evidence on the geriatric population, we propose clinical trials on elderly patients for each indication. 리팍시민은 그람양성균 및 그람음성균에 의한 급성 장염,장내 세균상의 이상으로 인한 설사(여름철 설사, 여행자 설사,소장결장염), 위장관 수술 전, 후 감염의 예방, 고암모니아혈증 치료의 보조 요법에 폭넓게 사용되어 왔으나, 임상 시험의 근거는 노인 환자에게 그리 많지 않았으며 노인 환자를대상으로 한 연구는 급성 세균성 설사를 대상으로 한 하나의연구에 불과하였다. 그러나 다양한 적응증에 대한 많은 임상시험에서는 대부분 노인 환자가 소수이지만 포함되어 있었고,리팍시민의 특성으로 살펴보면 체내 흡수가 거의 되지 않는장점으로 적응증 및 그 외의 소화기 질환에서 확실한 유효성을보이면서도 위약과 유사한 안전성 프로필을 보여주고 있다. 이런 점이 노인 환자에서 리팍시민을 안전하게 사용할 수있다는 간접적인 증거를 제시하고 있다고 할 수 있겠다. 이논문의 제한점은 고연령군의 환자에서 약제의 안전성 및 유효성에 대한 언급을 하기 위해서는 연령별 대조군 연구 및 메타분석의 통계적 분석이 필요하나, 노인 환자에 대한 자료가많지 않고, 또한 원 자료에 대한 접근이 가능하지 않아서시행되지 못한 점이다. 향후 이 점은 보완의 가능성을 염두에두고 있다. 또한 확증적인 추가적인 근거의 확보를 위하여특히 우리나라에 많은 과민성 장 증후군, 간성 뇌증 환자중 노인 환자에 대한 임상 시험이 더 시행된다면 그 근거의신뢰가 더 높아질 것이며, 이로 인하여 리팍시민과 같은 경구용 항생제의 적절한 사용례가 증가할 것으로 사료된다.
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A Posterior Petrous Meningioma with Recurrent Vertigo
최성준,이종빈,배준호,윤정희,이호진,김찬호,박기현,정연훈 대한이비인후과학회 2012 Clinical and Experimental Otorhinolaryngology Vol.5 No.4
Meningioma’s account for around 15% of all primary brain tumors with some 10% of meningiomas arising in the posterior fossa. In rare cases, a meningioma can form around the endolymphatic sac. When formed in the posterior fossa, meningioma tumors can produce vague, non-specific vertiginous symptoms. Research has observed that a subset of these lesions could produce symptoms indistinguishable from those of Ménière’s disease. Therefore, we described the clinical features of a case of posterior petrous meningioma with recurrent vertigo as well as the substantial resolution of symptoms after tumor removal via transmastoid approach.
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최성준,전은석,황승덕 한국심초음파학회 2001 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.9 No.2
Autosomal dominant polycystic kidney disease is a systemic disorder with cystic manifestations in the kidneys, liver, pancreas, seminal vesicles, and meninges;its noncystic manifestations affect mostly the vascular, cardiac, and connective tissues. Cardiovascular abnormalities, including mitral and aortic valvular prolapse and regurgitation and annuloaortic ectasia, have been considered important extrarenal manifestations of autosomal dominant polycystic kidney disease. But there were no reports with dilated cardiomyopathy in patients with polycystic kidney disease yet. We have experienced a case of dilated cardiomyopathy that is associated by autosomal dominant polycystic kidney disease in 40year old male patient. Abdominal ultrasonography revealed variable sizes of multiple cysts in both kidneys and echocardiography showed the marked dilatation of left ventricle and severely depressed left ventricular systolic function (ejection fraction=19%). He was treated with diuretics intravenously and orally. Then dyspnea and abdominal distension was improved. This is the first case of dilated cardiomyopathy with autosomal dominant polycystic disease in Korea
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열기반 DBMS를 위한 SIMD 명령어 기반의 효율적인 검색 연산자
최성준,민준기 한국정보과학회 2017 데이타베이스 연구 Vol.33 No.3
Data processinng techniques utilizing SIMD (Single Instruction Multiple Data) for efficient data processing in relational operations have been studied. SIMD is a representative parallelization method that loads multiple data into a SIMD register and process them simultaneously with SIMD instructions. As a basic relational operation in the database, scan operation selects the data satisfying a given query condition. In this paper, we propose a SIMD-based scan by using minimal branch condition resulting in reducing the performance degradation due to misprediction and by utilizing SIMD instructions to achieve data parallelism. In addition, we implement our proposed SIMD-based scan on a commercial column-oriented DBMS MonetDB and show the efficiency of our proposed SIMD-based scan. 관계 연산에서 효율적인 데이터 처리를 위해 SIMD (Single Instruction Multiple Data)를 활용하는 데이터처리 기법에 대하여 연구가 진행되어 왔다. SIMD는 SIMD 레지스터에 복수 개의 데이터를 적재하고 SIMD 명령어로 동시에 처리하는 대표적인 병렬화 방법이다. 검색 연산은 데이터베이스에서 기본적인 관계 연산으로 질의에서 주어진 조건을 만족하는 데이터만을 검색하는 연산이다. 본 논문에서는 분기를 최소화하여 분기 예측 실패로 인한 성능 저하의 유발을 최소화하고 데이터 병렬화를 이루기 위해 SIMD의 명령어들을 활용한SIMD 기반의 검색을 제시한다. 더불어, 제안한 SIMD 기반의 검색을 상용 열 기반 DBMS (Database Management System)인 MonetDB에 적용하고 실험을 통해 본 논문에서 제안하는 SIMD 기반의 검색이 효율적임을 보였다.
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