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치료를 받은 적이 없는 HIV 환자에서 항HIV 약제 내성
오명돈 ( Myoung Don Oh ) 대한내과학회 2007 대한내과학회지 Vol.73 No.3
Antiretroviral therapy for treatment of human immunodeficiency virus type 1 (HIV-1) infection has improved steadily since the introduction of combination therapy in 1996. With the advancement of antiretroviral therapy, the mortality of AIDS patients has markedly improved. However, drug resistance has been emerging as a major problem in HIV treatment. Several studies reported that the prevalence of transmitted resistant virus involving antiretroviral-naive people in developed countries was around 10%. Primary drug resistance is rare in HIV-1 infected patients in Korea. A cohort study is need to monitor resistant HIV-1 among newly infected individuals.(Korean J Med 73:235-236, 2007)
새로운 항생제 개발을 위한 일부 동의 약제의 항균력 검색
오명돈,김성민,신형식,최강원 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.2
Water or methanolic extracts of twenty herbs were screened for antoibacterial activity against ten pathogenic bacteria(S. aureus, S. pneumoniae, S. pyogenes, S. faecalis, E. coli, K. pneumoniae, P. vulgaris, P. aeruginosa, S. typhi, H. influenzae) by broth microdilution susceptibility test. Two of them-methanolic extract of the Lithespermum and Polygonum-were found to exhibit relatively broad antibacterial activity. But, neither CH₂CI₂ nor H₂O parts of methanolic extracts of them showed significant antibacterial activity.
오명돈 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1
Nalidixic acid를 비롯하여 oxolinic acid, cinoxacin 같은 1960년대에 처음 나온 퀴놀론들은 항균 영역이 좁고, 내성균이 곧 나타난다는 단점 때문에 널리 사용되지 못하고 주로 요로 감염중의 치료에 사용되었다. 1980년대에 개발된 새로운 퀴놀론계 항균제들은 항균 영역이 넓고, 경구 투여로 높은 혈중 농도를 얻을 수 있으며, 비교적 안전하다는 장점이 있어여러 감염증의 치료에 널리 사용되어 최근 수년 동안 그 사용량이 급속히 증가하고 있다.
후천성 면역부전증후군 환자에서 발생한 Cryptosporidium parvum 감염 2예의 보고
오명돈,최강원,신형식,김성민,최희정,강현재,김윤준,채종일 대한감염학회 1996 감염 Vol.28 No.5
Cryptosporiduim is an intracellular protozoan parasite and known as an important pathogen causing diarrheal illness in animals and man since 1970's. With the advance of epidemic of Acquired Immunodeficiency Syndrome(AIDS), Cryptosporidium has emerged as one of important pathogens in AIDS patients and is responsible for chronic diarrhea, cholecystitis, biliary tree obstruction and respiratory illness. Despite frequent reports of cryptosporidial diarrhea in other countries there has been no report of human cryptosporidial infection in AIDS patients so far in Korea. We report two cases with chronic cryptosporidial diarrheal illness in AIDS patients. C. parvum oocyst was identified by fecal smear with modified acid fast staining. In one patient the diarrheal illness was improved after 4 weeks supportive management only. But fecal excretion of oocyst continued after clinical improvement of the diarrheal illness. Another patient was died of respiratory failure after recurrent diarrheal illness. Cryptosporidial infection should be considered in differential diagnosis of chronic diarrhea especially, in AIDS patients.
임상검체에서 분리한 황색포도상 구균의 항생제 Tolerance에 관한 연구
오명돈,최강원,고창순 대한화학요법학회 1985 대한화학요법학회지 Vol.3 No.2
Cell-wall inhibitor can rapidly kill and many case lyse susceptible bacteria. But in tolerant strain, bactericidal antibiotics act primarily as bacteristatic agents. Determination of minimal bactericidal concentration(MBC) of antibiotics is important because infection in immunocompromised host may require bactercidal rather than bacteriostatic antibiotic level. Thirty-five Staphhlococcus aureus were isolated from various clinical specimens and MBC of cephalothin, gentamicin, methicillin, vancomycin was determined by macobroth dilution method. Time-kill curve was made by counting survior at 0, 4, 8, 24h of incubaton in minimal inhibitory corcentration(MIC) of antibiotics. By NCCLS criteria, 22, 13, 24, 32 stains of 35 S. aureus were susceptible to cephalothin, gentamicin, methicillin and vancomycin, respectively. Among the suscoptible strains, tolorance rate of each antibiotics were 10/22, 0/13, 14/24, 13/32, respectivly when S. aureus was defined as being tolerant if the ratio of MBC/MIC is greater than or equal to 32. By time-kill curve, 15/22, 1/13, 12/24, 12/32, were tolerant to cephalothin, gentamicin, methicillin and vancomycin, respectively. By MBC/MIC and time-kill curve method, 17/22, 12/13, 20/24, 23/32 showed the same tolerance to cephalothin, gentamicin, methicillin and vancomycin, respectively. The climical significance of these tolerant strains of S. aureus couldn't be evaluated in this study.
오명돈,최강원 대한감염학회 1991 감염 Vol.23 No.1
To estimate the prevalence of Tsutsugamushi disease, we tested sera from 312 residents (150 residents who live in Jawoon-ri, Nae-myon, Hongcheon-goon, Kangwon-do, 85 in Daeboo-do, Ongjin-goon, kyunggi-do, and 77 in Sagock-ri Chilsung-myon, Goesan-goon, Choongchungbook-do). These three villages are located in the remote rural area in the central part of Korea. L-929 cells were infected with Gilliam, Karp, Kato, and B119, a strain isolated from a Korean patient, respectively. After about 10 days L cells were harvested and pooled to make antigens which have three prototype (ie, Gilliam, Karp, Kato) and one local strain (B119). L cells were coated on 12 well slides and indirect fluorescent antibody test were performed with goat anti-human IgG and IgM antibodies. Ten (6.7%) out of 150 sera from Jawoon-ri, 4(4.7%) of 85 from Daeboo-do, and 3(3.9%) of 77 from Sagock-ri were reactive at 1:20 dilution to anti-IgG antibody. But no sera were reactive to anti-IgM antibody.