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구자윤,이찬호,하홍구 대한비뇨의학회 2015 Investigative and Clinical Urology Vol.56 No.11
Purpose: To evaluate the oncologic outcomes between adjuvant radiotherapy (ART) and salvage radiotherapy (SRT) in patients with locally advanced prostate cancer or with adverse pathologic factors including positive surgical margin and high Gleason score. Materials and Methods: We searched the literature published from January 2000 until December 2014 at MEDLINE, PubMed, Web of Science, Embase, ProQuest, and Cochrane Library. To be specific, included were studies comparing ART and SRT settings if they followed up oncologic outcomes more than 5 years. Results: Overall, 3 retrospective, nonrandomized, observational studies, 1 matched control analysis, and 3 prospective randomized controlled studies met our inclusion criteria including a total of 2,380 patients (1,192 ART vs. 1,188 SRT). Higher favorable results were found in ART than in SRT was seen in the 5-year and 10-year biochemical recurrence (BCR)-free survival (risk ratio [RR], 0.61 and 0.70; 95% confidence interval [CI], 0.54-0.69 and 0.63-0.76). ART had a significantly higher 5-year progression-free survival rate than that in SRT (RR, 0.64; 95% CI, 0.51-0.80), but this was not the same for the 10-year progression-free survival rate (RR, 0.88; 95% CI, 0.72-1.08). There was no significant difference for the 5-year and 10-year overall survival rates between ART and SRT (RR, 0.80 and 0.94; 95% CI, 0.59-1.07 and 0.80-1.11). Conclusions: ART showed favorable results in BCR-free survival during the 5-year follow-up period. However, the 10-year progression-free survival and overall survival did not show any difference between ART and SRT.
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구자윤,기우천,최재갑 대한안면통증구강내과학회 1998 Journal of Oral Medicine and Pain Vol.23 No.1
Personality characteristics were studied by means of SCL-90-R test, Behavioral problem and pain site was studied Isleep disturbance, irregular eating habit, decreased physical activity, decreased social activity, increased emotional tension) by examination sheets. This study was conducted to examine the mature and extent of psychological difference between the students who failed the college-entrance examination and freshment and to determine whether psychological distress acts as a precipitate for craniocervical pain. 96students who failed the college-entrance examination (examination-failed student) and 86 freshmen were included in this study. The obtained results were as follows : Mean T-score of SCL-90-R primary scaled and global Indies in examination-failed students were significantly higher than the freshmen group. In comparison with examination-failed student group, the prevalence of neck and shoulder pain was significantly higher than the freshmen group. When the study and control group were compared in behavioral problem the study group had not more sound sleep than the control group. The study group had more irregular eating habit than control group. The study group had the lower physical activity than control group. The study group had poor social activity than control group. There was no significant difference in emotional tension.
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구자윤,이정주,하홍구 대한비뇨의학회 2015 Investigative and Clinical Urology Vol.56 No.10
Purpose: To investigate the efficacy of androgen deprivation treatment (ADT) between continuous and intermittent ADT. Materials and Methods: Between January 2006 and May 2015, 603 patients were selected and divided into continuous ADT (CADT) (n=175) and intermittent ADT (IADT) (n=428) groups. The median follow-up in this study was 48.19 (1.0-114.0) months. The primary end point was time to castration resistant prostate cancer (CRPC). The types of ADT were monotherapy and maximal androgen blockade (i.e., luteinizing hormone-releasing hormone agonist and antiandrogen). Results: The characteristics of patients showed no significant differences between the CADT and IADT groups, except for the Gleason score (p<0.001). The median time to CRPC of all enrolled patients with ADT was 20.60±1.60 months. The median time to CRPC was 11.20±1.31 months in the CADT group as compared with 22.60±2.08 months in the IADT group. In multivariate analysis, percentage of positive core (p=0.047; hazard ratio [HR], 0.976; 95% confidence interval [CI], 0.953-1.000), Gleason score (p=0.007; HR, 1.977; 95% CI, 1.206-3.240), lymph node metastasis (p=0.030; HR, 0.498; 95% CI, 0.265-0.936), bone metastasis (p=0.028; HR, 1.921; 95% CI, 1.072-3.445), and CADT vs. IADT (p=0.003; HR, 0.254; 95% CI. 0.102-0.633) were correlated with the duration of progression to CRPC. The IADT group presented a significantly longer median time to CRPC compared with the CADT group. Additionally, patients in the IADT group showed a longer duration in median time to CRPC in subgroup analysis according to the Gleason score. Conclusions: This study found that IADT produces a longer duration in median time to CRPC than does CADT.
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구자윤 한국항해항만학회 2007 한국항해항만학회지 Vol.31 No.3
to the construction of Incheon Grand Bridge, there is driven a necessity for rearranging the function of Inner Port with the development of Outer South Port. In this paper, I'd like to simulate the port operation levels of Lock Gate in Inner Port with estimating the traffic volumes of 2011 and 2015, which will reveal the Demurrage Cost and the Accumulation Cost of Freight in Inner Port. Finally I will evaluate the economic movement effects of the container ship's calling from Inner port to South Port/Outer South Port from 2011 to 2015. The results are as followings ; (1) The average utilization of Lock Gates are reduced by 7~8 percentage point. (2) The mean queueing value are saved by 25 percentage point. (3) The Demurrage Cost and the Accumulation Cost of Freight except Lock Gate charges and the Benefit of Routeing Reduction are saved about 800 million Won annually. 인천항에서는 인천대교 건설을 계기로 남외항 건설을 추진함과 더불어 인천 내항 등의 기능 재배치가 추진되고 있다. 본 논문은 기능 재배치 계획에 따라 2011년과 2015년의 해상교통량을 추정하고, 내항의 갑문 운용에 따른 선박의 대기시간을 항만운용 시뮬레이션에 의하여 분석하여 내항에 기항하는 선박들의 체선체화비용을 산정분석하고자 하였으며, 최종적으로 2011년부터 2015년까지 내항에 기항하던 컨테이너선들의 남항/남외항으로의 이전에 따른 경제적 효과를 평가하고자 한다. 주요한 연구결과는 다음과 같다. (1) 갑문 이용율이 약 7~8%P 낮아졌다. (2) 갑문 대기시간 및 체선체화비용이 약 25%P 절감되는 효과가 나타났다. (3) 갑문 이용료와 선석 이전에 따른 항로 단축 편익 등을 제외하고 갑문 운용에 따라 발생되는 체선체화비용은 연간 약 8억원의 절감효과가 있었다.
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