A Study on Improvement and Degradation of Si/SiO2 Interface Property for Gate Oxide with TiN Metal Gate

이병현,Yong-Il Kim,Bong-Soo Kim,Dong-Soo Woo,Yong-Jik Park,Dong-Gun Park,Si-Hyung Lee,Yonghan Rho 한국전기전자재료학회 2008 Transactions on Electrical and Electronic Material Vol.9 No.1

In this study, we investigated effects of hydrogen annealing (HA) and plasma nitridation (PN) applied in order to improve Si/SiO₂ interface characteristics of TiN metal gate. In result, HA and PN showed a positive effect decreasing number of interface state (Nit) respectively. After FN stress for verifying reliability, however, we identified rapid increase of Nit for TiN gate with HA, which is attributed to hydrogen related to a change of Si/SiO₂ interface characteristic. In contrast to HA, PN showed an improved Nit and gate oxide leakage characteristic due to several possible effects, such as blocking of Chlorine (Cl) diffusion and prevention of thermal reaction between TiN and SiO₂.

A Study on Improvement and Degradation of Si/SiO₂ Interface Property for Gate Oxide with TiN Metal Gate

Lee, Byung-Hyun,Kim, Yong-Il,Kim, Bong-Soo,Woo, Dong-Soo,Park, Yong-Jik,Park, Dong-Gun,Lee, Si-Hyung,Rho, Yong-Han The Korean Institute of Electrical and Electronic 2008 Transactions on Electrical and Electronic Material Vol.9 No.1

In this study, we investigated effects of hydrogen annealing (HA) and plasma nitridation (PN) applied in order to improve $Si/SiO_2$ interface characteristics of TiN metal gate. In result, HA and PN showed a positive effect decreasing number of interface state $(N_{it})$ respectively. After FN stress for verifying reliability, however, we identified rapid increase of $N_{it}$ for TiN gate with HA, which is attributed to hydrogen related to a change of $Si/SiO_2$ interface characteristic. In contrast to HA, PN showed an improved Nit and gate oxide leakage characteristic due to several possible effects, such as blocking of Chlorine (Cl) diffusion and prevention of thermal reaction between TiN and $SiO_2$.

암 환자의 혈장 Transforming Growth Factor-β1 농도

박병규,하우송,이시은,이수진,박순태,박찬후,전지현,장정순 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCINE 1999 Journal of biomedical laboratory sciences Vol.5 No.2

한국인의 대표적인 성인 고형 종양인 위암, 간암, 유방암과 소아 백혈병 및 2종의 소아 고형 종양 환자로부터 혈장 transforming growth factor-ß1 (TGF-ß1) 농도를 sandwich ELISA 분석법을 이용해 측정함으로써 TGF-ß1을 이 질환들에 대한 새로운 종양표지자 (tumor marker)로 사용할 수 있는지 검토하였다. 또한 연령 및 성별에 따른 혈장 TGF-ß1 농도의 정상치를 조사하였다. 신생아에서 70대까지 혈장 TGF-ß1 농도의 차이는 없었고 남녀간의 차이도 없었다. 위암 환자의 혈장TCF-ß1 농도는 16.0±6.8 ng/ml (평균 ±표준편차)로 정상 대조군의 TGF-ß1 농도 (8.3 ±5.0 ng/ml) 보다 유의하게 높았으나 간암, 유방암 환자의 혈장 TGF-ß1 농도는 대조군과 차이가 없었다. 그리고 위암 환자 16명, 간암 환자 8명, 유방암 환자 7명 중 각각 7명 (43.7%), 1명 (12.5%), 1명 (14.3%)에서만 혈장 TGF-ß1 농도가 증가되었다. 5명의 소아 백혈병 환자에서는 관해 (remission) 여부와 상관없이 혈장 TGF-ßl 농도가 모두 정상 범위에 있었으나 2명의 소아 고형암 환자에서는 종양 절제 전에는 혈장TGF-ß1 농도가 높았다가 절제 후 정상으로 떨어졌다. 결론적으로 1)정상인의 혈장 TGF-ßl 농도는 연령 및 성별에 따른 차이가 없다는 것을 알 수 있었고, 2)성인 고형암인 위암, 간암, 유방암에서는 낮은 민감도로 인해 TGF-ß1을 진단을 위한 선별 검사로 이용하기에는 부적절한 것으로 판단되었으며, 3) 정상 대조군보다 혈장 TGF-ß1 농도가 높았던 위암 환자와 종양 절제 전후로 혈장 TGF-ß1 농도가 민감하게 변했던 소아 고형 암 환자에 대해서는 향후 표본 수를 늘려 부가적인 연구를 해 야 할 것으로 사료된다. To evaluate the usefulness of transforming growth factor-ß1 (TGF-ß1)as a new tumor marker, we determined the plasma TGF-ß1 levels using sandwich ELISA assay in cancer patients. Patients with three most common adult cancers in Korea (stomach, liver and breast cancer) and children's cancers (leukemia and two kinds of solid tumor) were enrolled for the study. Furthermore, 39 individuals were subjected to age and sex-stratified plasma TGF-ß1 analysis. No statistical difference was demonstrated with respect to age or sex. The mean plasma TGF-ß1 level (16.0 ng/ml) of stomach cancer patients was significantly higher than that (8.3ng/ml) of controls. However, there was no difference among the mean plasma TGF-ß1 levels of liver, breast cancer patients and controls. Seven of 16 patients (43.7%) with stomach cancer, one of 8 (12.5%) with liver cancer, and one of 7 (14.3%) with breast cancer showed higher TGF-ß1 levels compared to controls. Plasma TGF-ß1 concentrations of five leukemic children remained in the normal range regardless of the remission state. In contrast, initial high TGF-ß1 levels from two children with solid tumors returned to normal range on surgical resection of tumors. From the above results, we could conclude that plasma TGF-ß1 levels of apparently healthy individuals seem to be rather constant irrespective of difference in age or sex, and the plasma TGF-ß1 has the limited value as a screening test for the diagnosis of aforementioned adult cancers because of its low sensitivity. Finally, additional studies need to be pursed for the large number of stomach cancer and pediatric solid tumor patients in order to reach a secure conclusion on the usefulness of plasma TGF-ß1 as a tumor marker in these patients.

라벤더 에탄올 추출물의 피지생성 억제효과

박시준,김호민,한규수,성금수,신미란,문연자,우원홍 한국전통의학연구소 2006 한국전통의학지 Vol.15 No.1

Lavandula vera is indispensable member of the herb family, used for perfumes and potpourri. Androgens have profound effects on the physiology of the sebaceous gland. Sebum is secreted due to the effect of androgen, which starts to be secreted at puberty. Using the human sebocyte cell line SZ95, the author investigated the inhibitory effect of Lavandula vera on the lipid production. Light microscopic finding were examined numerous cytoplasmic lipid droplets SZ95 cells by Oil red staining and lipid droplets were increased markedly by testosterone. On the other hand, combined treatment with Lavandula vera and testosterone resulted in a lower lipid droplets than with testosterone alone in a dose-dependent manner. These findings indicate that Lavandula vera acts antagonistically to testosterone and inhibits the lipid synthesis of SZ95 cells at the cellular level.

냉기 치료에 따른 둔근에서의 피부 및 근육내 온도 변화

정우성,김미정,박시복,이상건,김영호,양길태,장윤희 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.2

대퇴동맥을 이용한 도자술에 합병된 대퇴 가성 동맥류의 비수술적 치료 : 수기 압박과 C-clamp의 병용사용

박사영,박시훈,신길자,이우형 梨花女子大學校 醫科大學 醫科學硏究所 1995 EMJ (Ewha medical journal) Vol.18 No.3

Femoral pseudoaneurysm is important complication after diagnostic femoral catheterizationor more complex procedure. With the increasing use of larger-size percutaneous instruments and periprocedual anticoagulant or antiplatelet agent the incidence of postcatheterization femorl artery injuries ncluding pseudoaneuiysm has increased in the past few years. Duplex ultrasonography and addition of color- flow Doppler provides an accurate, noninvasive. risk-free diagnosis and faster detection of intraaneurysrnal blood flow and the track betweenthe injured artery and the pseudoaneurysm. Though early surgical repair of the arterial defect is usually recommended because of severeand life-threatening complication such as rupture, fhrornboembolism, compression neuropathyetc, Ultrasono-Guided Compression Repair(UGCR) is to be first-line treatment for its advantagesuch as high success rate, low morbidity and cost-effectiveness. The authors report 2 cases of femoral psoudoaneurysrns treated using UGCR with nlanualcompression with C-clamp at the same time as a nonsurgical treatment.

음전하를 띤 Microsphere 에 의한 정전기적 반발력이 정밀여과에서 투과 플럭스에 미치는 영향 고찰

박정민,최성욱,방시원,함승주,김중현,김우식 한국화학공학회 2001 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.39 No.6

본 연구에서는 일정 압력하에서 음전하를 띤 microspheres의 정전기적 반발력에 따른 투과 플럭스의 변화에 관하여 고찰하였다. Microsphere의 정전기적 반발력에 관한 영향을 관찰하기 위해 표면전하 밀도(N_c: 0.45, 5.94, 10.25)가 각각 다른 poly(Styrene/Methacrylic acid) microspheres를 제조하였다. 교반속도는 300, 400, 600 rpm, 이온강도는 0.1, 0.01, 0.001로 변화시켜 실험하였다. 투과 플럭스는 표면전하밀도, 교반속도, 이온강도에 큰 영향을 받음을 알 수 있었으며, 투과 플럭스는 표면전하밀도가 클수록, 교반속도가 증가할수록, 이온강도가 작을수록 증가함을 알 수 있었다. 교반속도가 크면 막표면의 농도분극층의 두께가 얇아지기 때문에 투과 플럭스는 증가한다. 이온강도가 작을수록, 표면전하밀도(surface charge density)가 클수록 투과 플럭스가 커지는 원인은 microspheres의 정전기적 이중 층의 두께가 두꺼워짐에 따라 입자 사이의 거리가 멀어져 공극률(porosity)이 커지기 때문이다. 정상상태 플럭스 자료로부터 비 저항 정의식을 이용하여 케이크층의 공극률을 구할 수 있었다. 전하를 나타내지 않는 polystyrene microspheres의 입자크기가 480㎚일 때 농도분극 층의 이론적인 공극률은 0.211이었고, microspheres의 표면이 methacrylic acid로 완전히 개질된 것은 비 저항정의식에 의해 3.04로 계산되었다. 또한 microspheres들간의 정전기적 상호작용력이 작아지면 농도분극층의 공극률도 줄어드는 것을 알 수 있었다. The effect of the surface charge density(N_c: 0.45, 5.94, 9.14 and 10.25) and the stirrer speed(300, 400 and 600 rpm) on the variation of permeate flux was investigated in a stirred cell filled with negatively charged microspheres under constant pressure. It was found that the permeate flux depended on the surface charge density, the ionic strength and the stirrer speed. High permeate flux was obtained in the condition of high surface charge density, low ionic strength and high stirrer speed due to the force of electrostatic interaction between microspheres. The porosity of a cake layer was calculated from the steady-state flux data. It was found that the reduction of porosity was due to a decrease in repulsive interaction between microspheres.

서양산 고추냉이 추출물이 함유된 세치제의 효능에 대한 임상적 실험연구

서현우,박호원,김종수,이시영,신일식 大韓小兒齒科學會 2012 大韓小兒齒科學會誌 Vol.39 No.1

The purpose of this study was to find out the effect of dentifrice containing Horseradish (Armoracia rustica) root extracts on improvement of oral hygiene. The clinical evaluation was done participated by 80 adults volunteers who provided a informed consent for their participation. The participants were divided into two groups ; control group (using toothpaste without Horseradish extracts) and experimental group (using toothpaste containing Horseradish extracts). The checklist of the experiment includes the plaque index, gingival index and anti-caries activity. The anti-caries activity was measured by cultivating Streptococcus mutans for 48 hours then estimating the number of increased bacteria using Dentocult SM. The double-blind method was used in this study. The results of this study can be summarized as follows; 1. The plaque formation decreased 28% in control group, 58% in experimental group using dentifrice with Horseradish extracts compared to baseline data. 2. For gingival index, control group and experimental group showed 26% and 40% decrease compared to baseline data, respectively. 3. The score of caries activity test decreased by 4% for control group and 69% for experimental group compared to baseline data. According to the results, a dentifrice containing Horseradish extracts can improve oral hygiene. 식물성 자연추출물 중 하나인 고추냉이 추출물을 배합한 세치제의 구강환경 개선 효과를 알아보기위해 총72명을 대상으로 교차실험 및 이중맹검법을 실시하여 치면세균막지수, 치은염지수 및 우식활성도검사 등을 비교 검토한 결과 다음과 같은 결 론을 얻었다. 1. 치면세균막지수는 초기값에 비해 대조군은 28%, 고추냉이 추출물 배합세치군은 58%의 억제효과를 나타내었다. 2. 치은염지수는 초기값에 비해 대조군은 26%, 고추냉이 추출물 배합세치군은 40%의 억제효과를 나타내었다. 3. Dentocult-SM을 이용한 우식활성도 평가에서는 초기값에 비해 대조군은 4%, 고추냉이 추출물 배합세치군은 69%의 억제효과를 나타내어 고추냉이 추출물 배합세치군이 대조군에 비해 유의할만한 Streptococcus mutans 억제효과를 나 타내었다. 이상의 결과들로 보아 고추냉이 추출물을 배합한 세치제는 치면세균막 억제와 치은염의 감소 그리고 우식활성도 억제에 중 요한 역할을 하여 구강환경 개선에 뛰어난 효과를 보이는 것으로 사료된다.

한·일 국민학교 자연교과서 삽화 비교

박시현,우종옥 한국교원대학교 과학교육연구소 1994 청람과학교육연구논총 Vol.4 No.1

In this study, with the problem of "What is the desirable illustrations?", the problem points of the existing textbooks were analyzed, and the opinions of experts concerning desirable illustrations were examined through questionaire survey, and by developing 'Analysis Frameworkof Illustrations', and Korean-Japanese 'science' textbooks were analyzed and compared with. The conclusions for the direction of korean 'science' textbooks are summarized as follows: 1) The numbers of korean illustrations should be more about two than one of per one page of the existing textbooks. 2) The korean illustrations for the 6th grade should be more largely inserted. 3) The more econmic space utilizing measure should be groped for looking at from the such side. 4) Though the kinds of Korean illustrations are mostly composed of photographs, pictures, illustrations, cartoons, etc. should be positively utilized, and the shapes of photographs should be diversified by such as square, round shape, omissions of background and others. 5) The distribution of players by sex should be considered envenly for male and female from the ascendency of male (1.5:1). 6) It was found that it is desirable for the formation of role of illustrations of 20% for motive inducement, 45% for guidance for experimentation, 30% for presentation of data, and 5% for presentation of the results of experimentation. 7) The illustrations for guidance for experimentation should present important stages of experimentation process regardless the number of illustration. 8) It would be advantageous for motive induction to find the subject matters as possible as from the children's close actual life. 9) It is necessary to induce more freely method in utilizing printing plate for inserting illustrations. 10) It is the result of research that the existing Korean textbooks are not suitable in inducing interest, and the positive strategy to induce interest is demanded. 11) It is required to select their location freely in accordance with the content regardless the. 12) In order to develop such illustrations, it is required to cultivate expert illustrators, and more economic investment is required for development of illustrations, The emphasis matters of revision of the 6th educational process of 'Inducement of study motive and emphasis on interest' is the change of presenting form and method of illustrations, which is expected to be rewarded with much good fruits.

전인 건강의 신학적 기초와 실제적 적용

박시운, 황대우 고신대학교보건과학연구소 2020 보건과학연구소보 Vol.28 No.-

전인 건강의 신학적 기초와 실제적 적용