전산화단층사진을 이용한 하악골 비대칭 환자의 저작근 평가

최순철,이선복,이진구,이원진,허민석,이삼선 大韓口腔顎顔面 放射線學會 2004 Imaging Science in Dentistry Vol.34 No.1

Purpose : To compare the size of the masseter and lateral pterygoid muscle between the affected and the unaffected side of the patients who have the chief complaints of the mandibular asymmetry. Materials and Methods : Twenty two patients (male: 4, female: 18, average age: 21.3 year-old) were radiographed using posterior-anterior (P-A) cephalography and computed tomography (CT). On P-A cephalography, the degree of deviation was determined by the distance from the mentum to the vertical reference line through the crista galli and the anterior nasal spine. On the scanned tracing papers of the maximum cross-sectional area of the masseter and lateral pterygoid muscle using axial CT images, the pixel number was measured. The ratio of the affected : unaffected sides were obtained. For the masseter and lateral pterygoid muscle, the relationship between the muscular volume and degree of skeletal hypoplasia was studied. Results : The half cases showed no skeletal asymmetry. The lateral pterygoid muscle of the affected side was larger significantly than unaffected side (p<0.05). However, there was no significant difference between two sides in the cases of skeletal asymmetry. There was only significant difference in the cases without skeletal asymmetry (p<0.05). Conclusions : To some extent, the slight mandibular hypoplasia could affect the growth of some masticatory muscles.

경직성 뇌성마비 환아에서 선택적 후근 절제술 후 운동기능의 변화

이소영,최인성,한재영,정주찬,위정선,오명신,박승진,이삼규,김재휴 全南大醫大 2001 전남의대학술지 Vol.37 No.1

Saccharomyces uvarum의 인지질 생합성 및 지방산 조성에 미치는 탄소원의 효과에 관하여

이종삼,김선혜 성신여자대학교기초과학연구소 1988 基礎科學硏究誌 Vol.5 No.-

Saccharomyces uvarum을 30℃에서 Knopp's 최소배지에 자당결핍과 자당고농도 처리(15%)을 하여 배양시켰다. 이들 세포의 생장과 인지질 및 지방산 조성에 미치는 탄소원의 효과를 조사하기 위하여 배양 기간중 4, 7일 간격으로 일정량의 세포를 수확하여 생장률과 이에 따른 함량을 조사하였다. 자당 고농도 처리구는 배양 4일째에 생장감소 효과를 나타내었으며, 자당결핍구는 배양기간동안 세포생장을 관찰할 수 없었다. 주요 인지질의 지방산 palmitic acid와 oleic acid로 주로 이용되었으며, PC, PE에서는 대조구에 비하여 oleic acid가 조성상 급격한 이용의 증가를 나타내었다. Saccharomyces uvarum was cultured in the Knopp's media of the sucrose absence and the sucrose excess. In order to observe the effect of sucrose as carbon source on biosynthesis of phospholipids in these cells and the compositions of fatty acids, the cells were harvested at 4 and 7 days intervals of cultivations after inoculation. The growth rate at sucrose excess was decreased at 4 days of cultivation, but the growth rate of sucrose absence was not increase during whole period of cultivation. The fatty acids in major phospholipids were composed of palmitic acid and oleic acid. The amount of oleic acid in phosphatidylethanolamine and phosphatidylcholine was markedly increased to compared with those of the control.

성공적인 임플란트시술을 위한 방사선검사

이삼선,최순철 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.2

Recently implant has become an important field in dental clinic. Radiographic examination of pre- and postoperation is essential for successful treatment. Clinicians should have knowledge about the purpose of the radiographic examination, suitable imaging modality for the cases, anatomic landmarks of tooth and jaw bone, advantage and limitation of panoramic radiographic examination for implant, principle and interpretation of crosssectional imaging, bone mineral density, post-operative radiographic examination. This paper will be helpful to get above informations for dentists who want to do dental implant successfully.

구개열환자의 상악동발육과 비중격전위에 관한 방사선학적 연구

이삼선,유동수 大韓口腔顎顔面 放射線學會 1992 Imaging Science in Dentistry Vol.22 No.2

This study was designed to investigate the effects of the maxillary sinus development and nasal septum deviation on diseases of maxillary sinus with cleft palate. The materials was 152 cephalometric Waters' projections consist of 76 cleft patients and 76 normal subjects. The results were as follows ; 1. The disease of maxillary sinus was present in 49% of a cleft group and 14% of control group, and prevalent in cleft side. 2. It showed no statistically significant difference in size of the maxillary sinus in cleft plate patients compared to the control population and in the cleft side to the noncleft side(p<0.05) 3. Nasal septum deviation was more severe in the cleft patient its average value was 3.55mm, compared to the control group, 0.99mm(p<0.01) and 77% of the deviated nasal septum was deviated to the cleft side.

위암 환자에서 세포성 면역 기능에 관한 연구

이재익,윤일국,이종선,김종완,장준,안정기,송민호,정현용,이헌영,김삼용,김영건 충남대학교 암연구소 1991 癌共同硏究所 硏究誌 Vol.1 No.1

We performed a variety of lymphocyte stimulation tests, delayed hypersensitivity skin tests, and enumeration of several lymphocyte subpopulations in 21 patients with gastric cancer who did not receive any form of anticancer therapy, and in 20 healthy controls. The gastric cancer patients had significantly decreased number and total score of positive reactions in delayed hypersensitivity skin tests compared with the healthy controls. The percent of CD_(4) positive lymphocytes in the gastric cancer patients was significantly decreased compared to the normal control subjects, but it had no correlation with the total score of delayed cutaneous hypersensitivity reactions. The ratio of helper to suppressor cells was lower in the cancer group. The uptake of 3H-thymidine was markedly depressed in cancer patients when stimulated with various mitogens. There was little correlation between any of the stimulation tests and any of the lymphocyte subpopulation proportions to delayed hypersensitivity cutaneous reactions. Optimal proliferative response was found in lymphocytes stimulated with 10 micrograms of concanavalin-A and 10 microgram of phytohemagglutinin. Advanced stage patients had greatly depressed delayed hypersensitivity skin reactions and proliferative responses to mitogens compared with localized diseases. These results suggest that gastric cancer patients have depressed cellular immune functions, which mainly result from the decreased helper cells and defects in functional proliferative response to mitogens. Interleukin-2 and interferon-gamma restored the in vitro proliferative response of lymphocyte in patients with gastric cancer.

구강외과 수술용 스텐트 기반 영상유도 수술 시스템의 개발

이우진,김대승,이원진,이삼선,최순철,허민석,허경회,김명진,이지호 대한구강악안면방사선학회 2009 Imaging Science in Dentistry Vol.39 No.3

Purpose : The purpose of this study was to develop a stent-based image guided surgery system and to apply it to oral and maxillofacial surgeries for anatomically complex sites. Materials and Methods : We devised a patient-specific stent for patient-to-image registration and navigation. Threedimensional positions of the reference probe and the tool probe were tracked by an optical camera system and the relative position of the handpiece drill tip to the reference probe was monitored continuously on the monitor of a PC. Using 8 landmarks for measuring accuracy, the spatial discrepancy between CT image coordinate and physical coordinate was calculated for testing the normality. Results : The accuracy over 8 anatomical landmarks showed an overall mean of 0.56±0.16 mm. The developed system was applied to a surgery for a vertical alveolar bone augmentation in right mandibular posterior area and possible interior alveolar nerve injury case of an impacted third molar. The developed system provided continuous monitoring of invisible anatomical structures during operation and 3D information for operation sites. The clinical challenge showed sufficient accuracy and availability of anatomically complex operation sites. Conclusion : The developed system showed sufficient accuracy and availability in oral and maxillofacial surgeries for anatomically complex sites. (Korean J Oral Maxillofac Radiol 2009; 39 : 149-56)

화재시 임계유속 전후의 철도터널내 대피환경에 관한 연구

이승철,승삼선 三陟大學校 産業科學技術硏究所 2003 産業科學技術硏究論文集 Vol.8 No.2

This paper deals with evaluation the critical velocity by convectional one dimensional method at 10 MW fire size in a tunnel. Also a CFD analysis was conducted to evaluate the evacuation environment in terms of temperature distribution. visible distance distribution and CO concentration at some tunnel inlet velocity. 1m/s. 2m/s(near critical velocity), and 3m/s. At all inlet velocity, passenger should give away downward the flow direction because the inlet velocity can not afford to sufficient evacuation environment for passengers. While inlet velocity at 1m/s and 2m/s can not afford to sufficient evacuation environment for passengers, 3m/s inlet velocity can more safe evacuation environment for passengers. To provide more safe evacuation environment OR fire situation. tunnel inlet velocity should be larger than critical velocity.

외상성 골낭의 방사선학적 연구

이건일,이삼선,최순철 大韓口腔顎顔面 放射線學會 1994 Imaging Science in Dentistry Vol.24 No.1

Fifty-two cases of traumatic bone cysts in 50 patients were analysed clinically and radiologically. The obtained results were as follows; 1. Women showed a slightly higher incidence than did men (56% of patients) and the average age proved to be 18.6 years. 2. The majority of the cases were asymptomatic, being detected incidentally, and over the half of the cases occurred in the mandibular symphyseal region. 3. All cases were unilocular and the largest diameter of the lesions varied from 1 to 10㎝, mean 3㎝. 4. Some degree of marginal condensation was present in 28 cases and 23 cases presented pencil-sketch appearance. 5. Many anatomical cortical plates(especially, mandibular inferior cortex and lamina durae) consisted of the margin of the lesions partly. 6. Erosive change of the mandibular inferior cortex was caused by 12 cysts, but cortical expansion only by 3 cysts including 2 cases of buccal expansion. 7. The lesion enveloped the roots of the adjacent teeth in 27 cases and scalloping was present between roots in 17 cases. 8. Lamina dura of the teeth was destroyed by only 1 cyst, and in 1 case root resorption was noticed. But there was no divergence of the roots of teeth.

일차배양된 설치류 호흡기 상피세포로부터의 점액소 분비에 대한 수종 약물의 영향

이충재,석정호,이재흔,허강민,박지선,배소현,노삼길,박상철 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

1. PKC activator인 PMA는 일차배양 HTSE세포로부터의 뮤신분비를 0.1μM 농도에서 30%, 1μM 농도에서 80% 가량 증가시켰다. 2. 식물 유래 성분으로, flavonoid의 일종인 TFR은 일치배양 HTSE 세포로부터의 뮤신분비를 10μM 농도에서 50%, 100μM 농도에서 80% 가량 증가시켰다. 3. 양이온성 폴리펩티드인 PLL 및 PLA는 일차 배양 HTSE 세포로부터의 뮤신분비를 0.01 - 10μM 농도에서 용량의존적으로 감소시켰다. 4. 결론적으로, 본 연구에서 얻어진 결과들은 새로운 거담제 및 점액용해제나 단백분해 효소제가 아닌 호흡기 류신의 생성/분비를 조절해 줄 수 있는 신개념의 약물을 개발함에 있어 극히 일부분이나마 단서를 제공하고 있다고 하루 수 있을 것이다. In the present study, we tried to investigate whether phorbol myristate acetate(PMA), trihydroxymethoxy-flavanone rutinoside(TFR) and cationic polypeptides significantly affect mucin release(secretion) from cultured hamster tracheal surface epithelial cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled with 3H-glucosamine for 24 hr and chased for 30 min in the presence of each agent to assess the effect on 3H-mucin release. The results were as follows : (1) Both PMA and TFR significantly increased mucin release from cultured HTSE cells ; (2) Cationic polypeptides including po1y-L-lysine(PLL, mw 7,500) and poly-L-arginine(PLA, mw 10,800) significantly inhibited mucin release from cultured HTSE cells, in a dose-dependent manner. This finding suggests us that PMA and TFR be further studied for the possible use as mild expectorants and cationic polypeptides might function as a regulator for hyper-secretion of mucus, both by direct acting on airway mucin-secreting cells, during the treatment of chronic airway diseases.