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MiR-150-5p Suppresses Colorectal Cancer Cell Migration and Invasion through Targeting MUC4
Wang, Wei-Hua,Chen, Jie,Zhao, Feng,Zhang, Bu-Rong,Yu, Hong-Sheng,Jin, Hai-Ying,Dai, Jin-Hua Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
Growing evidence suggests that miR-150-5p has an important role in regulating genesis of various types of cancer. However, the roles and the underlying mechanisms of miR-150-5p in development of colorectal cancer (CRC) remain largely unknown. Transwell chambers were used to analyze effects on cell migration and invasion by miR-150-5p. Quantitative real-time PCR (qRT-PCR), Western blotting and dual-luciferase 3' UTR reporter assay were carried out to identify the target genes of miR-150-5p. In our research, miR-150-5p suppressed CRC cell migration and invasion, and MUC4 was identified as a direct target gene. Its effects were partly blocked by re-expression of MUC4. In conclusiomn, miR-150-5p may suppress CRC metastasis through directly targeting MUC4, highlighting its potential as a novel agent for the treatment of CRC metastasis.
Rong Jiang,Jianqing Zhu,김재원,Jihong Liu,Kazuyoshi Kato,김희승,Yuqin Zhang,Ping Zhang,Tao Zhu,Daisuke Aoki,Aijun Yu,Xiaojun Chen,Xipeng Wang,Ding Zhu,Wei Zhang,Huixun Jia,Ting-Yan Shi,Wen Gao,Sheng Yin,Yan 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.5
Background: Two randomized phase III trials (EORTC55971 and CHORUS) showed similarprogression-free and overall survival in primary or interval debulking surgery in ovariancancer, however both studies had limitations with lower rate of complete resection and lack ofsurgical qualifications for participating centers. There is no consensus on whether neoadjuvantchemotherapy followed by interval debulking surgery (NACT-IDS) could be a preferred approachin the management of advanced epithelial ovarian cancer (EOC) in the clinical practice. Methods: The Asian SUNNY study is an open-label, multicenter, randomized controlled,phase III trial to compare the effect of primary debulking surgery (PDS) to NACT-IDS instages IIIC and IV EOC, fallopian tube cancer (FTC) or primary peritoneal carcinoma (PPC). The hypothesis is that PDS enhances the survivorship when compared with NACT-IDS inadvanced ovarian cancer. The primary objective is to clarify the role of PDS and NACT-IDS inthe treatment of advanced ovarian cancer. Surgical quality assures include at least 50% of nogross residual (NGR) in PDS group in all centers and participating centers should be nationalcancer centers or designed ovarian cancer section or those with the experience participatingsurgical trials of ovarian cancer. Any participating center should be monitored evaluatingthe proportions of NGR by a training set. The aim of the surgery in both arms is maximalcytoreduction. Tumor burden of the disease is evaluated by diagnostic laparoscopy orpositron emission tomography/computed tomography scan. Patients assigned to PDS groupwill undergo upfront maximal cytoreductive surgery within 3 weeks after biopsy, followed by6 cycles of standard adjuvant chemotherapy. Patients assigned to NACT group will undergo 3cycles of NACT-IDS, and subsequently 3 cycles of adjuvant chemotherapy. The maximal timeinterval between IDS and the initiation of adjuvant chemotherapy is 8 weeks. Major inclusioncriteria are pathologic confirmed stage IIIC and IV EOC, FTC or PPC; ECOG performancestatus of 0 to 2; ASA score of 1 to 2. Major exclusion criteria are non-epithelial tumors as wellas borderline tumors; low-grade carcinoma; mucinous ovarian cancer. The sample size is 456subjects. Primary endpoint is overall survival. Trial Registration: ClinicalTrials.gov Identifier: NCT02859038
Vibration of T-type Timoshenko frames subjected to moving loads
Wang, Rong-Tyai,Lin, Jin-Sheng Techno-Press 1998 Structural Engineering and Mechanics, An Int'l Jou Vol.6 No.2
In this study, a theoretical method to analyze the vibration of a T-type Timoshenko frame is proposed. The effects of axial inertia, rotatory inertia and shear deformation of each branch are considered. The orthogonality of any two distinct sets of mode shape functions is also demonstrated. Vibration of the frame due to moving loads is studied by the method and the response characteristics of the frame are investigated. Furthermore, the effect of column length on the response of the frame is also studied.
An automated control system for concrete temperature development in construction
Sheng Qiang,Xue-jun Leng,Xiang-rong Wang,Jing-tao Zhang,Xia Hua 사단법인 한국계산역학회 2019 Computers and Concrete, An International Journal Vol.24 No.5
PLC and its expansion module, electric ball valve and cooling pipe, electric heating steel plate and various components of the system, which is used to control test and process data. By automatically adjusting the opening of the valve, the system makes the top temperature and cooling speed develop along the ideal temperature diachronic curve. Moreover, the system enables the temperature difference between inside and surface of test block limited in a given range by automatically controlling the surface board heating. The method of physical simulation test by sandbox with built-in cooling water pipe and heating rod is adopted. On the premise of a given standard value, the operation of the system is checked under different working conditions. Further, an extension of this system is proposed, which enables its application to obtain some thermal parameters when cooperating with numerical simulation.
Wang, Lin-Wei,Yang, Gui-Fang,Chen, Jia-Mei,Yang, Fang,Yuan, Jing-Ping,Sun, Sheng-Rong,Chen, Chuang,Hu, Ming-Bai,Li, Yan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4
Background: Breast cancer is the most common malignant tumor in females worldwide. Many differences exist in clinico-pathological characteristics of breast cancer patients between China and Western countries. This study aimed to analyze clinico-pathological characteristics of breast cancer from central China. Methods: Clinico-pathological information on breast cancer from three hospitals in central China was collected and analyzed. Results: From 1994 to 2012, 2,525 patients with a median age 50 years were included in this study. The 45-49-year age group and invasive ductal carcinoma not otherwise specified accounted for the highest proportions (19.1%, 480/2,525 and 81.0%, 1,982/2,446). Stages 0-I, II and III accounted for 28.0% (682/2,441), 48.4% (1,180/2,441), and 23.7% (578/2,441), respectively. Distribution of N stage showed that N0 accounted for 53.2% (1,344/2,525), and proportion of N0 rose from 51.1% (157/307) in 30-39-year age group to 64.3% (110/171) in ${\geq}$ 70-year age group, with an average increase of 2.1% in each age group. Modified radical mastectomy, radical mastectomy, breast-conserving surgery and simple mastectomy were performed for 71.8% (1,812/2,525), 18.0% (454/2,525), 5.2% (131/2,525) and 2.6% (66/2,525), respectively. Proportions of breast-conserving surgery in age ${\leq}$ 44-year group (68/132, 51.5%) and simple mastectomy in age ${\geq}$ 60-year group (57/89, 64.0%) were higher than in the other age groups. Breast cancers positive for estrogen receptor accounted for 53.0% (1,107/ 2,112). The comparisons among this study and other reports showed higher proportion of younger patients, lower proportion of breast-conserving surgery and positive estrogen receptor patients in China than western countries. Conclusions: Clinico-pathological characteristics in this study demonstrated clear differences between the center of China than Western countries. Additional classification systems should be developed to guide grading of early breast cancer more accurately, especially for N0 patients. Invasive ductal carcinoma is a focus for intensive research.
Random vibration of multispan Timoshenko frames due to a moving load
Wang, Rong-Tyai,Lin, Jin-Sheng Techno-Press 1998 Structural Engineering and Mechanics, An Int'l Jou Vol.6 No.6
In this paper, an analytic method to examine the random vibration of multispan Timoshenko frames due to a concentrated load traversing at a constant velocity is presented. A load's magnitude is a stationary process in time with a constant mean value and a variance. Two types of variances of this load are considered: white noise process and cosine process. The effects of both velocity and statistical characteristics of load and span number of the frame on both the mean value and variance of deflection and moment of the structure are investigated. Results obtained from a multispan Timoshenko frame are compared with those of a multispan Bernoulli-Euler frame.
Characteristics of Twin-Fluid Micro-Atomizer with Internal Mixing Mechanisms
( Muh Rong Wang ),( K. H. Yang ),( J. S. Chiu ),( Deng Sang Lai ),( T. S. Leu ),( Sheng Chih Shen ) 한국액체미립화학회 2005 한국액체미립화학회 학술강연회 논문집 Vol.2005 No.-
The twin-fluid atomizer has three micro channels fabricated via MEMS bulk micro-machining processes, one for the liquid supply and two for introducing the atomization gas. The effects of the length scale of the micro-channels on the atomization performance are investigated. The orifice hydraulic diameter (dH) of the micro atomizer is 45μm. Malvern Insitec RT-Sizer is used to measure the particle size. Results show that the twin-fluid micro-atomizer with internal mixing mechanisms can produce fine spray with Sauter Mean Diameter of 5μm under the gas pressure of 5kg/cm2 and liquid flow rate of 0.1ml/min, a performance better than the micro atomizers reported in the literature. Flow visualization through a microscope shows that the micro-spray is unstable when the two impinging gas flows are staggered inside the atomizer. The micro-spray began to twist by these two impinging gas flows when the gas pressure goes up to 2 kg/cm2. The twisting angle and the cone angle of the spray remain constant when the gas pressure is more than 3 kg/cm2. Significant decrease in the particle size takes place when the gas pressure is more than 4kg/cm2. The atomization efficiency of the twin-fluid micro-atomizer with internal mixing mechanism is several times higher than other type of twin-fluid atomizers.
( Muh Rong Wang ),( Tien Chu Lin ),( Che Jui Yang ),( Yang Sheng Huang ) 한국액체미립화학회 2005 한국액체미립화학회 학술강연회 논문집 Vol.2005 No.-
This paper investigates the droplet transport phenomenon in the developing region of the spray injected by the atomizer with internal impinging mechanisms. The characteristics of the spray are measured by a two-component phase Doppler particle analyzer (PDPA) and the images are taken by a high speed camera. Instantaneous flow image shows the intermittence of the spray jet as injected with internal impingement. On the other hand, a large-scaled sinusoidal flow structure along the axial direction is observed when the spray jet is injected without internal impingement. Hence flow impingement inside the atomizer has strong effects on the structure of the spray jet because of the enhanced mixing processes between the liquid and gas phases. It turns out that the spray jet with internal impingement has a wider and more uniform distribution. Measurements of the distribution of the spray droplets and volume flux justify the above observation.