中風病辨證診斷標準에 의한 臨床的 硏究

任長信,文祥官,高昌男,權正男,曺基湖,金永錫,裵亨燮,李京燮 경희대학교 1997 慶熙醫學 Vol.13 No.3

날록손으로 유발된 비아편계 통각감소 : 중뇌수도 주변 회백질 배측 (dorsal-PAG) 전해질 손상효과 Effect of Dorsal-Periaqueductal Gray Lesion

조소현,서미숙,김기석 한국심리학회 한국심리학회지 생물 및 생리 Vol.5 No.1

날록손과 열자극을 배쌍지어 제시하면 통증에 대한 민감성이 감소한다. 날록손으로 유발된 통각감소는 날록손이 사전에 처치되었음에도 불구하고 발생되었다는 점에서 특성상 비아편계가 매개하는 통각감소라 할 수 있다. 본 연구에서는 날록손과 열자극의 배쌍에 의해 유발된 비아편계 통각감소에 책임이 있는 뇌영역이 어디인지를 알아보고자 하였다. 실험장치로서는 열판 장치를 사용하였고 열자극은 53±0.5℃로 하였다. 통증에 대한 민감성 지표로서는 뒷발을 핥기까지의 잠재기를 측정하였다. 실험결과, 모의시술집단은 훈련시에 발생된 통각감소율이 검사시에도 계속 유지된 반면 중뇌수도 주변 회백질 배측부분이 손상된 실험집단은 훈련시 발생된 통각감소율이 훈련전의 기저선 수준으로 환원되었다. 이러한 결과는 중뇌수도 주변 회백질 배측부분이 날록손과 열자극의 배쌍으로 유발된 비아편계 통각감소에 책임이 있는 뇌 부위임을 시사해준다고 하겠다. Animals exposed to the naloxone-heat pairings reduced their sensitivity to the pain. Naloxone-induced analgesia may be, in nature, non-opioid in that was found in the rat pretreated with naloxone. The present study was conducted to examine the area which is the responsible for the analesia induced by naloxone-heat pairings. Hot-plate apparatus which was thermoregulated automatically at 53±0.5℃ was used for heat stimulus. The latencies for hind-paw lick was recorded as an index of pain sensitivity. The result of present experiment was as follows. Sham operated rats were maintained analgesia which developed in the training phase but, analgesia developed in the rats which belongs to the experimental group in the training phase was reduced to the baseline level after dorsal periaqueductal lesion. This result suggest that dorsal-periaqueductal gray is responsible for the analgesia induced by naloxone.

일측 하퇴 의족 착용자의 절단단 길이에 따른 보행특성

조병모,변주남,김기순,김석산,박종 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.1

This report studied 31 male patients who were in one hospital in Kwangju or came to a prosthesis clinic and are 15 normal control group to analyze the gait characteristics according to the stump length in the prosthesis users with the unilateral below-knee amputations. The patient group was divided into a short stump subgroup of 13 patients and a long stump subgroup of 18 patients according to the stump length, the control group was randomly sampled from 15 males who have similar age, height and weight to the experimental group. The results of analysis are summarized as follows. 1. There were no significant statistical differences of the general characteristics between patient and control groups and there was no difference of characteristics by patient groups except the mean gait distance a day. 2. Of 33 patients with amputation, 18 patients (57.8%) had phantom pain and 25 cases (80.6%) had neuroma. 3. Gait velocity, stride length of the affected side, step length of the sound side and base support among gait characteristics show a significant difference according to the stump length in the state excluding the effects of other factors (p<05) and the group with long stump showed closer gait characteristics to normal persons than those with short stumps. In conclusion, among the patients of unilateral below-knee amputations, the stump length affects the gait characteristics such as gait velocity, stride length, step and base of support and it is found that as the stump length gets longer, it shows the similar characteristics to gait characteristics of normal persons and long unilateral below-knee amputation can secure better gait characteristics.

청반손상 후에 L-dopa 를 투여한 쥐에서 나타나는 주의장애

조옥경,한정수,김기석 한국심리학회 1989 한국심리학회지 생물 및 생리 Vol.1 No.1

도파민 효능제인 L-dopa를 쥐에게 투여하면 강화와 짝지어지지 않은 부적절자극을 무시하는 주의 과정에 장애가 나타난다. 이같은 장애는 청반을 파괴하여 대뇌 노어에피네프린계의 이상을 초래한 경우에도 나타나므로 청반손상 후에 L-dopa를 투여하면 주의장애가 심해질 것으로 예상하였다. 왕복상자에서 회피반응을 쥐에게 학습시킨 후 검사시행에서는 훈련에 사용되었던 소리자극을 전기쇼크없이 제시하는 중간중간에 부적절자극인 빛자극을 무선적으로 제시하였다. 실험 결과, L-dopa집단이 주의장애를 보였고 청반손상집단은 주의장애가 없었으나 청반손상과 L-dopa 투여가 같이 처치된 집단은 부적절자극을 무시하는 능력에 상당한 장애를 보였는데 이는 L-dopa 단독 투여 효과를 훨씬 넘어서는 것이었다. 이같은 결과는 주의과정에 도파민과 노어에피네프린이 상호작용할 가능성을 시사하며 이는 정신분열증 환자에서 나타나는 주의장애에 대한 동물모형을 제시해 줄 수 있다고 생각된다. The attentional process by which animals learn to ignore an irrelevant stimulus was examined after the treatment with L-dopa or bilateral electrolytic lesions of locus coeruleus(LC). Rats received daily 100 trials of two-way avoidance training in which each trial was initiated by a 10-sec tone stimulus and terminated either by a shuttle response during the tone(avoidance) or by a response during the electric shock(escape). The training sessions continued until the animals met a criterion of eight avoidance responses during any ten consecutive trials. The same rats then received a 50 trials test session. A light, which was irrelevant because it had never been paired with shock, was randomly presented during the test period. The administration of L-dopa produced marked impairment in tuning out the irrelevant stimulus, but LC lesion group did not show any attentional deficits. When L-dopa injection was superimposed to LC lesions, the deficit was increased. It may be interpreted that the result is due to an interaction between the noradrenergic and dopaminergic system. This interaction in ignoring an irrelevant stimulus may provide an animal model of selective attention deficit observed among some schizophrenic patients.

공여자의 종류에 따른 간이식 후 감염성 합병증의 비교 : Comparison between Orthotopic and Living Donor Transplantation

기현균,손준성,오원섭,백경란,이남용,김성주,조재원,이석구,송재훈 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 최근 간이식 수요가 증가함에 따라 이에 대한 하나의 대안으로 생체 부분 간이식(LDLT) 시행례가 증가하고 있다. 이에 뇌사자 사체 간이식(OLT)과의 감염 양상을 비교하기 위하여 본 연구를 시행하였다. 방법 : 1996년 5월부터 2003년 8월까지 삼성서울병원에서 간이식을 시행 받은 284명의 환자들을 대상으로 후향적으로 분석하였다. 결과 : 188명은 LDLT를, 96명은 OLT를 시행 받았다. 간이식 후 감염증은 총 191명에서 발생하였고(67.0%) OLT 환자군과 LDLT 환자군 사이에 감염증의 발생 빈도와 원인 병원체의 빈도는 유의한 차이를 보이지 않았다. 병원체 별로는 Enterococcus 균정(16.2%) S. aureus(15.1%), coagulase negative staphylococci (13.4%)의 순서였다. 감염증의 종류는 복강 내 감염이 총 83례로 가장 많았는데, LDLT에서 OLT에 비하여 유의하게 높게 발생하였다(34.0% vs 19.8%, P=0.012). 요로 감염증(11.5% vs 4.3%, P=0.022)과 침습성 아스페르길루스증(7.3% vs 1.6%, P=0.034)은 OLT을 시행한 경우에 많았다. 기타 감염증은 통계적으로 유의한 차이가 없었다. 결론 : 간이식 환자에서 공여자의 종류에 따른 감염의 발생빈도는 차이가 없었으나 감염증 중 복강 내 감염은 LDLT에서 더 많이 발생하였다. 장구균 감염, 특히 반코마이신 내성 장구균이 간이식 후 발생하는 감염증의 중요한 원인 병원체임을 확인하였다. Background : Living donor liver transplantation (LDLT) has been performed more frequently to circumvent the shortage of donor organs. However, infectious complications after LDLT compared with orthotopic liver transplantation (OLT) have not been well investigated to date. Methods : We have retrospectively reviewed the medical records of all consecutive cases of liver transplantation, which had been performed at the Samsung Medical Center, Seoul, Korea, from May 1996 to August 2003. Results : Of the 284 patients enrolled, 188 (66.2%) underwent LDLT. Overall incidence of infectious complications after liver transplantation was 67.0% (191/284). Incidence of infections was not different between OLT group (67.7%) and LDLT group (67.0%) (P=0.9). Bacterial infections were the most common infectious complications (146 cases) followed by viral infections (32 cases), fungal infections (26 cases), and tuberculosis (4 cases). Enterococcus spp. (16.2%) were the leading pathogens followed by Staphylococcus aureus (15.1 %) and coagulase-negative staphylococci (13.4%). However, the distribution of etiologic agents was not different between OLT and LDLT group. Intra-abdominal infections (83 cases) were the most common type of infectious complications, which were more frequent in LDLT group (34.0%) than in OLT group (19.8%) (P=O.Ol). Conclusion : LDLT resulted in intra-abdominal infections more frequently than OLT. Enterococcus spp., especially vancomycin-resistant enterococci, are emerging pathogens in patients with liver transplantation.

도파민 과다활동이 저지수행에 미치는 영향 : Effects Apomorphine and Haloperidol Induced Supersensitivity

조옥경,김기석 한국심리학회 1990 한국심리학회지 생물 및 생리 Vol.2 No.1

본 연구는 중추신경계의 도파민 활동을 증가시키는 처치가 흰쥐의 저지학습에 미치는 영향을 알아보기 위한 것이다. 저지학습은 표준 왕복회피 상자에서 관찰하였는데 1단계 훈련에서는 소리를, 2단계 훈련에서는 불빛과 소리로 이루어진 복합자극을 전기쇼크를 알리는 신호로 사용하였다. 검사시행에서 이들 자극을 단독으로 제시하여 각 자극에 대한 조건화 정도를 측정하였으며 새로운 불빛 자극 하나를 더 첨가하여 이에 대한 반응의 정도도 관찰하였다. 실험 1에서는 도파민 효능제인 아포모르핀 1㎎/㎏를 투여한후 저지학습의 장애를 관찰하였다. 실험 2에서는 할로페리들을 장기투여하여 도파민 수용기가 과민해진 경우에 나타나는 저지학습의 장애를 관찰하였다. 또 도파민 수용기가 과민해진 동물에게 정상 쥐에서는 행동적 효과가 없는 소량의 아포모르핀을 투여한 경우에도 저지학습의 장애가 일어나는 것을 관찰하였다. 이와같은 저지장애를 부적절한 자극을 무시하는 능력의 장애라는 측면에서 고찰하였다. This study is to examine whether dopamine is involved in the conditioned blocking. In the blocking paradigm, prior training to a conditioned stimulus(CS-A) blocks the ability to attend to a second conditioned stimulus(CS-B) when the two form a compound stimulus(CS-AB) in a subsequent training. Blocking is an associative process by which animal learn to ignore CS-B because it contains no new information regarding the reinforcing event. The blocking effect was assessed in a standard shuttle box. The onset of the tone signalled the footshock in stage 1. In stage 2, the compound stimulus of the tone and the light signalled the shock. The testing stage consisted of 16 nonreinforced presentations each of CS-A, CS-B and a novel dim light stimulus. The blocking ratio was obtained by dividing the number of conditioned avoidance responses (CAR) emitted to the light by the total number of CARs emitted to both light and tone. Experiment 1 showed that 1㎎/㎏ apomorphine attenuated the blocking effect. In experiment 2, blocking was also disrupted with 0.1㎎/㎏ apomorphine coupled with dopamine receptor supersensitivity produced by prolonged pretreatment with haloperidol. These results suggest that dopamine hyperactivity in the brain disrupted blocking which is interpreted as a selective attention deficit. This attentional deficit bears some resemblance to attentional disorder seen among schizophrenic patients.

重化學工業機械의 國産化方案에 關한 硏究 : 特히 窯業에 있어서의 燒成爐, 粉碎機, 排風機, 冷却機, 電氣集마器 自動枰量供給器 等의 製作을 目的으로

趙哲衡,朴碩喆,丁太權,宋鐵,桭達福,金基玉,朴煥奎,趙煥從,朴善鐘,金種一,李茂錫 朝鮮大學校 1977 綜合論文集 Vol.1977 No.-

This is to investigate the posibility of home manufacturing of heavy chemical industry machines, such as rotary kiln, crusher, blower, cooler, electrostatic precipitator and weighing feeder of cement plant. It is concluded that even though we can not make all of them (some of them are made now and some others are going to be made in the near future, some of them are made whole and some others are made partially), we can build or export the cement plant by importing the important machines which we can not make now and by substituting them with ours gradually.

경견완 장애를 보이는 영상 단말기근로자들의 심리적 특성에 따른 분류와 업무지각특성

조선미,이세휘,임기영,이명숙 용인정신의학연구소 1999 용인정신의학보 Vol.6 No.2

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

제강전로슬래그를 이용한 하수슬러지 고화체의 미세구조 분석

李基錫,趙珍奎,李昇玟,金應鎬 弘益大學校 科學技術硏究所 1999 科學技術硏究論文集 Vol.10 No.1

The solidifying effect of solidified digested sewage sludge by converter slag was investigated through microscopic analyses including XRD, SEM and EDS. The XRD analysis of the solidified sludge showed that the main solidification products was CSH; in addition, Ca(OH)₂CAH and Ettringite were observed. The microstructure analysis by SEM showed that as the solidification proceeds, needlelike crystals and honeycomb appeared. The analysis of these crystals by EDS confirmed that the main components were Ca, Si etc. This also confirmed the general notion that the cement hydrate products had a solidifying effect.