Do We Still Use The Camitta"s Criteria For Severe Aplastic Anemia?

( Hyun Hwa Yoon1 ),( Sung Hyun Kim1 ),( Ji Hyun Lee ),( Seok Jae Huh ),( Suee Lee ),( Sung Yong Oh ),( Hyuk Chan Kwon ),( Hyo Jin Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.-

머리염색이 인체에 미치는 영향

윤형식,황성호,이현륭,김수호,박연석,권낙현,정호진,김동훈,노현주,홍성호,박병찬,이관,정해관 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.1

일상생활에서 모발염색은 흔히 접할 수 있는 미용의 한 종류로 특히 젊은층을 중심으로 폭발적으로 유행하고 있다. 염색을 위항 사용하는 약제는 표백제와 발색제 등 각종 화학약품이 사용되고 있으나 이로 인한 건강장해에 대한 연구는 그리 많지 않다. 저자들은 염색이 인체의 모발건강에 미치는 영향을 파악하기 위하여 염색과 관련된 주관적 증상과 모발의 변화에 대한 실험적 연구를 시행하였다. 동국대학교 경주 캠퍼스 재학생 80명을 대상으로 설문조사를 시행하여 염색 유 ·무 및 염색 후에 경험한 증상에 대해 설문 조사하였고, 의과대학 재학생 46명을 대상으로 피부 반응 테스트를 실시하였다. 또한 염색 전후의 모발 탄성도를 측정하였고 모발의 상태를 파악하기 위해 전자 현미경검사를 실시하였다. 설문조사 결과 염색 전에 비하여 염색 후 안구혼탁, 안구건조, 시력저하, 발진 및 접촉성 피부염, 모발손상, 모근손상 등의 증상을 더 많이 경험한다고 호소하였다(p<0.05). 모발손상과 모근손상은 헤어드라이어 사용 빈도에 따라 증가하는 것으로 조사되었다(p<0.05). 피부반응검사에서 가려움증이 가장 많은 증상이었으며 이는 여성보다는 남성에서 높은 것으로 조사되었다. 염색 전후의 모발장력은 염색 전 134.5±10.37g, 염색 128.0±30.69g, 염색 이틀 후 112.5±19.69g으로 나타났다. 염색 전후의 모발의 전자현미경 케라틴 층이 현저히 감소하고 모발이 가늘어지는 차이를 보였다. 염색은 모발손상, 모발 케라틴 손상 및 모근 손상, 발진 및 접촉성 피부반응, 안구혼탁, 안구건조, 시력 저하를 유발한다. 따라서 염색약으로 인한 손상에 대한 주의와 예방이 필요하다고 생각한다. 예방대책으로 염색 전 피부테스트를 통한 적합성 여부를 판단하는 것이 필요하며 가급적 염색을 피하는 것이 좋을 것이다. 염색약에 발암물질이 포함되어있다는 보고도 있어 염색 제조사의 철저한 실험과 염색 물질의 선별이 염색으로 인한 부작용을 최소화하는데 중요한 역할을 할 것이다. Hair coloring has became one of the most popular cosmetic activities to younger generations during last decade. However, there are few studies on the health effect of widespread use of chemical dyes. This study was conducted to study the effects of hair coloring dye on hair and other systems. We conducted a questionnaire survey of 80 persons in Kyongju campus, Dongguk University. We have done open patch skin test on 46 medical students. We also conducted scanning electron microscopy to examine the hair strength and structure before and after hair coloring process. Injury of hair and hair bulb, contact dermatitis, turbid eyes, xerophthalmia, and poor visual acuity were the main symptoms complained after hair coloring (p<0.05). Injury of hair and hair bulb were increased by frequency of hair-dryer use(p<0.05). In open patch test, pruritus was complanined by more than half of the subjects. Mean strength of hairs before and after hair coloring was as follows; 134.5 (SD 10.37)g before hair coloring, 128.0 (SD 30.69)g immediately after hair coloring, and 112.5 (SD 19.69)g after two days. The scanning electron microscopic findings of hair surface before and after hair coloring showed decreased keratin layer and thinning of the hair. Hair coloring induces injury to hair, its keratin layer, and hair bulb as well as contact dermatitis, turbid eyes, xerophthalmia, and poor visual acuity. Therefore, we think that precaution is needed in use of hair coloring dye. To prevent complications induced by hair coloring dye, it is necessary, especially to those with allergy or skin disorders, to perform skin test before action and avoid hair coloring whenever possible. Longterm health effects of hairdye should be studied and manufacturing companies should try to minimize complications induced by hair coloring dye.

국내산 중하(Metapenaeus joyneri) 내 주알레르겐 규명 : 가열 및 소화액에 의한 변화

윤성호,김현아,김현미,최정희,서창희,남동호,김윤근,민경업,박해심 대한알레르기학회 2004 천식 및 알레르기 Vol.24 No.2

The Relationship among Engagement in Workplace Learning Activities, Openness to Learning, and the Extent of Participant Involvement in Informal Learning

Yoon,Dong-Yeol,You,Jieun,Yun,Wi Seok,Hyun,Sunhae 한국인적자원관리학회 2011 인적자원관리연구 Vol.18 No.4

일터학습에 있어서 비공식학습의 중요성이 대두함에 따라, 많은 기업들은 직원들의 비공식 학습을 촉진할 수 있는 다양한 학습전략응사용하고 있다. 기존의 연구들은 기업 내 공식학습과 비공식학습은 상호 연관되어 있어, 공식학습을 제공할 경우 비공식학습도 동시에 활성화된다고 주장한다. 본 연구는 직원들이 기업에서 행해지고 있는 일터학습에 참여하는 정도가 비공식학습활동에 어떠한 영향을 미치는지 연구함으로써, 일터학습의 참여도와 비공식학습의 관계를 알아보고자 하였다. 일터학습에 참여하고 있는 제약회사의 직원들을 대상으로 한 설문조사에 대하여 회귀분석을 실시한 결과, 일터학습에 참여하는 것 자체는 직원들이 비공식학습에 몰입하는 정도에 유의미한 영향을 미치지 못하는 것으로 나타났다. 특히 실천공동체와 온라인 학습의 경우 비공식학습에 부정적 영향을 미치는 것으로 나타났다. 이는 기업이 일터학습을 제공하더라도, 체계적인 형태를 갖추지 못했거나 직원들 간의 상호작용을 촉진하지 못할 경우 일터학습이 오히려 비공식학습을 저해할 수 있다는 것을 보여준다. 그러나 개인의 학습 개방성은 비공식학습의 정도에 영향을 미치는 것으로 나타나, 일터학습의 참여도가 비공식학습의 정도에 미치는 영향에 조절효과를 보이는 것으로 나타났다. 끝으로 연구결과는 관리자 직급에 있는 근로자들의 경우 그렇지 않은 직원들에 비하여 비공식학습활동에 더 많이 참여하고 있다는 것을 보여준다. 관리자 직급의 근로자들은 학습에 대한 경험이 풍부하고, 학습의 필요성에 대해서도 충분히 인식하여 비공식학습활동에도 적극적으로 참여하고 있다고 볼 수 있다. 따라서, 기업 내에서 비공식학습을 활성화시키기 위하여, 종업원들에게 일터학습을 제공하고 이것에 참여하도록 유도하는 것뿐만 아니라, 직원들 스스로 학습에 참여할 수 있는 개방적 태도를 지닐 수 있도록 지원하는 것이 중요하다는 것을 보여준다. Informal learning in the workplace is becoming more important for improving employees’ competencies and organizational performance. Many business organizations use a variety of workplace learning strategies in order to facilitate informal learning among employees. Research on workplace learning explains that formal learning and informal learning interrelate and facilitate each other. This study investigated the relationship among engagement in workplace learning activities, openness to learning, and the extent of participant involvement in informal learning. As a result of quantitative research in a pharmacy company, this study showed the following: (a) openness to learning affects participant involvement in informal learning more than engagement in workplace learning activities does; (b) among types of workplace learning, communities of practice negatively influence internal informal learning, and web-based learning also has a negative effect on involvement in internal, external informal learning and informal learning among newly hired employees, but traditional classroom training positively affects participants’ involvement in informal learning among new employees; and (c) employees at the managerial level involve in informal learning activities more than other employees. These results suggest that business organizations and corporate management should support and facilitate employees to learn with openness as well as provide them with workplace learning opportunities.

급성전골수성백혈병에서 백혈구성분채집술에 이은 치명적인 뇌출혈 2예

오윤정,박소윤,김윤정,한동석,김현수,최진혁,남동기,임호영,김효철,주희재 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.1

The aim of this study is to report 2 cases of acute promyelocytic leukemia who died from intracranial hemorrhage following leukapheresis and to provide proper preventive measures against hemorrhage following leukapheresis. From 1994 to 1997, a total of twenty-six patients with leukemia underwent leukapheresis to control hyperleukocytosis at Ajou University Hospital. Two patients with acute promyelocytic leukemia received all-trans retinoic acid but developed drug-induced hyperleukocytosis. Shortly after leukapheresis, they died from intracranial hemorrhage. The risk factors for fatal hemorrhage are thought to be coexisting disseminated intravascular coagulation(DIC), thrombocytopenia aggravated by leukapheresis, exacerbated coagulopathy related to mechanical trauma through leukapheresis and the excess use of citrate during leukapheresis. To reduce the risk of the bleeding associated with leukapheresis, it is necessary to replace platelet sufficiently before and after leukapheresis and to give calcium to correct coagulopathy induced by excess citrate which is used as anticoagulant as well as the correction of disseminated intravascular coagulation.

교환계약에 있어서의 실지거래가액 과세에 관한 짧은 고찰

윤지현(Yoon Ji?Hyun) 한국법학원 2007 저스티스 Vol.- No.100

원칙적으로 실지거래가액에 의하여 과세표준을 산정하는 양도소득세제에서 특히 교환거래의 경우 실지거래가액을 무엇으로 볼 것이냐를 둘러싸고 실무상 많은 문제점이 발생하고 있다. 판례는 이에 관하여 교환거래를 ‘단순한 교환’과 시가감정 및 정산절차가 수반된, ‘단순하지 않은 교환’으로 나누고, 전자의 경우에는 실지거래가액이 존재하지 않으나 후자의 경우에는 실지거래가액이 존재하는 것으로 보고 있다. 이러한 판례의 입장은, 실지거래가액이란 당사자들이 ‘약정한 가액’이라는 전제 하에, ‘단순한 교환’의 경우 당사자들이 합의하는 것은 교환대상 자산의 절대적 가치가 아니라 상대적 교환비율에 불과하므로 실지거래가액이 존재하지 않는다고 보아야 하지만, ‘단순하지 않은 교환’의 경우에는 당사자들이 실제로 일정한 가액에 합의한 것으로 볼 수 있고 또 그러한 가액을 신빙할 수 있다는 이해에 근거를 둔 것으로 보인다. ‘단순한 교환’에 불과하여 실지거래가액을 알 수 없는 교환거래의 경우 현행법상 추계과세 대상이 된다는 명문의 규정은 없으나 다른 사유로 실지거래가액을 알 수 없는 경우에 준하여 추계과세의 대상이 되는 것으로 해석함이 타당하며, 소득세법은 추계과세의 경우 교환으로 인하여 취득하는 자산이 아닌 양도하는 자산 자체의 매매사례가액이나 감정가액 등에 의하여 양도가액을 산정하는 것으로 규정하고 있다. 다만 일반적인 추계과세의 경우와는 달리 납세자가 스스로 이와 같이 양도하는 자산의 가액을 평가하여 양도소득세를 신고납부할 수 있다고 해석하여야만 할 것이다. 궁극적으로는, 실지거래가액 과세제도가 당사자들이 실제로 얻은 양도소득을 과세대상으로 삼는 제도라는 측면에서 보았을 때, 양도소득세도 법인세법에서와 마찬가지로 교환으로 인하여 취득하는 자산의 가액에 의하여 산정하는 방향으로 전환하는 것이 바람직하며, 실지거래가액의 개념 역시 이러한 견지에서 해석하는 방향으로 나아가는 것이 해석론상, 또는 입법론상 타당한 것으로 생각한다. Under the Income Tax Act, Capital Gains Tax is levied based on "Actual Transaction Price" as opposed to "Government-Announced Price," but there is controversy as to what Actual Transaction Price means in the event of an exchange transaction. The Supreme Court generally defines the Actual Transaction Price as the price that has been "actually agreed on" between the parties. Based on this definition, the Supreme Court takes the position that the exchange transaction is divided into the two following categories: the "Non-Plain Exchange" where the parties have conducted valuation of the two exchanged assets and the difference in value between the two assets have been settled, and the "Plain Exchange" which is an exchange that, on the contrary, does not meet all of such requirements. The Supreme Court seems to believe that, in the event of a Plain Exchange, what the parties have agreed on is only the ratio of the exchange, and therefore there is no price actually agreed between the parties. However, in the event of a Non-Plain Exchange, the Supreme Court apparently reasons that, since there have been valuation of the assets and settlement of the difference in value, it is likely that the parties have actually agreed on the transaction price, which is reliable to a sufficient degree for capital gains tax purposes. Under the current Income Tax Act, the Plain Exchange where there is no Actual Transaction Price is subject to "Taxation based on Projection," where the value of the transferred asset rather than the asset received as a result of the exchange is taken into consideration in computing the capital gains tax. However, unlike in ordinary Taxation based on Projection, which is only the tax authorities' prerogative, here the taxpayer should also be able to file his or her tax return using the same method. In the end, considering that the taxation based on Actual Transaction Price is such a system where the "actual" capital gain is measured and used as basis for taxation, I believe it is more reasonable to compute capital gains tax based on the fair market value of the asset received through an exchange. I therefore believe that the Supreme Court should reverse its former position and rule that the Actual Transaction Price in an exchange is the fair market value of the asset received through an exchange, and if that is not feasible, then the legislative body should take the initiative to change the law to that effect.

성인에서 장기간 Furosemide오용과 연관된 신수질 석회화

김윤구,이윤하,이규백,장세호,김대중,오하영,김보현,김미경,조윤숙 대한신장학회 1996 대한신장학회잡지 Vol.15 No.4

축구선수의 Detraining과 Retraining이 혈청지질 및 호르몬농도에 미치는 영향

정정화,박재현,채종훈,성혜련,황지인,윤미숙,노금선,윤종관,윤영학,노순덕,정경숙,박일규,김은희,박현태,박상갑 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

The purpose of this study was to investigate the effects of detraining and retraining on serum lipid and hormones in soccer players. Subjects were seven male high-school soccer players. V˙O_2max was determined for each subjects by administering a treadmill test(initial speed: 90m/min, grade: 5%, increasing speed per 3 min: 30m/min). Serum lipid(T-C, TG, HDL-C LDL-C) and hormones(epinephrine, norepinephrine, growth hormones, cortisol) were assayed pre and post detraining in 10, 20, 30 days after retraining. The repeated ANOVA was used to determine significant differences. The 0.05 level of significance was as critical level for the study. The results of the study were as follows: 1. V˙O_2max(ml/min) were 3576.3±204.2ml/min pre detraining, 3234.1±198.9 ml/min post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/min) were 3601.4±170.9 ml/min. There were significantly(p<.05) increased in retraining periods. 2. V˙O_2max(ml/kg/min) were significantly(p<.05) decreased from 62.3±2.9 ml/kg/min to 55.9±4.7 ml/kg/min in detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/kg/min) were 62.4±3.4ml/kg/min, 62.7±2.3ml.kg/min, 67.3±7.2ml/kg/min respectively. There were significantly(p<.05) increased in retraining periods. 3. T-C were significantly (p<.05) increased from 166.6±8.5mg/dl to 175.3±10.3 mg/dl in detraining. In 10, 20, 30 days after retraining, T-C were 160.1± 3.2mg/dl, 156.7±3.7mg/dl, 140.3±9.0mg/dl. There were significantly(p<.05) decreased in retraining periods. 4. HDL-C were 61.4±6.6mg/di pre detraining, 5.3±6.6mg/dl post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, HDL-C were 56.9±7.1mg/dl, 56.4±9.2mg/dl, 57.7±9.1mg/dl respectively. There were no significant difference in retraining periods. 5. The hormones(epinephrine. norepinephrine, growth hormone, cortisol) were changed as same patterns. Epinephrine were 26.0±7.0[g/ml pre detraining, 24.6±3.2pg/ml post detraining. In 10, 20, 30 days after retraining, epinephrine were 26.9±5.6pg/ml, 30.6±6.2pg/ml, 29.4±5.6pg/ml respectively. There were no significant difference in retraining periods. In conclusion, HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were decreased, T-C, LDL-C and TG were increased in detraining. But HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were increased, T-C, LDL-C and TG were decreased in retraining.

두가지 혈류 유발방법에 의한 새로운 심폐소생술(이중 혈류 유발 심폐소생술)장치의 개발

황성오,김현,조준휘,오범진,임종천,최경훈,윤정한,이승환,김영식,이강현,이윤선 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

Background: There have been many efforts to augment blood flow during cardiopulmonary resuscitation. These efforts have focused on maximizing the effect of cardiac pump or thoracic pump alone. However, considering that the heart is the biggest blood reservoir and increase of intrathoracic pressure can generate blood flow, simultaneous exploitation of both mechanisms may have synergistic effect. We hypothesized that simultaneous chest constriction in addition to sternal compression by standard CPR may have additive hemodynamic effects by preventing deformation of the chest and increase of intrathoracic pressure. Methods and results: we built a new mechanical device to perform compression and thoracic constriction simultaneously. The device consists of two main elements. Piston in the center is to depress the sternum. Strap is to constrict the thorax circumferentially. Strap is attached to both sides of the piston. When the piston is pushed down, it depresses the sternum and pulls on the thoracic strap. To determine strap width to produce optimal hemodynamic effect, we measured hemodynamic parameters with variable widths of strap in two dogs after induction of ventricular fibrillation. Result of the experiment showed that 10cm wide strap was determined to be most effective. We also determined optimal depth of compression to produce maximal hemodynamic effect with animal experiments using two dogs. Animal experiments showed that the highest aortic pressure could be generated when the stemum was depressed to 5 cm. Cardiopulmonary resusciation using a new device could generate higher systolic aortic pressure, coronary perfusion pressure and end-tidal carbon dioxide tension in comparison with standard cardiopulmonary resuscitation in a pilot animal study using two dogs. Conclusion: New cardiopulmonary resuscitation method using a mechanical device designed by us could perform sternal compression and simultaneous thoracic constriction, and generate better hemodynamic effects than standard cardiopulmonary resuscitation in pilot animal experiments.

이질적인 무선이동통신시스템의 통합 구조에 대한 연구

윤현식 忠州大學校 2005 한국교통대학교 논문집 Vol.40 No.2

Rapid progress in research and development of wireless networking and communication technologies has created different type of wireless system. These systems are envisioned to coordinate with each other to provide ubiquitous high data-rate services to mobile users. In this thesis a new architecture, Architecture for Ubiquitous Mobile Communications(AUMC), is introduced that integrates these heterogeneous wireless systems. AUMC eliminates the need for direct service level agreements among service providers by using a third party, a network interoperating agent. Instead of developing a totally new infrastructure, AUMC extends the existing infrastructure to integrate heterogeneous wireless systems. It uses If as the interconnection protocol. By using IP as the gluing protocol, transparency to the heterogeneities of the individual systems is achieved in AUMC. New mobility management protocols are also developed to support seamless roaming between different wireless systems.