ORIGINAL ARTICLE : ORIGINAL ARTICLE : To Predict the Tendency of the Development of Urban Comprehensive Park through the Social Reform of China - The Example of Changes of Comprehensive Park in Wuhan City -

( Zhuang Yue ),( Hyunju Jo ) 한국환경과학회 2015 한국환경과학회지 Vol.24 No.9

This paper is to study the tendency of the development of the urban comprehensive park in the modern history of China, and take the urban comprehensive park of Wuhan as an example to study the local research through the literature.. In 1928, Wuhan Urban Comprehensive Park starting stage characteristics to the ideological education of the government as the center, in 1977 the policy of reform and opening to the outside world to entertainment center, ecology design point of view, the introduction of open space and urban plaza, to human centered design, application of science and technology. 2015 in Wuhan Urban Garden Expo theme can be seen in green life as the goal, through the design of urban comprehensive park ecology and human centered design, the application of science and technology development.

Heterologous expression of Solanum tuberosum NAC1 gene confers enhanced tolerance to salt stress in transgenic Nicotiana benthamiana

Yue Lu,Zhuang Yong,Gu Yuanyang,Li Hui,Tu Shengbin,Yang Xiaocheng,Huang Weizao 한국식물학회 2021 Journal of Plant Biology Vol.64 No.6

The plant-specific transcription factors NACs (NAM, ATAF1, 2, CUC), one major transcription factor family, play significant roles in various physiological processes including abiotic stresses. In our study, an NAC gene from potato (Solanum tuberosum L.) was cloned and named as StNAC1 for a high-sequence similarity to SlNAC1, a well-known tomato NAC gene regulating multiple stress responses and fruit ripening. StNAC1 gene was significantly induced under salt stress. Then, we constructed StNAC1-overexpressing transgenic Nicotiana benthamiana plants and obtained three homozygous transgenic lines. The phenotypic analysis results showed that StNAC1-overexpressing transgenic plants had not only higher seed germination and green leaf rates, but also accumulated less ROS and more proline than wide-type plants under salt stress, which resulted in improving transgenic plants salt tolerance. These suggested that StNAC1 gene might function as a positive regulator in plant response to salt stress.

Encainide, a class Ic anti-arrhythmic agent, blocks voltage-dependent potassium channels in coronary artery smooth muscle cells

Hongliang Li,Yue Zhou,Yongqi Yang,Yiwen Zha,Bingqian Ye,Seo-Yeong Mun,Wenwen Zhuang,Jingyan Liang,Won Sun Park The Korean Society of Pharmacology 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.4

Voltage-dependent K⁺ (Kv) channels are widely expressed on vascular smooth muscle cells and regulate vascular tone. Here, we explored the inhibitory effect of encainide, a class Ic anti-arrhythmic agent, on Kv channels of vascular smooth muscle from rabbit coronary arteries. Encainide inhibited Kv channels in a concentration-dependent manner with an IC₅₀ value of 8.91 ± 1.75 μM and Hill coefficient of 0.72 ± 0.06. The application of encainide shifted the activation curve toward a more positive potential without modifying the inactivation curve, suggesting that encainide inhibited Kv channels by altering the gating property of channel activation. The inhibition by encainide was not significantly affected by train pulses (1 and 2 Hz), indicating that the inhibition is not use (state)-dependent. The inhibitory effect of encainide was reduced by pretreatment with the Kv1.5 subtype inhibitor. However, pretreatment with the Kv2.1 subtype inhibitor did not alter the inhibitory effects of encainide on Kv currents. Based on these results, encainide inhibits vascular Kv channels in a concentration-dependent and use (state)-independent manner by altering the voltage sensor of the channels. Furthermore, Kv1.5 is the main Kv subtype involved in the effect of encainide.

A sigma class glutathione S-transferase gene regulated by the CncC pathway is required for phytochemical tolerance in the red flour beetle, Tribolium castaneum

Gao Shan-shan,Li Dong-yu,Huo Zhuang-kun,Zhang Yong-lei,Cao Yi-zhuo,Tan Yue-yao,Guo Xin-long,Zhang Jia-hao,Zhang Kun-peng,Li Rui-min 한국응용곤충학회 2022 Journal of Asia-Pacific Entomology Vol.25 No.4

Insect glutathione S-transferases (GSTs) play a crucial role in the detoxification of exogenous compounds, especially insecticides and plant allelochemicals. A sigma class GST gene, TcGSTS7, mediates the response to eugenol in Tribolium castaneum. However, the mechanism underlying this effect remains largely unknown. In this study, TcGSTS7, which exhibits a structural motif and domain organization characteristic of GSTs, was cloned from the T. castaneum genome. Spatiotemporal expression analysis revealed that TcGSTS7 was most highly expressed at the late larva stage and was mainly expressed in the fat body and epidermis of larvae and adults, suggesting that TcGSTS7 may play a potential role in the protection against toxic xenobiotics in T. castaneum. Furthermore, the expression of TcGSTS7 was significantly induced after exposure to eugenol, while RNA inter ference (RNAi) targeting TcGSTS7 enhanced the sensitivity of the beetle to eugenol, indicating that TcGSTS7 is involved in the tolerance of T. castaneum to this insecticide. Interestingly, the depletion of TcCncC, which encodes a transcription factor of the CncC pathway that has been associated with the regulation of detoxification-related genes in insects, led to a reduction in the TcGSTS7 transcript level following exposure to eugenol, which suggests that TcGSTS7 acts downstream of the CncC pathway. Combined, these results indicated that TcGSTS7 partici pates in the tolerance of T. castaneum to phytochemicals in a CncC pathway-dependent manner. These findings have implications for the development of novel drugs for use in pest control.

Appraisal of Guidelines for the Management of Blood Pressure in Patients with Diabetes Mellitus: The Consensuses, Controversies and Gaps

Menghui Liu,Shaozhao Zhang,Xiaohong Chen,Yue Guo,Xiangbin Zhong,Zhenyu Xiong,Yifen Lin,Huimin Zhou,Yiquan Huang,Zhengzhipeng Zhang,Lichun Wang,Xiaodong Zhuang,Xinxue Liao 대한당뇨병학회 2021 Diabetes and Metabolism Journal Vol.45 No.5

Background: Currently available guidelines contain conflicting recommendations on the management of blood pressure (BP) in patients with diabetes mellitus (DM). Therefore, it is necessary to appraise the guidelines and summarize the agreements and differences among recommendations.Methods: Four databases and the websites of guideline organizations were searched for guidelines regarding BP targets and thresholds for pharmacologic therapy in DM patients, and the included guidelines were appraised with the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument.Results: In 6,498 records identified, 20 guidelines met our inclusion criteria with 64.0% AGREE II scores (interquartile range, 48.5% to 72.0%). The scores of the European and American guidelines were superior to those of the Asian guidelines (both adjusted P<0.001). Most of the guidelines advocated systolic BP targets <130 mm Hg (12 guidelines, 60%) and diastolic BP targets <80 mm Hg (14 guidelines, 70%) in DM patients. Approximately half of the guidelines supported systolic BP thresholds >140 mm Hg (10 guidelines, 50%) and diastolic BP thresholds >90 mm Hg (nine guidelines, 45%). The tiny minority of the guidelines provided the relevant recommendations regarding the lower limit of official BP targets and the ambulatory BP monitoring (ABPM)/home BP monitoring (HBPM) targets and thresholds in DM patients.Conclusion: The lower official BP targets (<130/80 mm Hg) in patients with DM are advocated by most of the guidelines, but they contain conflicting recommendations on the official BP thresholds. Moreover, the gaps regarding the lower limit of official BP targets and the ABPM/HBPM targets and thresholds need to be considered by future study.

Enhancing the performance of LSSVM model in predicting rock fragmentation size via optimization algorithms

Haowen Zheng,Jun Liu,Ruihong Zhuang,Fu-tian Zhao,Meng-yang Zhen,Yue Wang,Zheng Liu 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.9

The prediction of rock fragmentation is critical to improve the efficiency and economy of blasting excavation. In this study, an attempt is made to predict the entire fragmentation size distribution using a least square support vector machine (LSSVM) model. In addition, three optimization algorithms – the bacterial foraging algorithm (BFO), artificial fish swarm algorithm (AFSA), and adaptive particle swarm optimization (APSO) – were used to determine the appropriate parameters of the LSSVM model. In the constructed LSSVM-BFO, LSSVM-AFSA and LSSVM-APSO models, the hole spacing, row spacing, change per delay and stemming were used as the input parameters, while the statistical rock fragmentation size was assigned as the output. The LSSVM model was also employed as a control group for comparing with the optimized models. The above-mentioned models were trained and tested based on a database comprising of 10 datasets collected from in-site testing of Altashi Water Control Project in China. The performance of the proposed models was compared by several statistical criteria. The viability and efficiency of the LSSVM-BFO model were confirmed with an R2 of 0.9960 and an RMSE of 1.8044, which were better than those of the LSSVM-AFSA, LSSVM-APSO and LSSVM. Last but not least, sensitivity analysis was also executed. The result of sensitivity analysis demonstrated when the size of rock fragmentation of prediction is less 80mm, the most effective parameter will be stemming; otherwise the most effective parameter will be hole spacing.

Stability Evaluation and Improvement of Adaptive Optics Systems by Using the Lyapunov Stability Approach

Liang Wang,Tao Chen,Xin-yue Liu,Xu-dong Lin,Xiao-xia Yang,Hong-zhuang Li 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.68 No.3

In this research, investigations on the closed-loop control stability of adaptive optics systems are conducted by using the Lyapunov approach. As an direct metric of the control stability, the error propagator includes the effects of both the integral gain and the influence matrix and is effective for control-stability evaluation. An experimental 97-element AO system is developed for the control-stability investigation, and the Southwell sensor-actuator configuration rather than the Fried geometry is adopted so as to suppress the potential waffle mode. Because filtering out small singular values of the influence matrix can be used to improve the control stability, the effect of the influence matrix and the effect of the integral gain are considered as a whole by using the error propagator. Then, the control stability of the AO system is evaluated for varying the integral gains and the number of filtered-out singular values. Afterwards, an analysis of the evaluations of the error propagator is made, and a conclusion can be drawn that the control stability can be improved by filtering out more singular values of the influence matrix when the integral gain is high. In other words, the error propagator is useful for trading off the bandwidth error and the fitting error of AO systems in a control-stability approach. Finally, a performance measurement of the experimental AO system is conducted when 13 smaller singular values of the influence matrix are filtered out, and the results show that filtering out a small fraction of the singular values has a minor influence on the performance of this AO system.