S-215 : Impact of Smoking on Clinical Outcomes in Female Patients with Acute Myocardial Infarction

( Yuna Jeong ),( Myung Ho Jeong ),( Hae Chang Jeong ),( Youngkeun Ahn ),( Young Jo Kim ),( Chong Jin Kim,),( Myeong Chan Cho ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Background/Aims: Cigarette smoking has been recognized as an important threat to women`s health. We investigated the impact of smoking on the long term outcomes in Korean female patients after acute myocardial infarction (AMI). Methods: Out of AMI patients who were enrolled Korean AMI Registry (KAMIR), 4,444 female patients included in this study. Patients were divided into three groups-non-smoker, current-smoker, past-smoker-according to cigarette smoking status. We compared the incidences and clinical outcomes during in-hospital mortality and major adverse cardiac events (MACE), including cardiac death, re-infarction, coronary artery bypass grafting, heart failure requiring re-hospitalization, and target lesion revascularization during one year clinical follow up between three groups. Results: BMI was higher in the non-smoker group than in the smoker group. Also, the non-smoker group had more patients with hypertension and diabetes mellitus. Left ventricular ejection fraction was not significantly different. However, the levels of total cholesterol, triglyceride, and low density lipoprotein cholesterol were higher in the current-smoker group. The in-hospital mortality was significantly higher in the smoker group (1.0% vs. 2.4% vs. 2.6%, p=0.002), and cardiac death during 12 months clinical follow-up was significantly more in the smoker group (2.3% vs. 4.3% vs. 5.1%, p=0.003). Total MACE during 12 months were higher in the smoker group (5.5% vs. 7.5% vs. 10.3%, p=0.007). Conclusions: Female smoker with acute myocardial infarction showed higher in-hospital mortality rates and MACE rates during one-year clinical follow-up period.

AVIoT: web-based interactive authoring and visualization of indoor internet of things

Yuna Jeong,Hyuntae Joo,Gyeonghwan Hong,Dongkun Shin,Sungkil Lee IEEE 2015 IEEE TRANSACTIONS ON CONSUMER ELECTRONICS - Vol.61 No.3

<P>Internet of things recently emerges as a common platform and service for consumer electronics. This paper presents an interactive framework of visualizing and authoring IoT in indoor environments such as home or small office. Building blocks of the framework are virtual sensors and actuators that abstract physical things and their virtual behaviors on top of their physical networks. Their behaviors are abstracted and programmed through visual authoring tools on the web, which allows a casual consumer to easily monitor and define their behaviors even without knowing the underlying physical connections. The user study performed to assess the usability of the visual authoring showed that the visual authoring is easy to use, understandable, and also preferred to typical text-based script programming.</P>

학습 데이터 선별을 위한 오토인코더 기반 학습 개선도 측정 방안

정유나(Yuna Jeong),황명권(Myunggwon Hwang),성원경(Wonkyung Sung) 한국정보과학회 2021 정보과학회논문지 Vol.48 No.2

머신러닝 알고리즘은 최근의 우수한 성능에도 불구하고 개발과 사용을 어렵게 하는 단점이 있다. 이는 머신러닝 알고리즘의 최적 모델 개발과 배포까지의 반복적인 과정이 높은 시간 비용을 요구하기 때문이다. 이에 본 논문에서는 이러한 시간 부하를 줄이기 위한 방안으로, 전체 학습 데이터셋 중 일부 데이터를 선별하여 빠르게 학습하면서도 근사 솔루션을 제공할 수 있는 방법에 관하여 논한다. 먼저 학습데이터는 오토인코더에 기반하여 저차원 잠재공간의 특징 벡터로 맵핑된다. 그리고 맵핑된 각 샘플의 위치를 기반으로, 상대적으로 학습하기는 어렵지만 학습 개선도가 높은 샘플은 높은 가중치를 부여받는다. 최종적으로 가중치를 기반으로 한 중요도 샘플링을 수행하여 데이터를 선별하고 이를 학습에 활용한다. 실험결과, 제안하는 방법이 무작위 샘플링에 비해 더 높은 학습 성과를 달성하는 샘플을 선정할 수 있음을 보일 수 있었다. Despite recent significant performance improvements, the iterative process of machine-learning algorithms makes development and utilization difficult and time-consuming. In this paper, we present a data-selection method that reduces the time required by providing an approximate solution . First, data are mapped to a feature vector in latent space based on an Autoencoder, with high weight given to data with high learning contribution that are relatively difficult to learn. Finally, data are ranked and selected based on weight and used for training. Experimental results showed that the proposed method selected data that achieve higher performance than random sampling.

Rg3-enriched red ginseng extracts enhance apoptosis in CoCl 2 -stimulated breast cancer cells by suppressing autophagy

Yun-Jeong Jeong,Mi-Hee Yu,Yuna Cho,Min-Young Jo,Kwon-Ho Song,Yung Hyun Choi,Taeg Kyu Kwon,Jong-Young Kwak,Young-Chae Chang 고려인삼학회 2024 Journal of Ginseng Research Vol.48 No.1

Background: Ginsenoside Rg3, a primary bioactive component of red ginseng, has anti-cancer effects. However, the effects of Rg3-enriched ginseng extract (Rg3RGE) on apoptosis and autophagy in breastcancer have not yet been investigated. In the present study, we explored the anti-tumor effects ofRg3RGE on breast cancer cells stimulated CoCl2, a mimetic of the chronic hypoxic response, and determinedthe operative mechanisms of action. Methods: The inhibitory mechanisms of Rg3RGE on breast cancer cells, such as apoptosis, autophagy andROS levels, were detected both in vitro. To determine the anti-cancer effects of Rg3RGE in vivo, the cancerxenograft model was used. Results: Rg3RGE suppressed CoCl2-induced spheroid formation and cell viability in 3D culture of breastcancer cells. Rg3RGE promoted apoptosis by increasing cleaved caspase 3 and cleaved PARP anddecreasing Bcl2 under the hypoxia mimetic conditions. Further, we identified that Rg3RGE promotedapoptosis by inhibiting lysosomal degradation of autophagosome contents in CoCl2-induced autophagy. We further identified that Rg3RGE-induced apoptotic cell death and autophagy inhibition was mediatedby increased intracellular ROS levels. Similarly, in the in vivo xenograft model, Rg3RGE induced apoptosisand inhibited cell proliferation and autophagy. Conclusion: Rg3RGE-stimulated ROS production promotes apoptosis and inhibits protective autophagyunder hypoxic conditions. Autophagosome accumulation is critical to the apoptotic effects of Rg3RGE. The in vivo findings also demonstrate that Rg3RGE inhibits breast cancer cell growth, suggesting thatRg3RGE has potential as potential as a putative breast cancer therapeutic

필드 심도를 위한 표현적인 색수차 누적 버퍼링

정유나(Yuna Jeong),이상민(Sangmin Lee),권순현(Soonhyeon Kwon),이성길(Sungkil Lee) 한국컴퓨터그래픽스학회 2016 한국컴퓨터그래픽스학회 학술대회 Vol.2016 No.7

믹스업 기법 기반 비대칭 텍스트 분류

정유나(Yuna Jeong),황명권(Myunggwon Hwang),성원경(Wonkyung Sung) 한국정보과학회 2021 한국정보과학회 학술발표논문집 Vol.2021 No.6

가계부 애플리케이션을 이용한 소비 패턴 분석

정유나(Yuna Jeong ),유진이(Jin-Yi Yu),한우경(Woo-Kyung Han),한경숙 (Kyung-Sook Han),오용철(Young-Chul Oh) 한국정보과학회 2011 한국정보과학회 학술발표논문집 Vol.38 No.2D

최근 스마트폰 사용이 빠른 속도로 늘어나고 있다. 사용자의 연령층도 다양해지고 애플리케이션의 종류와 범위도 확장되고 있다. 가계부 애플리케이션은 초창기부터 꾸준히 개발되어 왔지만 아직 부족한 면이 많다. 기본적인 소비 패턴 분석과 그래프를 통한 피드백은 대부분의 가계부 애플리케이션이 제공하고 있으나 한계가 있다. 또한 모든 연령층에 대한 고려는 찾아보기 힘들다. 본 논문은 현 가계부 애플리케이션이 갖추지 못한 기능인 음성 인식 입력 지출 유형 분석 및 개선방향 제시 PDF 파일 생성을 통한 스마트폰과 PC간의 상호작용을 중점으로 기반 기술에 대해 서술한다. 개발된 애플리케이션은 사용하기 쉬운 UI와 위젯을 통하여 사용자의 편의를 제공한다.

다중 해상도 필드 심도 렌더링

정유나(Yuna Jeong),이성길(Sungkil Lee) 한국HCI학회 2012 한국HCI학회 학술대회 Vol.2012 No.1

근래 실시간 필드심도 렌더링 가속을 위해 후처리 기반의 많은 방법들이 제안되고 있으나, 그 품질은 여전히 다중 시점 기반 분산/누적 방식의 distributed ray tracing/rasterization 방법의 결과에 미치지 못하고 있다. 그러나 이러한 다중시점 방식 렌더링의 부하는 필요한 렌즈 시점의 수에 비례하므로, 일반적으로 실시간에 쓰이기에 부적합하다. 이에, 본 논문은 다중 해상도의 3D 모델을 이용하여 필드 심도 렌더링의 성능을 현격히 향상하는 방법을 제안한다. 또한, 이산적인 다중 해상도의 모델 이용 시 불연속성을 없애기 위한 해상도 블렌딩 방법을 제안한다. 본 방법을 이용하여, 표준 렌더링 방법과 비슷한 품질을 유지하며, 최대 네 배가량의 성능향상을 얻었다. Rendering quality of recent approaches for real-time depth-of-field rendering has been far from those of object-based approaches such as distributed ray tracing or rasterization. Despite the higher quality of object-based approaches, costly rendering of multiple views impeded their use for real-time applications. This paper presents an acceleration method for depth-of-field rendering based on multi-resolution models. We also present the multi-resolution blending method that avoids popping artifacts resulting from transitions between discrete levels. Our implementation attained improvements in rendering performance up to four times, while maintaining quality similar to the reference solution.

Mycobacterial Regulatory Systems Involved in the Regulation of Gene Expression Under Respiration-Inhibitory Conditions

Oh Yuna,Lee Ha-Na,Ko Eon-Min,Jeong Ji-A,Park Sae Woong,Oh Jeong-Il 한국미생물학회 2023 The journal of microbiology Vol.61 No.3

Mycobacterium tuberculosis is the causative agent of tuberculosis. M. tuberculosis can survive in a dormant state within the granuloma, avoiding the host-mounting immune attack. M. tuberculosis bacilli in this state show increased tolerance to antibiotics and stress conditions, and thus the transition of M. tuberculosis to the nonreplicating dormant state acts as an obstacle to tuberculosis treatment. M. tuberculosis in the granuloma encounters hostile environments such as hypoxia, nitric oxide, reactive oxygen species, low pH, and nutrient deprivation, etc., which are expected to inhibit respiration of M. tuberculosis. To adapt to and survive in respiration-inhibitory conditions, it is required for M. tuberculosis to reprogram its metabolism and physiology. In order to get clues to the mechanism underlying the entry of M. tuberculosis to the dormant state, it is important to understand the mycobacterial regulatory systems that are involved in the regulation of gene expression in response to respiration inhibition. In this review, we briefly summarize the information regarding the regulatory systems implicated in upregulation of gene expression in mycobacteria exposed to respiration-inhibitory conditions. The regulatory systems covered in this review encompass the DosSR (DevSR) two-component system, SigF partner switching system, MprBA-SigE-SigB signaling pathway, cAMP receptor protein, and stringent response.

Activation of the SigE-SigB signaling pathway by inhibition of the respiratory electron transport chain and its effect on rifampicin resistance in Mycobacterium smegmatis

Oh Yuna,Lee Hye-In,Jeong Ji-A,Kim Seonghan,Oh Jeong-Il 한국미생물학회 2022 The journal of microbiology Vol.60 No.9

Using a mutant of Mycobacterium smegmatis lacking the major aa3 cytochrome c oxidase of the electron transport chain (Δaa3), we demonstrated that inhibition of the respiratory electron transport chain led to an increase in antibiotic resistance of M. smegmatis to isoniazid, rifampicin, ethambutol, and tetracycline. The alternative sigma factors SigB and SigE were shown to be involved in an increase in rifampicin resistance of M. smegmatis induced under respiration-inhibitory conditions. As in Mycobacterium tuberculosis, SigE and SigB form a hierarchical regulatory pathway in M. smegmatis through SigE-dependent transcription of sigB. Expression of sigB and sigE was demonstrated to increase in the Δaa3 mutant, leading to upregulation of the SigB-dependent genes in the mutant. The phoU2 (MSMEG_1605) gene implicated in a phosphatesignaling pathway and the MSMEG_1097 gene encoding a putative glycosyltransferase were identified to be involved in the SigB-dependent enhancement of rifampicin resistance observed for the Δaa3 mutant of M. smegmatis. The significance of this study is that the direct link between the functionality of the respiratory electron transport chain and antibiotic resistance in mycobacteria was demonstrated for the first time using an electron transport chain mutant rather than inhibitors of electron transport chain.