포도당과 이소프로테레놀에 의한 시상하부의 소마토스타틴 분비가 갑상선자극호르몬방출호르몬에 의한 갑상선자극호르몬에 미치는 효과

박철영,양인명,오승준,김덕윤,우정택,김성운,김진우,김영설,최영길 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.4·5

Variation of Bird community and Habitat use after Developing Hangang river Ecological Learning Center

Paik, In-Hwan,Jin, Seon-Deok,Jeon, Byung-Seon,Yu, Jae-Pyoung,Park, Chi-Young,Paek, Woon-Kee national science museum of korea 2010 Journal of Korean nature Vol.3 No.4

The Hangang (Han River) Ecological Learning Center is a river ecosystem park which was completed in December of 2002. The river ecosystem park was created based on the understanding of the problems of standard park-formed river which centers around convenient facilities instead of on the wish to accentuate the innate unique characteristics of a river. Therefore, the study was conducted in order to analyze the changes and habitation usage of the avifauna in the Hangang Ecological Learning Center to provide basic information for the improvement of bird species diversity in an ecosystem park. The study was conducted in July and October of both 2003 and 2005 to study the avian colonies of the same time period, and the habitat usage of four different areas were examined. Main dominant species includes species which preferred waterside and grassland, and 2005 showed higher levels of species, bird count and number of migratory birds. Furthermore, among the four regions used as habitats, the confluence region showed the highest level of increase, and this is predicted to have caused by the shallow depth of the confluence and the stability of the waterside plant colonies.

심한 골병변으로 발현된 기능성 낭종성 부갑상선 선종

전숙,김영희,박지영,고관표,박철영,김덕윤,우정택,김성운,김진우,김영설,고석환 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.2

낭종성 부갑상선 선종과 심한 골병변을 동반한 부갑상선 기능항진증은 매우 드문 질환으로서, 저자들은 양측 고관절의 통증을 초기 주소로 내원한 환자에서 고칼슘혈증과 부갑상선 호르몬 증가, 골병변의 방사선적 소견을 통해 부갑상선 기능항진증을 진단하고, 경부 초음파와 컴퓨터 단층 촬영, 부갑상선 스캔검사 및 수술중 부갑상선 낭종액 검사 등을 통해 기능성 부갑상선 낭종의 한 종류인 낭종성 부갑상선 선종을 진단하고 수술적 제거를 통하여 정상화된 1예를 경험하였다. A cystic parathyroid adenoma is rare. A case of primary hyperparathyroidism, with the cystic formation of a parathyroid adenoma and a severe bony lesion, is reported. A 52-year-old male was admitted due to pain in both hips and for evaluation of hypercalcemia. The plasma level of the intact parathyroid hormone (iPTH) was elevated to 1424 pg/mL. Ultrasonography and the computed tomography revealed a parathyroid cyst on the left thyroid lower pole. Parathyroid scintigraphy detected a parathyroid adenoma. A radiograph showed a subperiosteal bone resorption on the phalanges, and a brown tumor (osteitis fibrosa cystica) on the femur shaft was noted. A surgical excision of the parathyroid adenoma was performed. The PTH level in the cystic fluid was increased. A histological examination confirmed a cystic parathyroid adenoma. The PTH level was normalized after the operation (J Kor SOC Endocrinol 18:214-220, 2003).

결직장 암종에서 핵 내 β-catenin 발현이 cyclin D1 발현에 미치는 영향

박경선,김운원,오상훈,김상효,양영일 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Objectives : β-Catenin plays dual roles, a structural role in cell-cell juction for signal transduction and a regulatory role in the nucleus for gene expression. β-Catenin can translocate into the nucleus, where it forms a complex with transcription factor of the lymphoid enhancing factor (Lef-1), and activates the expression of mostly unknown genes. β-catenin mediated signal depends on its accumulation and subsequent translocation into the nucleus. Elevated β-catenin level in colorectal cancers is caused b y mutations in β-catenin itself or adenomatous polyposis coli(APC). Recent studies described that up-regulation of β-catenin might promote neoplastic conversion in colorectal cancers by triggering cyclin D1 expression. We investigated to determine whether the nuclear translocation of β-catenin can influence to in vivo expression of cyclin-D1, and growth pattern at the invasive front in sporadic colorectal cancers. 37 cases of sporadic colorectal carcinomas were retrospectively reclassified and investigated the expression patterns and degrees of β-catenin, cyclin-D1, and p53 by immuno-histochemical method, and also reanalyzed clinical and pathological parameters. In the majority of carcinoma cells in the superficial areas, expression patterns of β-catenin were mostly membramous pattern, and cytoplasmic or mixed pattern of membranous and cytoplasmic were occasionally observed. But nuclear expression of β-catenin were more frequently observed at the invasive border(22/37, 59.5%). High level expression(more than 40% of carcinoma cell) of cyclin-D1 was detected in 7 cases(7/37, 18.9%) of colorectal carcinomas, and the expressed location of cyclin-D1 was significantly related nuclear expression of β-catenin(p=0.0012). However, nuclear expression of β-catenin was not relationship with p53 expression and other clinicopathologic parameters(p>0.05). Conclusions : Conclusively, nuclear expression of β-catenin could promote cyclin-D1 expression, subsequently influences upon the cell cycle, and may be play an important role in tumor progression of sporadic colorectal carcinomas

GPS에 의한 자세결정 정확도에 영향을 미치는 요소

박운용,김정동,이흥규 동아대학교 건설기술연구소 1999 硏究報告 Vol.23 No.2

In this study, the attitude estimation software using direct and least square computation was developed, then the field tests were performed so as to assess the effects and characteristics which influence on accuracy of determined attitude by GPS observation errors like multipath, receiver noise, antenna phase center variation, and by elements which ought to be considered to operate systems like baseline length, number of satellite, geometry, and antenna configuration. As a result, it could be concluded that the multipath of GPS signal is the most important error and the accuracy of the estimated attitude parameters from GPS carrier phase is inversely proportional to baseline length through the accuracy analysis of attitude parameters from GPS. It was shown that the usage of much longer baseline was the easiest and most efficient method to determine attitude parameters of supra-accuracy.

한국산 긴몰개(Squalidus gracilis majime, Cyprinidae)의 난발생

박경서,홍영표,문운기,최신석,안광국 한국육수학회 2005 생태와 환경 Vol.38 No.1

한국산 긴몰개 (Squalidus gracilis majimae)의 난발생 과정을 연구하기 위하여, 긴몰개의 친어와 생태적 조사는 충청남도 보령시에 위치한 보령댐과 웅천천에서 실시하였다. 자연 산란에 의해 수정된 난과 배 발생의 형태학적 설명은 다음과 같이 요약된다. 수정란의 형태는 둥글고, 점착성이 있으며 투명하였고, 수정란의 평균직경은 2.9±0.3 ㎜ (n = 30)였고, 유구가 존재하지 않았으며, 수정란의 발생은 수온 26±1.5℃에서 관찰되었다. 수정 후 20분에 배반이 형성되었으며,48분 뒤 2세포로 나뉘어졌고, 포배기는 수정 후 5시간 40분에 나타났으며, 낭배기는 수정 후 6시간 55분에 관찰되었다. 배체의 형성은 수정 후 12시간 58분부터 시작되었고, 안포와 9개의 체절이 수정 후 17시간 05분에 발견되었다. 수정 후 23시간 30분에 이포가 생겼으며, 25~26개의 체절과 함께 안포안의 렌즈가 수정 후 32시간 35분에 발견되었다. 수정 후 37시간 27분에 뇌의 분화와 함께 배체가 꿈틀거리기 시작했으며, 심장박동과 안포내의 흑색소포가 수정 후 44시간 46분에 발견되었다. 수정 후 50시간 36분 가슴지느러미의 형성과 함께 몸 부분의 흑색소포가 형성되는 것을 끝으로하여 수정 후 57시간 49분에 수정란은 부화되었다. 이때 갓 부화된 자어는 전장이 3.3±0.2 ㎜(n= 120)이었다. 본 연구 결과는 최근 수질오염 및 종 다양성 감소가 시급한 상황에서 종 및 개체군 보존에 기여할 것으로 사료된다. This study was conducted, based on the field survey and laboratory observations, to elucidate egg developmental processes and their characteristics of the Korean slender gudgeon, Squalidus gracilis majimae. For the experiments, the mature adults were collected at the Woongcheon-Cheon Stream and Boreung Reservoir located in Boreung City, Chungnam Province and eggs were obtained from the natural spawning area. Morphological characteristics of the egg and embryonic development were su㎜arized as follows: The shape of the fertilized egg was spherical, adhesive and transparent. The fertilized egg was 2.9±0.3 ㎜ (n = 30) in mean diameter under water temperature of 26 ± 1.5℃, light white in color and had no oil droplets. After 20 minutes from the time of fertilization, a blastodisc was formed and divided into two cells at 48 minutes after fertilization. The blastular stage occurred at 5 hours 40 minutes after fertilization and the gastrular stage was detected at 8 hours 41 minutes after fertilization. The beginning of embryo formation was observed at 12 hours 58 minutes after fertilization and optic vesicles and 9 somites were discovered at 17 hours 05 minutes after fertilization. Differentiation of brains and embryo wiggling were observed at 37 hours 27 minutes after fertilization. Heart beating and the formation of melanophores in optic vesicles were detected at 44 hours 46 minutes after fertilization. The formation of pectoral fins and melanophores in the body were discovered at 50 hours 36 minutes after fertilization. Hatching occurred at 57 hours 49 minutes after fertilization. The newly hatched larvae were 3.3 ±0.2 ㎜ (n = 120) in total length. We believe that these results may contribute the species and population conservations under the situation of accelerated water pollution and the decreases of its diversity.

당뇨병성 다발성 신경병증에 대한 Thioctic acid의 유효성 및 안정성에 관한 연구

박철영,김영설,오승준,우정택,김성운,양인명,김진우,최영길 대한당뇨병학회 2001 임상당뇨병 Vol.2 No.1

연구배경: 당뇨병성 신경병증은 당뇨병 환자에서 흔히 나타나는 합병증으로서 임상 증상은 가볍거나 없을 수도 있지만 많은 경우에 통증, 작열감, 이감각증이나 무감각증 등의 증상을 동반하지만, 이에 대한 명확한 기전이나 뚜렷한 치료방법이 없었다. 최근에 신경세포내 산화성 스트레스의 증가로 신경세포의 손상이 발생된다는 기전이 주목을 받으면서, 당뇨병성 신경병증 환자에게 항산화제인 thiotic acid를 사용하여 좋은 효과를 관찰한 논문들이 발표되었다. 이에 저자들은 한국의 당뇨병성 다발성 신경병증 환자에서 thiotic acid를 경구 투여 후에 신경병증에 의한 효과 및 안정성을 평가하였다. 방법: 모든 대상 환자에게 Thioctic acid 600㎎ 을 1일 1회 아침 식전 30분에 8주간 투여하여 당뇨병성 다발성 신경병증에 대한 TSS의 개선여부에 대한 임상적 유효성 및 이상반응, 내약성, 실험실적 지표의 변화를 통한 안정성을 관찰하였다. 결과: 치료시작 전에 관찰한 환자가 호소하는 증상은 통증이 가장 많았으며 무감각, 작열감, 이상감각 순의 빈도를 보였다. 통증, 작열감, 이감각증, 무감각증의 평균 TSS는 1차 방문시 5.8± 1.8, 2차방문시는 4.4±1.7, 3차 방문시는 3.1±1.1로 사용기판에 따라 통계학적으로 유의한 증상의 호전이 있었다. 또한 TSS의 개선 뿐만 아니라 통증, 작열감, 이감각증 및 무감각증 각각의 증상도 치료전과 치료 4주 후 및 치료 8주 후를 비교했을 때 통계학적으로 유의한 증상의 호전이 있었다. TSS가 1차 방문 시와 비교했을 때 3차 방문시에 30% 이상 개선되었을 때(1차 방문시에 TSS 4인 환자는 2점 이상 개선되었을때) 임상적으로 의미가 있는 반응으로 간주하고 계산한 반응률은 71.3%였다. 결론: 당뇨병성 다발성 신경병중 환자에 대해 항 산화제인 thioctic acid 600㎎ 경구 투여요법은 당뇨병성 신경병증의 증상완화에 유용하며, 안전한 것으로 사료된다. Background: The study was peformed to evaluate the efficacy and safety of oral treatment with the antioxidant α-lipoic acid (Thioctcid??) in diabetic patients with peripheral polyneuropathy. Methods: Thioctacid?? 600㎎ was orally administered once a day for 8 weeks in 61 diabetic patients with peripheral polyneuropathy. Neuropathic symptom(pain, burning, paresthesia, and numbness) were scored before, and of 4 and 8 weeks after treatment. In addition, neuropathy by the physician and patients at the end of treatment. The primary endpoint was the response role after 8 weeks treatment, defined as an improvement in the total symptom score of at least more than 30%. Results: Efficacy was evaluated among forty-four patients who had completely the study according to the protocol and safety was evaluated among all of 61 patients who had taken the study medication. The response rate after 8 weeks was 77.3%. The total symptom score was significantly decreased of 4-week, and further decreased of 8-week. All the individual scores for neuropathic symptom were also significantly reduced of 4-week and further decreased at 8-week. Conclusion: These finding indicate that oral treatment with thioctacid?? at a dose of 600㎎/day for 8 weeks will improve peripheral polyneuropathy in diabetic patients, without causing any serious adverse events.

외과적 보조의 급속상악확장술 : 치험 5예 REPORT OF 5 CASES

박충열,이용욱,송종운,김영운,박홍주,오희균,유선열,이기현,황현식 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1

Five adults (3 cases of bilateral posterior crossbite, 2 cases of unilateral posterior crossbite) with intermaxillary discrepancy of over 5㎜ due to maxillary transverse deficiency were treated by surgically assisted rapid maxillary expansion (SARME). Bilateral maxillary horizontal osteotomies, osteotomies of pterygomaxillary junction and anterior lateral nasal wall, ans anterior palatal osteotomy were performed in 4 cases, and unilateral osteotomies in 1case, followed by palatal expansion with tooth-borne orthopedic applicance. No significant complication was observed. The mean palatal expansion was 7.2㎜ (5.8∼10.0㎜) in the maxillary first molar region. During the mean follow-up period of 4 years (5 months∼8 years 7 months), no recurrence of crossbite was observed in all cases. The SARME seemed to be a simple, stable, and reliable procedure for achieving a permanent increase of over 5㎜ in skeletal maxillary transverse width of adults.

남한강 상류수계 박대천의 어류상

박경서,문운기,홍영표,최신석 忠南大學校 環境問題硏究所 2001 環境硏究 Vol.19 No.-

남한강 상류 수계, 박대천 일대를 대상으로 2001년 4월부터 9월까지 총 11개 지점을 대상으로 조사하였으며, 종조성, 어류상과 군집 구조를 분석하였다. 총 7과 25속 33종으로 1570개체가 조사 기간동안 확인되었다. 전체 어류군집 중, 잉어과 어류가 24종으로 전체의 72.7%와 1531개체로 전체의 97.5%를 차지하였다. 전체 종에 대해 0.2%보다 적은 종은 L. andersoni, G. brevibraba, A. koreensis, C. rotundicaudata와 S. microdorsalis를 포함한 11종이었다. 박대천 수계에서 우점종은 상대풍부도가 28.66%로 Zacco temmincki가 우점하였고, Zacco platypus (28.28%)와 C. splendidus (12.55%)가 아우점하였다. 박대천의 각 지류에서, Zacco temmincki는 6개 지점에서, Zacco temmincki는 5개 지점에서 우점하였다. 박대천 수계로부터 총 33종 중 6과 14속 18종(54.5%)이 한국고유종이었다. 박대천에서 확인된 어류의 전체 군집 구조를 분석한 결과, 우점도 3.766, 다양도 0.903, 풍부도 10.012, 그리고 균등도는 0.594이었다. Sampes of the Bakdae-Cheon Stream, the upper Namhan-Gang River of Korea were collected at 11 stations from April to September 2001, and analyzed for the species composition, fish fauna, and species diversity. A total of 33 species (1570 individuals) and 25 genera belonging to seven families were collected during the study period. Cyprinid fishes occupied 72.7% of total 24 species and 97.5% of total 1531 individuals, respectively. The rare species which relative abundance is less than 0.2% of all were 1531 individuals, respectively. The rare species which relative abundance is less than 0.2% of all were about 11 species including Liobagrus andersoni, Gobiobotia brevibraba, Acheilognathus koreensis, Cobitis rotundicaudata, and Silurus microdorsalis. Dominant species in the Bakdae-cheon Stream was Zacco temmincki (relative abundance 28.66%), and subdominant species were Zacco platypus (28.28%), and Coreoleuciscus splendidus (12.55%). In each trivutaries of the Bakdae-cheon Stream, Z. temmincki was dominant species at six stations, and Z. platypus was dominant at five stations. Eighteen Species and 14 genera belonging to six families (51.5%) of total 33 species from the Bakdae-cheon Stream were well known as Korean endemic species. The species dominance (λ), diversity (H'), richness (RI), and evenness index (EI) of the fish community were 3.766, 0.903, 10.012, and 0.594, respectively.

위암과 식도암이 병발된 다발성 원발성 악성종양 1예

박사영,이나영,이효진,이선영,최진혁,이순남,심강섭,성순희,한운섭 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.3

Multiple primary cancer means that more that two cancers occur independently in an individual. Recently, the incidence of multiple primary cancer has increased with lengthened survival, of cancer patients, development of new diagnostic technique and increased clinical evaluation. We report a patient who had adenocarcinoma of stomach combined with squamous cell carcinoma of esophagus simultaneously.