정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

한국 최초의 근대식 의사 김익남의 가문에 관한 연구

이영아 ( Lee Young Ah ),황상익 ( Hwang Sang-ik ) 아시아문화학술원 2017 인문사회 21 Vol.8 No.4

김익남은 한국 최초의 근대식 의사이자, 근대의학 교육의 선구자이다. 그는 과거시험 폐지 이전에 `가숙(家塾)`에서 3년 동안 한의학을 공부했고, 과거제도가 폐지되자 곧 관립일어학교에 들어갔으며, 뛰어난 일본어 능력과 근대교육에의 적응력으로 당시 파일(派日) 유학생들 중에서도 가장 두각을 나타내어 한국인으로는 최초로 근대의학을 정식으로 배운 의학자가 되었다. 그런데 그동안 전형적인 양반 가문인 청풍김씨 가문의 후손으로 알려져 왔던 김익남의 직계 조상을 조사해 본 결과 그는 기술직 중인 가문의 후예로 보는 것이 타당함을 알 수 있었다. 또한 잡과방목 등에는 그의 직계조상들의 본관이 해주김씨로 기록되어 있었다. 이러한 점에서 김익남은 의과, 역과, 운과(음양과) 등으로 세전되어 온 기술직 중인 가문인 해주김씨의 후손이라는 사실을 발견하게 되었다. 한국근대의학의 선구자인 김익남의 조상들은 지금까지 알려졌던 것과는 달리 약 300년 동안 전형적인 기술직 중인 가문으로 살아왔다. 그리고 김익남이 1890년대 당시로는 쉽지 않았을 일본유학을 결정하고 낯선 유학생활을 무사히 마치고 한국인으로서는 최초로 근대식 의사가 된 데에는 중인 가문 출신이라는 배경이 긍정적으로 작용했을 것이다. Unlike what has been known so far, the ancestors of Dr. Kim Ik-Nam, the most forerunning figure in the modern Korean medical history, had lived not as yangban class but as the typical jungin class for almost 300 years. It is thought that they could incorporate into Kim lineage of Chungpoong, the famous yangban family, through the achievements of successive generations as professional middle class, and their desire of status ascension based upon the achievements. Dr. Kim Ik-Nam`s jungin class background is considered to have positively influenced on the decision of studying abroad to Japan to be the first modern Korean medical doctor, which was very difficult in the 1890s. And it would be the same case to his cousin`s son Kim Kyu-Sik, the famous independence activist.

非晶質合金의 物理的 및 化學的 性質 Ⅲ. : 液體急冷法 Fe-Cr-B-Si系 및 Fe-Co-Cr-B-S系 合金의 諸特性 The Properties of Rapidly Quenched Fe-Cr-B-Si and Fe-Co-Cr-B-Si Alloys

李龍浩,姜鉉植,高錫梵,李國行,신영진,梁東翊,朴鎭夏,黃在順,이종명 全北大學校 1983 論文集 Vol.25 No.-

Some physical and chemical properties of liquid quenched Fe_75-χ Cr_χB_15Si_10(0≤χ≤6) and Fe_5Co_70-χ Cr_χB_15Si_10(0≤χ≤9) amorphous alloys are investigated. The χ dependencies of saturation magnetization B_s, coercive force H_c, magnetostriction λ, Young's modulus E, resistivity ρ and magnetoresistance ρ_mρ_m are measured with varying tension σand magnetic field H. When χ increases, B_s, H_c, λ and ρ_m decrease monotonically, while E and ρ increase monotonically. Effective moments of Cr and B_15Si_10 are estimated about -5 and -1∼-0.5 Bohr magneton respectively. Uniaxial Anisotropy of Fe_75B_15Si_10 is about 2.2×10^4 erg/c.c by thermodynamical calculation. Magnetoresitance is closely related to magnetostriction, and shows maximum value about 0.13% at magnetic saturation and no stress in Fe riched alloy. Giant ΔE effect of Fe_75B_15Si_10 alloy is about 70% by static tension experiment. Effect of the amount of Cr on the corrosion behavior of amorphous Fe_5Co70-χ Cr_χ B_15Si_10 alloys are compared by immersion tests. The addition of Cr to this alloys lowers the corrosion rate in 1N HCl, but it has a little effect in 1N H_2SO_4.

위암 환자에서 세포성 면역 기능에 관한 연구

이재익,윤일국,이종선,김종완,장준,안정기,송민호,정현용,이헌영,김삼용,김영건 충남대학교 암연구소 1991 癌共同硏究所 硏究誌 Vol.1 No.1

We performed a variety of lymphocyte stimulation tests, delayed hypersensitivity skin tests, and enumeration of several lymphocyte subpopulations in 21 patients with gastric cancer who did not receive any form of anticancer therapy, and in 20 healthy controls. The gastric cancer patients had significantly decreased number and total score of positive reactions in delayed hypersensitivity skin tests compared with the healthy controls. The percent of CD_(4) positive lymphocytes in the gastric cancer patients was significantly decreased compared to the normal control subjects, but it had no correlation with the total score of delayed cutaneous hypersensitivity reactions. The ratio of helper to suppressor cells was lower in the cancer group. The uptake of 3H-thymidine was markedly depressed in cancer patients when stimulated with various mitogens. There was little correlation between any of the stimulation tests and any of the lymphocyte subpopulation proportions to delayed hypersensitivity cutaneous reactions. Optimal proliferative response was found in lymphocytes stimulated with 10 micrograms of concanavalin-A and 10 microgram of phytohemagglutinin. Advanced stage patients had greatly depressed delayed hypersensitivity skin reactions and proliferative responses to mitogens compared with localized diseases. These results suggest that gastric cancer patients have depressed cellular immune functions, which mainly result from the decreased helper cells and defects in functional proliferative response to mitogens. Interleukin-2 and interferon-gamma restored the in vitro proliferative response of lymphocyte in patients with gastric cancer.

열대 지역에서 통일형 초다수성 벼 품종의 생육 및 수량성 비교

이지윤,준현,성환,손영보,송유천,한상익,박동수,권영업,이철원,이종희 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

융모성림프구를 보이는 비장변연부 림프종 1예

진한영,손창학,주영돈,박정하,이재익,조영완,이원식 인제대학교 2006 仁濟醫學 Vol.27 No.-

Splenic marginal zone lymphoma is very rare B-cell lymphoma, characterized by an indolent clinical course. Clinical features are moderate-to severe splenomegaly, absolute lymphocytosis, and bone marrow intrasinusoidal infiltration of lymphocyte. We report the case of a 37-year-old male with SMZL. He complained of LUQ pain, who had a massive splenomegaly and moderate lymphocytosis in peripheral blood. Immunophenotyping findings and morphologic findings were consistent with SMZL. He underwent splenectomy and received chemotherapy with cyclophosphamide for eight months. Now, one year later after surgery he has a nearly normal blood count with no treatment.

간세포암의 고주파 열치료 후 천자침 경로를 통한 전이 1례

조영완,박석주,진한영,김준영,이재익,강명주,박정하,윤정희,박성재,지삼룡,이연재,이상혁,설상영 인제대학교 2006 仁濟醫學 Vol.27 No.-

Radiofrequency ablation(RFA), as a form of minimally invasive therapy for hepatocellular carcinoma, has become an important treatment modality. Because of limitation of surgery, RFA has become standard therapy for hepatocellular carcinoma in some situations. But there are some complications of RFA such as bleeding, infection, hematoma, adjacent organ thermal damage including intestinal perforation, needle track seeding, and so on. There are few reports in the literature that systematically evaluate the incidence of needle tract seeding and its associated risk factors. And only 2 cases of needle tract seeding of hepatocellular carcinoma after RFA were reported in Korea. We report a case of needle tract seeding of hepatocellular carcinoma after RFA.

노인의 생활체육활동 참가와 신체적, 정신적 기능상태의 관계

이영익(Lee, Young-Ik) 한국노년학회 2008 한국노년학 Vol.28 No.4

이 연구는 노인의 생활체육활동 참가와 신체적, 정신적 기능상태의 관계를 구명하는데 그 목적이 있다. 본 연구의 조사 대상은 2008년 현재 서울지역에 거주하는 만 65세 이상 노인을 모집단으로 설정한 후, 유층집락 무선표집법(systematic stratified cluster random sampling)의 방법을 이용하여 양로원, 노인정, 노인대학 집단 등을 중심으로 표집틀(sampling framework)을 작성한 후, 생활체육참여자 180명, 비참여자 180명 총 360명의 표본을 추출하였다. 독립변인으로는 여가스포츠활동 참가여부와 참가정도(기간, 빈도, 강도)로 분류하였으며, 그리고 종속변인인 신체적 기능상태는 정경희 등(1998), 김양례(2005a)등이 사용한 문항을 토대로 본 연구에 맞게 수정, 보완하여 사용하였다. 정신적 기능상태는 인지기능 척도와 우울척도를 사용하였다. 먼저, 인지기능 척도는 개인이 지능을 이용하여 당면문제를 해결하는 정도로써, 한국판 MMSE-K(Mini Mental State Examination-Korea)를 사용하였으며, 우울증 척도는 Beck(1978)가 개발하고 이영호, 송종용(1991)이 번안한 설문지를 조규황(2003)이 한국 실정에 맞게 수정한 설문지를 본 연구의 목적에 맞게 수정ㆍ보완하여 사용하였다. 연구결과의 분석을 통해서 다음과 같은 결론을 얻었다. 첫째, 노인의 생활체육활동 참가여부에 따라 신체적ㆍ정신적 기능상태에 부분적으로 영향을 미친다. 즉, 생활체육활동에 참가하는 노인집단이 참가하지 않는 노인집단보다 일상생활수행능력ㆍ인지기능과 우울증 하위변인 중 인지적ㆍ신체적ㆍ행동적 요인이 높았다. 둘째, 노인의 생활체육 참가정도는 신체적ㆍ정신적 기능상태에 부분적으로 영향을 미쳤다. 즉, 생활체육 참가정도에 따라서 신체적, 정신적 기능상태의 하위변인인 일상생활수행능력에서는 참가기간, 참가강도가 인지기능에서는 참가기간, 그리고 우울증의 하위변인 중 인지적ㆍ정서적 요인에는 참가기간, 참가빈도가 영향을 미쳤고, 신체적ㆍ행동적 요인에는 참가기간, 참가빈도, 참가강도 모두 영향을 미치는 것으로 나타났다. The purpose of this study was to study the Relationships between Sport for All Participation and Physical and Mental Function affecting the Elderly's Self-perceived Health. For accomplishing this purpose of this study, the 308 subjects were selected by the multi-stage stratified cluster sampling method from the Seoul, in the years of 2008. presently. Out of the 360 questionnaires responded to, only 308 were used for data analysis because 52 were responded to incompletely or incorrectly. The survey questionaries were used to collect data. The questionary for physical function state were developed and standardized by kung-hee chung(1993), yang-lae Kim(2005). And mental function state were divided two parts; self-perceived scale and depress scale. The questionary for self-perceived scale were based on MMSE-K(Mini Mental State Examination-Korea). The questionary for Depression were based on Depression Scale developed by Beck(1978), adapted in Korean and standardization by Lee Young-ho & Song Jong-yong(1991), regulated by Jo Gyu-whang(2004). From the analysis of this study, the following conclusions were obtained: First, according to the elderly people's participation in leisure sport activities, it partially affected physical and mental function state. Second, according to the degree of elderly people's participation in leisure sport activities, it partially affected physical and mental function state.

지역사회 정신의학 전공의 교육과정 실태조사

홍진표,황순찬,이영문,이선형,신나리,이종일,박종익,장동원,정인원 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.1

Objectives : There is a increasing need to recruit and retain more psychiatrists who can plan and implement organized programs to work with chronic mentally ill patients in community settings. The aim of study is to discover what training is currently in place to prepare psychiatrist for work in "community" or "public" settings. Methods : Survey questionnaires were mailed to 85 residency training directors and 10 leaders of community mental health in 2005. Response rate was 75%. Results : Academic seminar about community mental health were not administered to residents in 63% of training hospitals. Forty one out of 64 training hospitals had community mental health rotation programs, Community mental health center (50%) and day hospital (36%) were the most common type of programs. Few general hospital had affiliation with community mental health programs. The amount of time for clinical rotation varied from less than three months part time to 6 months fulltime, with most frequent form of one day per week for three month in second or third year of psychiatry residents. Conclusion : Further steps are needed to improve residency training curricula and to encourage well qualified psychiatrist to choose careers in community psychiatry.

바터 팽대부에 생긴 유암종 1예

강명주,지삼룡,박석주,이재익,조영완,김준영,박성재,박은택,이연재,이상혁,설상영,배상균 인제대학교 2006 仁濟醫學 Vol.27 No.-

Carcinoid tumors have been reported in a wide range of organs but most commonly involve the lungs, bronchi and gastrointestinal tract. Within the gastrointestinal tract, appendix is the most common location for carcinoid, followed by the distal small intestine, the rectum, and the stomach. Among these, primary involvement of the ampulla of Vater is extremely rare. We report a case of carcinoid tumor of ampulla of Vater. A 62-year-old man presented with epigastric soreness. Gastroduodenal endoscopy showed hyperemic bulging mass on ampulla of Vater and diagnosed as carcinoid tumor by histologic finding, with immunohistochemical study. In ^(111)In-octreoscan, tumor had regional lymph node metastasis, but no evidence of distant metastasis. Pancreatoduodenectomy with lymph node dissection was performed.