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내시경적 절제로 진단된 폴립 형태의 심재성 낭종성 위염 2예
허종현,조영화,성용완,유재훈,구동영,김갑식,노지훈,문원 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2
Gastritis cystica profunda (GCP) is a disease characterized by hyperplastic and significant extension of cystic dilatation of the gastric mucous glands, which results in a cystic lesion in gastric submucosa. It often occurs on the part of gastroenterostomy, but can be found in the stomach without any previous surgery. GCP has variable gross finding including solitary polyps, diffuse ones, submucosal tumors, and rare giant gastric mucosal fold. It is difficult to tell GCP from a cancerous lesion by gross finding that the disease demands a necessary tissue biopsy, though GCP is commonly showed as a benign in the progress. We report a case of GCP in polypoid types diagnosed by endoscopic polypectomy.
김용배,장원기,황보영,김화성,안규동,이병국,이용진,이종은,이준숙,이찬구,이한정,이성수 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1
Objective : Serum uric acid has now been identified as a marker for a number of metabolic and hemodynamic abnormalities. The aim of this study is to evaluate risk factors which influence hyperuricemia in the citizens of Asan. Method : The study design was cross-sectional and research subjects were 1086 citizens of Asan. General characteristics, cigarette smoking, alcohol consumption, and past history were obtained by interview using a structural questionnaire. Also, we measured height, weight and blood pressure, and serum uric acid of the subjects. Results : The mean serum uric acid level was 5.27 ㎎/㎗ in men and 4.01 ㎎/㎗, in women, In the multiple logistic regression analysis, statically significant risk factors of hyperuhcemia were gender, body mass index, blood lead concentration, and serum creatinine. Conclusion : Our results suggest that gender, body mass index, blood lead concentration, and serum creatinine might be the most important risk factors of hyperurcemia. Education program as well as routine check-up for serum uric acid was highly recommended for the effective prevention of hyperuricemia.
내시경적 밴드 결찰술로 치료한 출혈을 동반한 위 혈관이형성증 1예
김갑식,허종현,성용완,조영화,구동영,유재훈,노지훈,문원 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2
Gastric angiodysplasia is vascular ectasia in mucosa and submucosa of the gastric wall. It is an uncommon cause of upper gastrointesinal hemorrhage that may occur in the stomach or duodenum. There are many kinds of endoscopic treatments, such as argon plasma coagulation, electrocoagulation, heat probe, and submucosal injection of hypertonic saline mixed with epinephrine for gastric angiodysplasia. However, these treatment methods are associated with high rate of rebleeding. In order to avoid the recurrence, endoscopic band ligation has recently been used as an alternative method for endoscopic treatment of gastric angiodysplasia. We encountered a case of gastric angiodysplasia that presented with overt bleeding and anemia, and was successfully treated with endoscopic band ligation.
Goo, Young-Hwa,Lee, Soo-kyung,Na, Soon-Young,Lee, Jae Woon 이화여자대학교 세포신호전달연구센터 2001 고사리 세포신호전달 심포지움 Vol. No.3
ASC-2 is a recently isolated transcriptional co integrator molecule, which is amplified in human cancers and stimulates transactivation by nuclear receptors, AP-1, NFĸB, SRF, and numerous other transcription factors. ASC-2 contained two nuclear receptor-interaction domains; i.e., the C-terminal LXXLL motif specifically interacting with oxysterol receptors and the N-terminal motif binding a broad range of nuclear receptors. Interestingly, ASC-2 contained a distinct, indirect androgen receptor-interacting domain that involves Rb/Swi/Snf complexes. In addition, we found that the previously defined autonomous transactivation function of ASC-2 also requires Rb/Swi/Snf. Surprisingly, Rb/Swi/Snf was required for ASC-2 to mediate transactivation by androgen and glucocorticoid receptors but not retinoid and thyroid hormone receptors. These results strongly suggest that distinct, ASC-2-containing coactivator complexes are actively assembled in a target factor-specific manner in vivo.
Goo, Young-Hwa,Sohn, Young Chang,Kim, Dae-Hwan,Kim, Seung-Whan,Kang, Min-Jung,Jung, Dong-Ju,Kwak, Eunyee,Barlev, Nickolai A.,Berger, Shelley L.,Chow, Vincent T.,Roeder, Rober G.,Azora, David O.,Meltze 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12
Many transcription coactivators interact with nuclear receptors in a ligand- and C-terminal transactivation function (AF2)-dependent manner. These include activating signal cointegrator 2 (ASC-2), a recently isolated transcriptional coactivator molecule, which is amplified in human cancers and stimulates transactivation by nuclear receptors and numerous other transcription factors. In this report, we show that ASC-2 belongs to a steady-state complex of approximately 2 MDa (ASC-2 complex [ASCOM]) in HeLa nuclei. ASCOM contains retinoblastoma-binding protein RBQ-3, α/β-tubulins, and trithorax group proteins ALR-1, ALR-2, HALR, and ASH2. In particular, ALR-1/2 and HALR contain a highly conserved 130- to 140-amino-acid motif termed the SET domain, which was recently implicated in histone H3 lysine-specific methylation activities. Indeed, recombinant ALR-1, HALR, and immunopurified ASCOM exhibit very weak but specific H3-lysine 4 methylation activities in vitro, and transactivation by retinoic acid receptor appears to involve ligand-dependent recruitment of ASCOM and subsequent transient H3-lysjne 4 methylation of the promoter region in vivo. Thus, ASCOM may represent a distinct coactivator complex of nuclear receptors. Further characterization of ASCOM will lead to a better understanding of how nuclear receptors and other transcription factors mediate transcriptional activation.
A New Waxy Wheat Cultivar "Shinmichall" with Stress Tolerance
Hwa Young Heo,Chul Soo Park,Moon Suk Kang,Hyung Ho Park,Chun Kee Lee,Hong Sik Kim,Bon Chul Goo,Jong Chul Park,Kwang Geun Park,Young Keun Cheong,Jung Gon Kim 한국육종학회 2007 한국육종학회지 Vol.39 No.3
“Shinmichal1”, a waxy red winter wheat (Triticum aestivum L.) cultivar was developed by the National Institute of Crop Science, RDA. It was derived from the cross “Alchan”/“Chal2”during 1997. “Alchan” is a soft red winter wheat with high yield and good noodle quality. “Chal2” is a waxy wheat line crossed by “Kanto107” (Wx-A1b and Wx-B1b) and “BaiHuo” (Wx-D1b). “Shinmichal1” was evaluated as “Suwon306” in Advanced Yield Trial Test in 2002. It was tested in the regional yield trial test between 2003 and 2006. “Shinmichal1” is an awned, semi dwarf and soft red winter wheat, similar to “Uri” (check cultivar). The Heading and maturing date of “Shinmichal1” were similar to “Uri”. Culm and spike length of “Shinmichal1“ were 79 cm and 7.8 cm. “Shinmichal1“ had greater test weight (802 g) and lower 1,000-grain weight (31.8 g) than “Uri” (782 g and 35.2 g, respectively). It has resistance to winter hardiness, wet-soil tolerance, lodging tolerance and moderate post-harvest sprouting damage. “Shinmichal1” had higher flour yield (66.2%), ash (0.73%), protein (10.9%) and SDS sedimentation volume (40.7 ml) than “Uri” (64.7%, 0.53%, 9.3%, and 32.5 ml, respectively) and similar flour color to “Uri”. “Shinmichal1” had higher dough extensibility and lower dough strength than “Uri”. It is 5.2% of amylose content and had typical waxy starch pasting properties. Average yield of “Shnmichal1” in the regional adaptation yield trial was 5.24 MT ha-1 in upland and 5.58 MT ha-1 in paddy field, which was 3% and 8% lower than those of “Uri” (5.39 MT ha-1 and 6.09 MT ha-1, respectively). “Shinmichal1” would be suitable for the area above the daily minimum temperature of -10℃ in January in Korean peninsula.
원주지역 설사 환자에서 분리한 Small Round Structured Viruses ( SRSV ) 염기서열 분석
지영미(Young Mi Jee),김기순(Gee Sun Kim),천두성(Doo Sung Chun),박정구(Jung Goo Park),강영화(Young Hwa Kang),정윤석(Yoon Suk Jung),고운영(Woon Young Ko),신영학(Young Hak Shin),윤재득(Jae Deuk Yoon) 대한바이러스학회 1999 Journal of Bacteriology and Virology Vol.29 No.4
Small round structured viruses (SRSV) are the major ethological agents which can cause outbreaks of non-bacterial gastroenteritis or food poisoning both in children and adults. The classification of family Caliciviridae to which SRSV belong, is based on the genome encoding three open reading frames. The rotavirus is another major pathogen which causes diarrhea in young children. We examined stool specimens obtained from diarrheal patients in Wonju from which bacterial pathogens were not found. To detect causative viruses from stool specimens of patients, reverse transcription (RT)-polymerase chain reaction (PCR) or nested PCR using rotavirus or SRSV specific primers was performed. In this study, RT-nested PCR procedure which can amplify a 330 bp fragment derived from RNA dependent RNA polymerase (RDRP) region within ORF1 was applied for the detection of SRSV. For the detection of rotaviruses, a 877 bp fragment from the VP4 region of rotavirus genome was amplified. As a result, rotavirus was not detected while SRSV sequences were detected from one out of five specimens. The nucleotide and amino acid sequences of the Wonju isolate were compared with other 6 Korean isolates which have been isolated and sequenced in our laboratory. Sequence analysis revealed that the Wonju isolate was rather distinct from other Korean isolates: the Wonju isolate was closer to genogroup I of SRSV while other 6 Korean isolates belonged to genogroup II.