성인 IgA 신병증의 임상적 고찰

김영학,권용은,허경무,윤채중,김종인,김건영,배학연,정종훈 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

'전환기소설'로서의『우리같은 영웅들』 : 독일 통일에 대한 문학적 숙고 Ein literarisches Nachdenken Ober die deutsche Wiedervereinigung

허영재 독일어문학회 2002 독일어문학 Vol.18 No.-

PHA로 자극된 T cell에서 분비된 미지의 물질이 지니는 Human Neutrophil의 수명연장, Superoxide 및 Leukotriene C₄생산증가 작용효과

허억,양영목 大韓免疫學會 1993 大韓免疫學會誌 Vol.15 No.-

There are several direct and indirect ways in which T cells could enhance the anti-bacterial capabilities of neutrophils. However it is not yet clear out which molecule or cytokine produced by T cells is involved in the phagocytic action and viability sustaining activity of neutrophils. The aim of this study was about a factor, which produced by the phytohaemagglutinin(PHA)-stimulated T cells, may control those neutrophil actions. Human peripheral blood T cells and neutrophils were isolated by Ficoll-paque density sedimentation from heparinized blood of healthy adult donors. The purity of these cells were more than 90%. T cells were stimulated in various dose(0.1-10gg/ml) of PHA for various times of incubation(0-3 days), and then PHA-stimulated T cell conditioned medium was collected in order to find an optimal dose and incubation time for the neutrophil viability. It was found out that 1,ug/ml of PHA in 12 hours incubation was maximal effective condition for the neutrophil sustaining viability. The effects of PHA-stimulated T cell conditioned medium(TCM) on the neutrophils were used for the comparison with PHA-nonstimulated TCM or enriched medium alone. Neutrophil sustaining viability with PHA-stimulated TCM for 24 hours incubation was significantly higher than other groups (80 ± 10 vs 25 ±15 vs 13 ± 9; p <0.01). The superoxide prodution from neutrophils with PHA-stimulated TCM for 24 hours incubation were also significantly higher than other groups(25±4 vs 11±4 vs 7±5; p <0.01). In the leukotriene C4 (LTC4) release, neutrophils with PHA-stimulated TCM for 24 hours incubation were different from other group (105 ± 20 vs 65 ±1O vs 25 ± 32 ; p <0.01), and unlikely other parameters the cells with PHA-nonstimulated TCM was different from the cells with enriched medium alone(65 -1:10 vs 25-± 32; p<0.05). In two dimension electrophoresis it was shown that PHA-stimulated T cells enhanced three proteins(66kD, 60kD, 45kD) and diminished one(40kD) in the production and/or release of proteins in comparison with PHA-nonstimulated T cells. These data suggest that these proteins from the PHA-stimulated T cells might be involved in the phagocytic actions of neutrophils.

System 信賴度 및 安全係數設計의 確率的 方法에 관한 硏究

허성관,정용식 대구대학교 (한사대학) 산업기술연구소 1988 産業技術硏究 Vol.7 No.-

The purpose of this study is to suggest is to the probabilistic methodology of system Reliability and Safety Factor designs. Generally, the factors having an effect on System Reliability and Safety Factor designs are caused by two random variables of stress and strength, and System Reliability and Safety Factor designs are possible by deriving from functional relation of two distributions. Therefore, this study suggested all kinds models about random variable of stress-strength distribution and defined probability of reliability in interference of stress-strength density function. Also, supposing that stress-strength conform to a normal distribution, Reliability and Safety Factor designs used Bienayme-Chebyshev inequality. Finally, Reliability bounds are possible by deviding interference area of stress-strength distribution in to subintervals. In conclusion, this study will give engineering designers a great help about the system Reliability and Safety Factor designs.

PDMS와 유리를 이용한 제한효 반응용 마이크로바이오칩 개발

허영선,염혜정,조철호,안유민,황승용 한양대학교 이학기술연구소 2005 이학기술연구지 Vol.8 No.-

최근 생화학 심험 분야에서 초미세 구조를 이용한 소형화 분야가 두드러지게 나타나고 있다. 소형화의 가증 큰 이점은 적은 양의 시료가 사용되기 때문에 실험 비용이 줄어들 뿐 아니라 실험 시간이 단축 된다는 것이다. 게다가 하나의 칩으로 바이오 실험의 모든 단계가 수행되는 랩 온어 칩의 통합을 위한 가능성을 나타내어 준다, 우리는 제한 효소 반응 실험에 응용하기 위해 새로운 마이크로바이오칩을 개발하였다, 이 마이크로 바이오칩은 PDMS와 유리를 사용해 제작하였고 총 실험 반응 양의 10㎕이다, 마이크로바이오칩을 이용한 제한효소 실험은 일반적으로 행해지는 실험 방법에 비해 반응 시간과 시료 양을 단축하는데 성공적이었다. In recent years, significant advances emerged in the area of miniaturzation of biochemical experiment using micro fabricated structures The key sdvantages of the miniaturization would be reduces assay costs due to the low consumpation of expensive reagent and increased experiment speed The additional benefits can be intergrated into Lab-on -a chip in which all the steps necessary in bio assays is performed in a single chip We have developed a novel Microbiochip for th application of Restriction Enzyme cut reaction The Microbiochip with reaction volum of 10 ㎕was fabricated using PDMS/glass The Restriction Enzyme cut reaciton using the microbiochip was successfully done with less time sample compared to the conventioal way

초등학교 화산과 지진 단원의 실험보조자료집 구성

허영아 청주교육대학교 과학교육연구소 2001 科學과 數學敎育論文集 Vol.22 No.-

GlycinecinA의 분비에 관여하는 secretor gene의 cloning

김영미,허정식,허규희 제주대학교 생명과학기술혁신센터 2002 제주생명과학연구 Vol.5 No.-

Xanthomonas campestris pv. glycines 8ra produces bacteriocin, glycinecin, which inhibits the growth of bacteria specifically belong to Xanthomonas spp. Xanthomonas spp. includes many important plant pathogenic bacteria such as X. c. pv. vesicatoria which cause the bacterial leaf spot in pepper and tomato and X. oryzae pv. oryzae which causes bacterial leaf blight in rice. Glycinecin has many of good properites as a biological control agent. Since glycinecin inhibit the growth of phytopathogenic Xanthomonas sp, it can be used to control disease without any harm to beneficial bacteria for pant mostly belonged to Pseudomonas sp. However, it needs some modification to develop glycinecin as a effective bilogical control agent. The clone involved in the secretion of bacteriocin production were isolated and named glyAsec.

운동 유발성 횡문근 융해를 동반한 요로결석 2례

허진,최원혁,조진혁,함영희,홍정범,정성규,김현,허동 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Two men were admitted to hospital with flank pain, hematuria, which was diagnosised as ureteral stone. Elevation of aspartate aminotransferase (AST) without typical pattern of toxic hepatitis was observed. Careful history taking, several laboratory tests, abdominal and pelvis computered tomography was done. Findings from theses examinations supported the clinical diagnosis of ureteral stone complicated of exercised induced rabdomyolysis. Early recognization of rhabdomyolysis in clinical setting is important, because clinical manifestations have ranged from asymtomatic elevation of creatine kinase to acute renal failure which is a life threating medical emergency. Authors report two cases of exercised induced rhabdomyolysis initially admittied as ureteral stone managed with hydration

유아 리더십에 영향을 미치는 개인 및 가정환경 변인분석

허소영 ( So Young Her ),김수영 ( Su Young Kim ) 한국아동교육학회 2013 아동교육 Vol.22 No.3

본 연구는 유아 리더십과 유아의 개인변인, 환경변인과의 상관관계를 알아보고 상대적 기여도를 종합적으로 분석하여 유아의 리더십에 더 많은 영향을 주는 연인을 알아보는 것이 목적이다. 이를 위하여 D시와 K시에 위치한 유치원과 어린이 집에 다니는 만 4,5세 유아 254명의 담임교사가 유아의 배경특징을 조사하고 유아의 리더십, 사회성 파 자기조절력을 측정하였다. 유아의 어머니들에게 질문지를 배부하여 어머니의 배경특징, 양육태도와 리더십을 조사하였으며, 자료분석을 위해 Pearson의 상관분석과 중마회귀분석을 실시하였다. 연구결과는 다음과 같다. 첫째, 유아의 러더십과 유아의 개인변인 중 사회성, 자기조절력과 상관관계가 나타났다. 둘째, 유아의 리더십과 유아의 환경변인 중 어머니의 양육태도와 상관관계가 나타났다. 셋째, 유아의 리더십에 영향을 미치는 상대적 기여도는 유아의 사회성, 유아의 자가조절력, 어머니의 애정적 양육태도 순으로 나타났다. This study investigated the relationships between young children`s leadership and their individual and environmental variables. It also analyzed the relative contributions of these variables to young children`s leadership, For this purpose, teachers of 254 young children aged -four through five in kindergartens and child care centers in D and K cities were asked to survey their children`s characteristics. The teachers also assessed the children`s leadership. Sociability, and self-control ability. The mothers of the children`s were asked to answer the survey questions on their characteristics. rearing-attitudes and leadership, The data were analyzed by Pearson correlation and multiple regression analysis. The study results revealed that among the children`s individual variables, sociability and self-control ability showed significant relationships with the children`s leadership. while the mothers` rearing-attitudes showed significant relationships with the children`s leadership among the children`s environmental variables, In terms of the relative contributions of the variables to the children`s leadership, the children`s sociability seemed the most influential. followed by the children`s self-control ability and the mothers" affectionate rearing-attitudes.

Value of Ventricular Stiffness Index and Ventriculoarterial Interaction in Patients With Nonischemic Dilated Cardiomyopathy

Her, Ae Young,Kim, Jong-Youn,Choi, Eui-Young,Kim, Sung-Ai,Jae, Rhee Sang,Shim, Chi Young,Kang, Seok-Min,Ha, Jong-Won,Chung, Namsik Japanese Circulation Society. 2009 CIRCULATION JOURNAL Vol.73 No.9

<P><B><I>Background:</I></B> Whether echo-Doppler-derived index of ventricular elastance or ventriculoarterial interaction can reliably reflect circulatory efficiency in various conditions was investigated in the present study and whether they can be helpful in predicting exercise capacity in patients with dilated cardiomyopathy (DCM). <B><I>Methods and Results:</I></B> The 25 patients with DCM, 25 age- and gender-matched hypertensive patients, and 25 marathon runners underwent symptom-limited graded supine bicycle exercise echocardiography after resting echo-Doppler evaluation. Echo-Doppler-derived left ventricular (LV) diastolic elastance index (Ed), ventricular-vascular coupling index (10 × Ea/Ees), based on arterial elastance index (Ea) to LV end-systolic elastance index (Ees), and hemodynamic parameters were measured during rest and exercise. DCM patients had lower Ees, higher Ed and Ea/Ees with blunted exercise responses of Ees than the other groups, and the hypertensive patients had lower Ees and ΔEes compared with the marathon runners. Resting Ed, Ea/Ees, and total stiffness index (10 × Ed × Ea/Ees) correlated with exercise duration independent of age and gender. A stiffness index of 0.8 could reliably predict impaired exercise capacity. <B><I>Conclusions:</I></B> Echo-derived elastance is predictive of exercise capacity in patients with DCM. (<I>Circ J</I> 2009; <B>73:</B> 1683-1690)</P>