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Kee, Youn Kyung,Park, Jung Tak,Yoon, Chang-Yun,Kim, Hyoungnae,Park, Seohyun,Yun, Hae Ryong,Jung, Su-Young,Jhee, Jong Hyun,Oh, Hyung Jung,Han, Seung Hyeok,Yoo, Tae-Hyun,Kang, Shin-Wook International Society for Peritoneal Dialysis 2017 Peritoneal dialysis international Vol.37 No.5
<P>Conclusion: Peritoneal dialysis can be considered as a long-term renal replacement therapy option, especially in non-diabetic, not overweight, and young ESRD patients.</P>
( Youn Kyung Kee ),( Tae Hyun Yoo ),( Seung Gyu Han ),( In Mee Han ),( Chang Yun Yoon ),( Eunyoung Lee ),( Young Su Joo ),( Jung Tak Park ),( Seung Hyeok Han ),( Beom Seok Kim ),( Shin Wook Kang ),( K 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Continuous renal replacement therapy (CRRT) has been widely used in critically ill acute kidney injury (AKI) patients. Moreover, some centers operate a specialized CRRT team (SCT) composed of physicians and nurses, but few studies have yet determined the superiority of SCT control. Methods: A total of 334 among 534 patients in original cohort, who started CRRT for severe AKI between August 2007 and September 2009 in Yonsei University Health System and were matched with a propensity score (PS), were divided into two groups based on SCT application. Moreover, we compared CRRT-related outcomes including down-time per day and lost time per filter-exchange between the two groups. The primary outcomes were 28- and 90-day all-cause mortality, and the secondary outcomes were the rates of renal function recovery at 28- and 90-day. Results: The down-time per day, lost time per filter-exchange, and RBC-transfused numbers during CRRT treatment were significantly lower after SCT approach compared with the group before SCT, while net ultrafiltration rate in after SCT group was significantly higher compared to the before SCT group. During the study period, the 28- and 90-day all-cause mortality rates were significantly decreased after SCT application. Cox regression analysis revealed that 28- and 90-day all-cause mortality rates were significantly lower under SCT control, after adjusting for primary diagnosis, emergent surgical cases, Charlson Comorbidity Index and biochemical parameters. However, there were no significant differences in the rate of renal function recovery before and after SCT approach in CRRT. Conclusions: A well-organized CRRT team could be beneficial for the clinical outcomes of AKI patients requiring CRRT.
Kee, Youn Kyung,Yoon, Chan-Yun,Kim, Seung Jun,Moon, Sung Jin,Kim, Chan Ho,Park, Jung Tak,Lim, Beom Jin,Chang, Tae Ik,Kang, Ea Wha,Kie, Jeong Hae,Yoo, Tae-Hyun,Jeong, Hyun Joo,Kang, Shin-Wook,Han, Seun Williams & Wilkins Co 2017 Medicine Vol.96 No.44
<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>Proteinuria is a major determinant of adverse renal outcome, and its reduction slows renal progression in glomerular diseases. However, the optimal target of proteinuria in glomerular diseases is unclear, and discrepancies in the definition of proteinuria produce ambiguous findings. Here we investigated the optimal target of proteinuria by using different definitions of proteinuria. We analyzed 574 IgA nephropathy (IgAN), 175 membranous nephropathy (MGN), and 177 focal segmental glomerulosclerosis (FSGS) cases from 3 Korean kidney centers. We evaluated the impact of proteinuria on renal outcome with 2 definitions: time-average proteinuria (TAP) and time-varying proteinuria (TVP). The endpoint was renal progression, defined as a 50% decline in glomerular filtration rate or end-stage renal disease. During a median follow-up of 57.3 months, the primary outcome occurred in 54 patients with IgAN, 26 with MGN, and 30 with FSGS. Multivariate Cox regression using TAP indicated that there was a linear association between proteinuria and risk of renal progression in IgAN. However, moderate proteinuria was not associated with an increased risk of renal progression in MGN and FSGS. In contrast, the analysis by TVP showed that the risk significantly increased in proportion to proteinuria during follow-up in all 3 diseases. Our findings suggest that TVP-based model can delineate association between proteinuria and risk of renal progression better than TAP-based model, considering that TVP reflects the dynamic change of proteinuria over time. Thus, proteinuria reduction to the lowest possible level is required to improve renal outcomes in patients with glomerular diseases.</P></▼2>
( Kyung Ho Song ),( Hye Kyung Jung ),( Byung Hoon Min ),( Young Hoon Youn ),( Kee Don Choi ),( Bo Ra Keum ),( Kyu Chan Huh ) 대한소화기기능성질환·운동학회 2013 Journal of Neurogastroenterology and Motility (JNM Vol.19 No.4
Background/Aims A self-report questionnaire is frequently used to measure symptoms reliably and to distinguish patients with functional gastrointestinal disorders (FGIDs) from those with other conditions. We produced and validated a cross-cultural adaptation of the Rome III questionnaire for diagnosis of FGIDs in Korea. Methods The Korean version of the Rome III (Rome III-K) questionnaire was developed through structural translational processes. Subsequently, reliability was measured by a test-retest procedure. Convergent validity was evaluated by comparing self-reported questionnaire data with the subsequent completion of the questionnaire by the physician based on an interview and with the clinical diagnosis. Concurrent validation using the validated Korean version of the Short Form-36 Health Survey (SF-36) was adopted to demonstrate discriminant validity. Results A total of 306 subjects were studied. Test-retest reliability was good, with a median Cronbach`s α value of 0.83 (range, 0.71-0.97). The degree of agreement between patient-administered and physician-administered questionnaires to diagnose FGIDs was excellent; the κ index was 0.949 for irritable bowel syndrome, 0.883 for functional dyspepsia and 0.927 for functional heartburn. The physician`s clinical diagnosis of functional dyspepsia showed the most marked discrepancy with that based on the self-administered questionnaire. Almost all SF-36 domains were impaired in participants diagnosed with one of these FGIDs according to the Rome III-K. Conclusions We developed the Rome III-K questionnaire though structural translational processes, and it revealed good test-retest reliability and satisfactory construct validity. These results suggest that this instrument will be useful for clinical and research assessments in the Korean population. (J Neurogastroenterol Motil 2013;19:509-515)
Original Article : Geographic difference of epidemiological features of HCV infection in Korea
( Kyung Ah Kim ),( Sook Hyang Jeong ),( Eun Sun Jang ),( Young Seok Kim3 ),( Youn Jae Lee ),( Eun Uk Jung ),( In Hee Kim ),( Sung Bum Cho ),( Mee Kyung Kee ),( Chun Kang ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.4
Background/Aims: The prevalence of hepatitis C virus (HCV) infection in Korea exhibits significant geographic variation, with it being higher in Busan and Jeonam than in other areas. The reason for this intranational geographic difference was investigated in this study by conducting a comparative analysis of the risk factors related to HCV infection among three geographic areas: the capital (Seoul), Busan, and the province of Jeolla. Methods: In total, 990 patients with chronic HCV infection were prospectively enrolled at 5 university hospitals located in Seoul (n=374), Busan (n=264), and Jeolla (n=352). A standardized questionnaire survey on the risk factors for HCV infection was administered to these three groups of patients, and a comparative analysis of the findings was performed. Results: The analysis revealed significant regional differences in exposure to the risk factors of HCV infection. By comparison with patients in Seoul as a control group in the multivariate analysis, patients in Busan had significantly more experience of invasive medical procedures, acupuncture, cosmetic procedures, and multiple sex partners. In contrast, patients in Jeolla were significantly older, and they had a higher prevalence of hepatocellular carcinoma, a lower prevalence of multiple sex partners, and had experienced fewer invasive procedures. Conclusions: There was a significant geographic difference in the exposure to potential risk factors of HCV infection between patients from the three studied regions. This may explain the regional variation of the prevalence of HCV infection in Korea, and should be taken into account when planning strategies for the prevention and management of HCV infection. (Clin Mol Hepatol 2014;20:361-367)
( Kyung Hea Park ),( Seok Jong Lee ),( Moon Bum Kim ),( Il Hwan Kim ),( Sook Jung Yun ),( Dong Youn Lee ),( Mi Woo Lee ),( Kee Yang Chung ),( Kwang Hyun Cho ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Cutaneous melanoma in Korean is as rare as approximately 2,085 new patients in South Korea from 2006 to 2010 therefore little data are available in Korea. Objectives: The Purpose of our study is to investigate the current status of clinico-pathological diagnosis and management of melanoma in Korea. Methods: We surveyed melanoma patients from 8 hospitals with questionnaire including overall clinical characteristics, evaluation tool, behavior of pathologic diagnosis and management. Results: Data revealed that 905 new melanoma cases (43.4% from total 2,085 patients) were enrolled from 8 hospitals during past 5 years (2006~2010). Half of them operate the multidisciplinary meeting. Seven performed a sentinel lymph node biopsy, the percentage ranged from 4.1% to 83.5% (average 29.5%). Information routinely included in pathological report is various; Breslow thickness (7 hospitals), ulceration (7), mitotic rate (7), Clark level (5) and etc. There was a diagnostic mismatch (0~5.3%) between pathologist and dermatologist and it was developed mostly due to differentiation between malignancy and benignancy. Strategy for surgery including surgical margin was almost similar. However interferon for stage 3 was employed from 0% to 62.2% and dacarbazine was used variably (6.0% ~ 54.5%) for stage 4 melanoma. Conclusion: Korean standard for melanoma has to be established due to considerable discrepancy in terms of pathological diagnosis and clinical management of melanoma from hospital to hospital.
원발성 간암환자에서 간동맥 색전술의 치료효과 - 2. 중간 추적 생존율 -
고윤석(Youn Suck Koh),노임환(Im Hwan Roe),안정경(Jung Kyung Ahn),함준수(Joon Soo Hanm),이민호(Min Ho Lee),기춘석(Choon Suhk Kee),박경남(Kyung Nam Park),이은희(Eun Hee Lee),서흥석(Heung Suk Seo) 대한내과학회 1988 대한내과학회지 Vol.35 No.3
N/A Currently, primary hepatocellular carcinoma (HCC) is the second most common cause of cancer death in men in Korea. Generally, the tumor is unresectable due to underlying liver cirrhosis. As a palliative therapy of HCC, transcatheter arterial embolization (TAE) was performed in 53 patients (57 times) from April 19S5 until December 1986 at Hanyang University hospital, of which the conditions of only 35 patients could be followed after TAE therapy. We have analyzed the effectiveness of TAE therapy on these 35 patients. The results were as follows: In patient who didn't have tumor thrombosis in the first or second portal branches, the mean 8 months survival was 58.2%, while in patients with tumor thrombosis, it was 8.3%. The ratio of the tumor size to the liver measured by a planimeter in hepatic angiography was found to be meaningful in the prognosis; In patients with a ratio below 20%, the 6 months survival rate was 66.7%, and in patients with a ratio of 20% or more, it wis 43.4%, The results suggest that TAE is more beneficial in unresectable HCC which doesn't have tumor thrombosis in the first or second portal branches, and which has a ratio of tumor size to liver below 20% as measured by angiography.
김기돈(Kee Don Kim),이정한(Jung Han Lee),민경택(Kyung Taek Min),문영진(Young Jin Moon),김경태(Kyoung Tai Kim),조삼현(Sam Hyun Cho),황윤영(Youn Yeung Hwang),임호준(Ho Jun Lim),이항(Hang Lee) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.2
N/A Objective: The purpose of this study was to review the incidence, types, chemotherapy regimens, operation me#thods, pregnancy rate and propiosis of the ov#arian malignancy under the age of twenty years old. Methods: Retrospective reviews of the medical recordings for 22 patients with ovarian malignancy under the age of twenty years old in the Department of Obstetrics and Gynecology, Hanyang University from 1986 to 1997 were done. Results: Gerin cell tumor accounts for the majority of cases (77%), whereas 5 patients(23%) belong to the common epithelial poup which were all mucinous type. Our experiences with 22 cases are as followings: 5 mucinous cystadenocarcinoma, 8 immature teratoma, 4 endodermal sinus tumor, 3 dysgernma and 2 mixed germ cell tumor. The incidence of this group was 8.2% (22/266) in all ovarian malignancy. Fourteen of them are stage I, each one is, stage II and IV, and six patients are stage III. The average age was 14.9 years old in germ cell tumor and 18.4 yems old in mucinous cystadenoearcinoma. Malignant ovarian cancer under the age of twenty can be treated with conservative surgery, followed by adjuvant chemotherapy. Commonly used chemotherapeutic regimens were VAC(Vincristine, Actinomycin-D; Cyclophosphamide), VBP(Vinblastine, Bleomycin, Cisplatin) and BEP(Bleomycin, Etoposide, Cisplatin). Second look operations were done in 11 patienth and histologic positive findings were detected in 4 of them. The length of follow-up ranged ftom 3 months to 137 months and median value was 44 rnonths. Conclusions: It is concluded that for young women who wish to preserve child-bearing capacity, regardless of the stage of the tumor, fertility preserving surgery with complete surgical staging, if necessary followed by combination chemotherapy is an appropriate treatment.