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Shin, Da-Yong,Cheon, Kwang-Hee,Song, Eun-Ho,Seong, Yun-Jeong,Park, Ji-Ung,Kim, Hyoun-Ee,Jeong, Seol-Ha Elsevier 2019 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.123 No.-
<P><B>Abstract</B></P> <P>The creation of a moist environment and promotion of cell proliferation and migration together with antibacterial property are critical to the wound-healing process. Alginate (Alg) is an excellent candidate for injectable wound dressing materials because it can form a gel in a mild environment. Taking advantage of its gelation property, an injectable nano composite hydrogel containing nano-sized (about 90 nm) calcium fluoride (CaF<SUB>2</SUB>) particles was developed using <I>in-situ</I> precipitation process. The amount of released fluorine (F<SUP>−</SUP>) ion from the nanocomposite hydrogel increased with increasing CaF<SUB>2</SUB> content inside the composite hydrogel and the ions stimulated both the proliferation and migration of fibroblast cells <I>in vitro</I>. The antibacterial property of the composite hydrogel against <I>E. coli</I> and <I>S. aureus</I> was confirmed through colony formation test where the number of bacterial colonies significantly decreased compared to Alg hydrogel. The <I>in vivo</I> results based on a full-thickness wound model showed that the nanocomposite hydrogel effectively enhanced the deposition of the extracellular matrix compared to that of the Alg hydrogel. This study demonstrates the potential of this nanocomposite hydrogel as a bioactive injectable wound-dressing material with the ability to inhibit bacterial growth and stimulate cell proliferation and migration for accelerated wound healing.</P>
당뇨병성 말초혈관장애에 대한 Cilostazoe ( Pletaal ) 의 효과
강성구,이광우,손호영,차봉연,한제호,윤건호,권혁호,김용성,오현상,신순현 대한내분비학회 1993 Endocrinology and metabolism Vol.8 No.1
Peripheral vascular disease is a common complication in diabetes mellitus. Accelerated atherosclerosis leading to impaired circulation in the legs is one of the most important causes of gangrene and amputation. In previous studies, a critically low systolic ankle and toe blood pressure has been shown to indicate a high probability for development of diabetic gangrene. The aim of the presint prospective study was to report the results of the treatment of 200 mg/day Cilostazol which has a vasodilating and antithrombotic action in 30 diabetic patients with peritheral vascular disease. The results were as follows: 1) The score of resting pain, numbness, cold sensation, claudication and granuloma were significantly decreased after Cilostazol treatment for 8 weeks. 2) The ankle pressure index was increased from 0.92±0.21 to 0.96±0.15, after Cilostazol treatment for 8 weeks. The score of arterial palpation and dopler wave were markely improved in both groups after Cilostazol treatment. 3) Facial flushing, headae and chest pain were noted, but geadache and chest pain were dissappeared spontaneously during Cilostazol administration 4) The assessement of overall safety of the drug evaluated by the attending-physician bases on the assessement of $quot;safe$quot; and $quot;almost safe$quot; amounted to 96.7%. The assessment of overall improvement of the deasease made by the attending physician based on the improvement of resting pain, cold sensation, claudication, numbness, ulcer and granuloma indicated that the percent improvement based on the combined assessments of $quot;markedly improved$quot;, $quot;improved$quot; and $quot;slightly improved$quot; amounted to 86.6% 5) Fasting blood sugar, postprandial 2 hour sugar and HbAlc levels were significantly decreased after Cilostazol administration. 6) Before and after Cilostazol treatment, there were no significant differences in physical findings, CBC, blood chemistry, and total cholesterol level. After Cilestazol administration, HDL·cholesterol levels were increased, and triglyceride levels were decreased, but the changes were not statistically significant. Theses results suggest that Cilostazol was useful in the treatment of diabetic peripheral vascular disease accompanied by ischemic symptoms such as resting pain, cold sensation, claudication, numbness, ulcer and granuloma in the extremities. (J Kor Endocrinol 8:78∼87. 1993)
Feasibility and response of helical tomotherapy in patients with metastatic colorectal cancer
Sun Hyun Bae,Seong Kwon Moon,Yong Ho Kim,Kwang Hwan Cho,Eung Jin Shin,Moon Sung Lee,Chang Beom Ryu,Bong Min Ko,Jina Yun 대한방사선종양학회 2015 Radiation Oncology Journal Vol.33 No.4
Purpose: To investigate the treatment outcome and the toxicity of helical tomotherapy (HT) in patients with metastatic colorectal cancer (mCRC). Materials and Methods: We retrospectively reviewed 18 patients with 31 lesions from mCRC treated with HT between 2009 and 2013. The liver (9 lesions) and lymph nodes (9 lesions) were the most frequent sites. The planning target volume (PTV) ranged from 12 to 1,110 mL (median, 114 mL). The total doses ranged from 30 to 70 Gy in 10–30 fractions. When the α/β value for the tumor was assumed to be 10 Gy for the biologically equivalent dose (BED), the total doses ranged from 39 to 119 Gy10 (median, 55 Gy10). Nineteen lesions were treated with concurrent chemotherapy (CCRT). Results: With a median follow-up time of 16 months, the median overall survival for 18 patients was 33 months. Eight lesions (26%) achieved complete response. The 1- and 3-year local progression free survival (LPFS) rates for 31 lesions were 45% and 34%, respectively. On univariate analysis, significant parameters influencing LPFS rates were chemotherapy response before HT, aim of HT, CCRT, PTV, BED, and adjuvant chemotherapy. On multivariate analysis, PTV ≤113 mL and BED >48 Gy10 were associated with a statistically significant improvement in LFPS. During HT, four patients experienced grade 3 hematologic toxicities, each of whom had also received CCRT. Conclusion: The current study demonstrates the efficacy and tolerability of HT for mCRC. To define optimal RT dose according to tumor size of mCRC, further study should be needed
Estimation of Methane Emission by Water Management and Rice Straw Application in Paddy Soil in Korea
신용광,윤성호,박무언,Shin, Yong-Kwang,Yun, Seong-Ho,Park, Moo-Eon 한국토양비료학회 1995 한국토양비료학회지 Vol.28 No.3
Methane flux from a rice paddy in Korea was measured to study the effects of water management and rice straw application on methane emission under different water managements ; flooding and intermittent irrigation, and with or without rice straw application. Methane emission ranged from 0.066 to $0.455g\;CH_4m^{-2}d^{-1}$. Intermittent irrigation has shown a mitigation effect of methane emission, 70% in NPK plot and 47% in NPK plus rice straw plot, relative to that of flooding. Methane emission from Korean paddy was estimated as 399,590tons per year assuming that paddy fields were managed under intermittent irrigation and rice straw application. This estimation was lower than that of OECD's by 56%, Neue's by 51%, and Matthew's by 62%, while higher than that of Taylor's by 118%. 논토양에서 물관리 및 볏짚시용이 메탄배출에 미치는 영향을 알기 위하여 물관리로는 상시담수와 간단관개의 2처리로 하고 각각에 삼요소를 대조로 하여 볏짚의 시용효과를 조사하였다. 메탄배출량은 $0.066g\;CH_4m^{-2}d^{-1}{\sim}0.455g\;CH_4 m^{-2}d^{-1}$의 범위였다. 상시담수보다 간단관개의 NPK구에서는 70%, NPK+볏짚시용구에서는 47%의 메탄 배출저감효과가 인정되었다. 간단관개조건에서 볏짚을 전량 작토에 환원한다고 가정할 때 우리나라 메탄 총배출량은 399,590톤/년으로 추정된다. 이 양은 OECD의 참고값 대비 56%, Neue와는 51%, Matthew와는 62%로 낮고 Taylor와는 118%로 높다.
A Simplified Closed Static Chamber Method for Measuring Methane Flux in Paddy Soils
신용광,이량수,윤성호,박무언,Shin, Yong-Kwang,Lee, Yang-Soo,Yun, Seong-Ho,Park, Moo-Eon 한국토양비료학회 1995 한국토양비료학회지 Vol.28 No.2
Various factors such as sampling height in the chamber, sampling interval, sampling time at daytime and the effects of pedoturbation on methane emission during chamber installation were evaluated using a simplified closed static chamber method to measure methane flux in paddy soils. Sampling height of the chamber for representative samples was 65cm. An additional DC fan was required to attain an even methane gradient in the chamber. Considering the change of methane concentration and air temperature in the chamber, sampling is recommended to finish within 30 minutes after starting sampling. The aim of setting DC fan in the chamber was to get the thermal equilibrium in the chamber as well as the representative samples. Suitable time to collect the gas samples representing the day's methane flux was 0900~1200 hours. Gas sampling was possible even after installation of small chambers if the elapsed time was more than 6 hours and supporting stand would be to be added to minimize pedoturbation. 논포장에서 배출되는 메탄가스를 측정하기 위하여 간이폐쇄정태 chamber법을 이용하여 대표적인 시료를 채취할 수 있도록 chamber내 시료채취 높이, 시료채취시 시간간격, 하루중 시료 채취시간을 검토하였다. 1. 대표적인 시료채취를 위한 chamber내 높이는 65cm이었고 chamber 하반부에서 시료가 균일하게 섞이도록 DC fan을 추가로 설치할 필요성이 인정되었다. 2. 시간경과에 따른 chamber내 메탄농도의 변화 및 기온의 변화에서 보면 시료채취를 개시하여 30분이내에 시료를 채취하는 것이 바람직하였다. DC fan으로 chamber내부의 공기가 섞이도록 하는 것은 대표적인 시료를 얻기 위한 것 뿐 아니라 chamber내열평형을 이루어 시료(試料) 채취기간중(採取期間中) 식물(植物)의 생리적(生理的) 활성(活性)에 최소한(最小限)의 변화를 주는 방법으로 판단되었다. 3. 하루중 대표적인 메탄 배출량을 나타내는 오전 9시~12시에 시료를 채취하여 분석하되 부득이한 경우에는 또 하나의 평균적인 배출량을 나타내는 오후 6시~8시의 시료를 채취하여 분석하여도 가능할 것으로 판단되었다. 4. 수도주간(水稻株間)진 토양(土壤)에서 메탄 배출을 측정하는데 사용하는 소형의 chamber는 토양을 교란할 수 있으므로 설치한 후 최소한 6시간이 경과되어야 chamber내 메탄농도가 주위의 메탄 농도로 회복되었다.