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박병건,노용관,차경,김재곤,백병주 大韓小兒齒科學會 1997 大韓小兒齒科學會誌 Vol.24 No.3
The effect of glossopharyngeal nerve transection on the taste buds of the rat vallate papilla was examined by using the method of DNA nick-end labeling (TUNEL) and standard electron microscopic technique at 1,3,5,7,9 days after denervation. In general, the number and size of taste buds decreased as more days passed after denervation. They started decreasing on day 3 post denervation. In studies using TUNEL method, TUNEL postive cells markedly increased in their numbers one day post denervation, as compared with controls. The number of apoptotic taste bud cells per taste bud profile was averaged to be 0.64 and 0.44 for day 1 and 3 post denervation, respectively, whereas it was 0.10 in controls. In electron microscopy, apoptotic cells were identified by the presence of condensed and fragmentary nuclei in a cytoplasm, which resulted in increased density. In control rats, only few apoptotic cells were found. On days 1 and 3 post denervation, nerve fibers almost disappeared from the taste buds and some apoptotic cells were apparent. On days 7 and 9 post denervation, a few taste bud cells were still present in the epithelium of the bottom of the trench wall of the vallate papilla and most of them showed apoptotic changes. The results indicate that the death of taste bud cells in normal conditions is controlled by apoptosis and the decrease and disappearance of taste buds sfter denervation is also caused by apoptosis of taste bud cells.
아동 및 청소년기의 하악각부 피질골 두께에 관한 방사선학적 연구
백병주,김미라,노용관,김문현,김재곤 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.1
The purpose of this stufy was to determine the thickness of the cortical bone at the mandibular angle in children and adolescents. The subjects were composed of 153 subjects who were 3 to 17 years of age that had not been history of bone disease or metabolic disease and no dental caries or tooth loss on mandibular molars. The subjects were divided into three age groups, group Ⅰ(preschool children) was 3 to 5 years of age and group Ⅱ (school children) was 6 to 11 years of age and froup Ⅲ (adolescence) was 12 to 17 years of age. Panoramic radiographs of these patients were collected and measurements of the thickness of the cortical bone were obtained at the mandibular angle. The average thickness of the cortical bone in the group Ⅰ was 1.01±0.18 mm in boys and 1.07±0.22 mm in girls. In the group Ⅱ was 1.23±0.18 mm inboys and 1.32±0.18 mm in girls. In the group Ⅲ was 1.60±0.23 mm in boys and 1.58±0.20 mm in girls. Statistical analyses did not reveal any significant difference was exist between the right or left side of the mandible but difference was exist between the same age groups by sex, especially in group Ⅱ (p<0.01), except in group Ⅲ. The greater thickness of cortical bone in the older age group was shown to be statistically significant. The correlation coefficient between age and the thickness of the cortical bone at the mandibular angle showed a high value of r=0.76.
노용관 ( Yong Kwan Rho ),유광호 ( Kwang Ho Yoo ),김범준 ( Beom Joon Kim ),김명남 ( Myeung Nam Kim ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.9
Hodgkin`s disease (HD) is a lymphoproliferative disorder that presents as a clinically asymptomatic mass or painless lymph node swelling. Cutaneous HD is a very rare manifestation in patients with HD. A 66-year-old man complained of a maculopapular rash waxing and waning for one year. A painful mass had developed on his left axilla 7 weeks prior to presenting. The biopsy specimens of both skin and lymph node revealed Hodgkin`s lymphoma with atypical lymphoid cells and Reed-Sternberg cells. We report a case of cutaneous involvement of HD, which had been presented as a maculopapular rash for one year. (Korean J Dermatol 2008;46(9):1262~1265)
노용관 ( Yong Kwan Rho ),김범준 ( Beom Joon Kim ),김명남 ( Myeung Nam Kim ),노병인 ( Byung In Ro ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.6
Background: Androgenetic alopecia is the most common form of hair loss in people with a genetic predisposition. It is characterized by the miniaturization of terminal hair follicles and the formation of vellus-like follicles. Objective: The aim of this study was to evaluate the prevalence, clinical manifestation, genetic and endocrine factor, and associated diseases of Korean patients with androgenetic alopecia. Methods: We studied 789 Korean men and women with androgenetic alopecia. A detailed history was taken and their hormonal values were measured. A pelvic ultrasound scan was performed to check for abnormalities the ovaries and uterus of 56 women with androgenetic alopecia. Results: The number of men was 1.9 times more (520) than that of women (269). Most of them were in their twenties (male 223; 42.8%, female 85; 31.5%). In the 520 male patients, Norwood class IIIv was dominant (161 patients; 30.9%). In the 269 female patients, Ludwig class I was superior (218 patients; 81%). 395 (75.9%) of male patients and 198 (73.6%) of female patients had a family history of androgenetic alopecia. The most common associated disorder was seborrheic dermatitis (male 407; 78.2%, female 155; 57.6%). And others included atopic dermatitis, hypertension, thyroid disease, etc. Serum testosterone levels were increased in 92 (17.6%) of the male patients and in 36 (13.3%) of the female patients. Abnormal pelvic ultrasound findings were observed in 10 (18%) of 56 female patients, and the conditions were ovarian cysts (8.9%), Uterine myoma (5.4%), uterine mass (2%), endometrial mass (2%). Conclusion: Androgenetic alopecia is a disease that has genetic and familial tendency and is associated with the androgen level. The number of androgenetic alopecia patients was increasing and type IIIv was most common in the male patients. The pelvic ultrasound showed an increased rate of abnormal findings in the female patients with androgenetic alopecia, but ultrasound is not an appropriate routine test to evaluate. (Korean J Dermatol 2008;46(6):729∼735)
노용관 ( Yong Kwan Rho ),유광호 ( Kwang Ho Yoo ),김지영 ( Ji Young Kim ),이갑석 ( Kap Sok Li ),서성준 ( Seong Joon Seo ),홍창권 ( Chang Kwun Hong ),송계용 ( Kye Yong Song ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.1
Epidermal nevi are harmatormas that are the result of developmental malformations of the epidermis, and these lesions present with a variety of clinical and histological characteristics. Some tumors can arise in epidermal nevi because epidermal nevi develop from multipotent germinative cells. We report here on a 57-year-old woman who had epidermal nevi arranged in a linear pattern since childhood. Her epidermal nevi were located in her left chest, arm and shoulder, upon which multiple trichillemal cysts seemed to develop after several years. We think that this patient with linear epidermal nevi associated with multiple trichilemmal cysts is a rare and distinctive case. (Korean J Dermatol 2009;47(1):55~58)
스테로이드 단기투여로 신속히 호전된 대상포진 환자의 안구 외전 마비
노용관 ( Yong Kwan Rho ),이진웅 ( Jin Woong Lee ),김지영 ( Ji Young Kim ),이갑석 ( Kap Sok Li ),서성준 ( Seong Joon Seo ),홍창권 ( Chang Kwun Hong ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.10
Herpes zoster ophthalmicus involving the first division of the fifth cranial nerve produces various clinical manifestations. Among them, external ocular motor palsy is a rare and uncomfortable complication, but it is generally transient and self-limited. This palsy can have a neural, vascular ormuscle origin. We report here on a case of ocular abduction palsy in a patient with herpes zoster ophthalmicus, and this palsy cleared up after treatment with systemic steroid for two weeks. (Korean J Dermatol 2008;46(10):1395∼1397)