항정신병약물 사용 중인 정신분열병 환자에서 올란자판으로의 교체 방법에 관한 연구(II) : Comparison of Safety 안전성 비교

안용민,권용실,권준수,민성호,박두병,양문정,소형석,송종호,신윤식,우행원,유범희,이홍석,정한용,한창환,김용식 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.5

연구목적: 이 다기관 공동임상연구는 사용 중인 항정신병약물을 ’직접 교체 방법’또는 ’시작-감량 교체 방법’중 한 가지 방법으로 올란자핀으로 교체한 후, 안정성 측면에서 두 교체 방법 간의 비교와 교체후의 변화를 관찰하기 위한 것이다. 방법: 국내 13개 병원의 입원 및 외래에 내원한 환자들 중 ICD-10 지단기준으로 정신분열병에 해당되며, 임상적으로 항정신병약물 교체가 필요한 환자를 대상으로 하였다. 두 가지 교체 방법 중 한 가지를 무작위로 피험자에 적용하였으며, ’직접 교체 방법’에 배정된 경우에는 사용중인 항정신병약물을 일시에 중단하고 10㎎의 올란자핀을 바로 투여하였고, ’시작-감량 교체 방법’에 배정된 경우는 10㎎의 올란자핀 투여하고 2주에 걸쳐서 기존 약물을 감량하여 중단하였다. 올란자핀 사용기간은 총 6주이며, 용량은 5∼20㎎ 범위로 제한하였다. 한정성 평가를 위해서 체중, 생명징후, 자발적인 이상반응 복, 실험실 검사 그리고 Simpson-Angus Scale(SAS), Barnes akathisia rating scale(BARS), Abnormal involuntary movement scale(AIMS). Liverpool University neuroleptic side effect rating scale(LUNSERS)등을 이용하였다. 결과: 총 103명의 정신분열병 환자를 대상으로 하였다. 사용한 올란자핀의 용량, 벤조디아제핀의 병용률, 탈락률과 탈락 사유, 자발적인 이상반응 보고, 생명징후, 실험실 검사 그리고 대부분의 부작용 척도 상에서 임상적으로 의미 있는 차이를 두 교체 방법간에 발견하지 못하였다. 다만 AIMS의 감소는 ’직접 교체 방법’군에서 보다 적었고, 항콜린제의 병용률은 ’시작-감량 교체 방법’군에서 보다 많았다. 기저 상태에서 전체 피험자의 SAS와 BARS 점수는 각각 3.5점과 1.8점이었으며 70% 이상의 피험자가 고프로락틴 혈증을 보였다. 올란자핀으로 교체한 후, SAS, BARS, AIMS 점수의 유의한 감소가 있었으며 고프로락틴 혈증을 보인 피험자 분율도 약 30%이하로 감소하였다. 그러나 교체 방법과 상관없이 올란자핀 교체 후 유의한 체중 증가가 있었다. 결론: 이 연구를 통해 교체 방법에 관계없이 비교적 안전하고 용이하게 올란자핀으로 교체 할 수 있음을 알 수 있었다. 그리고 기존 항정신병약물을 올란자핀으로 교체함으로써 일부 부작용들을 줄일 수 있음을 간접적으로 관찰할 수 있었다. 하지만 이 연구는 여러 제한점과 문제점을 지니고 있기 때문에 보다 체계적인 연구를 통해 검정이 필요하리라 생각된다. Objectives: This multicenter clinical trial involving 13 hospital sites compared the safely of switching to olanzapine between ’direct switching method’ and ’start-tapering switching method’. Method: This study included both inpatients and outpatients who fulfilled the criteria for schizophrenia as defined in the ICD-10, and were in need to be appropriate for switching antipsychotics. Subjects were randomly assigned to one of the two switching methods. For ’direct switching method’group, previous antipsychotics were abruptly discontinued and 10㎎ of olanzapine was administered, and previous antipsychotics was gradually tapered for 2 weeks. Olanzapine was used for 6 weeks and the dose was adjusted within the range of 5-20㎎. The safety of switching to olanzapine was measured with vital sings including body weight, adverse events reported spontaneously, laboratory tests, and various scales such as Simpson-Angus Scale(SAS), Barnes Akathisia Rating Scale(BARS). Abnormal Involuntary Movement Scale(AIMS), and Liverpool University Neuroleptic Side Effect Rating Scale(LUNSERS). Results: 103 patients were switched to olanzapine in this study. The comparison between two switching methods did not show any significant difference in the dosage of olanzapine used, the concomitant use of benzodiazepine, the rate and reasons of drop-out, the adverse events, vital signs, laboratory tests, and most scales for measuring side-effects. However, the decrease in AIMS scores was significantly lower in ’direct switching method’ group, and the concomitant use of anticholinergics was comparatively greater in ’start-tapering switching method’ group. At baseline, SAS and BARS scores were 3.5 and 1.8 points respectively, and more than 70% of the subjects showed hyperprolactinemia. After switching to olanzapine, SAS, BARS, and AIMS scores were significantly decreased and the proportion of the patients with hyperprolactinemia was also decreased to less than 30%. However significant weight gain after the treatment of olanzapine was observed regardless of switching method. Conclusion: This study may suggest that switching to olanzapine can be done with relatively high safety regardless of switching methods and olanzapine can significantly decrease some side-effects induced by other antipsychotics.

방사선 조사선량에 따른 백서 악하선의 caspase-3 발현양상

권기정,최용석,황의환,이상래,고광준 대한구강악안면방사선학회 2006 Imaging Science in Dentistry Vol.37 No.1

Purpose : To investigate the caspase-3 expression in the acinar and ductal cells of rat submandibular glands after the irradiation of various doses. Materials and Methods: The male Sprague-Dawley rats weighing approximately 250 gm were used for this study. The experimental group was irradiated with a single absorbed dose of 2, 5, 10, and 15 Gy on the head and neck region. The rats were sacrificed on the 1st, 3rd, 7th, 14th, 21st, and 28th day after irradiation. The specimens including the submandibular gland were sectioned and observed using histopathological and immunohistochemical methods. Results : The local destruction of the acinar and ductal cells and the karyopyknotic nuclei of the acinar cells were observed in the 2 Gy and 5 Gy irradiation groups later than in the 10 Gy and 15 Gy irradiation groups. And the expression of caspase-3 was prominent only in the ductal cells in the 2 Gy and 5 Gy irradiation groups. Conclusion : This experiment suggests that radiation-induced apoptosis in the ductal cells of rat submandibular glands was induced by a low dose radiation associated with the activation of caspase-3 and radiation-induced necrosis was induced by a high dose radiation. (Korean J Oral Maxillofac Radiol 2006; 36 : 7-15)

朝鮮王朝時代 人口推定에 關한 一詩論

權泰煥,愼鏞廈 서울대학교 동아문화연구소 1977 東亞文化 Vol.14 No.-

In this study, we have attempted to estimate the population size of Korea during the entire period of the Yi dynasty, 1392-1910, utilizing various historical materials on population, mainly data from household registry and Hojog records. To evaluate the quality of the household registry data, we have conducted a partial examination of Hojog record and consistency checks for population figures for different years. Also population trends available directly from various historical materials have been analysed in terms of stable population concepts as to determine the extent of errors in population enumeration for various sub-periods. Based on those evaluations, we have developed a series of assumptions and methodological procedures for estimating the population size. The major findings in this study can be summarized as follows: a. Historical data on household and population in the Yi dynasty are of very poor quality with completeness between 10-50 per cent. b. Despite the fact that the quality of household and population data is poor, the population trends for the period 1639-1861 discerned from the reported figures respond receptively to the traditional factors in population change, such as famine, war, and other major miseries. c. From an analysis of Hojog record, a significant under-registration is noticed, for the child and young adult population, households without adult working males, and single households. d. The completeness of population registration in the Yi dynasty was closely associated with the average size of household reported. e. The population at the beginning of the dynasty (1392) was estimated as about 5,550,000. The population increased to about 14,000,000 two hundred years later just before the Korean-Japanese War in 1592. During the 45 years of socio-political disturbance, 1592-1637, in which two wars and a series of famines and epidemics took place, an absolute loss of 4,000,000 people was estimated. f. According to the estimates, the most marked growth of the population was observed during the 40 year period, 1654-1693. The population peaked in 1750 and again in 1807. The estimates were 18,660,000 and 18,620,000 respectively. The population at the end of the Yi dynasty (1910) was estimated at 17,430,000. g. The average annual rate of population growth during the entire Yi dynasty period was calculated as 0.22 per cent.

Relationship between Meteorological Elements and Yield of Hot Pepper in Yeosu Area of Korea

Kwon,Byung-Sun,Choi,Seong-Kyu,Shin,Jeong-Sik,Shin,Jong-Sup,Shin,Dong-Young,Hwan,Kyu-Hyun,Kim,Hak-Jin,Kuk,Yong-In,Choi,Kyong-Ju 한국자원식물학회 2003 Plant Resources Vol.6 No.1

This study was conducted to investigate the relationships between yearly variations of meteorological elements and yearly variations of productivity in hot pepper. In addition, correlation coefficients among the yields and yield components were used to find out the relationships between meteorological elements and productivity. Yearly variation of the mean air temperature in May and July showed large with coefficients of variation(C.V.) of 25.0,8.9%, respectively, but the variation of the duration of sunshine in May were relative small. Yield and plant height was greatly with C.V. of 7.14,11.6%, respectively, diameter of fruit showed more or less C.V. of 2.28% and length of fruit showed less variation. Correlation coefficients between maximum temperature in period of cultivation from May and yield are positively significant at the level of 1 %. Correlation Coefficients between precipitation in period of cultivation from May to August and yield are negative significant at the level of 5 and 1 %, respectively. Correlation coefficients amount the plant height, length of fruit, diameter of fruit per plant, and seed yield were positively significant at the level of 1 %, respectively.

브레이징법에 의한 TiA1 금속간 화합물의 접합에 관한 연구

권영순,권용재,김지순,김환태 울산대학교 1995 공학연구논문집 Vol.26 No.2

본 연구에서는 Al을 삽입금속으로 사용하여 브레이징법으로 접합한 TiAl 금속간화�물의 접합특성에 대하여 조사하였다. 삽입금속인 Al과 모재인 TiAl과의 반응에 의해 접합계면에서는 반응생성층으로서 경도가 모재보다 높고 취약한 TiAl₃가 형성되었으며, 접합온도가 600℃로 낮았거나 가열속도가 30K/min으로 너무 빠를 경우에는 반응생성층내에 void와 미소균열과 같은 접합결함이 존재하였다. 이와 같은 접합결함들은 700℃보다 높은 온도에서 접합하거나 가열속도를 10K/min보다 낮게 하여 접합한 경우에는 나타나지 않았다. 한편 접합체의 기계적 성질의 향상을 위하여 접합 후 Ar가스 분위기에서 열처리를 행한결과, 1300℃에서 3시간 동안 열처리를 했을 경우 모재와의 조성의 균일화가 완전히 이루어지지 않았으며 또한 반응생성층의 형태도 변화가 없었다. 그러나 1350℃에서 3시간 동안 열처리한 결과 조성의 균일화와 함께 반응생성층은 ??단상으로 변하였으며, 반응생성층의 미소경도는 층상조직인 모재의 미소경도보다 조금 낮게 나타났다. In this study, Joining properties of TiAl intermetallic compound bonded by brazing method using an insert metal of Al foil were investigated. A brittle reaction product layer. TiAl₃was formed at the joining interface and its microhardness was very higher than that of base metal. When the specimen was bonded at low temperature of 600℃ or with high heating rate of 30K/min respectively, joining defects like void and micro-crack were formed in the in the inside of reaction layer. These joining defects were disapeared when the speciment had been bonded at higher temperature than 700℃ or with lower heating rate than 10K/min. For the purpose of improving the mechanical properties of joints, effects of the post-bond heat treatment in Ar gas atmosphere on microstructure and hardness distribution of the bonded speciment were studied. When the joint was geat-treated at 1300℃ for 3 hr, homogenization of the compositions in the joining interface region was not achieved completely and morpholgy of the reaction product layer was still remained without morphological change. However, when the joint was heat-treated at 1350℃ for 3 hr, homogenization of the compositions in the joining interface region was achieved and the reaction product layer changed to γ single phase. And micro-vickers hardness of reaction layer region was slightly lower than that of base metal.

신경회로망 제어기를 이용한 PID 파라미터 추정에 관한 연구

權重東,裵銀敬,金恩基,全基英,李承桓,吳鳳煥,李勳九,金容珠,韓慶熙 明知大學校 産業技術硏究所 2006 産業技術硏究所論文集 Vol.25 No.-

In this paper, supposed to solve these problem to PID parameters controller algorithm using ANN. In the proposed algorithm, the parameters of the controller were adjusted to reduce by on-line system the error of the speed of IM. In this process, EBPA NN was constituted to an output error value of an IM and conspired an input and output. The performance of the self-tuning controller is compared with that of the PH) controller tuned by conventional method (Ziehler-Nichols). The effectiveness of the proposed control method is verified thought the Matlab Simulink and experimental results.

악교정 환자의 악교정 수술전후 발음양상에 대한 비교연구

권경환,김수남,이동근,조용민,이숙향 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.2

The purpose of this study was undertaken to determine the effects of orthognathic surgery on speech. The hyposis stated herein is that functional behaviors of the dentofacial complex, such as speech production, may be adversely affected by deviations of a structural nature(especially, Class III malocclusion) . Twenty adults with Class III malocclusion(13 female and 7 male) were studied preoperative, immediate postoperative and either 6 or 12 months postoperative lateral cephalograms. They had mandibular prognathism and had undergone mandible setback operation. The position of tongue, soft palate(Uvula), hyoid bone, respiratory track width, and pharyngeal depth were assessed on lateral cephalograms with 23 cephalometric variables, ANOVA, Paired t-tests and Pearson's product-moment correlation coefficient tests were used to evalute the operative changes in all cephalometric parameters. A experienced speech and language pathologists performed narrow phonetic transcriptions of tape-recorded words and sentences produced by each of the ninth patients and the recording tapes were analyzed by phonetic computer program(Computerized Speech Lab(CSL) Model 4300BI(U.S.A.)) These judges also recorded their ratings of each patient's overall consonants, hypernasality, hyponasality, and articulation proficiency. The results obtained are as follows ; 1.There were significant changes in distance of posterior pharyngeal wall to tongue (TI-TW2, TS-TW3) after the surgery at 6 months postoperatively(each p<0.01 p<0.05) 2.The posterior tongue point(TI, TS, PPT) moved posteriorly after surgery and remained to its changed position at 6 months postoperatively(p<0.05) . The displacement of tongue was correlated with the movement of mandibular setback amount(p<0.05). The hyoid bone moved posteriorly superiorly after immediate postoperative period. There was significant changes in hyoid bone movement after immediated post-operative period(p<0.05), but returned to its original position during the follow-up period(p>0.05) 3.The soft palate was displaced posteriorly superiorly after immediated operative period and remained to its changed position at 6 months postoperatively(p<0.05) ANS-PNS-SPT angle increasing, PPU-PPPo distance narrowing was showed after surgery, and remained its appearance 6 months postoperactively (p<0.05) 4.There were significant changes in formant value and squre diagram of vowel sound after the orthognathic surgery and the follow-up period. There were significant changes in /ㅅ/sound and posterior tongue sound. 5.The posterior movement of tongue and the posteriosuperior movement of soft palate was correlated with mandibular setback amount after orthognathic surgery. On the vowel squre diagram, the author found that the place of articulation after operation moved downward, backward, upward. 6.In assessing speech abnormalities, dental occlusion should be considered as a contributing factor. The vast majority of subjects with preoperactive misarticulations eliminated or reduced their errors following orthognathic surgery. There was significant difference in speech impovement between pre- and post-operation.

Yield of Rice Affected by Meteorological Elements in Yeosu Area of Korea

Kwon,Byung-Sun,Choi,Seong-Kyu,Shin,Jeong-Sik,Shin,Jong-Sup,Shin,Dong-Young,Hyun,Kyu-Hwan,Kuk,Yong-In,Park,Hee-Jin 한국자원식물학회 2003 Plant Resources Vol.6 No.2

This study was conducted to investigate the relationships between yearly variations of meteorological elements and yearly variations of productivity in rice. In addition, correlation coefficients among yield and yield components were used to find out the relationships between meteorological elements and productivity. Yearly variation of the mean air temperature in May was large with coefficients of variation(C.V.) of 25.0%, but the variation of the duration of sunshine in May were relative small. No. of panicles per hill and 1,000 grains wt. of brown rice were great with C.V. of 21.1, 19.7%, respectively, brown rice yield show more or less C.V. of 5.5% and milled rice show still less variation. Correlation coefficients between temperatures in period of cultivation from May and yield were positive correlations. Correlation Coefficients between precipitation in period of cultivation from Sep. to Oct. and yield are positive correlations. Correlation coefficients amount the panicle length, no. of panicles, no. of spikelets, ratio of ripened grains, 1,000 grains wt. of brown rice, milled rice yield, brown rice yield and milled rice yield were positively significant at the level of 1 %, respectively.

수직하향핀이 부착된 수평 평판에서의 자연대류 열전달에 관한 해석적 연구

권순석,권용일,양성환 동아대학교 공과대학 부설 한국자원개발연구소 1989 硏究報告 Vol.13 No.2

This study has been carried out to investigate into the natural convection heat transfer from the isothermal horizontal plate with downward projecting fins numerically. The governing equations for the system are solved by the finite difference method and sucessive under relaxation method at Ra=10^(5), Pr=0.71, C_(F)=7.75. Mean Nusselt numbers, velocities, temperatures and stream functions are obtained for various dimensionless fin lengths. The results are as follows ; 1. The dimensionless temperature distributions decrease rapidly in fins and linearly in fluid as x/s increase 2. The mean plate, fin and total Nusselt number are decreased by increasing the dimensionless fin lengths 3. The mean late Nusselt number is less than the mean fin Nusselt number at l/s>8.0 4. The local fin Nusselt number is increased rapidly near the fin tip and that of the fin tip is decreased rapidly by increasing the dimensionless fin lengths.

흰쥐에서의 카르복시메칠셀룰로오스나트륨과 겔란검 혼합겔의 유착방지 효과

권윤환,이시범,이정권,박용덕,박정숙,황성주 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.6

The aim of the present study was to investigate the efficacy of a mixed gel formulation composed of sodium carboxymethyl cellulose and gellan gum (Na-CMC gel) for the prevention of adhesions after laminectomv. The anti-adhesive effect of the Na-CMC gel was tested in a controlled randomized study using an animal model of lumbar laminectomv. The animals (60 female Sprague-Dawlev rats) were randomly allocated into two treatment groups to receive the Na-CMC gel on the injured area or no gel (control). The incidence of adhesions and their grade were blindly evaluated at 4. 8 and 12 weeks after surgery. The amount of scar tissue and tenacity were grossly reduced by the Na-CMC gel at postoperative 4. 8. and 12 weeks. The mean adhesion scores were 0.75. 125. and 1.38 at 4. 8. and 12 weeks in the gel-treated group. respectively. No significant inflammatory reaction was observed and the healing of wound was not affected by the Na-CMC gel. The Na-CMC gel reduced the amount of scar formation and tenacity in rat laminectomv model without affecting the healing of operation wound and other complications. Therefore. the Na-CMC gel may be the potential to prevent postsurgical adhesions in clinical state.