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( X. M. He ),( L. J. Rong ) 대한금속재료학회 ( 구 대한금속학회 ) 2006 METALS AND MATERIALS International Vol.12 No.4
Martensite in TiNi-based alloys is reported to be thermally stabilized after a moderate deformation. Hence, this paper investigates the effect of deformation via stress-induced martensitic transformation on the reverse transformation behavior of (Ni(47)Ti(44))(100-x)Nbx(x=3, 9, 15, 20, 30 at.%) alloys. The stress-induced martensite appears to be stabilized in relation to the thermal-induced martensite that forms on cooling. This observation is confirmed by an increase in the reverse transformation start temperature, during which time the transformation temperature hysteresis reaches about 200℃. Moreover, the Nb content in Ni-Ti-Nb alloy has a great influence on the transformation temperature hysteresis of stress-induced martensite as well as on the process of stress-induced martensitic transformation. The mechanism of wide transformation temperature hysteresis is explained in terms of the microscopic structure of (Ni(47)Ti(44))(100-x)Nbx alloys. Furthermore, the temperature interval of the reverse transformation of stress-induced martensite was found to increase slightly as the strain of the high Nb-content alloy increased, though the value was much smaller than that of the thermally induced martensite. Finally, the paper explains the relation between this unique phenomenon and the elastic strain energy.
Whale, Alexandra S.,Jones, Gerwyn M.,Pavx161,ix10d,, Jernej,Dreo, Tanja,Redshaw, Nicholas,Akyü,rek, Sema,Akgö,z, Mü,slü,m,Divieto, Carla,Sassi, Maria Paola,He, Hua-Jun,Cole, Kennet American Association for Clinical Chemistry, Inc. 2018 Clinical chemistry Vol.64 No.9
<P><B>BACKGROUND:</B></P><P>Genetic testing of tumor tissue and circulating cell-free DNA for somatic variants guides patient treatment of many cancers. Such measurements will be fundamental in the future support of precision medicine. However, there are currently no primary reference measurement procedures available for nucleic acid quantification that would support translation of tests for circulating tumor DNA into routine use.</P><P><B>METHODS:</B></P><P>We assessed the accuracy of digital PCR (dPCR) for copy number quantification of a frequently occurring single-nucleotide variant in colorectal cancer (<I>KRAS</I> c.35G>A, p.Gly12Asp, from hereon termed G12D) by evaluating potential sources of uncertainty that influence dPCR measurement.</P><P><B>RESULTS:</B></P><P>Concentration values for samples of <I>KRAS</I> G12D and wild-type plasmid templates varied by <1.2-fold when measured using 5 different assays with varying detection chemistry (hydrolysis, scorpion probes, and intercalating dyes) and <1.3-fold with 4 commercial dPCR platforms. Measurement trueness of a selected dPCR assay and platform was validated by comparison with an orthogonal method (inductively coupled plasma mass spectrometry). The candidate dPCR reference measurement procedure showed linear quantification over a wide range of copies per reaction and high repeatability and interlaboratory reproducibility (CV, 2%–8% and 5%–10%, respectively).</P><P><B>CONCLUSIONS:</B></P><P>This work validates dPCR as an SI-traceable reference measurement procedure based on enumeration and demonstrates how it can be applied for assignment of copy number concentration and fractional abundance values to DNA reference materials in an aqueous solution. High-accuracy measurements using dPCR will support the implementation and traceable standardization of molecular diagnostic procedures needed for advancements in precision medicine.</P>
Wang J.J.,Deng Q.J.,He Y.Y.,Feng Y.N.,Kang M.P.,Duan X.L.,Yang Y.L. 한국물리학회 2022 Current Applied Physics Vol.39 No.-
CCTO (Calcium copper titanate) powder as inorganic filler was synthesized by the Sol-gel method firstly. CCTO/ PVDF (Polyvinylidene fluoride) composite was fabricated by solution mixing based on high temperature resistance of PVDF and insulated property of CCTO. The composite of CCTO/PVDF were characterized by X-ray diffraction, Fourier Transform infrared spectroscopy, Scanning Electron Microscope and impedance analysis. The results showed that the addition of CCTO and increasing in its content did not affect the phase- and microstructure of the composites,but the increase of CCTO content can induce the generation of C–F new bonds. PVDF/CCTO composites were enhanced in performance of thermal and frequency-depended stability with increasing in the fraction of CCTO. The dielectric constant of CCTO/PVDF composite materials with 50% CCTO achieved to a maximum value of 50 almost, which is 5 times higher the pure PVDF. The conductivity felled into 10-8 to 10-1 S m-1 during the frequency of 102–108 Hz. The composite material would be expected to be applied in the field of integrated circuit.
R&D Status of High-current Accelerators at IFP
J. J. Deng,J. S. Shi,W. P. Xie,L. W. Zhang,K. Z. Zhang,S. P. Feng,J. Li,M. Wang,Y. He,L. S. Xia,Z. Y. Dai,H. T. Li,L. Wen,S. F. Chen,X. Li,Q. G. Lai,M. H. Xia,Y. C. Guan,S. Y. Song,L. Chen 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.61
High-current accelerators have many important applications in Z-pinches, high-power microwaves, and free electron lasers, imploding liners and radiography and so on. Research activities on Zpinches, imploding liners, radiography at the Institute of Fluid Physics (IFP) are introduced. Several main high-current accelerators developed and being developed at IFP are described, such as the Linear Induction Accelerator X-Ray Facility Upgrade (LIAXFU, 12 MeV, 2.5 kA, 90 ns), the Dragon-I linear induction accelerator (20 MeV, 2.5 kA, 60 ns), and the Primary Test Stand for Z-pinch (PTS, 10 MA, 120 ns). The design of Dragon-II linear induction accelerator (20 MeV, 2.5 kA, 3 × 60 ns) to be built will be presented briefly.
Nano-Layer Structure of Silicon-on-Insulator Materials
X Wang,x Wang,J Chen,L. L. Tian,M Chen,P He,X. H. Liu,Y. M. Dong,Z. L. Liu 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.42 No.III
Silicon-on-insulator (SOI) has been recognized as a promising semiconductor starting material for ICs where high speed and low power consumption are desirable, in addition to its unique applications in radiation-hardened circuits. In the present paper, three novel SOI nano-layer structures have been demonstrated. ULTRA-THIN SOI has been fabricated by separation by implantation of oxygen (SIMOX) technique at low oxygen ion energy of 45 keV and implantation dosage of 1.8´1017/cm2. The formed SOI layer is uniform with thickness of only 60 nm. This layer is of crystalline quality, and the interface between this layer and the buried oxide layer is very sharp. PATTERNED SOI nano-structure is illustrated by source and drain on insulator (DSOI) MOSFETs. The DSOI structure has been formed by selective oxygen ion implantation in SIMOX process. With the patterned SOI technology, the floating-body effect and self-heating effect, which occur in the conventional SOI devices, are significantly suppressed. In order to improve the total-dose irradiation hardness of SOI devices, SILICON ON INSULATING MULTILAYERS (SOIM) nano-structure is proposed. The buried insulating multilayers, which are composed of SiO$_x$ and SiN$_y$ layers, have been realized by implantation of nitride and oxygen ions into silicon in turn at different ion energies, followed by two steps of high temperature annealing process, respectively. Electric property investigation shows that the hardness to the total-dose irradiation of SOIM is remarkably superior to those of the conventional SIMOX SOI and the Bond-and-Etch-Back SOI.
Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis
Park, M. C.,Kang, T.,Jin, D.,Han, J. M.,Kim, S. B.,Park, Y. J.,Cho, K.,Park, Y. W.,Guo, M.,He, W.,Yang, X.-L.,Schimmel, P.,Kim, S. Proceedings of the National Academy of Sciences 2012 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.109 No.11
Park, M.J.,Phuntsho, S.,He, T.,Nisola, G.M.,Tijing, L.D.,Li, X.M.,Chen, G.,Chung, W.J.,Shon, H.K. Elsevier Scientific Pub. Co 2015 Journal of membrane science Vol.493 No.-
The preparation and performances of the newly synthesized thin film composite (TFC) forward osmosis (FO) membranes with graphene oxide (GO)-modified support layer are presented in this study. GO nanosheets were incorporated in the polysulfone (PSf) to obtain PSf/GO composite membrane support layer. Polyamide (PA) active layer was subsequently formed on the PSf/GO by interfacial polymerization to obtain the TFC-FO membranes. Results reveal that at an optimal amount of GO addition (0.25wt%), a PSf/GO composite support layer with favorable structural property measured in terms of thickness, porosity and pore size can be achieved. The optimum incorporation of GO in the PSF support layer not only significantly improved water permeability but also allowed effective PA layer formation, in comparison to that of pure PSf support layer which had much lower water permeability. Thus, a TFC-FO membrane with high water flux (19.77Lm<SUP>-2</SUP>h<SUP>-1</SUP> against 6.08Lm<SUP>-2</SUP>h<SUP>-1</SUP> for pure PSf) and reverse flux selectivity (5.75Lg<SUP>-1</SUP> against 3.36Lg<SUP>-1</SUP> for pure PSf) was obtained under the active layer facing the feed solution or AL-FS membrane orientation. Besides the improved structural properties (reduced structural parameter, S) of the support layer, enhanced support hydrophilicity also contributed to the improved water permeability of the membrane. Beyond a certain point of GO addition (≥0.5wt%), the poor dispersion of GO in dope solution and significant structure change resulted in lower water permeation and weaker mechanical properties in support as well as FO flux/selectivity of consequent TFC membrane. Overall, this study suggests that GO modification of membrane supports could be a promising technique to improve the performances of TFC-FO membranes.
Hu, X -T,Zhang, F -B,Fan, Y -C,Shu, X -S,Wong, A H Y,Zhou, W,Shi, Q -L,Tang, H -M,Fu, L,Guan, X -Y,Rha, S Y,Tao, Q,He, C Macmillan Publishers Limited 2009 Oncogene Vol.28 No.26
Located at the important tumor suppressor locus, 3p22, PLCD1 encodes an enzyme that mediates regulatory signaling of energy metabolism, calcium homeostasis and intracellular movements. We identified PLCD1 as a downregulated gene in aerodigestive carcinomas through expression profiling and epigenetic characterization. We found that PLCD1 was expressed in all normal adult tissues but low or silenced in 84% (16/19) gastric cancer cell lines, well correlated with its CpG island (CGI) methylation status. Methylation was further detected in 62% (61/98) gastric primary tumors, but none of normal gastric mucosa tissues. PLCD1 methylation was significantly correlated with tumor high stage. Detailed methylation analysis of 37 CpG sites at the PLCD1 CGI by bisulfite genomic sequencing confirmed its methylation. PLCD1 silencing could be reversed by pharmacological demethylation with 5-aza-2′-deoxycytidine, indicating a direct epigenetic silencing. Ectopic expression of PLCD1 in silenced gastric tumor cells dramatically inhibited their clonogenicity and migration, possibly through downregulating MMP7 expression and hampering the reorganization of cytoskeleton through cofilin inactivation by phosphorylation. Thus, epigenetic inactivation of PLCD1 is common and tumor-specific in gastric cancer, and PLCD1 acts as a functional tumor suppressor involved in gastric carcinogenesis.Oncogene (2009) 28, 2466–2475; doi:10.1038/onc.2009.92; published online 18 May 2009
He, X.,Bonaparte, N.,Kim, S.,Acharya, B.,Lee, J.Y.,Chi, L.,Lee, H.J.,Paik, Y.K.,Moon, P.G.,Baek, M.C.,Lee, E.K.,Kim, J.H.,Kim, I.S.,Lee, B.H. Elsevier Science Publishers 2012 Journal of controlled release Vol.162 No.3
Chemotherapy-induced apoptosis of tumor cells enhances the antigen presentation and sensitizes tumor cells to T cell-mediated cytotoxicity. Here we harnessed the apoptosis of tumor cells as a homing signal for the delivery of T cells to tumor. Jurkat T cells were anchored with ApoPep-1, an apoptosis-targeted peptide ligand, using the biocompatible anchor for membrane (BAM), an oleyl acid derivative. The ApoPep-1-BAM conjugate was efficiently anchored to cell membrane, while little anchoring was obtained with ApoPep-1 alone. The retention period of the ApoPep-1-BAM conjugate on cell membrane was approximately 80 and 40min in the absence and presence of serum, respectively. ApoPep-1 was resistant to degradation in serum until 2h. The apoptosis-targeted T cells that were anchored with the ApoPep-1-BAM preferentially bound to apoptotic tumor cells over living cells. When intravenously injected into tumor-bearing mice, the number of apoptosis-targeted T cells and in vivo fluorescence signals by the homing of the cells to doxorubicin-treated tumor were higher than those of untargeted T cells. Accumulation of apoptosis-targeted T cells at other organs such as liver was not detected. These results suggest that the chemotherapy-induced apoptosis and subsequent enhancement of T cell delivery to tumor by the membrane anchoring of the apoptosis-targeted peptide could be a novel strategy for cancer immunotherapy.