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The pivotal role of PDGF and its receptor isoforms in adipose-derived stem cells.
Kim, Won-Serk,Park, Hyung-Sook,Sung, Jong-Hyuk Gutenberg 2015 Histology and histopathology Vol.30 No.7
<P>Platelet-derived growth factor (PDGF) is one of the growth factors that reportedly regulates cell growth and division of mesenchymal cells. Although PDGF isoforms and their receptors reportedly play a pivotal role in mesenchymal stem cell regulation, there is a paucity of literature reviewing the role of PDGF in adipose-derived stem cells (ASCs). Therefore, we summarized previous reports on the expression and functional roles of PDGF and its receptor isoforms in this review. In addition, we examined findings pertaining to underlying molecular mechanisms and signaling pathways with special focus on PDGF-D/PDGFRβ. ASCs only express PDGF-A, -C, -D, PDGFRα, and PDGFRβ. PDGFRα expression decreases with adipocyte lineage, while PDGFRβ inhibits white adipocyte differentiation. In addition, PDGFRβ induces proliferation, migration, and angiogenesis and up-regulates the expression of paracrine factors in ASCs. Although PDGF-B and -D mediate their functions mainly by PDGFRβ and ROS generation, there are many differences between them in terms of regulating ASCs. PDGF-D is endogenous, generates ROS via the mitochondrial electron transport system, and regulates the autocrine loop of ASCs in vivo. Furthermore, PDGF-D has stronger mitogenic effects than PDGF-B.</P>
Kim, Jin-Hyung,Kim, Dae-Won,Cheong, Min-Serk,Kim, Hoon-Sik,Mukherjee, Deb Kumar Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.6
The investigation of the catalytic activity of supported rhodium(I) complex [Rh(P-S)$(CO)_2$] (P-S; polymer anchored salicylic acid) toward the reductive carbonylation of nitrobenzene in DMF medium has been reported. Use of basic cocatalysts in the reaction medium enhanced the percentage of more useful phenyl carbamates. Spectroscopic studies indicate that the reaction proceeds through a dimer species [Rh(HS)(CO)(C(O)$OCH_3$)(${\mu}-OCH_3)]_2$ and phenyl isocyanate is formed as an intermediate. A plausible reaction mechanism based on the identification of reactive intermediates from the soluble rhodium variety has been proposed for the carbonylation process.
Ultrasonographic Evaluation of the Lymphedema
Kim, Dong Ik,Lee, Byung Boong,Yeo, Un Cheol,Lee, Eil Soo,Kim, Won Serk,Chun, Ho Soo,Hwang, Ji Hye 대한피부과학회 1997 Annals of Dermatology Vol.9 No.2
Background : Lymphedma occurs when tissue swelling develops through a failure of lymph drainage in the face of a normal capillary filtration. Little is known about water behavior in lymphedma. Objective : Our purpose was to investigate, by means of ultrasound, the distribution of intradermalfluid in patients with lymphedema in response to 2 weeks' physical therapy. Method : Ten patients with lymphedema were treated by 2 weeks' physical therapy. Before and after 2 weeks' treatment, circumference and ultrasonographic evaluation was done. Ultrasound images were obtained with a 20 ㎒ scanner. The echogenicity of the dermis and the skin thickness were quantified by in-built image analyzer. Results : Low echogenic pixels showed the most noticeable and consistent change after 2 weeks' physical therapy. Conclusion : Ultrasonographic evaluation could be a useful tool in evaluating lymphedema.
Effect of Enhancers on in vitro and in vivo Skin Permeation and Deposition of S-Methyl-ʟ-Methionine
Kim, Ki Taek,Kim, Ji Su,Kim, Min-Hwan,Park, Ju-Hwan,Lee, Jae-Young,Lee, WooIn,Min, Kyung Kuk,Song, Min Gyu,Choi, Choon-Young,Kim, Won-Serk,Oh, Hee Kyung,Kim, Dae-Duk The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.4
S-methyl-$\small{L}$-methionine (SMM), also known as vitamin U, is commercially available as skin care cosmetic products for its wound healing and photoprotective effects. However, the low skin permeation expected of SMM due to its hydrophilic nature with a log P value of -3.3, has not been thoroughly addressed. The purpose of this study thus was to evaluate the effect of skin permeation enhancers on the skin permeation/deposition of SMM. Among the enhancers tested for the in vitro skin permeation and deposition of SMM, oleic acid showed the most significant enhancing effect. Moreover, the combination of oleic acid and ethanol further enhanced in vitro permeation and deposition of SMM through hairless mouse skin. Furthermore, the combination of oleic acid and ethanol significantly increased the in vivo deposition of SMM in the epidermis/dermis for 12 hr, which was high enough to exert a therapeutic effect. Therefore, based on the in vitro and in vivo studies, the combination of oleic acid and ethanol was shown to be effective in improving the topical skin delivery of SMM, which may be applied in the cosmetic production process for SMM.