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Superconducting MgB2 Wire Drawing Considering Anisotropic Hardening Behavior and Hydrostatic Effect
Young‑Seok Oh,Ho Won Lee,Kook‑Chae Chung,Duck‑Young Hwang,Seong‑Hoon Kang,Jeong Whan Yoon 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.7
Numerical modeling was conducted to investigate the deformation behavior of powder mixture during multi-pass drawingprocesses for multi-filamentary MgB2wire. A modified Drucker-Prager Cap (DPC) model with an elliptical cap surface usingthe new material characterization method was developed to capture the anisotropic hardening behavior and hydrostatic effectof the powder mixture. A number of uniaxial die compaction, cold isostatic pressing, diametrical compression, and uniaxialcompression tests were conducted using different powder densities to characterize the modified DPC model. A commercialfinite element software ABAQUS with a user subroutine was used to simulate the drawing of the MgB2wire. The densityand area fraction of the powder mixture during the wire-drawing process were verified with experimental results. The differencein packing density at the inner and outer filaments of the MgB2wire was successfully captured by simulation. Inaddition, the effect of the initial packing density on the superconducting properties of MgB2wire was numerically studied. It is shown that the increase in the superconducting area, which results from a high initial packing density, should be moreeffective compared to the increase in the grain connectivity in enhancing the critical current properties for the MgB2wirewhen the final packing density is saturated after a number of drawing processes.
Won Seok Chae,Chun Nam Cha,Chang Yeul Yoo,Suk Kim,Hu Jang Lee 한국예방수의학회 2017 예방수의학회지 Vol.41 No.4
This study examined the acute toxicity of Super-Neophensan containing florfenicol and acetaminophen in male and female Sprague-Dawley rats. Rats were orally administered the drug at dose levels of 0, 250, 500, 1,000 and 2,000 mg/kg body weight (BW) for the single-dose toxicity test. BW changes in all treated groups were not significantly different to those in the control treated with saline. In hematological and blood biochemical analyses, all parameters were unaffected by the drug. In the same way, there were no significant differences between all treated groups and the control group in terms of markers for liver and kidney functions. As no adverse effects were observed with the drug in the single-dose oral toxicity test, even at the highest concentration of the drug, the lethal dose 50 (LD50) of Super-Neophensan is estimated to be greater than 2,000 mg/kg BW.
Chae, Won-Seok,Moon, Jung-Nim,Kim, Kang-Jin 한국분석과학회 1995 분석과학 Vol.8 No.4
The charge transfer rate in polypyrrole(PPy) electropolymerized within poly(acrylonitrile-co-butadiene)(PAB) was compared with that in PPy deposited Pt electrodes by using cyclic voltammetry, chronoamperometry, and chronopotentiometry in acetonitrile. For both electrodes anodic and cathodic peak currents were proportional to scan rates below 100 mV/sec, but to square root of scan rates beyond 200 mV/sec. The apparent diffusion coefficient of $ClO{_4}^-$ in the PPy/PAB composite is estimated to be 1.6 times larger than that in PPy. The PPy films composited within PAB layer showed higher anodic and cathodic currents and possessed faster charging-discharging process and larger capacity.
Chae, Sun Young,Ahn, Sei Hyun,Kim, Sung-Bae,Han, Sangwon,Lee, Suk Hyun,Oh, Seung Jun,Lee, Sang Ju,Kim, Hee Jeong,Ko, Beom Seok,Lee, Jong Won,Son, Byung Ho,Kim, Jisun,Ahn, Jin-Hee,Jung, Kyung Hae,Kim, Elsevier 2019 LANCET ONCOLOGY Vol.20 No.4
<P><B>Summary</B></P> <P><B>Background</B></P> <P>A biopsy of first recurrence or metastatic disease is recommended to re-evaluate oestrogen receptor status in patients with breast cancer and to select appropriate treatment. However, retesting for oestrogen receptor status with rebiopsy is not always feasible, depending on lesion location and the risk associated with biopsy, and in these cases clinicians continue to treat patients according to the oestrogen receptor status of the primary tumour. Consequently suboptimal therapy might be offered to these patients. We assessed the diagnostic accuracy and safety of 16α-[<SUP>18</SUP>F]fluoro-17β-oestradiol (<SUP>18</SUP>F-FES) PET-CT to assess oestrogen receptor status in patients with recurrent or metastatic breast cancer.</P> <P><B>Methods</B></P> <P>We did a prospective cohort study at the Asan Medical Center, Seoul, South Korea. Eligible patients had breast cancer, with first recurrence or metastatic disease at presentation, were 19 years or older, and had an Eastern Cooperative Oncology Group performance status of 0–2. The primary objective was to show the agreement between qualitative <SUP>18</SUP>F-FES PET-CT interpretation and the results of oestrogen receptor expression by immunohistochemical assay, a non-reference standard test. Whole-body <SUP>18</SUP>F-FES PET-CT imaging was done after intravenous injection of 111–222 MBq of <SUP>18</SUP>F-FES, with dosing primarily determined by radiation dosimetry analysis. <SUP>18</SUP>F-FES uptake above background intensity was interpreted as positive. Efficacy was assessed in all patients with histologically confirmed recurrent or metastatic breast cancer who received <SUP>18</SUP>F-FES and had PET-CT images available (intention-to-diagnose analysis), and safety was assessed in all patients who received <SUP>18</SUP>F-FES. This study is registered with ClinicalTrials.gov, number NCT01986569.</P> <P><B>Findings</B></P> <P>Between Nov 27, 2013, and Nov 10, 2016, 93 patients were enrolled. Of the 85 patients included in the efficacy analysis, 47 (55%) were oestrogen receptor-positive and 38 (45%) were oestrogen receptor-negative. Positive status percent agreement between the <SUP>18</SUP>F-FES PET-CT results and oestrogen receptor status by immunohistochemical assay was 76·6% (95% CI 62·0–87·7) and the negative status percent agreement was 100·0% (90·8–100·0). Patients who were oestrogen receptor-positive and had a positive <SUP>18</SUP>F-FES PET-CT result had a significantly higher progesterone receptor expression than those who were oestrogen receptor-positive and had a negative <SUP>18</SUP>F-FES PET-CT result (23 [68%] of 34 patients <I>vs</I> 0 of 11 patients; p<0·0001). The most common adverse event was procedural pain in nine (10%) of 90 patients injected with <SUP>18</SUP>F-FES. No adverse events were related to the study drug except injection site pain in one (1%) patient. No serious adverse events were recorded.</P> <P><B>Interpretation</B></P> <P>The high negative percent agreement between <SUP>18</SUP>F-FES PET-CT and oestrogen receptor status by immunohistochemical assay in this cohort suggests that positive <SUP>18</SUP>F-FES uptake by recurrent or metastatic oestrogen receptor-positive breast cancer lesions could be an alternative to oestrogen receptor assays in this setting. Staging assessment should include <SUP>18</SUP>F-FES PET-CT when retesting oestrogen receptor status is not feasible.</P> <P><B>Funding</B></P> <P>Asan Institute for Life Sciences, Ministry of Health and Welfare, South Korea.</P>
Functional polymorphism in the MicroRNA-367 binding site as a prognostic factor for colonic cancer.
Chae, Yee Soo,Kim, Jong Gwang,Kang, Byung Woog,Lee, Soo Jung,Lee, Yoo Jin,Park, Jun Seok,Choi, Gyu Seog,Lee, Won Kee,Jeon, Hyo-Sung Potamitis Press 2013 Anticancer research Vol.33 No.2
<P>As microRNAs play important roles in cancer development and progression by regulating the expressions of oncogenes and tumor suppressor genes though interacting with the 3' untranslated region (UTR) of target genes, we aimed to evaluate the association between genetic variants of miRNAs and their binding sites and prognosis in patients with colorectal cancer (CRC).</P>