Elderly kidney transplant recipients have favorable outcomes but increased infection-related mortality

임정훈,Lee Ga Young,Jeon Yena,Jung Hee-Yeon,Choi Ji Young,CHO, JANG-HEE,Park Sun Hee,김용림,Kim Hyung-Kee,Huh Seung,유은상,Won Dong Il,Kim Chan-Duck 대한신장학회 2022 Kidney Research and Clinical Practice Vol.41 No.3

Background: The number of elderly patients with end-stage kidney disease has been increasing, but the outcomes of kidney transplants (KT) remain poorly understood in elderly patients. Therefore, we evaluated the clinical outcomes of elderly KT recipients and analyzed the impact of elderly donors. Methods: This retrospective cohort study included patients who underwent KT between 2000 and 2019. KT recipients were divided into four groups according to a combination of recipient and donor age (≥60 or <60 years); elderly recipients: old-to-old (n = 46) and young-to-old (n = 83); young recipients: old-to-young (n = 98) and young-to-young (n = 796). We compared the risks of mortality, graft failure, and acute rejection between groups using Cox regression analysis. Results: The incidence of delayed graft function, graft failure, and acute rejection was not different among groups. Annual mean tacrolimus trough level was not lower in elderly recipients than young recipients during 10-year follow-up. Mortality was significantly higher in elderly recipients (p = 0.001), particularly infection-related mortality (p < 0.001). In multivariable Cox regression analysis, old-toold and young-to-old groups had increased risk of mortality (adjusted hazard ratio [aHR], 2.89; 95% confidence interval [CI], 1.14– 7.32; p = 0.03; aHR, 3.06; 95% CI, 1.51–6.20; p = 0.002). However, graft failure and acute rejection risks were not increased in elderly recipients. Conclusion: In elderly recipients, graft survival and acute rejection-free survival were not inferior to those of young recipients. However, mortality, especially risk of infection-related death, was increased in elderly recipients. Thus, low immunosuppression intensity might help decrease mortality in elderly recipients.

성인병에 대한 한방치료법(증치의학과 사상의학)에 관한 연구 : 고혈압에 대한 한방치료법(중치의학과 사상의학)에 관한 연구

박동일,김영균,안창범,이인선,김종원,권정남,장경전,이인선,이성근,장용우,신영민 동의대학교 한의학연구소 1999 동의한의연구 Vol.3 No.-

We had a result of the treatment as below when is devided Korean medicine Tx.. Western medical Tx., Cooperative Tx.. 1) At the improvement of BP control, an average in Korean medicine Tx. (from 170㎜Hg/100㎜Hg to 150㎜Hg/90㎜Hg), an average in Western medical Tr. (from 170㎜Hg/100㎜Hg to 130㎜Hg/80㎜Hg), an average in Cooperative Tx.(from 180㎜Hg/110㎜Hg to 130㎜Hg/90㎜Hg), generally all pars had improvements of BP control. But it is not significant of each case. 2) At the improvement of symptoms by the apologetics, Cooperative Tx. is profitable in cases of 'GanHwa',' DamEum', 'EumYangYangHer', 'EumHer'. Korean medicine Tx. is superior in case of 'GiChe'. 3) At the improvement of symptoms by a questionnaire, Korean medical Tx., Western medical Tx., Cooperative Tx. groups had improvements, but each practice group didn't have specific significance. Only it was somewhat profitable to Korean medical Tx. in the 210㎜Hg/110㎜Hg, Western medical Tx. in the 180㎜Hg/110㎜Hg, Cooperative Tx, in the 170㎜Hg/90㎜ Hg. 4) There are the apparent improvements in patients whose BP are over 200㎜Hg of Korean medical Tx. group, whose BP are over 190㎜Hg of Western medical Tx. group and whose BP are over 170㎜Mg of Cooperative Tx. group. There are the improvement of diastolic BP in 110㎜Mg(Korean medical Tx., Western medical Tx.) and 90㎜Hg(Cooperative Tx.). 5) At the improvement of Pulse pressure, generally Pulse pressure are decreased. There are similar improvements in all of Korean medical Tx., Western medical Tx., and Cooperative Tx.. 6) At the Symptomatic approvement according to ages, Korean medical Tx., Cooperative Tx. are somewhat good for his twentieth, and Western medical Tx. is somewhat good for his forties. 7) the correlation of Obesity-grade and BP, as Obesity-grade is higher as BP is higher, but there are no similarity in the improvement. 8) At the EAV improvements, as examination into correlation with the point of 1~3th, we could get results as below. There are high improvements of DRHTM, DRALM, DLLYM, DLLIM in Cooperative Tx. There are high improvements of DRPASI, DLLARI in the Korean medical Tx. group. There are high improvements of DRFADM in Western medical Tx. group.

산업자재용 폴리에스터 섬유의 강도 향상에 관한 연구

박영신,남영식,정상영,최재호,장기혁,박원호,Park, Young-Shin,Nam, Young-Sik,Jung, Sang-Young,Choi, Jae-Ho,Jang, Ki-Hyuk,Park, Won-Ho 한국섬유공학회 2012 한국섬유공학회지 Vol.49 No.1

In this work, effects of total draw ratio change on the mechanical properties of polyester fibers were studied. The process parameter was a total draw ratio and the draw ratios that were used ranged from 6.6 to 7.0. Tensile properties are determined from the tensile tester, and crystallite parameters from the density measurement and X-ray diffraction were discussed with the different total draw ratios. The tenacity, young's modulus and crystallinity were increased to 10.6 g/d, 123.2 g/d and 42.1%, respectively, with increase in the total draw ratio. The relations between total draw ratio and mechanical properties of high tenacity polyester fiber were discussed.

우리나라 노인여성의 골다공증성 척추골절로 인한 경제적 부담 추계

강혜영,강대룡,장영화,박성은,최원정,문성환,양규현,Kang, Hye-Young,Kang, Dae-Ryong,Jang, Young-Hwa,Park, Sung-Eun,Choi, Won-Jung,Moon, Seong-Hwan,Yang, Kyu-Hyun 대한예방의학회 2008 예방의학회지 Vol.41 No.5

Objectives : To estimate the economic burden of osteoporotic vertebral fracture (VF) from a societal perspective. Methods : From 2002 to 2004, we identified all National Health Insurance claims records for women ${\geq}50$ years old with a diagnosis of VF. The first 6-months was defined as a "clearance period," such that patients were considered as incident cases if their first claim of fracture was recorded after June 30, 2002. We only included patients with ${\geq}$ one claim of a diagnosis of, or prescription for, osteoporosis over 3 years. For each patient, we cumulated the claims amount for the first visit and for the follow-up treatments for 1 year. The hospital charge data from 4 hospitals were investigated to measure the proportion of the non-covered services. Face-to-face interviews were conducted with 106 patients from the 4 study sites to measure the out-of-pocket spending outside of hospitals. Results : During 2.5 years, 131,453 VF patients were identified. The patients had an average of 3.38 visits, 0.40 admissions and 6.36 inpatient days. The per capita cost was 1,909,690 Won: 71.5% for direct medical costs, 20.6% for direct non-medical costs and 7.9% for indirect costs. The per capita cost increased with increasing age: 1,848,078 Won for those aged 50-64, 2,084,846 Won for 65-74, 2,129,530 Won for 75-84and 2,121,492 Won for those above 84. Conclusions : Exploring the economic burden of osteoporotic VF is expected to motivate to adopt effective treatment options for osteoporosis in order to prevent the incidence of fracture and the consequent costs.

ECG 압축 알고리즘에 관한 연구

장원석,윤영로 연세대학교 보건과학연구소 1997 보건과학논집 Vol.7 No.-

Niacin이 조골세포 분화에 미치는 영향

민현영 ․ 장원구 대구대학교 산업기술연구소 2018 産業技術硏究 Vol.29 No.2

Niacin (Vitamin B3) is a necessary nutrient for humans and animals. This study was conducted to examine the effect of niacin on osteoblast differentiation. Previous study shows that precursor of niacin suppress osteoclast formation. However, the mechanism of niacin in osteoblast differentiation is not well known. In this study we investigated the effect of niacin in osteoblasts. Niacin induced osteogenic differentiation marker genes including distal-less homeobox 5(Dlx5), runt-related transcription factor 2(Runx2), alkaline phosphatase(ALP), and osteocalcin(OC). These results suggest that niacin contributes to osteoblast differentiation by inducing the osteogenic genes.

디지털 설계를 위한 수정된 감마(ϒ)곡선의 알고리즘

장원우,김주현,하주영,강봉순 東亞大學校附設 情報技術硏究所 2005 情報技術硏究所論文誌 Vol.13 No.1

This paper proposes the algorithm of improved gamma(γ) line by using the of least squares method. Because it is difficult that gamma correction of exponential form is implemented into the method of hardware, exponential form have to be replaced by polynomial form to use least squares polynomial. Exponential form is not tremendously equal to proposed polynomial function, thus errors is generated. To solve this problem, we propose that the whole range of input points is divided into a few sections and find that approximating functions that passes through every point to use least squares polynomial.

보의 전단 내력에 관한 실험적 연구

장원영,고봉수,은희창,서일교 제주대학교 공과대학 첨단기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.2

The objective of this study is to describe the shear behavior of reinforced concrete beams. Twenty-four specimens were tested with the variables of concrete strength, the strength and spacing of shear bars, and support conditions. The specimens without the shear reinforcement bars showed the shear failure with the abrupt deterioration of shear capacity. The ones with the shear bars exhibited the enhanced capacity with the yielding of longitudinal bars or crushing of compressive concrete. It was observed that the specimens had an flexural effect. Also, the specimens with the continued support condition showed more flexural and shear capacity than the ones with the simple supports, and it was shown that the results satisfied the ACI code.

소각재 용융슬래그를 이용한 제올라이트 Na-A의 합성

장영남,채수천,배인국,류경원 한국광물학회 2005 광물과 암석 (J.Miner.Soc.Korea) Vol.18 No.1

소각재 용융슬래그를 출발물질로 하여 알카리 조건하에서 활성화시킴으로써 Na-A형 제올라이트를 합성하였다. 합성실험은 스텐레스 철재로 제작된 반응용기를 사용하였다. 출발물질은 슬래그 외에 수정인공합성 공장에서 배출되는 '규산질 수용액'과 NaA1O₂수용액을 사용하였는데, 전자의 화학조성은 SiO₂5.7 wt% Na₂O 3.2 wt%이고, 후자는 몰비가 Na₂O/A1₂O₃= 1.2와 H₂O/Na₂O=9의 조건으로 알루미늄 드로스와 NaOH 수용액을 반응시켜 제조하였다. 위에서 언급된 슬래그, '규산질 수용액' 그리고 NaAlO₂ 수용액을 혼합시킨 혼성물을 약 80℃에서 7~8시간 반응시키면 Na-A형 제올라이트가 단일상으로 합성되었다. 출발물질의 이상적인 혼합비율은 Na₂O : Al₂O₃: SiO₂의 물비가 1.3~l.4 : 0.8~0.9 : 2이었으며 반응용액과 슬래그의 비율은 1 : 7~10 (g/㏄)이었다. 합성된 제올라이트의 형태는 균일한 입방형이었으며 입도는 약 1 ㎛이었다. 한편, Ca^(²+)이온에 대한 이온교환 용량(CEC)은 180~210 meq/100 g이었으므로 통용되는 세제용 제올라이트와 비교하면 약 80% 수준이었으므로 폐수처리나 오염된 중금속처리와 같은 환경처리용으로 사용될 수 있을 것이다. Na-A zeolite were synthesized from melting slag of the incinerated ash by the alkaline activation processes. The experiments were performed in stainless steel vessels, with continuous stirring during the reaction periods. The silica-rich solution, a starting material, which was the waste of crystal growth factory, contains 5.7 wt% SiO₂ and 3.2 wt% Na₂O And NaAlO₂was made by the reaction of aluminium dross and NaOH solution and its molar ratios were Na₂O/ Al₂O₃ = 1.2 and H₂O/Na₂O=9. During the residence time of 7~ 8 h at 80℃, the mixing of the silica-rich solution, NaAlO₂and melting slag yields the production of homogeneous Na-A zeolite. The optimal reactant composition in molar ratio of Na_₂O : Al₂O₃: SiO₂was 1.3~l.4 : 0.8~0.9 : 2 and mixing ratio of solution and slag was 1/7~10 (g/㏄). Synthesized Na-A zeolite has cubic form uniformly and its size ranges about 1㎛. Ca^(²+) ion exchange capacity of the Na-A was about 180~210 meq/100 g, corresponding approximately 80% to the commercial detergent builder.

안면신경초종의 수술적 치료

이원상,지장훈,전영명,박기현 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.7