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Wen-Ting Li,Yu Wang,Fen-Fang Deng,Li-Li Liu,Hai-Jun Nan,He Li 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.8
A novel electrochemical immunosensor for determination of carcinoembryonic antigen (CEA) in human serum was fabricated by depositing Mo–Mn3O4/MWCNTs/Chits nanocomposite onto an indium-tin oxide (ITO) electrode. Mo-doped Mn3O4 (MMO) was synthesized by sol–gel method and the presence of molybdenum improved its electrochemical properties. The MMO/ MWCNTs/Chits nanocomposite could accelerate the electron transfer rate and enlarge the surface area to capture a large number of Carcinoembryonic Antigen (CEA). The factors influencing the performance of the immunosensor were investigated, such as incubation time, incubation temperature and pH. Under optimal conditions, the electrochemical immunosensor could detect CEA in a linear range from 0.1 ng · mL-1 to 125 ng · mL-1 with a detection limit of 4.9 pg · mL-1 (S/N = 3). In addition, it exhibited high sensitivity and acceptable stability on a promising immobilization platform for signal amplification, which could be extended to other labeled recognition systems. This electrochemical immunosensor may provide potential applications for the clinical diagnosis.
( Wen Ting Li ),( Chuan Long Zhu ),( Yi Li ),( Quan Wu ),( Ren Tao Gao ) 대한소화기학회 2014 Gut and Liver Vol.8 No.3
Background/Aims: The Wnt/β-catenin signaling pathway has been reported to play an important role in liver fibrosis. This study was designed to investigate whether mesoderm-specific transcript homologue (Mest), a strong negative regulator of Wnt/β-catenin signaling, could inhibit liver fibrosis. Methods: pcDNA-Mest was transfected into hepatic stellate cells (HSCs) and rats. Rats were randomly divided into four groups: normal group (normal saline), treatment group (pcDNA- Mest+CCl4), control group (pcDNA-neo+CCl4), and model group (normal saline+CCl4). Changes in liver pathology were evaluated by hematoxylin and eosin and Masson’s trichrome staining. The levels of alanine transaminase, aspartate transaminase, lactic dehygrogenase, hyaluronic acid, and laminin in the serum and hydroxyproline in the liver were detected by biochemical examination and radioimmunoassay, respectively. The expression and distribution of β-catenin, α-smooth muscle actin (α-SMA), Smad3, and tissue inhibitor of metalloproteinase type I were determined, and the viability of the HSCs was tested. Results: Our data demonstrate that Mest alleviated CCl4-induced collagen deposition in liver tissue and improved the condition of the liver in rats. Mest also significantly reduced the expression and distribution of β-catenin, α-SMA and Smad3 both in vivo and in vitro, in addition to the viability of HSCs in vitro. Conclusions: We found that Mest attenuates liver fibrosis by repressing β-catenin expression, which provides a new therapeutic approach for treating liver fibrosis.
Ting-Ting Li,Wenna Dai,Liwei Wu,Hao-Kai Peng,Xiayun Zhang,Bing-Chiuan Shiu,Jia-Horng Lin,Ching-Wen Lou 한국섬유공학회 2019 Fibers and polymers Vol.20 No.2
In order to deeply explore the fiber characteristics influencing on stab resistance of shear thickening fluid (STF)-impregnated fabrics, two different weaving fabrics, ultra-high molecular weight polyethylene (UHMWPE) fabric and Kevlar fabrics are saturate the various concentrations and particle size of STFs. Result shows that, SiO2/PEG-200 blends demonstrate quick shear-thickening property, and the critical shear rate lowers to 1.2-45 s-1 with higher concentration of 75 nm SiO2. STF concentration and particle size significantly affect spike puncture resistance property, but the knife stab resistance mainly depends on fiber characteristics. Comparatively, STF-UHMWPE composite fabrics exhibit better knife stab resistance but weaker spike puncture resistance than STF-Kevlar fabrics. This study can provide an optimization for structure design of stab resistance armors in the future.
Grain Size Effect on Multi-Stage Micro Deep Drawing of Micro Cup with Domed Bottom
Wen Ting Li,Ming Wang Fu,Ji Lai Wang,Bao Meng 한국정밀공학회 2016 International Journal of Precision Engineering and Vol.17 No.6
A two-stage micro deep drawing system was designed and developed to manufacture a micro cup with domed bottom. The copper blank was annealed at three different conditions to obtain different grain sizes in such a way to study the grain size effect on the deformation behavior and thickness variation of the micro part. To investigate the instantaneous effect and deformation behavior, finite element simulation was used to simulate the whole drawing process. It revealed that the fracture in the place with the thinnest thickness in the micro part drawn from a circle blank with residual stress induced in blanking can be easily happen and the deformation load in the first-stage decreases more than that in the second-stage with the increase of grain size. Moreover, the micro part with a larger grain size has more nonuniform thickness and severer thinning around the punch corner. The surface roughness at the bottom of micro part increases with the grain size. The surface roughness at the wall of it, however, decreases with the deformation stage mainly due to the ironing effect. The research promotes the understanding of grain size effect on multi-stage micro deep drawing and facilitates the development of microforming process.
Ting-Ting Li,Fei Sun,Xing Liu,Hua-Ling Wu,Ching-Wen Lou,Jia-Horng Lin 한국섬유공학회 2018 Fibers and polymers Vol.19 No.6
High-modulus PET filaments and thermal bonding are used to reinforce the puncture resistance stability of the insole composite. This study aims to discuss the influences of the amount of low-melting-point polyester fibers (LMPET) and needle densities (ND) on tensile, bursting, and quasi-static puncture resistance properties. Besides, significance of LMPET amount and ND on puncture resistance against flat-head (A), spherical-head (B), and pointed-head (C) probes are in particular investigated to simulate the diversified application environments for insoles. Research result shows that, LMPET amount significantly affects the static puncture resistance against three probes; ND only significantly influences the puncture resistance against Probe A and C. Thermal bonding significantly improves the puncture strength against Probe B with various LMPET amounts of insoles, but evidently increases the puncture resistance against Probe A and C when being punched at various ND. The amount of LMPET fibers has a positive influence on the puncture strength of insoles, and 70 wt% of LMPET provide the average static puncture resistance up to 342.6 N. The high-modulus resultant insoles have advantages of flexibility, ease of process, and bendability with a higher and more stabilized puncture resistances.
A NEURAL NETWORK EXPERT SYSTEM FOR AERONAUTIC MAINTENANCE QUALITY EVALUATION
Li, Jiang Wen,Jun, Li Ting,He, Liu Long 대한전자공학회 1992 HICEC:Harbin International Conference on Electroni Vol.1 No.1
It is a new way for AI to apply ANNs (Artificial Neural Networks) to expert system. ANNs provide an effective solution to the provlems encountered in building systems that emulate a management expert. In this artical, taking the advantage of learning algorithms of ANNs to simulate management experts experience, we build an expert system for aeronautic maintenance quality evaluation. Results showed that it is practicable and reliable.
Cushion Polyurethane Sandwich Composite Structures Strengthened by a Concave-Convex Fabric Panels
Ting-Ting Li,Peiyao Liu,Bing-Chiuan Shiu,Hongyang Wang,Hao-Kai Peng,Jia-Horng Lin,Ching-Wen Lou 한국섬유공학회 2022 Fibers and polymers Vol.23 No.12
In order to improve the low velocity impact resistance, flexible PU foam composites (FPUC) with a sandwichstructure are proposed. The interlayer is composed of a concave-convex fabric structure while the top/bottom layers are madeof polyurethane foam (PU). The core is prepared as follows. Seven warp knitted spacer fabric types (WKSF) (WKSF.1-7) arelaminated with different number of layers to form cuboids, which are fixed firmly between two layers of low melting pointpolyester (LMPET) fabrics via hot melting. The effects of spacer yarn density, spacer yarn inclination angle, combination ofspacer fabrics, and number of lamination layers on the dynamic cushion performance are evaluated. With the impact energybeing 16 J, FPUs demonstrate an energy absorption level that is 19 % and 39 % greater than PU and WKSF. Furthermore,ultra-high molecular weight polyethylene fabric can effectively enhance the surface strength. Finally, the results arecomputed via theoretical prediction formulae of dynamic buffer resistance is in conformity with the experimental test results.