스텝이송을 이용한 미세구멍가공

한진욱,이응숙,정윤교 國立 昌原大學校 産業技術硏究所 1995 産技硏論文集 Vol.9 No.-

Micro drilling is one of the most important machining types and its importance becomes more and more increased in the whole field of industry. Micro drilling, however, has few the case of practical application, because it requests high techniques; manufacturing micro drill, treating, chip, producing precise hole shape and progressing machining efficiency. Micro drilling has a technical problem; drill breakage from drill breakage from the lack of drill stiffness and the interruption of chip. It is, therefore, essential to select of proper cutting conditions and of step fed for the method solving the lack of stiffness and the interruption of chip. Especially, study on step feed is requested more than the present. The purpose of this paper is to investigate experimentally about cutting conditions which affect on tool life and round errors and to estimate about the efficiency of step feed.

자운천 유역의 강우특성에 의한 하천 탁도 발생에 관한 연구

김종욱,박수진,최한규 江原大學校 産業技術硏究所 2007 産業技術硏究 Vol.27 No.B

This research investigates the turbidity and flow of river for an year, 2005, in order to examine the relation of the generation of turbidity according to the outflow of min water. For this research, the region of Jawoon river where is the area of high land vegetable growing in the upper Soyang Reservoir is selected to observe actual floating materials that generate negative nutrition and turbidity of the Reservoir water and the changes of water quality by raining of each month, In addition, the researcher has conducted statistical inspection methods, such as correlation analysis and regression analysis on strength of raining force, and rain continuance time among the elements affecting the outflow of floating materials.

강원도 사북-고한 지역의 석탄광 폐석에 대한 물리적, 역학적 특성 연구

임한욱,정윤영,목진호,김종훈,김재동,신동오 강원대학교 석재복합신소재제품연구센터 1996 석재연 논문집 Vol.1 No.-

석탄광 폐석의 건설용 골재로서 활용 가능성을 검토하기 위하여 폐석의 주요 구성암석인 사암, 사질혈암, 혈암, 탄질혈암을 대상으로 기초물성실험, 역학적 실험 및 골재원 특성 실험을 실시하였다. 시험결과치의 평균값을 기준으로 할 때 사암, 사질혈암, 혈암은 골재로서 활용이 가능하나, 실험치의 분산도가 심하여 활용가능 폐석과 불가능한 폐석이 혼재되 있음을 확인하였다. 반면에 탄질혈암은 골재원 특성이 가능하나 강도등 물성에서는 사용이 곤란한 것으로 판단되었다. 따라서 앞으로 폐석중 활용가능한 사암, 사질혈암 및 혈암을 효율적으로 분급하는 방안과 금번에 실시하지 못한 골재의 알카리 반응시험 등이 추가로 보완되었으면 한다. An experimental program was undertaken to test rock wastes from coal mines, for use as a new source of aggregate. Physical and mechanical properties, required for aggregate materials, of major constituents of rock wastes including sandstones, sandy shales, shales, and coal shales, were measured in the laboratory. Test results showed that the sandstones, sandy shales and shales tested in this study might possibly be used for construction aggregates, the highly scattered test data indicated considerable proportion of unusable rocks. In case of coal shales, the aggregate characteristics were generally adoptable but some physical properties such as rock strength were lower than required. In conclusion, it is suggested that an effective procedure for sorting the rock wastes, and additional tests such as alkali-aggregate reaction should be supplemented.

항우울제 장기 투여에 의한 흰쥐 해마에서 PhosphoCREB의 발현 증가

김소양,한진희,이창욱,백인호 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.5

목 적 : 저자들은 paroxetine(selective serotonin reuptake inhibitor). desipramine(selective norepinephrine reuptake inhibitor), moclobemide(reversible monoamine oxidase inhibitor)의 항우울제를 흰쥐에 장기 투여한 후 해마에서 phosphoCREB의 발현정도를 측정하고 이를 항정신병약물, 항불안제 및 control을 장기 투여하였을 때의 발현정도와 비교해 보고자 하였다. 방 법 : 실험동물로는 체중 200∼300g의 Sprague-Dawley 수컷 흰쥐 240마리를 사용하였고, paroxetine 투여군, desipramine 투여군, moclobemide 투여군, haloperidol 투여군, lorazepam 투여군과 대조군으로 나누고 각각의 약물을 1일간, 3일간, 7일간, 14일간 각각 하루 한차례씩 복강내 주입을 하였다. 흰쥐는 마지막 투약 15분후에 대뇌를 적출하였고 면역조직화학법을 이용하여 해마에서 발현되는 phosphoCREB(+)신경원 수를 측정하였다. 결 과 : 항우울제인moclobemide 투여군에서 3일째부터 phosphoCREB의 발현을 증가시켜 7일째와 14일째 모두 증가되었고 paroxetine 투여군과 desipramine 투여군도 7일째와 14일째 증가를 나타내었다. 그러나 항우울제가 아닌 약물을 투여한 군(lorazepam 투여군과 haloperidol 투여군)에서는 대조군과 비교하였을 때 투여 기간에 따른 phosphoCREB의 증가는 없었다. 결 론 : 다양한 항우울제의 장기 투여는 항정신병약물과 항불안제의 장기 투여와 비교하면 모두 해마에서 phosphoCREB의 발현을 증가시킴을 알 수 있었다. 따라서 이는 다른 약제와 구별되는 항우울제만의 특이한 공통적 약물작용기전으로 생각된다. Objectives : This study was designed to assess the expression of phosphoCREB in rat hippocampus after chronic administration of various antidepressants in comparison with chronic administration of antipsychotic and antianxiety drugs. Methods : Male Sprague-Dawley rats(200-300g) were used for this experiment. The subjects were divided into 6 groups according to specific treatment agents(paroxetine, desipramine, moclobemide, haloperidol, lorazepam, vehicle) which were administered daily for 1day, 3day, 7day, and 14days by intraperitoneal injection respectively. Brains were removed 15 minutes after the last treatment. PhosphoCREB immunoreactivity was measured by phosphoCREB(+) cell counts in hippocampus of rats. Results : Expression of phosphoCREB was significantly increased from day 3 in moclobemide group, from day 7 in paroxetine and desipramine groups, and increased most significantly from day 14 in all antidepressant-administered groups, with no increase in other two groups(lorazepam and haloperidol groups) throughout the experiment and even after 14 days of treatment. Conclusion : These result suggest that increased expression of phosphoCREB after chronic administration of antidepressants, not of antipsychotic or antianxiety drugs, demonstrates pharmacolgical specificity of antidepressant treatment in rat hippocampus regardless of their receptor preference.

한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

파킨슨氏 病 患者에서 副腎 髓質-尾狀核 自家 移植術 後 發生한 器質性 妄想 障碍 2例

金寶淵,李昶旭,韓辰熙 서울醫大 1991 精神醫學 Vol.16 No.4

획을 이용한 소형 전자기기용 한글 입력 시스템

정영준,엄종진,박민현,한욱표 강원대학교 정보통신연구소 2007 정보통신논문지 Vol.11 No.-

With advance of cellular phone technologies, the use of short message transmission with small or portable electronic devices has been explosively increasing. In spite of such demands there have been not many studies for Korean characters and their symbol combinations (below "Hangul"). While some other studies have been focused on the Hangul vowel, in this paper we proposed a new Hangul input system which presents Hangul consonants with basic symbol components (called as "hweok"). And we have performed performance evaluation with comparison to SK's Chunjiin and LG's Naragul in terms of the number of key buttons, finger moving distance and key strokes. The proposed system can make all of Korean characters with 5 or 6 Hangul hweoks without significant degradation of system performance.

베체트 장질환의 외과적 치료 성적

김기흥,박규주,양한광,박재갑,김상준,이건욱,최국진,김진복 대한대장항문학회 1997 Annals of Coloproctolgy Vol.13 No.3

저빈도 반복성 경두개 자기자극이 정상인의 시각적 단기 기억에 미치는 영향

오해정,김원,이경욱,박원명,전태연,한진희,채정호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5

Objectives : Repetitive transcranial magnetic stimulation (rTMS) is a novel, noninvasive method of brain stimulation. Since conventional rTMS does not cause seizure, marked advantage over electroconvulsive therapy (ECT), rTMS can be used easily and widely. Once the effects of rTMS on cognitive function are elucidated, its application will be further extended. However, the effects of rTMS on cognitive function have not been well examined. This study aimed to evaluate the effect of low frequencyr TMS on visual short term memory. Methods : Forty normal healthy volunteers were randomly assigned to rTMS (n=20) or sham (n=20) groups. The rTMS group were again randomly divided into left prefrontal (n=10) and right prefrontal (n=10) groups. For each group rTMS was given at 1 Hz for 20 minutes with 100% of motor threshold. As a cognitive task, Corsi Block Tapping Test (CORSI) in the computerized Vienna Test System, which can assess visual short term memory, was performed before, during, and after the rTMS. Results : No significant difference was found in the visual short term memories between the rTMS and the sham groups before, during, or after 1 Hz rTMS, nor between the left and right prefrontal rTMS groups. Conclusion : This study demonstrates that rTMS, contrary to ECT, has no adverse visual short term memory effect when used as the standard treatment paradigm. Therefore, rTMS could be a new and safe treatment method in various neuropsychiathc fields without any interference of cognitive function.

Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).