http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Shunpeng Song ),( Peter M Elias ),( Theodora M Mauro ),( Mao Qiang Man ) 한국피부장벽학회 2013 한국피부장벽학회지 Vol.15 No.2
Aged skin is featured by compromised epidermal permeability barrier homeostasis. Improvement of epidermal permeability barrier in aged skin is quite a challenge. Previous study demonstrated that topical hesperidin improves epidermal permeability barrier homeostasis in young mice. However, whether topical applications of hesperidin benefit epidermal permeability barrier function is not known yet. In the present study, we assessed the influence of topical applications of hesperidin on epidermal permeability barrier function and its underlying mechanisms in aged murine model. 12-15 month old hairless mice were topically treated with either 2% hesperidin or 70% ethanol alone twice daily for 25 days. At the end of study, stratum corneum function was assessed with an MPA5 physiology monitor. And barrier recovery rates were determined at 2 and 4 hours after barrier disruption by repeated tape-stripping. Our results show that topical applications of hesperidin lowered basal skin surface pH and increased basal transepidermal water loss. However, barrier recovery was significantly accelerated by hesperidin. The improved barrier function correlated with up-regulation of barrier-related protein, lipid synthetic enzyme and their mRNA expression. Moreover, topical hesperidin also significantly increased expression of epidermal mRNAs for mBD3, NHE1 and sPLA2g2f. These results suggest that topical application of hesperidin could be useful for preventing skin aging and treating aged skin.
Man, Mona,Hupe, Melanie,Mackenzie, Donald,Kim, Hyunjung,Oda, Yuko,Crumrine, Debra,Lee, Seung Hun,Martin‐,Ezquerra, Gemma,Trullas, Carles,Mauro, Theodora M.,Feingold, Kenneth R.,Elias, Peter M.,M Blackwell Publishing Ltd 2011 Experimental dermatology Vol.20 No.3
<P><B>Abstract: </B> Chinese herbal medicine (CHM) has been shown to have beneficial effects for both skin disorders with barrier abnormality and as skin care ingredients. Yet, how CHM exerts their benefits is unclear. As most, if not all, inflammatory dermatoses are accompanied by abnormal permeability barrier function, we assessed the effects of topical CHM extracts on epidermal permeability barrier function and their potential mechanisms. Topical CHM accelerated barrier recovery following acute barrier disruption. Epidermal lipid content and mRNA expression of fatty acid and ceramide synthetic enzymes increased following topical CHM treatment in addition to mRNA levels for the epidermal glucosylceramide transport protein, ATP‐binding cassette A12. Likewise, CHM extract increased mRNA expression of antimicrobial peptides both <I>in vivo</I> and <I>in vitro</I>. These results demonstrate that the topical CHM extract enhances epidermal permeability barrier function, suggesting that topical CHM could provide an alternative regimen for the prevention/treatment of inflammatory dermatoses accompanied by barrier abnormalities.</P>