사립체 DNA 뉴클레오타이드 3243 A→G 돌연변이 [MTTL1^*MELAS3243G]에 의한 MELAS 증후군

박기형,김승현,이영주,김희태,김주한,김명호,박성섭 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

요 검사용 스트립의 분광학적 분석을 위한 Computer Simulation

김성철,진병문,김재형,김정배,조진욱,전계록,이승진,김건우 동의대학교 기초과학연구소 1999 基礎科學硏究論文集 Vol.9 No.1

The spectroscopic properties of 9 pads in a urine strip were studied to develop a urine analysis system. From the present work, we determined the wavelength range which could accurately distinguish the degrees of 9 test items. A computer simulation was performed to distinguish the primary color reaction in the urine strips by using the reflectance of the urine strips, the iuminous intensity of light-emitting diodes, and the spectral sensitivity of photodiodes. The simulation results agree well with the experimental results obtained by using a UV-Visible spectrophotometer.

Drosophila quinaria Species Group의 遺傳的 近緣關係

成耆昌,金正洙,金大鎰,金彧,金溶聲 성균관대학교 기초과학연구소 1985 論文集 Vol.36 No.2

The genetic relatedness among the Korean Drosophila quinaria species group, including D. nigromaculata, D. unispina, D. brachynephrose, and D. angularis, has been examined by using horizontal starch gel electrophoresis. The results showed that none of the ten isozyme patterns examined for these four species was identical. The average genetic similarity among the four species was found to be 0.440. The similarity among three species. D. unispina, D. brachynephrose, and D. angularis was 0.466. The relatedness was found to be closest between D. nigromaculata and D. unispina, showing 0.640. D. nigromaculata and D. angularis showed relatedness of 0.258. The results suggested that these four species appear to be genetically related at the level of sibling species. The percent polymorphism in D. brachynephrose was found to be 76.9%, showing significant genetic variations.

百濟의 遼西經略에 對하여

金庠基(Kim Sang-kee) 백산학회 1967 白山學報 Vol.- No.3

Sung-shu(宋書)gives an account for the first time that Bekje (百濟) brought Liao-Hsi(遼西)area (an area west of Liao-ho (遼河) under its rule and established there its own administrative districts with Chinp’ing Hsien(晋平縣), Chin-p’ing Chun(晋平郡)as the center. This occupation seems to have been realized toward the end of the thirteenth king Kŭnch’oko-wang’s (近育古王) reign. It was in his time that Bekje was powerful enough to emulate with Kokuryo(高句麗), and eventually after repeated battles in the Debang (帶方) (now, Hwanghe-do 黃海道) area, its army killed Kokuryŏ’s sixteenth king Kokukwŏn-wang(故國原王)below the Pyongyang(平壤) Castle. Before during the era of its fifteenth king Mich’ŏn-wang 美川王, Kokuryŏ occupied the Liao-Tung(遼東)area(or the Liaotung Peninsula) and evacuated from the area thereafter with no fear of threat from the north. Thus it is probable that by advancing into Liao-Hsi area by sea, Bekje as a naval power attempted to check Kokuryŏ’s southward force. The reason why Kokuryŏ and Bekje could so easily seize Liao-Tung and Liao-Hsi areas respectively is that in the continent the so-called Wu-hu Shih-liu-kuo (五胡十六國) were at odds with each other in a chaotic situation, and there was no force that could reach their eastern frontier. Later the Liao-Hsi area occupied by Bekje was attacked by Hou-wei(後魏)(Pei-wei 北魏), and there was a time in the era of the twenty-fourth king Tongsong-wang(東城王)when Bekje defeated a large force of Hou-wei, and according to a record in Nan-ch’i-shu(南齊書), it requested the Ch’i(齊)Dynasty (of Nan-ch’ao 南朝), which was then against Hou-wei, to confer a peerage on the victorious general named Sabŏbmyŏng(沙法名). No historical record is available as to how Bekje’s power changed in Liao-Hsi area thereafter, but from the fact that Hou-wei finally unified areas north of the Yangtze River, we can infer that Bekje’s influence in Liao-Hsi area was crippled by Hou-wei, Bekje’s occupation of Liao-Hsi area is recorded mostly in Sung-shu and Nan-Ch’i-shu. Compiled by Shên Yüeh(沈約), who wrote history for both the Sung and Ch’i Dynasties and was an official in the Liang(梁) Dynasty, Sung-shu was published in the sixth year of Ch’i’s King Wu(武)(A.D.488). And Hsiao Tzŭ-hsien(蕭子顯), compiler of Nan-ch’i shu, was a member of Nanch’i’s(南齊)royal household, and upon the fall of the dynasty, he went to serve King Wu of the Liang (梁) Dynasty and presented him with the book. As the two books were compiled by witnesses to the days, their reliability is unquestionable.

打令調民謠의 考察

金成基 국민대학교 어문학연구소 1981 語文學論叢 Vol.1 No.-

In this essay I have tried to examine the names, origins, status and distribution of Korean folk songs, especially ballad-style ones (Taryong打令). The term Taryong initially meant one of Chang jo (Song tune 唱調), but it came to also mean the title of songs. It is sung sometimes merrily and touchingly, and came to become a form of song which is sung repeatedly. It came into existence around the end of the Yi Dynasty in combination with Pansori and miscellaneous songs, and gradually spread across the country. Secondly, the position of Taryong ballads among the Korean folk songs is as popular as labor folk songs, enjoying a steady position. Taryong ballads are widely spread all over the provinces, except for Chungchong-pukto province, with Seoul and the Kyonggi Province area enjoying the highest popularity followed by the Honam area, that is, Cholla-namdo and Cholla-pukto provinces. It is noteworthy that Taryong ballads are spread even in Yongnam(嶺南), Chungnam (忠南), Kangwon(江原) and northern Korea, where miscellaneous songs are not sung. The same lyric lines as Taryong are sung also as miscellaneous songs, having been influenced considerably by Pansori. The contents of Taryong may be assorted into two major kinds:those the main theme of which is love affairs and those whose main theme is boasting of something, with each category reaching 31 in number, followed by those on sarcasm and on difficulty of living, and so on. Of those dealing with love affairs, most words express the general feeling of love, with their mode of expression being rather humorous and joking than serious or pathetic. Kosari Taryong of Chongyang(靑陽) realistically depicts the psychological state of woman parting with her lover, while Doryong Taryong of Chonnam, which expressesunchaste love affairs, sings the words about contraceptive method. In Bombok Taryong of Yesen(禮山), a woman insists on loving her adulterer even while being beaten by her husband. Those on boasting include lines praising foods and nature, while those on sarcasm and living difficulty include Jimkum Taryong of Kimhae(金海) and Kanan (poverty) Taryong of Cholla(全羅), which describe the difficult situation of a family suffering from excessive debts. Kanan Taryong sympathetically speaks for the poverty of the masses, while expressing pity to such animals as the cattle and deer, comparing their situation with that of poor masses. There are about 50 or more other Taryong texts, including those on seasons or on various chores of life. A small number of those ballads express admiration of agriculture and morality or one's affection of rivers and native land. As a whole, many of Taryong ballads are composed of Silsa(實寫) and Sasul (辭說), with a considerable number of them being unclear about the theme. For instance, in Heung Taryong and Nim Taryong, there are lines reading, "...people of Inchon Jemulpo can hardly live on because of those bothering Japs...." followed by such words as "Chun-hyang, Simchong, wife and daugters..." Also in Nalgai (wing) Taryong, we can hardly find consistency in the lyric lines dealing with such as "Chunhyang, tale on seasons, go-betweens, fruits and zest of living." Same in Boncho (本調) Arirang in which the absurdity of society is criticized first, then abruptly come words of praising bumper crops. In some songs are found modern words, suggesting that they might have been devised during the years of Japanese domination or after the Liberation of the country. In short, Taryong ballads have been spread as widely as labor folk songs, expressing candidly the thought and things which the general mass of people wanted to express. Consequently, we come to know that Taryong ballads are a major genre of folk songs which have been sung widely unitil recently.

개에서 관찰된 모기질세포종의 증례보고

조성환,손화영,김혜성,최종윤,류시윤,박배근,윤원기,홍성혁,김덕환 충남대학교 수의과대학 동물의과학연구소 2002 動物醫科學硏究誌 Vol.10 No.-

Pilomatricoma was histopathologically diagnosed in a 2.5-year-old male Alaskan malamute. The patient was referred to Chungnam National University, Veterinary Medical Teaching Hospital with solitary, firm and well-circumscribed mass at shoulder. Grossly, the mass was dome shaped to tumor like and 10 x 8 x 5㎝ in size. Some lesions had gritty or bony consistency and was chalky when sectioned Histopathologic feature included mumerous clusters of tightly arranged, basaloid cells with evenly distributed chromatin and ghost cells were characterized by a central unstained zone. The ghost cells often become calcified and osseous metaplasia was also present.

사상체질론의 정신의학적 타당성에 대한 연구

민성길,김동기,박진균,전세일 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.3

연구목적 : 건간한 의대상 312명과 신경증적 장애를 가진 환자 288명을 대상으로 하였다. 사상체질의 구별은 노정우 및 김달래 두 전문가에 의한 판정, 그리고 경희의대 사상체질 설문지(QSCC Ⅱ)에 의한 판정 등 3가지 방법에 의하였다. 연구 대상에게 정신과적 증상척도(SCL-90), 체질특성척도 및 성격척도를 사용하여 자가 평가하게 하였다. 각종 척도들의 타당도와 신뢰도는 입증되었다. 이 척도들을 통계적으로 분석하고 고전적 설명과 어느 정도 일치하는 지를 검토하였다. 연구결과 : 1) 3가지 분류방법간에 차이가 컸었다. 그 중 전문가의 직접적 면담에 의한 감별보다 QSCCⅡ 설문지형이 비교적 감별력이 컸다. 3) QSCCⅡ가 감별력이 비교적 크다고 하더라도 그 결과가 소음군의 대인공포-강박증, 불면-식용상실, 무력-예민-소화기-한기-피부증후군 그리고 정력부족등 신경증적 증상과 소극-비사교적, 내향형 성격 및 이성적 성격특징 등 몇가지 특징을 감별하는 데에만 비교적 유의하였고, 태음군의 특정인 독특한 신념, 온기, 활달-사교적 성격에 대해서는 부분적으로 그 특징을 감별하였다. 또한 소양군의 활달-사교형 성격과 감정형 성격의 특징 등은 극히 부분적으로 감별하였다. 결 론 : 이러한 결과는 현존하는 사상체질 구분방법에 일치점이 결여되어 있다는 것, 각종척도를 사용한 결과는 사상체질에 관한 고전적 설명을 부분적으로만 입증하고 있다는 것, 따라서 사상체질구분에 대한 향후보다 객관적인 연구가 필요하다는 것을 시사한다. Object : This study is to examine the validity of constitutional classification of Sa-sang medical theory. This theory classifies the human constitution to 4 types according to classical oriental philosophy on yin and yang. Subjects and Method : Subjects were 312 medical students and 288 neurotic patients with diagnosis of neurotic, stress related and somatoform disorders and minor depressive episodes according to ICD-10. Medical students were classified to 4 Sa-sang Constitution Classification(QSCCⅡ). For assessmnent of symptoms and signs, Korean version of SCL-90, a constitution scale and personality scale which were designed for this study were used. These instruments were found to be reliable and valid through statistical analysis. Subjects were asked to rate these scales. The data were analysed with factor analysis and factor scores were compared among 4 Sa-sang constitutions by ANOVA and t-test. The data from patient group were analysed with factor analysis and the results were compared with the Sa-sang medical theory. Results : Results of classification by 3 ways were inconsistent showing a significant difference among them. Among them, QSCCⅡ was most reliable. In QSCC Ⅱ, only the factor scores of factors of homophobia-obsession, weakness-sensitiveness-indigestion-chillness-skin syndrome, sexual weakness, passive-unsociable personality, introverted personality and rational, personality, were significantly high in So-um (small yin) group of medical students. A factor of warmnes and active-sociable personality were significantly high in Tae-um(big yin)group. Also active-sociable and effective pesonality was partly related with So-yang(small yang)group. Conclusion : These results suggest that those present classification methods inconsistent, that these methods are proving only parts of Sa-sang medical theory, and that objective and scientific studies are needed for reliability and validity of Sa-sang medical theory.

Original Article : Geographic difference of epidemiological features of HCV infection in Korea

( Kyung Ah Kim ),( Sook Hyang Jeong ),( Eun Sun Jang ),( Young Seok Kim3 ),( Youn Jae Lee ),( Eun Uk Jung ),( In Hee Kim ),( Sung Bum Cho ),( Mee Kyung Kee ),( Chun Kang ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.4

Background/Aims: The prevalence of hepatitis C virus (HCV) infection in Korea exhibits significant geographic variation, with it being higher in Busan and Jeonam than in other areas. The reason for this intranational geographic difference was investigated in this study by conducting a comparative analysis of the risk factors related to HCV infection among three geographic areas: the capital (Seoul), Busan, and the province of Jeolla. Methods: In total, 990 patients with chronic HCV infection were prospectively enrolled at 5 university hospitals located in Seoul (n=374), Busan (n=264), and Jeolla (n=352). A standardized questionnaire survey on the risk factors for HCV infection was administered to these three groups of patients, and a comparative analysis of the findings was performed. Results: The analysis revealed significant regional differences in exposure to the risk factors of HCV infection. By comparison with patients in Seoul as a control group in the multivariate analysis, patients in Busan had significantly more experience of invasive medical procedures, acupuncture, cosmetic procedures, and multiple sex partners. In contrast, patients in Jeolla were significantly older, and they had a higher prevalence of hepatocellular carcinoma, a lower prevalence of multiple sex partners, and had experienced fewer invasive procedures. Conclusions: There was a significant geographic difference in the exposure to potential risk factors of HCV infection between patients from the three studied regions. This may explain the regional variation of the prevalence of HCV infection in Korea, and should be taken into account when planning strategies for the prevention and management of HCV infection. (Clin Mol Hepatol 2014;20:361-367)

24주간 추적하는 임상 연구에서 한국인 남자 알코올 의존 환자의 비재발률

강철중,김성곤,남궁기,조동환,이병욱,최인근,최용성,박성봉,제영묘,김현경,김성연 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.1

Objetives : In order to provide useful data tbr the further clinical studies with Korean alcohol-dependent patients, enrollment and non-relapse rates were investigated while alcohol-dependent patients wcre followed up for 24 weeks. Methods : The subjects of this study were alcohol-dependent male patients who, for the first time, visited a hospital among 3 groups of hospitals, University Hospital, General Hospital or Mental Hospital, or those who needed to be followed up after discharge from those hospitals. After assigning 12 subjects to each hospital, we investigated enrollment and non-relapse rates while cognitive-behavioral therapy and pharmacotherapy were provided. Results : 1) Forty-eight patients were enrolled and the rate of enrollment was 36.4%. The enrollment rate in the University Hospital group was 52.1%, in the General Hospital group 50.0%. and in the Mental Hospital group 10.4%. 2) In 48 patients, non-relapse rate was 27.1% at 12 week and 18.8% at 24 weeks after starting follow-up. It was 24.4% and 20.0% at 12 and 24 weeks, repectively, in the University Hospital group while the General Hospital group showed 33.3% and 16.7%, respectively, and the Mental Hospital Group showed 20.0% at both 12 and 24 weeks. Conclusion : These results provide important data for further clinical studies of Korean alcohol-dependent patients.

학국에서 심방세동의 임상양상에 관한 연구

이선미,조정휘,홍순조,최윤식,안신기,김성순,김영훈,김윤년,조정관,차태준,김유호,최기준,김준수,이상민,신동구 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.5