成人의 身體組成 評價를 위한 生體電氣低抗法의 妥當性 檢討

李東洙,金基學,梁金山,權善鈺 慶北大學校 師範大學 體育學硏究會 1992 體育學會誌 Vol.20 No.-

This study is concerned with a comparison of the UW and the BI methods as they are applied to the evaluation of body composition. The validity of the BI method is studied in detail, and the SFT method is also examined in detail in comparison with the other methods. Altogether 49 healthy adults(13 males and 36 females)were estimated, and the following results have been obtained: 1. A comparison of the % body fat measured by the three methods is schematically summarized below: ◁표 삽입▷(원문을 참조하세요) 2. There was a higher correlation between the UW and the BI methods than between the UW and the SFT methods in the estimate of the body composition. 3. The measurements of the %body fat, the height and weight, and the fat thickness by means of the UW method did not reveal significant correlation with respect to the physical constitution of the males, but there was a significant correlation(0.5754) with respect to the weight of the females. 4. In the estimated of the % body fat, the BI method showed a smaller standard and relative deviation than the SFT method both for the male and the female subjects, and the highest degree of accuracy was obtained in the BI method applied to the male subjects.

방선균 분리주가 생산하는 Phospholipase C 저해물질인 MT2617-2B의 분리 및 특성

고학룡,이현선,오원근,안순철,김보연,강대욱,민태익,안종석 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.1

방선균 분리주 MT2617-2의 배양액으로 부터 phospholipase C (PLC) 저해물질인 MT2617-2B를 n-butanol 추출 및 column chromatography 법을 이용하여 분리하였다. MT2617-2B는 IR ^13C- 및 ^1H-NMR 그리고 ESI-MS에 의한 구조분석 결과, 한 개의 hemiketal ring, polyhydroxyl 및polymethyl groups으로 구성되었으며 side chain으로 한 개씩의 malonate 및 guanidine group을 가지는 분자량 1057의 macrolide 화합물이었다. 따라서, MT2617-2B를 기존의 macrolide 항생제인 copiamycin 및 niphithricin A로 동정하였다. 한편, MT2617-2B는 methanol 용액에서 실온에서 방치하였을 때 도일한 분자량을 가진 두 개의 이성질체를 생성하였다. PLC γ1과 -β1에 대해 각각 25 및 50㎍/㎖의 IC_50 값을 가지며, Staphylococcus aureus 와 Candida albicans에 대해서는 항균활성을 나타내지만 Escherichia coli에는 나타내지 않았다. A phospholipase C (PLC) inhibitor (MT2617-2B) was isolated from the culture broth of actionmycetes isolate MT2617-2 by the extraction with n-butanol and column chromatographic techniques. The molecular weight of the inhibitor was 1057, by the spectroscopic analyses of IR ^13C- and ^1H-NMR and ESI-MS. The chemical structure of MT2617-2B was found to be a macrolide compound consisted of a hemiketal ring, polyhydroxyl and polymethyl groups, which had a malonate and guanidine group as its side chain. MT2617-2B produced its two isomers having the same molecular weight by standing in methanol solution at room temperature. Therefore, MT2617-2B was identified as copiamycin and niphithricin A, macrolide antibiotics. The values of IC_50 against PLC γ1 and PLC-β1 were 25 and 50㎍/㎖, respectively. MT2617-2B had antimicrobial activities against Staphylococcus aureus and Candida albicans, but not against Escherichia coli.

主觀的인 評價에 의한 靑少年의 肥滿傾向 分析

權善鈺,金基學,李東洙,鄭鎭國 慶北大學校 師範大學 體育學硏究會 1992 體育學會誌 Vol.20 No.-

This study was conducted to analyze the tendency of obesity by subjective evaluation method in measuring the skinfold thickness in adolescents. The validity norms were height, weight, the sum of skinfold thickness, Db1, %Fat1, %Fat2, and BMI. The subjects surveyed were 2,442 boy and girl students of middle and high school in medium and small city and big city. The results are summarized as follows; 1. Weight of adolescents evaluated as obesity was over 76㎏ in boy's middle, over 67㎏ in gril's middle school, over 79㎏ in boy's high school, and over 68㎏ in girl's high school, the sum of skinfold thickness was over 40㎜, over 39㎜, over 54㎜, and over 41㎜ respectively. 2. Except the case of height in girl's middle, boy's high and girl's high school, in height in boy's middle, weight, the skinfold thickness, Db1, %Fat1, %Fat2, and BMI, difference among the degree of obesity evaluated subjectively was significant(p<.05). 3. Except heigh in girl's middle, boy's and girl's high school, correlation between the degree of obesity evaluated subjectively and height in girl's middle school, weight, the sum of skinfold thickness, Db1, %Fat1, %Fat2, BMI respectively was high and significant(p<.01 or p<.001) Therefore, on the basis of above results, I think we can evaluate the tendency of obesity in adolescents validly by subjective evaluation method as well.

S-363 Chemical pleurodesis using mistletoe extracts via spray catheter during medical thoracoscopy

( Sun Hack Lee ),( Jung Seop Eom ),( Tae Hwa Kim ),( Kyu Min Lee ),( Ji Yeon Shin ),( Han Na Lee ),( Bo Hye Song ),( Yong Ki Sim ),( Geewon Lee ),( Jeong Ha Mok ),( Hyo Yeong Ahn ),( Min Ki Lee ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

We present three cases of successful chemical pleurodesis with a liquid solution of mistletoe extract using a spray catheter during medical thoracoscopy. The medical thoracoscopy was performed in all presented cases to remove pleural effusion and conduct chemical pleurodesis to manage symptomatic malignant pleural effusion. A spray catheter was used to instill the mistletoe extract evenly into the pleural cavity, and there were no pleurodesis-related complications. Respiratory symptoms caused by pleural effusion improved after pleurodesis, and successful pleurodesis was maintained for more than 3 months after medical thoracoscopy in all three patients. Lee and Colt reported that instilling lidocaine via a spray catheter is effective for pain control before chemical pleurodesis during medical thoracoscopy. Using a spray catheter in the same way, we performed pleurodesis with a mistletoe extract via a spray catheter in three patients with MPE. A complete response, defined as no pleural effusion within 4 weeks after the last pleurodesis6, was achieved in all three patients. Several studies have used liquid mistletoe extract via a chest tube for chemical pleurodesis. Stumpf et al. reported that the overall response to mistletoe extract pleurodesis was 72% in 20 patients with MPE. Mistletoe extract, which was previously verified as an effective sclerosant for pleurodesis via a chest tube, could be evenly sprayed into the pleural cavity during thoracoscopy using a spray catheter. Distributing the sclerosant evenly into the pleural cavity with a spray catheter may lead to successful pleurodesis, particularly in patients who underwent medical thoracoscopy. In conclusion, We found that instilling the mistletoe extract using a spray catheter was an effective pleurodesis method and could possibly be performed as an alternative to talc poudrage.

Differential regulation of mouse and human Mu opioid receptor gene depends on the single stranded DNA structure of its promoter and α-complex protein 1

Lee, Dong-Sun,Law, Ping-Yee,Ln, Wei,Loh, Horace H.,Song, Kyu Young,Choi, Hack Sun Spandidos Publications 2017 Biomedical reports Vol.6 No.5

Inductively Coupled Plasma Etching of AZO and ZnO in CI2/CH4/H2/Ar and BCI₃/CH4/H2/Ar Chemistries

Hack Joo Lee,Bong Soo Kwon,Young Rok Park,Joung Ho Ahn,Jin Sung Kim,Sun Il Kim,Hyun Woo Kim,Nae Eung Lee 한국표면공학회 2008 한국표면공학회 학술발표회 초록집 Vol.2008 No.-

Triterpene Acid ( <i>3</i> - <i>O</i> - <i>p</i> -Coumaroyltormentic Acid) Isolated From Aronia Extracts Inhibits Breast Cancer Stem Cell Formation through Downregulation of c-Myc Protein

Choi, Hack Sun,Kim, Su-Lim,Kim, Ji-Hyang,Deng, Hong-Yuan,Yun, Bong-Sik,Lee, Dong-Sun MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.9

<P>Cancer stem cells (CSCs) are drug-resistant and radiation-resistant cancer cells that are responsible for tumor progression and maintenance, cancer recurrence, and metastasis. Targeting breast CSCs with phytochemicals is a new paradigm for cancer prevention and treatment. In this study, activity-guided fractionation from mammosphere formation inhibition assays, repeated chromatographic preparations over silica gel, preparatory thin layer chromatography, and HPLC using aronia extracts led to the isolation of one compound. Using <SUP>1</SUP>H and <SUP>13</SUP>C 2-dimensional nuclear magnetic resonance (NMR) as well as electrospray ionization (ESI) mass spectrometry, the isolated compound was identified as <I>3</I>-<I>O</I>-<I>p</I>-coumaroyltormentic acid. This compound inhibits breast cancer cell proliferation and mammosphere formation in a dose-dependent manner and reduces the CD44<SUP>high</SUP>/CD24<SUP>low</SUP> subpopulation and aldehyde dehydrogenase (ALDH)-expressing cell population as well as the expression of the self-renewal-related genes <I>CD44</I>, <I>SOX2</I>, and <I>OCT4.</I><I>3</I>-<I>O</I>-<I>p</I>-Coumaroyltormentic acid preferentially reduced the protein levels of c-Myc, which is a CSC survival factor, by inducing c-Myc degradation. These findings indicate the novel utilization of <I>3</I>-<I>O</I>-<I>p</I>-coumaroyltormentic acid for breast cancer therapy via disruption of c-Myc protein, which is a CSC survival factor.</P>

Mid-term Clinical Outcomes in a Cohort of Asymptomatic or Mildly Symptomatic Korean Patients with Bicuspid Aortic Valve in a Tertiary Referral Hospital

Byung Joo Sun,Jin Kyung Oh,Sun Hack Lee,Jeong Yoon Jang,Ji Hye Lee,Sahmin Lee,Dae-Hee Kim,JongMinSong,Duk-Hyun Kang,Jae-Kwan Song 한국심초음파학회 2019 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.27 No.2

BACKGROUND: Although bicuspid aortic valve (BAV) is one of the most common congenital heart diseases, clinical outcome data regarding BAV are still limited. We evaluated clinical characteristics and mid-term clinical outcomes of asymptomatic Korean patients with bicuspid aortic valve. METHODS: We initiated a prospective registry in 2014 at a tertiary referral hospital. To develop a cohort of asymptomatic patients, we excluded patients who previously underwent open heart surgery (OHS) or who had OHS within 6 months of referral. RESULTS: A total of 170 patients (117 male [69%], age 50 ± 13 years) were enrolled. More than 70% (n = 124, 73%) were incidentally diagnosed with BAV during routine health examinations or preoperative screening for non-cardiac surgery. At the time of enrollment, moderate to severe aortic stenosis (AS) or regurgitation (AR) was present in 77 patients (45%) and 98 (58%) showed aortic dilation: 42 (25%) had non-significant valvular dysfunction without aortic dilation. During a median follow-up of 4 years, AS severity increased significantly (p < 0.001), while there was no significant change in AR severity (p = 0.361). A total of 27 patients (16%) underwent OHS, including isolated aortic valve (AV) surgery (n = 11, 41%), AV with combined aortic surgery (n = 12, 44%), and isolated aortic surgery (n = 4, 15%): no patient developed aortic dissection. Moderate to severe AS (hazard ratio [HR] 4.61; 95% confidence interval [CI] 1.83-11.62; p = 0.001), NYHA class ≥ 2 (HR 2.53; 95% CI 1.01-6.35; p = 0.048) and aortic dilation (HR 2.13; 95% CI 0.87-5.21; p = 0.099) were associated with surgical events. CONCLUSIONS: Progression patterns of valvular dysfunction and impacts of BAV phenotype on OHS should be explored in future studies with longer follow-up durations.

Salmonella typhi Salmonella typhimurium 및 Salmonella enteritidis의 항균제 감수성(1997)

신영학,유정식,김기상,정동준,오경수,이점규,이상원,이근영,박미선,이복권,김호훈 대한화학요법학회 1998 대한화학요법학회지 Vol.16 No.3

목적 : 국내에서 토착화 발생하여 공중보건학상 중요관리 대상 병원체인 장티푸스균과 최근 범세계적 유행추세를 보이고 있으며 우리나라에서도 급속히 증가추세를 보이고 있는 세균성 식중독의 원인균인 S. Enteritidis 및 S. Typhimurium을 대상으로 시험관내 항균제 감수성시험을 실시하여 항균제 내성양상을 파악하고자 하였다. 방법 : 1997년 1월부터 12월사이 전국 16개 시도 보건 환경 연구원 및 일부 종합병원으로부터 수집 동정한 장티푸스균 79주, S. Enteritidis 114주 및 S. Typhimurium 83주를 대상으로 미량 액체 희석 법으로 최소 발육 억제농도를 측정하고, break Point를 적용 내성양상을 분석하였다. 사용한 항균제는 β-lactam계 항균제로 ampicillin, amoxacillin, carbenicillin, cefoxitin, cephalothin, ceftriaxone, timentin(ticarcillin/clavulanic acid)을, aminoglycoside계로 streptomycin, amikacin, gentamicin, kanamycin을, quinolone계로 ciprofloxacin을 기타 tetracycline, nalidixic acid, chloramphenicol, trimethoprim, trim e th oprim/sulfamethoxazole등 총 17종 이었다. 결과 : 17종의 항균제중 1 종 이상의 항균제에 내성을 지니고 있는 균주가 장티푸스균 79주 중 15주 (19.0%), S. Enteritidis 114주중 14주(12.3%) 그리고 S. Typhimurium 83주 중 67주(80.7%) 였다. 시험에 공시된 살모넬라균종에 대해 전체적으로 tetracycline 및 페니린계의 항생제에 대한 내성균 검출빈도가 높았다. 다만 장티프스균의 경우 chloramphenicol 내성균주가 12주(15.2%) 검출되었으며, S. Typhimurium은 Streptomycin 내성 균주가 37주 (44.5%) 검출되어 높은 내성율을 보였다. 3균종 모두에서 ceftriaxone 및 ciprofloxacine 에 내성을 보이지 않았다. 다제내성 양성을 보면 장티프스균은 한가지 이상의 균제에 대해 내성을 나타낼 15주 중 10균주가 tetracycline, chloramphenicol, ampicillin, 및 trimethoprim등 4종 이상의 항균제에 대해 내성을 갖는 다제 내성 균주로 전체 내성균의 66.7%를 차치하였고 특히 9종의 항균제에 내성을 갖는 균이 3주, 8종의 항균제에 내성을 갖는 균이 5주나 검출되었다. S. Enteritidis균의 다계 내성 양상은 gentamycin을 비롯한 8종의 항균제에 내성을 지닌 균주가 1주 있었으며 4종이상의 항균제에 내성을 갖는 다제내성균이 6주로 내성균의 42.8%를 차지하였다. 주로 tetracycline과 페니실린계 항생제에 동시에 내성을 갖는 것으로 나타났다. S. Typhimurium의 다제내성양상은 tetracycline 및 streptomycin 등 2종의 항생제에 내성을 가진 형이 25주로 가장 많았으며, tetracycline 과 페니실린계 항생제에 동시에 내성을 나타내는 경우도 많았다. 또한 4종 이상의 항균제에 내성을 갖는 다제 내성균이 29주로 내성균의 43.3%를 차지했으며, S. Typhimurium DT104 주와 유사한 항균제 내성 양상을 나타내는 균주도 확인되었다. 결론 : 국내에서 분리된 장티푸스균, S. Enteritidis 및 S. Typhimurium 감수성 시험 결과 항균제 내성이 현재까지 일반적인 항균제에 국한되어 있으나 S. Typhimurium DT104주와 유사한 항균제 내성 양상을 보이는 균주가 확인되었고 과거에는 분리 보고가 흔하지 않았던 4종이상의 항균제에 내성을 지닌 장티푸스균이 다수 검출되었으므로 항균치료제 선택에 신중을 기함은 물론 내성균주 감시를 체계적이고 지속적으로 실시하여야 할 것으로 사료된다. Background : Salmonella Typhi, an endemic in Korea, S. Enteritidis and S. Typhimurium, major organisms of bacterial food poisoning, which have been responsible for numerous outbreak in the m7orld including Korea currently are important organisms to be in control. At this point, to understand current antimicrobial resistance of the three Salmonella serovars in Korea, we conducted in vitro susceptibility studies to 17 antimicrobial agents. Methods : We tested antimicrobial susceptibility by a microbroth dilution method. The target organisms are 79 isolates of S. Typhi, 114 isolates of S. Enteritidis, and 83 isolates of S. Typhimurium collected on January through December 1997 in Korea. Results : The resistance rates to one or more antimicrobial agents are 19.0%(15/79 isolates) for S. Typhi, 12.3% (14/114 isolates) for S. Enteritidis, and 80.7% (67/83 isolates) for S. Typhimurium. Grossly, the organisms' resistance rates to tetracycline and penicillins are higher than that of other agents with two exceptions : 15.2% to chloramphenicol (12/79 isolates) for S. Typhi and 44.6% to streptomycin (37/83 isolates) for S. Typhimurium. Multi-drug resistant (MDR) strains to four or more antimicrobial agents among the resistant organisms are quite high: 66.7% (10/15 isolates), 42.8% (6/14 isolates), and 43.3% (29/67 isolate) for S. Typhi, S. Enteritidis, and S. Typhimurim, respectively. Conclusion : From this investigatron, we found that the MDR strains of S. Typhi, S. Enteritidis, and S. Typhimurim have increased than previous studies. It implies that limitation of unnecessary use of drugs is very important. in order to maintain the efficacy of drugs.

외ㆍ내부 압력을 받는 안전판의 형상 설계

이기선(Gy-Sun Lee),신영훈(Young-Hun Shin),이영민(Young-Min Lee),김인학(In-Hack Kim) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.11

In this study, to obtain basic data for the shape design of the safety plate that is used in the battery section of underwater vehicle, we carried out the structure analysis and pressure tests about it. The safety plate is the important part that prevents the breakage of a underwater moving body by the pressure increase inside that. The safety plate must holds pressure outside and inside of a moving body and clear up pressure increase by the burning of a battery section inside it. So, to design the shape of a safety plate is satisfied these conditions, we carried out structure analysis and pressure tests and designed and applied these results to the shape design of the safety plate these results.