카르보닐화합물에 대한 유기티타늄화합물의 화학선택성에 대한 연구

이근설,김희정 상명대학교 기초과학연구소 1992 기초과학연구 Vol.6 No.-

카르보음이온 화학은 탄소-탄소 결합을 형성하는 유기합성분야에서 가장 중요한 부분중의 하나이다. 고전적인 카르보음이온, 예를 들어 알킬리튬 또는 Grignard 시약은 카르보닐화합물에 대해 높은 반응성을 나타내는 반면 낮은 선택성을 갖는다. 반면에 RTiX3로 표현되는 유기티타늄 화합물은 카르보닐 화합물에 대해 화학적이고 입체적인 선택성이 높은 것으로 알려졌다. 본 연구에서는 trichlorophenyltitanium을 합성하여 이것의 카르보닐 화합물에 대한 반응성을 본 결과 다른 유기티타늄 화합물과 같이 알데히드 화합물에 선택적인 반응성을 나타내는 것을 알 수 있었다. Carbanion chemistry is one of the most important field in organic synthesis, expecially for the formation of C-C bond. Though the classical carbanions, for example alkyllithium or Grignard reagent, show high reactivity for the carbonyl compounds, but they react with low selectivity. On the other hand, it is well known that organotitanium compounds generally expressed as RTiX₃(R=methyl, allyl) have high chemo-and stereoselectivity. In this study trichlorophenyltitanium was prepared in situ from phenyllithium and titaniumtetrachloride and was added to carbonyl compounds in order to investigate its reactivity. As a result this reagent was proved to have the same aldehyde reactivity as the other organotitanium compounds.

2-(N, N- dimethylamino) phenyl triisopropoxy titanium 화합물의 카르보닐 화합물에 대한 첨가 반응 연구

이근설,김희정 상명대학교 기초과학연구소 1992 기초과학연구 Vol.7 No.-

카르보음이온 화학은 탄소-탄소 결합을 형성하는 유기합성분야에서 가장 중요한 부분중의 하나이다. 고전적인 카르보음이온, 예를들어 알킬리튬 또는 Grignard시약은 카르보닐 화합물에 대해 높은 반응성을 나타내는 반면 낮은 선택성을 갖는다. 반면에 RTiX₃(R=methyl, allyl)로 표현되는 유기티타늄 화합물은 카르보닐 화합물에 대해 화학적이고 입체적인 선택성이 높은 것으로 알려졌다. 본 연구에서는 2-(N, N-dimethylamino phenyl) triisopropoxy titanium을 합성하여 이것의 카르보닐 화합물에 대한 반응성을 본 결과 다른 유기티타늄 화합물과 같이 알데히드 화합물에 선택적인 반응성을 나타내는 것을 알수있었다. Carbanion chemistry is one of the most important field in organic synthesis, expecially for the formation of C-C bond. Though the classical carbanions, for example alkyllithium or Grignard reagent, Show high reactivity for the carbonyl compounds, but they react with low selectivity. On the other hand, it is well known that organotitanium compounds generally expressed as RTiX₃(R=methyl, allyl) have high chemo-and stereoselectivity. In this study 2-(N, N-dimethylamino phenyl) triisopropoxy titanium was prepared in situ from 2-(N, N-dimethylamino) phenyllithium and chloridetriisopropoxytitanium and was added to carbonyl compounds in order to investigate its reactivity. As a result this reagent was proved to have the same aldehyde reactivity as the other organotitanium compounds.

한우, 칡소 및 제주 흑우 Calpain-Calpastatin 유전자 다양성

이승환,김승창,조수현,최봉환,Aditi Sharma,임다정,당창권,장선식,김재환,고문석,양보석,강희설 충남대학교 농업과학연구소 2013 농업과학연구 Vol.40 No.2

The aim of study was to investigate genetic diversity for the calpain/calpastatin gene in three Hanwoo breeds [(Brown (n=62), Brindle (n=81) and Jeju Black (n=30)]. Random samples from three breeds of Hanwoo were selected and genotyped for the 7 SNPs of calpain/calpastatin using TaqMan method. Allele frequencies were investigated for CAPN1/CAST gene. Allele frequency of CAST2 SNP was 0.75, 0.59 and 0.22 for Brown, Brindle and Jeju black, respectively. The CAST3 revealed allele frequency of 0.59 and 0.57 in Brown and Jeju Black, while it showed very low allele frequency (0.07) in Brindle. In particular, favorable allele (G allele) for the CAPN1-2 SNP which was shown a strong association with tenderness in Taurine and Indicine cattle revealed 16% and 17% higher allele frequency in Brown Hanwoo (0.82) comparing Brindle (0.66) and Jeju Black Hanwoo (0.65). AMOVA demonstrated that among population variance occupied only 10% of total variance and among individual variance was 0%, while within individual variance was 90% of total variance. This result showed that population effect contributed very small portion of genetic to these three Hanwoo breeds, while within individual variance contributed large portion of genetic diversity within these Hanwoo breeds. In conclusion, three Hanwoo breeds (Brown, Brindle and Jeju black) showed a genetically homogeneous based on the 7 SNPs of CAPN1/CAST gene and it came from same ancestor to form modern Hanwoo breed.

Validation of the oxford classification of iga nephropathy: A Single-Center Study in Korean Adults

( Ho Young Lee ),( Sul Hee Yi ),( Mi Seon Seo ),( Jin Nam Hyun ),( Jin Seok Jeon ),( Hyunjin Noh ),( Dong Cheol Han ),( Seung Duk Hwang ),( So Young Jin ),( Soon Hyo Kwon ) 대한내과학회 2012 The Korean Journal of Internal Medicine Vol.27 No.3

Background/Aims: The recently published Oxford classification of IgA nephropathy (IgAN) proposed a split system for histological grading, based on prognostic pathological features. This new classification system must be validated in a variety of cohorts. We investigated whether these pathological features were applicable to an adult Korean population. Methods: In total, 69 adult Korean patients with IgAN were analyzed using the Oxford classification system at Soonchunhyang University Hospital, Seoul, Korea. All cases were categorized according to Lee`s classification. Renal biopsies from all patients were scored by a pathologist who was blinded to the clinical data for pathological variables. Inclusion criteria were age greater than 18 years and at least 36 months of follow-up. We excluded cases with secondary IgAN, diabetic nephropathy combined other glomerulopathies, less than 36 months of follow-up, and those that progressed rapidly. Results: The median age of the patients was 34 years (range, 27 to 45). Mean arterial blood pressure was 97 ± 10 mmHg at the time of biopsy. The median follow-up period was 85 months (range, 60 to 114). Kaplan-Meier analysis showed significant prognostic predictions for M, E, and T lesions. A Cox proportional hazard regression analysis also revealed prognostic predictions for E and T lesions. Conclusions: Using the Oxford classification in IgAN, E, and T lesions predicted renal outcome in Korean adults after taking clinical variables into account.

흉추부 신경병증에서 체성감각 유발전위검사의 임상적 유용성

안경회,오진주,김희상,이종하,정용설 대한근전도전기진단의학회 2003 대한근전도 전기진단의학회지 Vol.5 No.1

[P140] Psoriasis, vitiligo and crohn`s disease co-existing in a single patient: a variant type of multiple autoimmune syndrome?

( Sul Hee Lee ),( Seung Min Lee ),( Ga Hee Jung ),( Moon Kyun Cho ),( Sung Yul Lee ),( Young Lip Park ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Multiple autoimmune syndrome (MAS) is a rare condition, in which at least three well-defined autoimmune diseases co-occur in a single patient. Although the pathogenesis of MAS remains poorly understood, genetic, immunological, hormonal, and environmental factors may all play a role. Although three classic subtypes of MAS are well known, several cases that could not be placed into any of these three categories have recently been reported. To the best of our knowledge, the co-existence of psoriasis, vitiligo, and Crohn`s disease has been reported in only one patient, who had a total of five autoimmune diseases (alopecia areata and oral lichen planus in addition to the three conditions mentioned). We herein describe a rare case of MAS presenting with psoriasis, vitiligo, and Crohn`s disease, and suggest that tumor necrosis factor-α may be associated with the pathogenesis of all three conditions.

Health-related quality of life and mental health status in Korean adults with atopic dermatitis

( Sul Hee Lee ),( Ji Yeoun Shin ),( Kyu Rak Hong ),( Sang Hoon Lee ),( Jong Suk Lee ),( Sung Yul Lee ),( Young Lip Park ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Atopic dermatitis (AD) is a pruritic eczematous skin disorder. Patients with AD often suffer from a lot of mental distress and poor health-related quality of life (HRQoL). Objectives: The aim of this study was to investigate the association of several mental health statuses and poor HRQoL with AD in an adult population in Korea. Methods: A total of 38,741 adults who participated in the Korean National Health and Nutrition Examination Survey, a nationwide, population-based, cross-sectional health survey between 2008 and 2013 were included. HRQoL was assessed by EuroQoL (EQ) 5-dimension questionnaire and EQ-visual analog scale scores. Multiple logistic regression analysis was performed to identify the association of stress, sleep duration, depressive mood, depression, suicidal ideation, and HRQoL with AD relative to matched controls. Results: After adjusting confounding factors, stress, depressive mood, depression, suicidal ideation and poor HRQoL were significantly associated with AD. Conclusion: Dermatologists should be concerned with improving HRQoL and managing the mental health status of adult AD patients.

Isoflavone Content and Estrogen Activity in Arrowroot Puerariae Radix

Hee-Yun Kim,Jin-Hwan Hong,Dong-Sul Kim,Kil-Jin Kang,Sang-Bae Han,Eun-Ju Lee,Hyung-Wook Chung,Kyung-Hee Song,Kyung-A Sho,Seung-Jun Kwack,Soon-Sun Kim,Kui-Lea Park,Si-Kyung Lee,Myung-Chul Kim,Chang-Min 한국식품과학회 2003 Food Science and Biotechnology Vol.12 No.1

한국식품성분에 관한 연구 : 지방산 함량 측정(Ⅱ) Determination of fatty acid contents(Ⅱ)

이달수,권혁희,김소희,김인복,권오란,이혜영,장재희,최종택,김동술,윤인숙,박지영,강주희 식품의약품안전청 1997 식품의약품안전청 연보 Vol.1 No.-

본 연구는 식품의 종류에 따른 인공감미료(아스파탐, 삭카린나트릅)의 소비실태 파악하고 국내의 식이를 통해 실제섭처되는 인공감미료의 총 섭쒸량을 조사하여 Ffto/w됐0에서 설정한 일일섭취허용량(ADI)과 비교검토함으로서 인공감미료에 대한 ADI관련 기초자료를 확보하고, 인공감미료의 실제 섭취량과 현행 사용기준사이의 안전수준평가 및 사용기준에 환련된 국가정책반됨 자료로 활용하고rl수행하였파. 이에 똔 연국에서는 시증에서 유통되고 있는 제품중 시리얼, 껌, 캔디류, 다류, 주퓨, 쥬스, 탄산음료, 아이스크림, 발효유의 총 9종 239품목(아스파탐) 및 쥬스, 탄신음료, 어묵, 잣갈류의 총 4종 115품목(삭카린나트륨)을 래상으로 시료를 수짐한 후 분석대상식품별로 함량을 측정하고 국띤영양조사잔료에 근거하여 진제 섭취량을 산출하였다. HPLC에 의해 분석한 결과 아스파탐 분석데상식품의 회수율은 91.97~97,04%으로 매우 양호하였으며 대살식품 239품목중 22품목이 검출되었고, 검출된 대상식품별 평균농도 41.6~3308.OPpm으로 나타났다. 삭카린나트륨 분석대상식품의 회수율은 88.39~91.48%로 양호한 결과를 얻얼으며 대상식품 115품목중 6품목이 검출되었고, 검출된 대상식품별 편균농도는 8.3~41.appm의 범위였다. 국민영양조 사표의 식품별 1인 1일당섭취쟈과 평균검출농도를 곱한 일일추정섭취량(EDT)을 산출하였을 매 아스파탐은 2.334ing으로 ADI(0"40mg/kg b.w.fday을 국민평균체중 S5kg으로 환산하였을 래의 0~2200mg)와 배교하였을 때 파우 낮은 수치를 보였으며 삭카린나트륨도 0.259rng으로 ADI(e~Smg/kg b.w./day을 국민평균체중 55kg으로 환산하였을 때의 0"275ing)과 비교.하였을 때 매우 낮은 결과를 나타내었다. 이상에서 가공식품을 통한 조사대상 인공감미료꿀 아스파탐과 삭카린나트륨의 한국인 일일섭취량은 FAO/WHO에서 정가된 일일섭취허용량(ADT)의 1% 미만이므로 대상식품을 통한 첨가물 썹취는 안전하다고 평가된다. The types and quantity of fatty acids are very important fot the public health due to their different functions on the body and their relationship with the cardiovascular disease. Thus, it's necessary to establish fatty acid database, by which we can estimate more accurately nutritional ststus of the people. The fatty acid database, however, is lacking in Korea. Therefore, we determined fatty acid contents and the composition of 50 species in Korean common foods in 1996, and continued to do those of 60 species in 1997. And the results obtained were as follows. Grains, fungi, seeds nuts and pulses had much more n-6 fatty acids than any other fatty acids and the important n-6 fatty acid was linoleic acid. In contrast, vegetables and seafoods were high in n-3 fatty acids, and linolenic acid was the major fatty acid in case of leaff vegetables, on the other hand, eicosapentaenoic acid and docosaheraenoic acid were the major fatty acids in case of seafoods. Meats had high saturated fatty acids in comparison with other food groups. Monounsaturated fatty acid was relativety high in seeds · nuts and meats. The results will be basic data on several nutritional studies, education and policy to improve the public health and to prevent them from disease.

Psoriasis, Vitiligo and Crohn’s Disease Co-Existing in a Single Patient: A Variant Type of Multiple Autoimmune Syndrome?

( Sul Hee Lee ),( Ye Seul Kim ),( Hyun Ju Kim ),( Young Lip Park ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.6

Multiple autoimmune syndrome (MAS) is a rare condition, in which at least three well-defined autoimmune diseases co-occur in a single patient. Although the pathogenesis of MAS remains poorly understood, genetic, immunological, hormonal, and environmental factors may all play a role. Although three classic subtypes of MAS are well known, several cases that could not be placed into any of these three categories have recently been reported. To the best of our knowledge, the co-existence of psoriasis, vitiligo, and Crohn’s disease has been reported in only one patient, who had a total of five autoimmune diseases (alopecia areata and oral lichen planus in addition to the three conditions mentioned). We herein describe a rare case of MAS presenting with psoriasis, vitiligo, and Crohn’s disease, and suggest that tumor necrosis factor-α may be associated with the pathogenesis of all three conditions. (Ann Dermatol 29(6) 782∼785, 2017)