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Inhibition of poly(I:C)-induced inflammation by salvianolic acid A in skin keratinocytes
( Su-hyuk Yim ),( Qing-ling Zhang ),( Xue Mei Li ),( Jin Gwi Yoo ),( Dong-kyun Hong ),( Jin-hyup Lee ),( Chong Won Choi ),( Kyung Duck Park ),( Young Lee ),( Chang Deok Kim ),( Young-joon Seo ),( Jeun 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: Skin keratinocytes participate actively in inducing immune responses when external pathogens are introduced, thereby contributing to elimination of pathogens. However, in condition where the excessive inflammation is occurred, chronic skin disease such as psoriasis can be provoked. Objectives: We tried to screen the putative therapeutics for inflammatory skin disease, and found that salvianolic acid A (SAA) has an inhibitory effects on keratinocyte inflammatory reaction. The aim of this study is to demonstrate the effects of SAA in poly(I:C)-induced inflammatory reaction in skin keratinocytes. Methods: The keratinocytes were pretreated with SAA then stimulated with poly(I:C). Inflammatory reaction of keratinocytes, then we verified using RT-PCR, ELISA and Western blot. Results: When skin keratinocytes were pre-treated with SAA, it significantly inhibited poly(I:C)-induced expression of inflammatory cytokines including IL-1β, IL-6, IL-8, TNF-α, and CCL20. SAA inhibited poly(I:C)-induced activation of NF-κB signaling. And SAA also inhibited inflammasome activation, evidenced by decrease of IL-1β secretion. Finally, SAA markedly inhibited poly(I:C)-induced NLRP3 expression. Conclusion: These results demonstrate that SAA has an inhibitory effect on poly(I:C)-induced inflammatory reaction of keratinocytes, suggesting that SAA can be developed for the treatment of inflammatory skin diseases such as psoriasis.
Hypertrichosis lanuginosa acquisita associated with autoimmune hepatitis
( Su-hyuk Yim ),( Jin-hyup Lee ),( Dong-kyun Hong ),( Kyung-duck Park ),( Chong Won Choi ),( Young-joon Seo ),( Jeung-hoon Lee ),( Young Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Hypertrichosis lanuginosa acquisita (HLA) is a very rare condition characterized by the appearance of fine lanugo hairs on the face, which are relatively long and have a few pigment. The lanugo hairs grow from the face, spread to the other part, which become darker and coarse. A 46-year-old woman presented with dense hair growth on face, neck, shoulder and back, which began a year ago. Blood tests and imaging studies were performed to exclude the possibility of malignancy or hormonal and autoimmune disorders associated with sudden onset of acquired hypertrichosis. There was abnormal in liver function test and positive in autoimmune antibody test. Furthermore, the hepatitis viral markers were negative and liver biopsy confirmed the prominent autoimmune hepatitis. Finally, the patient was diagnosed with HLA associated with autoimmune hepatitis. HLA is often associated with endocrine or metabolic disorders (e.g. hyperthyroidism and porphyria), malignancy and medication (e.g. cyclosporine, phenytoin, minoxidil). HLA with autoimmune hepatitis is rare and the precise mechanisms of autoimmune hepatitis and HLA have not been elucidated yet. Our observation expands the spectrum of diseases associated with HLA.
A case of Sweet's syndrome localized in photodistributed area
( Su-hyuk Yim ),( Jin-hyup Lee ),( Kyung-duck Park ),( Chong Won Choi ),( Young Lee ),( Young-joon Seo ),( Jeung-hoon Lee ),( Dong-kyun Hong ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Sweet's syndrome is characterized by fever, pain, and an increase in neutrophil counts in peripheral blood with erythematous papules or plaques with sudden pain. Histologically, it has a characteristic feature of neutrophilic infiltration in the dermis. Fever and increased neutrophil count in peripheral blood may vary from patient to patient. A 68-year old man visited our clinic with 2-month history of erythematous papules and pseudovesicles with sudden onset itching sense on the bilateral forearms. The lesions have some pain and mainly located on the sun exposed areas. Skin biopsy was performed on the forearm lesion. Histopathological examination revealed vacuolated basal keratinocyte and neutrophil populations in the dermis layer and solar elastosis. The treatment with antihistamines, topical steroids and sunscreen were effective and the patient was improved. Sweet's syndrome usually occurs on the face, neck, trunk, arms and legs. In this case, the lesions appeared only the sun exposed part of both arms. Herein, we report a case of photodistributed sweet's syndrome that is confined to the sun exposure area.
Tumor suppressive function of NQO1 in cutaneous squamous cell carcinoma cells
( Su-hyuk Yim ),( Qing-ling Zhang ),( Dongkyun Hong ),( Kyoung Eun Jung ),( Chong-won Choi ),( Young Lee ),( Chang-deok Kim ),( Young-joon Seo ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: Cutaneous squamous cell carcinoma (SCC) is an easily occurred cancer, which can worsen the quality of life considerably. It is known that external stimulus induces cutaneous SCC via provoking oxidative stress. NAD(P)H dehydrogenase 1 (NQO1) has functions as a guardian against oxidative stress. However, the effect of NQO1 on cutaneous SCC is not clearly elucidated. Objectives: In this study, we investigated the effect of NQO1 on cutaneous SCC cells. Methods: To examine the effects of NQO1, we transduced SCC lines (SCC12 and SCC13) with the NQO1 expressing or knockdown adenovirus. Results: Overexpression of NQO1 resulted in significant decrease of cell proliferation and colony forming activity of SCC lines. By contrast, knockdown of NQO1 increased the cell proliferation and colony forming activity. Accordingly, the levels of proliferation-related regulators, such as CDK4, CDK6, SOX2 and p63, were decreased by overexpression of NQO1, while those were increased by knockdown of NQO1. In addition, NQO1 affected the invasion and migration of SCC cells in a very similar way, with the regulation of epithelial-mesenchymal transition (EMT)-related molecules, including E-cadherin, N-cadherin, Vimentin, Snail and Slug. Finally, overexpression of NQO1 decreased the level of phosphorylated AKT, JNK and p38 MAPK, while knockdown of NQO1 increased the level of phosphorylated signaling molecules. Conclusion: Based on these data, NQO1 has tumor suppressive function in cutaneous SCC cells.
Bullous fixed drug eruption due to topiramate
( Su-hyuk Yim ),( Jin-hyup Lee ),( Kyung-duck Park ),( Chong Won ),( Choi Young Lee ),( 3young-joon Seo ),( Jeung-hoon Lee ),( Dong-kyun Hong ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Fixed drug eruption is a well-demarcated, erythematous, patchy or blistering skin lesion that occurs repeatedly at the same site. The lesion occurs when exposed to the causative agent, leaving hyperpigmentation after healing. A 32-year-old young woman visited our clinic with a wrinkled blister-like lesion on her wrist 3-4 days earlier. She had a similar lesion occurred in the same site and the scar was left. She had no specific illness but was taking acetaminophen, alginic acid, caffeine and topiramate for the purpose of weight loss. Based on the fact that the lesion recurred mainly in similar locations, patch tests were performed on the normal skin of the patient for the four suspected drugs. Patch test showed positive finding for topiramate. In the case of a fixed drug eruption showing a blister lesion observed on the wrist, it may be necessary to distinguish between friction blister and other bullous diseases. In recent years, the use of weight-loss drugs has been increasing, so it is necessary to recognize the drug eruption of these drugs. Therefore, we report a rare case of bullous fixed drug eruption caused by topiramate for the weight loss.
( Su-hyuk Yim ),( Dongkyun Hong ),( Kyoung Eun Jung ),( Young Lee ),( Young-joon Seo ),( Chong-won Choi ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
finding that physicians can often observe. Most cases of LM are benign and wait-and-see is a preferred approach for LM; however it is import for clinicians to distinguish subungal melanoma (SUM) from other benign conditions. Objectives: To evaluate the demographic and clinicopathologic characteristics of LM in Korean population and to identify distinguishing features of SUM from other benign conditions. Methods: This was a single center retrospective cohort study including patients who underwent nail biopsy for LM from January 2000 to May 2019. To investigate the predictor for SUM, multivariable logistic regression analysis was performed. Results: A total 68 cases of biopsy proven LM were included in the analysis. Among the 68 cases, 8 cases were SUM. The patients diagnosed with SUM were older (P=.005), had a longer duration of LM (P=.016). Also, they presented with a right side of extremities (P=.046), wider width of LM (P=.002), and more frequent nail dystrophy (P=0.15) than patients who diagnosed with benign conditions. The width of LM was the predictor for SUM among LM (odds ratio 1.084, 95% confidence interval 1.022-1.149). Conclusion: SUM has distinct demographic and clinical features, such as old age, longer duration of LM, right side of extremities, dystrophic nail and wider width of LM. Clinicians should consider the width of LM to determine possibility of malignancy among patients with LM.
( Su-hyuk Yim ),( In Sun Kwon ),( Dongkyun Hong ),( Kyung Eun Jung ),( Young Lee ),( Young-joon Seo ),( Chong Won Choi ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.2
Background: Longitudinal melanonychia (LM) is a common clinical finding. Most cases of LM are benign, and a wait-and-see approach is preferred in the management of this condition. Nevertheless, it is important for clinicians to distinguish subungual melanoma (SUM) from other benign LMs. Objective: To evaluate the demographic and clinicopatho-logic characteristics of LM in the Korean population and to identify the predictor of SUM against other benign conditions. Methods: This was a single-center retrospective cohort study including patients who underwent nail biopsy for LM from January 2000 to May 2019. To identify the predictor of SUM, receiver operating characteristic (ROC) analyses was performed. Results: A total of 68 cases of biopsy-proven LM were included in the analysis. Among the 68 cases, 8 were SUM. In univariable analysis, patients diagnosed with SUM were older (p=0.035) and had a longer disease duration (p=0.004). They also showed multicolor pigmentation of LM (p=0.022), a larger width of LM (p<0.001), and associated nail plate dystrophy (p=0.010) than patients diagnosed with benign conditions. In multivariable logistic regression, width of LM showed statistical significance (odds ratio, 1.083; 95% confidence interval, 1.018∼1.153). ROC analysis suggested that an LM width >28% of the whole nail was the predictor of SUM (area under the curve=0.883; p<0.001). Conclusion: SUM has distinct demographic and clinical features. The width of LM can predict SUM against other benign LMs. (Ann Dermatol 33(2) 147∼153, 2021)