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Jeong Gu Kang,Sang Yoon Park,Suena Ji,In Sook Jang,Su Jin Park,Hyeon Gyu Seo,Hanbyeol Kim,Eun Ah Kim,Ho Jung Seo,Yang Shin Lee,Jürgen Roth,Jin Won Cho 한국당과학회 2010 한국당과학회 학술대회 Vol.2010 No.1
The O-GlcNAc modification is a quite different fro m conventional glycosylation in two aspects. First, it occurs in cytoplasm and nucleus and does not in endoplasmic reticulum or Golgi apparatus. Second, this is a single sugar modification and is not a long chain oligosaccharide modification. O-GlcNAc is covalently modified on hydroxyl group of serine and threonine and usually this modification affects or competes with phosphorylation. Thus this modification might modulate many cellular events due to inhibiting or sometimes accelerating phosphorylation. O-GlcNAc transferase and O-GlcNAcase are two important enzymes for modifying proteins with O-GlcNAc. More than 800 proteins have been identified as O-GlcNAcylated proteins. Today I am going to summarize results obtained last 10 years and discuss about future aspects in O-GlcNAc biology.
빅데이터를 활용한 기후변화와 연계된 생태계서비스 연구 동향분석
서자유 ( Seo J A-yoo ),최요한 ( Choi Yo-han ),백지원 ( Baek J I-won ),김수경 ( Kim Su-kyoung ),김호걸 ( Kim Ho-gul ),송원경 ( Song Won-kyong ),주우영 ( Joo Woo-yeong ),박찬 ( Park Chan ) 한국환경복원기술학회 2021 한국환경복원기술학회지 Vol.24 No.6
This study was performed to investigate the ecosystem service patterns in relation to climate change acceleration utilizing big data analysis. This study aimed to use big data analysis as one of the network of views to identify convergent thinking in two fields: climate change and ecosystem service. The keywords were analysed to ascertain if there were any differences in the perceiving problems, policy direction, climate change implications, and regional differences. In addition, we examined the research keywords of each continent, the centre of ecosystem service research, and the topics to be referred to in domestic research. The results of the analysis are as follows: First, the keyword centrality of climate change is similar to the detailed indicators of The Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) regulations, content, and non-material ecosystem services. Second, the cross-analysis of terms in two journals showed a difference in value-oriented point; the Ecosystem Service Journal identified green infrastructure as having economic value, whereas the Climate Change Journal perceives water, forest, carbon, and biodiversity as management topics. The Climate Change Journal, but not the former, focuses on future predictions. Third, the analysis of the research topics according to continents showed that water and soil are closely related to the economy, and thus, play an important role in policy formulation. This disparity is due to differences in each continent's environmental characteristics, as well as economic and policy issues. This fact can be used to refer to the direction of research on ecosystem services in Korea. Consistent with the recent trend of expanding research regarding the impacts of climate change, it is necessary to study strategies to scientifically predict and respond to the negative effects of climate change.
Seo, Kinya,Rainer, Peter P.,Shalkey Hahn, Virginia,Lee, Dong-ik,Jo, Su-Hyun,Andersen, Asger,Liu, Ting,Xu, Xiaoping,Willette, Robert N.,Lepore, John J.,Marino Jr., Joseph P.,Birnbaumer, Lutz,Schnackenb National Academy of Sciences 2014 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.111 No.4
<P>Chronic neurohormonal and mechanical stresses are central features of heart disease. Increasing evidence supports a role for the transient receptor potential canonical channels TRPC3 and TRPC6 in this pathophysiology. Channel expression for both is normally very low but is increased by cardiac disease, and genetic gain- or loss-of-function studies support contributions to hypertrophy and dysfunction. Selective small-molecule inhibitors remain scarce, and none target both channels, which may be useful given the high homology among them and evidence of redundant signaling. Here we tested selective TRPC3/6 antagonists (GSK2332255B and GSK2833503A; IC<SUB>50</SUB>, 3–21 nM against TRPC3 and TRPC6) and found dose-dependent blockade of cell hypertrophy signaling triggered by angiotensin II or endothelin-1 in HEK293T cells as well as in neonatal and adult cardiac myocytes. In vivo efficacy in mice and rats was greatly limited by rapid metabolism and high protein binding, although antifibrotic effects with pressure overload were observed. Intriguingly, although gene deletion of TRPC3 or TRPC6 alone did not protect against hypertrophy or dysfunction from pressure overload, combined deletion was protective, supporting the value of dual inhibition. Further development of this pharmaceutical class may yield a useful therapeutic agent for heart disease management.</P>
Seo, Seongho,Kim, Su J,Kim, Yu K,Lee, Jee-Young,Jeong, Jae M,Lee, Dong S,Lee, Jae S SAGE Publications 2015 Journal of cerebral blood flow and metabolism Vol.35 No.12
<P> In recent years, several linearized model approaches for fast and reliable parametric neuroreceptor mapping based on dynamic nuclear imaging have been developed from the simplified reference tissue model (SRTM) equation. All the methods share the basic SRTM assumptions, but use different schemes to alleviate the effect of noise in dynamic-image voxels. Thus, this study aimed to compare those approaches in terms of their performance in parametric image generation. We used the basis function method and MRTM2 (multilinear reference tissue model with two parameters), which require a division process to obtain the distribution volume ratio (DVR). In addition, a linear model with the DVR as a model parameter (multilinear SRTM) was used in two forms: one based on linear least squares and the other based on extension of total least squares (TLS). Assessment using simulated and actual dynamic [<SUP>11</SUP>C]ABP688 positron emission tomography data revealed their equivalence with the SRTM, except for different noise susceptibilities. In the DVR image production, the two multilinear SRTM approaches achieved better image quality and regional compatibility with the SRTM than the others, with slightly better performance in the TLS-based method. </P>
Seo, Kyu Won,Choi, Yong-Su,Gu, Man Bock,Kwon, Eilhann E.,Tsang, Yiu Fai,Rinklebe, Jö,rg,Park, Chanhyuk Elsevier 2017 CHEMOSPHERE - Vol.186 No.-
<P><B>Abstract</B></P> <P>A pilot-scale investigation of membrane-based aerobic digestion system dominated by endospore-forming bacteria was evaluated as one of the potential sludge treatment processes (STP). Most of the organic matter in the sludge was removed (90.1%) by the particular bacteria in the STP, which consisted of mixed liquor suspended solid (MLSS) contact reactor (MCR), MLSS oxidation reactor (MOR), and membrane bioreactor (MBR). The sludge was accumulated in the MBR without wasting, and then the effluent in STP was fed into the first step in water resource recovery facility (WRRF). According to the analysis of microbial communities in all reactors, various <I>Bacillus</I> species were present in the STP, mainly due to their intrinsic resistance to the extreme conditions. As the surviving <I>Bacillus</I> species might consume degraded microorganisms for their growth, these endospore-forming bacteria-based STP could be suitable for the sludge reduction when they operated for a long time.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A pilot-scale sludge treatment process was developed and investigated. </LI> <LI> Membrane-based aerobic digestion system could accumulate the sludge. </LI> <LI> 90% of sludge reduction was achieved in sludge treatment process. </LI> <LI> <I>Bacillus</I> species was dominant and influenced on the sludge reduction. </LI> <LI> Endospore-forming bacteria-based process could be suitable for sludge reduction. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Jeonghwan Seo,Huang Xing,Su Jang,Sunghan Kim,Hee-Jong Koh 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07
Hybrid sterility is a critical barrier of inter-subspecific crosses in rice. However, hybrid sterility can be overcome by wide compatibility variety. The HWC-line of rice had slender grain shape, tall culm length, wide compatibility with both indica and japonica cultivars. For QTL analysis of HWC-line, two F2 populations were derived from the crosses between the HWC-line and each of two Korean variety, Dasan (Korean Tongil-type cultivar) and Hwacheong (temperate japonica cultivar). In the cross between HWC-line/Dasan (HD), 93 STS markers and 13 SSR markers were mapped on 12 chromosomes. In the population from HWC-line/Hwacheong (HH) cross, 28 STS markers, 29 SSR markers and 1 FNP marker were mapped on 11 chromosomes. Eight agronomic characters were evaluated for QTL analysis in two F2 populations and parents. The F2 population from HD cross revealed 21 M-QTLs and 3 E-QTL for culm length, spikelet per panicle, spikelet fertility, grain length, grain width, grain shape and 100 grains weight. 8 QTLs of culm length, grain length, grain width and grain shape were newly detected in this study. In the F2 population from HH cross, 17 M-QTLs were detected for culm length, panicle length, spikelet fertility, grain length, grain width, grain shape and 100 grains weight. 6 QTLs of culm length, grain length, grain width and grain shape were newly found in this study. These QTLs will be able to provide basic information on putative functional genes related with agronomic characters and promote breeding new rice cultivar. HWC-line could be used as bridge for inter-subspecies crosses and in hybrid breeding.