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Lee, Kiho,Kwon, Byoung-Mog,Kim, Kangjeon,Ryu, Jekyung,Oh, Soo Jin,Lee, Kye Sook,Kwon, Mu-Gil,Park, Song-Kyu,Kang, Jong Soon,Lee, Chang Woo,Kim, Hwan Mook Taylor Francis 2009 Xenobiotica Vol.39 No.3
<P>The pharmacokinetics and metabolism of 2'-benzoyloxycinnamaldehyde (BCA) was characterized in male Sprague-Dawley rats as part of the preclinical evaluations for developing this compound as an antitumour agent. BCA was not detected in the plasma following either intravenous or oral dose, whereas its putative metabolites 2'-hydroxycinnamaldehyde (HCA) and o-coumaric acid were present at considerable levels. In separate pharmacokinetics studies, HCA exhibited a high systemic clearance and a large volume of distribution, whereas both pharmacokinetic parameters were much lower for o-coumaric acid. The terminal half-life of both metabolites was approximately 2 h. BCA was converted rapidly to HCA in rat serum, liver microsomes and cytosol in vitro; HCA was subsequently converted to o-coumaric acid in a quantitative manner only in the liver cytosol. In addition, the formation of o-coumaric acid was inhibited significantly by menadione, a specific inhibitor for aldehyde oxidase. Taken collectively, the results suggest that the rapid systemic clearance of HCA is likely due mainly to hepatic clearance occurring from aldehyde oxidase-catalysed biotransformation to o- coumaric acid. In conclusion, the present work demonstrates that the anticancer drug candidate BCA is highly likely to work as its active metabolite HCA in the body.</P>
Lee, Soon-Tae,Chu, Kon,Jung, Keun-Hwa,Kim, Se-Jeong,Kim, Dong-Hyun,Kang, Kyung-Mook,Hong, Nan Hyung,Kim, Jin-Hee,Ban, Jae-Joon,Park, Hee-Kwon,Kim, Seung U,Park, Chung-Gyu,Lee, Sang Kun,Kim, Manho,Roh, Macmillan ; Oxford University Press 2008 Brain Vol.131 No.3
<P>Neural stem cell (NSC) transplantation has been investigated as a means to reconstitute the damaged brain after stroke. In this study, however, we investigated the effect on acute cerebral and peripheral inflammation after intracerebral haemorrhage (ICH). NSCs (H1 clone) from fetal human brain were injected intravenously (NSCs-iv, 5 million cells) or intracerebrally (NSCs-ic, 1 million cells) at 2 or 24 h after collagenase-induced ICH in a rat model. Only NSCs-iv-2 h resulted in fewer initial neurologic deteriorations and reduced brain oedema formation, inflammatory infiltrations (OX-42, myeloperoxidase) and apoptosis (activated caspase-3, TUNEL) compared to the vehicle-injected control animals. Rat neurosphere-iv-2 h, but not human fibroblast-iv-2 h, also reduced the brain oedema and the initial neurologic deficits. Human NSCs-iv-2 h also attenuated both cerebral and splenic activations of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and nuclear factor-kappa B (NF-kappaB). However, we observed only a few stem cells in brain sections of the NSCs-iv-2 h group; in the main, they were detected in marginal zone of spleens. To investigate whether NSCs interact with spleen to reduce cerebral inflammation, we performed a splenectomy prior to ICH induction, which eliminated the effect of NSCs-iv-2 h transplantation on brain water content and inflammatory infiltrations. NSCs also inhibited in vitro macrophage activations after lipopolysaccharide stimulation in a cell-to-cell contact dependent manner. In summary, early intravenous NSC injection displayed anti-inflammatory functionality that promoted neuroprotection, mainly by interrupting splenic inflammatory responses after ICH.</P>
이순아(Soon-A Lee),강희석(Hee-Seog Kang),이상묵(Sang-Mook Lee) 한국조리학회 2017 한국조리학회지 Vol.23 No.2
이 연구는 포지셔닝 전략에 관한 연구로서 프랜차이즈 분식점 브랜드의 경쟁관계를 분석하고, 고객의 욕구를 충족시켜주는 선택속성이 무엇인지 파악하여 효율적인 포지셔닝 전략을 수립함으로 발전적인 마케팅 방향을 제시하였다. 요인분석을 통하여 고객들이 인지하는 프랜차이즈 분식점들의 선택속성은 총 25의 문항들은 총 3개의 요인으로(음식의 품질, 직원들의 서비스, 물리적 환경)으로 범주화 되었다. 이용동기에 집단 간 유의미한 차이가 있는지를 알아보기 위하여 일원배치분석(ANOVA)를 실시하여 Duncan을 통하여 사후분석하였고, 다차원척도법(MDS)을 통하여 브랜드 유사성, 선택속성과 브랜드 선호도를 검증하였다. 아딸은 음식, 서비스, 물리적 환경 속성에서 평균보다 높은 점수를 받았으며, 봉구스 밥버거는 서비스와 물리적 환경, 고봉민 김밥은 음식과 물리적 환경속성이 평균보다 높았다. 김밥천국은 음식, 서비스, 물리적 환경의 세 요인 모두에서 평균보다 낮게 나타났다. 본 연구의 결과는 5개의 프랜차이즈 분식점에 대한 유용한 경쟁관계를 나타내는 포지셔닝 맵과 실용적인 제안을 제공하였다. This study is focused on five franchise snack bars to create an effective marketing strategy by analyzing the competitive relationships among them and by grasping selection properties that satisfy customers. Discriminant Analysis was utilized to suggest methodological frameworks, and the results show three factors (food quality, employees’ service, and physical environment) were extracted that contains twenty five questions. A one-way analysis of variance (ANOVA) was carried out in order to verify if there were statistically meaningful differences in the Franchise snack bars, and post hoc comparisons were conducted using the Duncan method. In addition, Multidimensional Scaling (MDS) was used to measure brand similarity, selection attributes, and brand preferences. The results of the analysis show that Addal had the highest scores on average in all three factors (food quality, employees’ service, and physical environment), Bong-Gus Babberger had two higher scored factors (employees’ service and physical environment) than the average, and Gobongmin kimbab had also two higher scored factors (food quality and physical environment) than the average. Kimbab chunguk appeared to have lower scores than the average in all three factors (food quality, employees’s service, and physical environment). The findings of this study provide a useful positioning map of competitiveness among five brands and offer practical marketing proposals.