개방형 API 기반 네트워크 서비스 기술

송희헌,한미숙 安東大學校 工業技術硏究所 2001 공업기술연구논문집 Vol.8 No.1

In this paper, we introduce the standardization trend toward open networks, and we propose an architecture of open service network that is based on open API (Application Programming Interface). This architecture is able to provide Internet-oriented services al well as the integration service of wire/wireless and Internet by third-party.

갑상선 유두선암 환자의 말초 혈액 단핵구로부터 수지상세포분화와 자가 세포독성 T 림프구 활성화 유도

송수근,최영식,박요한,이대희,장희경 고신대학교 의학부 2004 高神大學校 醫學部 論文集 Vol.19 No.1

Background: Dendritic cells (DCs) are rare leucocytes that are uniquely potent in their ability to capture, process and present antigens to T cells, and so selectively migrate through tissues to reach lymph nodes and spleen where initiation of immune responses takes place. It has been reported that a dense infilteration of dendritic cells correlates with a favorable prognosis in several types of cancer. A similar correlation also has been noted in patients with papillary carcinoma of thyroid. The purpose of this study is to determine whether DCs are generated from peripheral blood monocytes by using cytokines such as GM-CSF, TNF-α, and IL-4 and whether cytotoxic T cells activated by DCs attack the papillary carcinoma tissues. Methods: Peripheral blood was obtained from 2 patients with thyroid papillary cancer. DCs were established from monocytes by culturing in the presence of GM-CSF, Flt-3 ligand. TNF-α , and IL-4 for14 days. At day 14, expression of surface markers typical for DCs was analyzed morphologically. The immunophenotypic features of DCs such as CDla, CD83, and CD86 were analyzed by phase contrast microscopy. At day 15 DCs were incubated with thyroid cancer tissues and normal thyroid tissues for 7 days. Results: DCs were generated from the peripheral blood monocytes. The generated cells had the classic morphology of DCs. Activated cytotoxic T lymphocytes (CTLs) were observed. Veiled cell known as circulating DCs attached to the thyroid cancer tissues were observed. The CTLs activated by DCs were observed to attack the papillary carcinoma tissues by scanning electron microscope. However, normal tissues were not attacked by CTLs. Conclusion: DCs can be generated from the peripheral blood monocytes. Futhermore, the CTLs activated by DCs also can attack the papillary carcinoma tissues. These results that DCs can be used as adjuvants for adoptive immunotherapy of papillary thyroid cancer.

허리 통증 환자의 MMPI 반응 특성

송현주,유희정,한오수 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.4

연구목적 : MMPI를 통한 심리평가 결과, Hs, D, Hy세 척도가 실제 기질적인 문제의 심각성에 비해 허리 통증을 과도하게 호소하는 정형외과 환자 집단을 변별해 낼 수 있는지와 더불어 MMPI의 이 세 척도가 치료예후에 관한 예측 인자로서의 가능성을 검증해 보았다. 방 법 : 정형 외과 환자 37명과 정상 통제집단 36명의 MMPI결과를 얻어 MMPI 13개 척도에 대 한 집단간차이 검증과 판별 분석이 실시되었다. 또한 환자 집단중 19명을 대상으로 전화 면담을 통한 치료 만족도를 평가하여 치료 만족 집단과 불만족 집단을 구분한 후 역시 MMPI 13개 척도에 대한 집단간 비교를 하였다. 결 과 : MMPI의 13개 척도 중 다른 척도들에 비해 Hy, Hs, D척도에서 환자 집단 평균 점수가 정상 집단에 비해 보다 더 유의미하게 높았다. 또한 Hy, Hs, D척도를 사용하여 두 집단을 판별 분석한 결과, 74%의 분류 정확률을 보였으며 Hy, Hs, D척도의 순으로 판별해 내었다. 치료 만족 집단과 불만족 집단 비교에서는 사례수 부족으로 인해 통계적으로 유의미한 결과가 산출될수 없었다. 그러나 Hy, Hs척도의 집단간 평균 비교에서 불만족 집단의 평균 점수가 만족 집단의 점수보다 높았다. 결 론 : MMPI는 통증을 과도하게 호소하는 집단을 변별해 내는데 유용하다는 사실을 시사하며 추후 연구에서는 통증을 과도하게 호소하는 집단 특유의 심리적 변인 및 이에 관한 세부 특성을 보다 체계적이고 포괄적으로 밝혀 낼수 있는 연구가 이루어 져야 할 것이다. Objective : The goal of this study was to examine whether MMPI scores could discriminate between normal group and exaggerated pain group and predict treatment prognosis in exaggerated pain group. Methods : For psychological evaluation, MMPI was administered to 37 low back pain patients and 36 normal controls. MMPI findings in two group were compared, using t-test and discriminant function analysis. Nineteen patients of exaggerated low back pain group contacted by telephone were questioned about treatment satisfaction degree. And satisfaction group(9 patients) and dissatisfaction group(6 patients)'s MMPI findings were compared. Result : Hy, Hs, D scale scores in exaggerated pain group were higher than in control group. In discriminant function analysis by Hs, Hy, and D, percent of correctly classified 'gouped' cases was 74%. Discriminant function of Hy scale was the highest and that of D scale was the lowest. In satisfaction degree study, no finding was significant. Conclusion : MMPI findings were effective in discriminating between exaggerated pain group and normal control group. Further researches will need more structured and comprehensive approach.

사람 갑상선자극호르몬 수용체를 발현하는 Chinese Hamster Ovary(hTSHR-CHO)세포를 이용한 자극형 갑상선자극호르몬 수용체 항체 활성 측정의 임상적 유용성

한희정,원진호,채수홍,김현진,송민호,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.1

Detection of thyroid stimulating hormone receptor(TSHR) autoantibodies has clinical value in establishing the diagnosis of Graves ' disease, and in predicting its clinical course with high sensitivity and high specificity. Especially, TBII using radioreceptor assay has been widely used. Recently, for detecting thyroid stimulating antibody(TSAb), a sensitive method using human TSH receptor-transfected Chinese Hamster Ovary(CHO) cells has been developed and clinically used. The aims of this study are to determine the change and discrepancy of 2 TSHR autoantibodics in clinical course and to evaluate the correlation between 2 autoantibodies. We measured TSAb and TBII in 30 newly diagnosed and untreated patients and in 73 previously diagnosed as Graves ' disease and treated with antithyroid drug. Also we compared the changes of the antibodies in clinical course and correlation between 2 antibodies. Thes results are summarized follows. 1. In newly diagnosed patients, all of the 30 patients had positive TBII and/or TSAb. None of them had negative TBII and negative TSAb. And in newly diagnosed patients, mean TBII and mean TSAb values are 46.8% and 361%, respectively. In 73 treated patients mean values are 18. 7% and 196% each other. Therefore, newly diagnosed group has significant greater TBII and TSAb than antithyroid drug-treated group. 2. TBII was significantly different between euthyroid group and thyrotoxic group in antithyroid drug-treated patients, but TSAb was not. 3. TBII was sequentially decreased as increased medication duration, but TSAb was not shown sequential decrease as increased medication duration. 4. There was significant negative correlation between cumulative doses of antithyroid drug and TBII, but no significant correlation between cumulative doses and TSAb. 6. There was significant positive correlation between TBII and TSAb in total patients group and in antithyroid drug medication group, but not in newly diagnosed group. In conclusion, in Graves ' disease patients, detection of TSHR antibodies are clinical values in establishing the diagnosis and prediction of clinical course. A method detecting TSAb using hTSHR-CHO cells should be further studied for standardization of measurement, and for detecting the changes of TSAb in clinical course, long-term follow-up of patients are important.

식품 기준·규격의 합리적 관리 ·운영에 관한 연구(Ⅰ) : 두부,식용유지, 전분의 분말상 원료에 관하여 Powdered marerials of Tofu, Edible oil, Starch

김희연,홍진환,박혜경,한상배,박종석,이은주,이정성,송경희,최은희,최영준,소경아,성영제,이주엽 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

본 연구는 분말상 원료(전분, 대두분)의 저장유통시 품질변화를 건전성과 안전성 측면에서 검토하여 식품의 기준 ·규격 설정f.」 합지적으로 반영하고자 하였다. 전분과 패두분의 이물을 검사하고, 2종 대두분(중국산, 미국산)을 ?0일간 IS'c와 30t에 저장하면서 성상, 수분, 산가, 과산화물가, 지방산 조성,아플라톡신 BB의 생성여부를 분석하였다. 중국산 대두분 30'』 저장군에서 50일 이후 곰팡이가 발생한 것 이외에 모든 시료에서 양호한 성상을 나타내었고, 전분과 대두닥 모든 시료에서 이물은 검출되지 않았다. 산가는 중국산과 미국산 시료간에 편차를 보여 증국산 30"C, 50일 저장시료에서 약 10배끙도 증가하였고, 과산화물가는 저장 90일후 15'E 저장군은 약 2.3배, 30'c 저장군은 3배정도 증가하였다. 대두분의 주요 지방산은 linoleic acidf18. 2), oleic acid(18 : 1), palmitic acid(16 : 0)이었으며, 3개월 저장에 따른 지방산 함량의 변화는 미미하였다. 아플라톡신 B₁은 모든 시료에서 검출되지 않았다. The objective of this study was to investigate auality changes of type raw materials(starch, soy flour) during various storage conditions. Starchflour(source of China, U.S.A) were slfred under two temperature(15'C, 30'c) forSensory evaluation, (o.reign material test, moisture content, acid value, peroxide ualue,composition, aflatorin Bi were analyzed. China soy flour(stor·ed 30'f) was contaminated by fungj on 50 days. Except for soy flour contardnated by fungi, sensory characteristics were not changed and foreign mater;als were notdetected. Acid value of China soy flour(stored at 30'C, 90 days) was about 10 times higherlevel before storage and acid value was more influenced by source(China, USA). Peroxide valuewas in proportion with the storage period slightly. The major fatty acid of soy flour waslinoleic acid(18 . 2), an(3 the change of fatty acid composition was not observed. Aflatoxlrl Blwas not detected.

전력계통 송배전선로 2회선 1선지락사고 고장거리 검출 알고리즘

이한웅,최면송,이승재,강상희 明知大學校 産業技術硏究所 2003 産業技術硏究所論文集 Vol.22 No.-

Abstract - This paper presents a fault location algorithm when there are parallel circuits in power system networks. In transmission networks, a fault location method using the distribution factor of fault currents is introduced and in distribution networks a method using direct 3-phase circuit analysis is developed, because the distribution networks are unbalanced. The effect of parallel circuits in fault location is studied in this paper. The effect is important for the range of protecting zones of distance relay in transmission networks and fault location in distribution networks. The result of developed fault location algorithm shows high accuracy in the simulation that using the EMTP.

DCJTB를 도핑시킨 NPB/Alq₃ 복층소자에서 엑시톤 확산

송석태,채희백,한찬수 순천향대학교 기초과학연구소 2011 순천향자연과학연구 논문집 Vol.17 No.2

Red dye DCJTB was doped 2% with thickness 1nm in NPB(40nm)/Alq₃(60nm) bilayer in order to investigate the diffusion of exciton. The location of the dopant layer was varied from the junction of NPB/Alq by 5nm. The emission zone was distributed narrow in Alq side near the junction. The diffusion length of exciton was 15nm ± 5nm which was confirmed from the measurements of Rubrene doped NPB(40nm)/Alq₃(60nm) bilayer system.

아조벤젠 분자(Disperse Red 1)를 포함한 측쇄형 고분자에서 광유도 복굴절의 실시간적 조사

신희득,주원제,오차환,송석호,김필수,한양규 한양대학교 자연과학연구소 2001 自然科學論文集 Vol.20 No.-

아조벤젠 그룹을 포함한 측쇄형 고분자 필름(PDR1)에서 광 유도된 이방성을 실시간적으로 조사하였다. 수평, 수직한 흡수율의 변화를 광 유도된 복굴절의 기록, 감쇠, 소거, 완화 과정에 따라 측정하여, 매질 내의 아조벤젠 분자의 정렬상태와 복굴절과의 관계를 광 이성화과정으로 설명하였다. 또한 기록빔의 세기를 따른 수직, 수평한 흡수율의 변화와 유도된 복굴절의 관계를 조사하였다. The photo-induced anisotropy for a polymeric film(PDR1) containing azobenzene group as side-chain was investigated dynamically. The change of absrobances with parallel and perpendicular components was measured in recording, decaying, erasing and relaxation processes of photo-induced birefringence, so the relation between the alignment of azobenzene groups and the birefringence was well explained according to the photo-isomerization. Also, the dependence of the photo-induced birefringence on intensity of recording beam was investigated with changes of both absorbance and birefringence.

고분자 코팅된 리포좀의 입자 크기 및 열적 특성

진병석,한송희 동덕여자대학교 2003 생활과학연구 Vol.8 No.-

Polymercoated liposomes using water-soluble poly(vinyl alcohol) and chitosan were prepared in order to enhance the stability of liposome. Droplet sizes of liposomes, ranged from several hundred nm to 2㎛, dependon the consition components, preparation method, and coating. Lyotropic liquid crystalline phase transition of polymer coated liposomes were characterized by diffrential scanning calorized optical microscopy.

NIHSS 활용을 통한 뇌졸중 환자 간호의 질향상 전략

박경현,송경애,공혜성,나화주,유수경,박소영,김상희,최혜림,배희준,한문구,양미화 한국의료QA학회 2009 한국의료질향상학회지 Vol.15 No.2

문제: 뇌졸중 환자를 돌보는 간호현장에서는 급성기 뇌졸중 환자의 증상악화에 대한 조기사정과 적절한 대처가 매우 중요한 문제이다. 그러나 임상현장에서는 이를 객관화하고 수치화하여 모든 의료진이 의사소통할 수 있는 유용한 도구를 사용하고 있지는 못하는 실정이다. 이러한 문제를 해결하기위해 NIHSS(National Institute of Health Stroke Scale)를 신경과 진료의사를 중심으로활용하고 있지만 아직 간호현장에서는보편적으로사용하지 않고있다. 이에 뇌졸중환자간호에 NIHSS를 활용하여 뇌졸중 증상악화의 조기사정과 빠른 대처로 궁극적으로는 뇌졸중환자 간호의 질을보다 향상시키기 위하여 본활동이 시도되었다. 목적: 첫째, 간호사의 NIHSS 측정 신뢰도의 현수준을 점검하고 이를향상시키기 위한 프로그램을 개발·적용한다. 둘째, 간호사가급성기 뇌졸중환자에게 NIHSS 측정을 통하여 뇌졸중악화를 얼마나 예측할 수 있는지 분석하고 이를 향상시킬수있는 방법을 모색한다. 셋째, 궁극적으로 급성기 뇌졸중 환자의 증상악화의 조기 발견과치료를위한의료진의 올바른 대처지침을 마련하여 이를 적용한다. 의료기관: 경기도에 소재한 대학병원의 뇌졸중 집중치료실 질 향상 활동: 첫째, 간호사의 NIHSS 측정 신뢰도 향상을 위해 「NIHSS 간호사 교육 프로그램」을 마련하였다.