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Development and Evaluation of the Interferon Gamma Test for Detecting Bovine Tuberculosis in Korea
So yoon Ryoo,Yun ho Jang,Na rae Kim,Yoon ra Jang,Doan Lan Pham,Shin seok Kang,Hyeon Seop Byeon,So young Park,Woong seog Song,Suk Chan Jung,In Heo,Bong Kwan Choi,Jae Myung Kim 대한수의학회 2013 대한수의학회 학술대회발표집 Vol.2013 No.-
( So Yoon Ryoo ),( Suk Ha Lee ),( Seung Hyun Jo ),( Si Young Lee ),( Areum Kwak ),( Eun Som Kim ),( Jong Ho Lee ),( Jae Woo Hong ),( Hyun Jhung Jhun ),( Young Min Lee ),( Anshul Shyam Sobti ),( Soo Hy 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.3
Avascular necrosis of the femoral head (ANFH) is commonly observed in patients treated with excessive glucocorticoid (GC). Single administration of lipopolysaccharide (LPS) has shown to induce immune stimulatory factors. However, the effect of repeated administration of LPS on GC-induced ANFH has not been studied. Thus, the purpose of this study was (i) to examine the cytokine profile induced by repeated LPS administrations and (ii) to test the effect of repeated LPS treatments on GC-induced ANFH. A mouse necrosis model of ANFH was designed by chronic GC administration with co-treatment of LPS. Mice body weights in the LPS/prednisolone (PDN) co-treated group were lower than that of the untreated control group, but spleen weights were greater than the control group. The levels of IL-6, TNFα, and IL-33 in the liver and spleen of the LPS/PDN group were lower than the untreated control group, whereas TNFα level in the femoral head of the LPS/PDN group increased. Collectively, the effect of repeated LPS on the pathogenesis of GC-induced ANFH was associated with the TNFα level in the femoral head, but the pathogenesis did not correspond to cytokine levels in immune tissues.
( So Yoon Ryoo ),( Yun Ho Jang ),( Na Rae Kim ),( Yoon Ra Jang ),( Shin Seok Kang ),( Hyun Sub Byun ),( Suk Chan Jung ),( Bong Kwan Choi ),( Jung Ho Kim ),( Dong Hyuk Kim ),( Jae Myung Kim ) 한국예방수의학회 2014 예방수의학회지 Vol.38 No.2
The aim of the present study was to evaluate the use of an immunochromatographic test (ICT) strip using recombinant MPB70 (rMPB70) protein as a complementary tool for the diagnosis of naturally occurring tuberculosis in cattle. The study was performed on 249 cattle from populations known to be free from Mycobacterium bovis (M. bovis) and 119 cattle with M. bovis infection, confirmed postmortem. Compared to reference standards (culture isolation and/or visible lesion), the sensitivity of ICT was 94.12% (95% CI: 89.89∼98.35%) while the specificity was 96.80% (95% CI; 94.62∼96.82%). The findings indicate that the ICT strip is efficient for diagnosing bovine tuberculosis in cattle from Korea.
( Sang Min Yoon ),( Baek-yeol Ryoo ),( So Jung Lee ),( Jong Hoon Kim ),( Ji Hoon Shin ),( Jihyun An ),( Han Chu Lee ),( Young-suk Lim ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Patients with hepatocellular carcinoma (HCC) showing macroscopic vascular invasion (MVI) bear an extremely poor prognosis. Sorafenib is the sole treatment option for advanced stage HCC with MVI with unsatisfactory response rate and survival benefit. Combined transarterial chemoembolization (TACE) plus external beam radiotherapy (RT) has shown promising results in these patients by observational studies. Here, we report the efficacy and safety of TACE plus RT compared to sorafenib in patients with advanced HCC and MVI. Methods: This study was a randomized, open-label trial at an academic tertiary care center. Between July 2013 and October 2016, 90 treatment-naive patients with liver-confined HCC showing MVI were randomly assigned to receive sorafenib (400 mg twice-daily; n = 45; sorafenib group) or TACE (every 6 weeks) plus RT (within 3 weeks after the first TACE; n = 45; TACE+RT group). Primary endpoint was 12-week the progression-free survival (PFS) rate by intention-to-treat analysis. Radiologic response was assessed by independent review according to Response Evaluation Criteria in Solid Tumors (version 1.1). Crossover of treatment was permitted after confirming disease progression. Results: Patients were 33 to 82 years of age, and 85.6% were male. All patients had portal vein invasion of HCC and Child- Pugh class A liver function. The median maximal tumor diameter was 9.7 cm. Most (78.9%) patients had multiple lesions. At week 12, the PFS rate was significantly higher in the TACE+RT group than the sorafenib group (86.7% vs. 34.3%; P<0.001). The TACE+RT group showed significantly higher radiologic response rate (33.3% vs. 2.2% at 24 weeks; P<0.001), significantly longer median time to disease progression (31 weeks vs. 11.7 weeks; P<0.001), and significantly longer overall survival (55 weeks vs. 43 weeks; P=0.04), compared with the sorafenib group. No patients in the TACE+RT group discontinued treatment due to hepatic decompensation. Conclusions: In patients with advanced HCC showing MVI, first-line treatment with TACE+RT was well-tolerated and provided improved progression-free survival, objective response rate, time to disease progression, and overall survival, compared with sorafenib.
Kyung Jae Lee,Eell Ryoo,Yoo Min Lee,Jung Min Yoon,Hyo-Jeong Jang,So Yoon Choi,You Jin Choi,Hyun Jin Kim,Ju Young Chung,Jung Ok Shim 대한소화기 기능성질환·운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.3
Background/AimsThe effects of probiotics in children vary based on diseases and probiotic strains. We aim to investigate the effectiveness of Saccharomyces boulardii and lactulose for treating childhood functional constipation. MethodsThis open-label randomized controlled trial was conducted at 10 university hospitals in Korea. Children who were diagnosed with functional constipation were allocated to 3 groups (lactulose monotherapy, combination therapy, and S. boulardii monotherapy). The primary outcome was treatment success rate that was accordingly defined as ≥ 3 bowel movements without incontinence at week 12. The cumulative successful maintenance and drug maintenance rates without drug changes were calculated throughout the study period. We compared stool frequency, incontinence, consistency, and painful defecation at week 2 among the 3 groups. ResultsOverall, 187 children were assigned to the lactulose monotherapy (n = 69), combination therapy (n = 68), or S. boulardii monotherapy (n = 50) groups. The primary outcome was significantly higher in the lactulose monotherapy group (26.1%) or combination therapy group (41.2%) than in the S. boulardii monotherapy group (8.0%). The S. boulardii monotherapy group showed a significantly lower cumulative successful maintenance and drug maintenance rate than the other 2 groups. There were no significant intergroup differences in the frequency of defecation, incontinence, painful defecation, or stool consistency during the follow-up at week 2. ConclusionS. boulardii monotherapy was not superior to lactulose monotherapy or combination therapy and showed a higher drug change rate, supporting the current recommendation of probiotics in the treatment of childhood functional constipation.