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Chang-ling Fan,Wei-hua Zhang,Tao-tao Zeng,Ling-fang Li,Xiang Zhang,Shao-chang Han 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.11
Poly(vinyl alcohol), whose pyrolysis carbon possesses high conductivity of 8.88 × 10−1 S/cm, was used to synthesize xLiFePO4/C·(1 − x)Li3V2(PO4)3/C cathode. It was characterized by X-ray diffraction, scanning electron microscopy, conductivity, cyclic voltammetry, and galvanostatic charge and discharge experiments. Results show that LiFePO4/C and Li3V2(PO4)3/C coexists in the cathode. The particles sizes of 0.75LiFePO4/C·0.25Li3V2(PO4)3/C (x = 0.75) are much smaller than 100 nm due to the role of poly(vinyl alcohol). Its conductivity is 8.79 × 10−2 S/cm. The oxidative and reductive peaks in cyclic voltammetry are sharp and symmetrical. Their low potential gaps indicate that the extractions and insertions of lithium ion possess excellent reversibility. Its discharge capacities at 1 and 5 C are 141.1 and 100.1 mAh/g. The more Li3V2(PO4)3/C in cathode results in the deterioration of electrochemical performances due to its low theoretical capacity. It is concluded that poly(vinyl alcohol) is an effective carbon source in the preparation of xLiFePO4/C·(1 − x)Li3V2(PO4)3/C composite cathode with excellent performances.
Shao, Shu-Li,Cui, Ting-Ting,Zhao, Wei,Zhang, Wei-Wei,Xie, Zhen-Li,Wang, Chang-He,Jia, Hong-Shuang,Liu, Qian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
Up-regulation of multidrug resistance-associated protein 1 (MRP1) is regarded as one of the main causes for multidrug resistance (MDR) of tumor cells, leading to failure of chemotherapy-based treatment for a multitude of cancers. However, whether silencing the overexpressed MRP1 is sufficient to reverse MDR has yet to be validated. This study demonstrated that RNAi-based knockdown of MRP1 reversed the increased efflux ability and MDR efficiently. Two different short haipin RNAs (shRNAs) targeting MRP1 were designed and inserted into pSilence-2.1-neo. The shRNA recombinant plasmids were transfected into cis-dichlorodiamineplatinum-resistant A549 lung (A549/DDP) cells, and then shRNA expressing cell clones were collected and maintained. Real time PCR and immunofluorescence staining for MRP1 revealed a high silent efficiency of these two shRNAs. Functionally, shRNA-expressing cells showed increased rhodamine 123 retention in A549/DDP cells, indicating reduced efflux ability of tumor cells in the absence of MRP1. Consistently, MRP1-silent cells exhibited decreased resistance to 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and DDP, suggesting reversal of MDR in these tumor cells. Specifically, MRP1 knockdown increased the DDP-induced apoptosis of A549/DDP cells by increased trapping of their cell cycling in the G2 stage. Taken together, this study demonstrated that RNAi-based silencing of MRP1 is sufficient to reverse MDR in tumor cells, shedding light on possible novel clinical treatment of cancers.
Li, Shao-Chang,Hsu, Ru-Chin The Korean Society for Quality Management 2004 The Asian Journal on Quality Vol.5 No.2
The Taiwan National Quality Award (TNQA) has been conducted for 14 years. However, small and medium-sized companies (SMSCs) rarely win the TNQA. This study undertakes a capability analysis to explore how SMSCs do win the TNQA. A survey instrument involving 149 questions extracted from 'the 2001 Handbook of Standard Criteria for Evaluation of TNQA' is used to measure the capability of SMSCs in competing for the TNQA. The paper concludes with a summary of the essential qualities required by an SMSC if it is to compete successfully for the TNQA.
The Study of Criteria Weight for Taiwan National Quality Award by Fuzzy Hierarchical Analysis
Li, Shao-Chang,Fu, Hsin-Pin The Korean Society for Quality Management 2006 The Asian Journal on Quality Vol.7 No.2
In this paper, fuzzy hierarchical analysis (FHA) is used to explore the process by which the criteria weights of the Taiwan National Quality Award (TNQA) are assigned by TNQA committee members. Each member is allowed to employ fuzzy scales in place of exact scales. Each pairwise comparison of criteria is made through a questionnaire from each TNQA committee member. The membership function of trapezoidal fuzzy numbers is introduced to specify TNQA committee members' intentions. After FHA, the reasonable range of each criterion weight of TNQA is determined. The current criteria weights of TNQA are properly verified.
A Mean Field Game-Theoretic Cross-Layer Optimization for Multi-Hop Swarm UAV Communications
Tong Li,Cong Li,Chungang Yang,Junqi Shao,Yue Zhang,Lei Pang,Lizhong Chang,Lingli Yang,Zhu Han 한국통신학회 2022 Journal of communications and networks Vol.24 No.1
Unmanned aerial vehicle (UAV) multi-hop communicationnetworks are foreseen to be widely employed inboth military and civilian scenarios. However, in ultra-densescenarios with swarm UAVs, nodes are highly dynamic mobile,ultra-dense deployment and non-centralized distribution. Thesecharacteristics make the centralized resource management policynot apply. Meanwhile, existing routing protocols can’t meetthe performance challenges of high dynamic, topology and linkfrequency changes of ultra-dense scenarios with swarm UAVs. Tosolve the above challenges of resource management and routingprotocol, a cross-layer optimization method is presented witha novel mean field game (MFG) in this paper. It is based onthe cross-layer design method of the MFG theory and jointlyconsiders the power resources in the physical layer, frequencyresources in the medium access control (MAC) layer, and routingresources in the network layer. By dividing into subproblems,the original problem is solved. Meanwhile, the optimal datatransmission path can be selected through the management andallocation of frequency resources and power resources. A crosslayerresource management dynamic source routing (CLRMDSR)protocol is designed based on that which adds link qualitymeasurement. The simulation results show that the presentedCLRM-DSR with the proposed resource management schemecan improve the data packet transmission rate, reduce end-toenddelay, and lower routing overhead for the multi-hop swarmUAV communication network.
Two-Step Reset in the Resistance Switching of the Al/TiO<sub><i>x</i></sub>/Cu Structure
Shao, Xing L.,Zhao, Jin S.,Zhang, Kai L.,Chen, Ran,Sun, Kuo,Chen, Chang J.,Liu, Kai,Zhou, Li W.,Wang, Jian Y.,Ma, Chen M.,Yoon, Kyung J.,Hwang, Cheol S. American Chemical Society 2013 ACS APPLIED MATERIALS & INTERFACES Vol.5 No.21
<P>Two-step reset behaviors in the resistance switching properties of the top Al/TiO<SUB><I>x</I></SUB>/bottom Cu structure were studied. During the electroforming and set steps, two types of conducting filaments composed of Cu and oxygen vacancies (Cu-CF and V<SUB>O</SUB>-CF) were simultaneously (or sequentially) formed when Al was negatively biased. In the subsequent reset step with the opposite bias polarity, the Cu-CFs ruptured first at ∼0.5 V, and formed an intermediate state. The trap-filled V<SUB>O</SUB>-CFs were transformed into a trap-empty state, resulting in a high-resistance state at ∼1 V. Matrix phase in the electrochemical metallization cell can play an active role in resistance switching.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2013/aamick.2013.5.issue-21/am403498q/production/images/medium/am-2013-03498q_0007.gif'></P>
Chung-Lin Lee,Ying-Hsu Chang,Chung-Yi Liu,Ming-Li Hsieh,Liang-Kang Huang,Yuan-Cheng Chu,Hung-Cheng Kan,Po-Hung Lin,Kai-Jie Yu,Cheng-Keng Chuang,Chun-Te Wu,See-Tong Pang,I-Hung Shao 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.5
Purpose: Metastatic castration-resistant prostate cancer (mCRPC) has a poor prognosis. Abiraterone acetate (AA), enzalutamide, and chemotherapy are first-line treatments for patients with mCRPC. This study examined prognostic factors for AA response in the form of prostate-specific antigen (PSA) kinetics throughout androgen-deprivation therapy (ADT) in chemonaïve patients with mCRPC. Materials and Methods: We retrospectively included data from 34 chemonaïve patients with mCRPC who had received AA at some point between January 2017 and December 2018. We separated patients into two study arms according to the decrease in PSA percentages after use of AA for 3 months. We correlated PSA kinetics parameters with response and compared the two study groups with respect to PSA kinetics. Results: The patients’ median age was 77 years. In the total group of patients, 64% had a response to AA, whereas 35% did not. The ratio of the PSA level at nadir to the level during ADT was significantly higher in the AA-sensitive group (19.78 vs. 1.03, p=0.019). Conclusions: Patients who experienced a dramatic change in PSA level during ADT were more likely to be resistant to AA after progression to mCRPC. Chemotherapy rather than AA might be more suitable as a first-line treatment for these patients.
Teo Shao Jin,Yeo William,Ling Marcus Zhixing,Fong Poh Ling,Guo Chang Ming,Chen John Li Tat,Soh Reuben Chee Cheong 대한척추외과학회 2021 Asian Spine Journal Vol.15 No.4
Study DesignRetrospective cohort study.PurposeThis study aims to analyze the relationship between body mass index (BMI) subjective patient-reported outcomes (PRO) after 1- and 2-level anterior cervical discectomy and fusion (ACDF).Overview of LiteratureThe prevalence of cervical spondylosis and ACDF in expected to continue rising among the aging population of Asia. Moreover, the prevalence of obesity is also increasing. However, limited information is available about the mechanism by which BMI affects PRO after ACDF.MethodsTotal 878 patients underwent ACDF between 2000 and 2015. After excluding patients with previous cervical instrumentation, >2 levels fused, missing BMI measurement, or neoplastic/trauma indication for surgery, 535 patients were included. The PRO measures of the Neck Disability Index, Numerical Pain Rating Scale (NPRS) for Neck Pain, NPRS for Limb Pain, American Academy of Orthopaedic Surgeons–Neurogenic Symptom Score, and Japanese Orthopaedic Association myelopathy score were used. Patients were grouped based on their preoperative BMI, as per the World Health Organization guidelines for Asian populations. PRO scores were collected preoperatively, at 6 months postoperatively, and 2 years postoperatively. A generalized linear model was used to analyze the relationship of BMI category with the individual score, accounting for several factors that are likely to affect the outcomes.ResultsTotal 19 (3.4%) were underweight, 155 (28.0%) were normal weight, 112 (20.3%) were overweight, and 267 (48.3%) were obese. Patients across all BMI categories experienced significant and similar improvements in their postoperative PRO scores. There were no significant differences in the preoperative, 6-month postoperative, and 2-year postoperative PRO scores of the groups. Rate of reoperation was highest in patients with grade II obesity at 8.07%; however, the difference was not statistically significant.Conclusions Irrespective of the BMI, all patients exhibited similar satisfactory outcomes following ACDF. The results support surgery in all subgroups of patients with symptomatic nerve compression in the cervical spine.