방광요관 역류환아에서 항역류수술후 99mTc-DMSA 신주사 소견의 분석

오승준,고재준,이경철,임대정,이승배,이안기,김광명,최황 大韓泌尿器科學會 1998 Korean Journal of Urology Vol.39 No.9

조기 위암의 조직 분화도에 따른 내시경적 육안 소견

김남재,이경태,김진희,송규상,이승민,정현용,김석현,노승무,이병석,조준식 대한소화기내시경학회 2000 Clinical Endoscopy Vol.20 No.2

Background/Aims : The aim of this study was to investigate the endoscopic findings of early gastric cancer according to histological differentiation. Methods : One hundred eight cases of early gastric cancer (EGC) which had been confirmed surgically over a 1 year and 7 month period, were studied to assess the relationship between histological differentiation and endoscopic findings. Results : All elevated types of EGC (41 cases) were found to be differentiated carcinoma. 48.2% (30/67 cases) of the depressed type EGC was determined to be differentiated carcinoma, while the others (51.8%) were undifferentiated carcinoma. Twenty-four of thirty cases with differentiated depressed type EGC showed a reddish discolored surface (80%), and the others manifested a whitish or mixed colored surface of red and white. In the undifferentiated depressed type EGC, 73% (27/37 cases) revealed a whitish or mixed colored surface, while the others (27%) showed a reddish discoloration. In the differentiated depressed type EGC, the character of the depressed surface was mainly regular and soft or fine granular (77%), while that of the undifferentiated cases appeared as uneven large granules (43.2%) or fine granules (43.2%), sclerotic (2.8%) and/or elevated (10.8%). The margin of the depressed type EGC with differentiated carcinoma was mainly of a shoaling beach type (83.3%), and that of the undifferentiated carcinoma was not uniform and existed as a cliff type (60%), Riasis coast type (11.4%) and shoaling beach type (28.6%). Conclusions : All elevated types of EGC showed differentiated types, and histological differentiation of depressed type EGC was macroscopically determined by the size of lesions, color, and character of the depressed surface and margin of the depression.

N-아세틸시스테인 투여후 발생한 급성 무기폐 : 증례보고

이광범,안용미,이철승,최준석,박천희 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.34 No.1

Causes of atelectasis under general anesthesia are tracheal foreign body, blood clot, aspiration of bronchial secretion, one-lung ventilation and relative predominance of parasympathetic system. N-acetylcysteine is mucolytic agent which improves the capability of sputum drainage. After administration of N-acetylcysteine, an increased volume of liquified bronchial secretions may occur. When cough is inadequate, the airway must be maintained open by mechanical suction. In case that is a mechanical block due to local accumulation, the airway should be cleared by endotracheal aspiration. A 49-year-old female was admitted for bilateral laparoscopic oophorectomy due to ovarian tumors. There was not any problem during a general anesthesia induction. After instillation of N-acetylcysteine into endotracheal tube, acute atelectasis was developed in right lower lung.

위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동

이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.

편평세포폐암에서 p53 돌연변이의 발현과 TNM 병기와의 상관관계

이상숙,한승범,전영준 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Primary lung cancer is now recognized as a major cause of cancer death in Korea as well as the whole world. Non-small-cell lung cancers(NSCLC) comprise about 75% of lung cancer and squamous cell carcinoma is the most common type in Korea. Mutations of p53 gene are common in variety of human cancers, including lung cancer. The p53 gene appears to inhibit the proliferation of cells from the G1 to the S phase of cell cycle and is able to suppress the transformations of cells by other oncogenes, to inhibit the growth of malignant cells in vitro and suppress the tumorigenic phenotype of transformed cells. Alteration or inactivation of p53 by mutation, or by its interactions with oncogene products of DNA tumor viruses, can lead to cancer. These mutations seems to be the most common genetic changes in human cancers. p53 gene mutation is known to be a poor prognostic marker in breast cancer and has significant association with lymph node involvement. But in human lung cancer the association of p53 mutations and TNM stages are controversial. Immunohistochemical staining can detect only mutant p53 protein bacause of markedly prolonged half life of mutant p53 protein. We performed the immunohistoschemical staining on 48 surgically resected and 10 bronchoscopically biopsized specimens of primary squamous cell carcinoma of the lung with monoclonal antibody(DO 7) and analyzed the relationship between the expression of p53 protein and clinical TNM stages. p53 protein was detected in 60.3% of total 58 cases. p53 protein was positive in 52.9% of stage I(17cases), 83.3% of stage Ⅱ(6 cases), 72.2% of ⅢA(18 cases), 42.9% of ⅢB(7 cases) and 50% of stage Ⅳ(10 cases) which revealed no significant correlation between p53 protein detection and stages. There was no significant correlation between p53 protien detection and No and N₁-₃as well Mo and M₁. In conclusion, we couldn't find any significant correlation between p53 protein detection and TNM stages which suggests p53 mutation is frequent in squamous cell carcinoma of the lung but play different role in progression of clinical stages.

정형회과영역에서의 Cefmetazole(Cefmetazon^(�)) 임상적 효과

이정웅,문형석,안상로,이준규,이광진,윤승호 최신의학사 1988 最新醫學 Vol.31 No.5

치아 이상의 발생 빈도와 양상에 관한 연구

이제호,손홍규,전승준,최형준 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.2

An object definition of the anomaly is not avaliable and most investigators define the term differently or fail to describe their criterion.Because dental anomaly may lead to many complications,early detection and diagnosis of dental anomalies are essential steps in the evaluation of the child patient and in treatment planning.These procedures require detailed medical and dental histories,through clinical examination and the use of radiographs.So,this study was designed to find out the prevalece of dental anomalies.The clinical and roentgenographic examination was undertaken for 8,054 children at age from 0 to 15 years and statistical analysis was done.The results were as follows: 1.Among the examined subjects 2,134 subjects(26.5%) showed dental anomalies.The prevalance of individure dental anomalies were as as follows:Supernumerary teeth 15.6% congenitally missing teeth 6.6%,fusion 2.2%,odontoma 0.35%,microdontia 1.2%,macrodotia 0.05%,gemination 0.22%,talon cusp 0.36%,dens evaginatus 0.24%,dens invaginatus 0.15%,dilaceration 0.27%,taurodontism 0.09%,abnormal tooth position 1.7%,natal $ neonatal teeth 0.92%,amelogenesis imperfecta 0.01%. 2.Significant correlations between the groups with individual dental anomalies were as follows:between groupⅠand other groups,there was nagative correlation,especially groupⅠ and groupⅡ.And the correlation coefficient between male and female showed differences. 3.For the supernumerary teeth group,the prevalence of male was higher than female(p<0.001).While for the congenitally missing teeth,macrodontia,microdontia,abnormal tooth position group,the prevalence of female was greater than male(p<0.001). 4.For the congenitally missing teeth group,the mandibular primary lateral incisor showed the highet incidence in primary dentition,while mandibular lateral incisor in permanent dentition.In the mandible(72.5%),this site showed higher prevelence than in maxilla.In this case with deciduous congenitally missing teeth,the prevelence of successive permanent congenitally missing teeth was about 33.9%,the incidence was highet in mandibular lateral incisors. 5.Most supernumerary teeth existed on middle area and showed inverted position and unerupted state.In addition,supernumerary teeth showed higher incidence on maxilla(99.3%). 6.In the case with deciduous fused teeth,the prevelence of successive permanent congenitally missing teeth was 39.9%,while that of successive permanent fused teeth was 2.7%.And the highet rate of the prevalence(40.3%) appeared in fusion of mandibular deciduous lateral incisor and canine. 7.In the case of odontoma,the prevelence was higher in maxilla(78.6%) and anterior region(82.7%) the mandible and posterior region.

한국의 태안반도에서 CH₄의 지역적 배경농도에 관한 연구 : 1990 ∼ 1992 년 자료를 중심으로

이근준,정용승 한국교원대학교 환경과학연구소 1994 환경연구논문집 Vol.- No.2

Since November 1990, the observations of methane (CH₄) level have been carried out at Tae-ahn Peninsula (TAP) in Korea. Analysis on atmospheric data obtained in the period from November 1990 to August 1992 is carried out and the results are included in this study. We note that CH₄ does not have a clear seasonal cycle with a minor maximum in August-September and with a minimum in June-July. The variations in monthly average level are much larger with 1765.01∼1857.21 ppb (amplitude 92.20 ppb). The occurrence of a minimum in June-July is due to the inflow of the North Pacific air, an increase of OH radical and due to a decrease in CH₄ emission from rice paddy. A maximum in August and September appears to result from an increase in organic materials in agriculture (rice paddy) and forests, inputs of local sources due to weak airflows, stagnation of the warm and moist air and from a decrease in OH radical. The present analysis indicates that according to CH₄ data from Mongolia and from several sites in North Pacific TAP is influenced as much as 31 ppb in average from the inputs of Chinese emission. When the atmospheric CH₄of TAP is compared with data observed at Korea National University of Education (KNU), the values of KNU are higher (127 ppb) than those of TAP. It is clear that air samples taken at KNU are influenced strongly by local sources in central Korea than those at TAP. According to analysis of trajectories and airflows, we find that there are 4 types in classification. Firstly, when an air flow is originated mainly in China values of CH₄ gas are in medium ranges. Secondly, when an airflow is from both local(Korea) and China we find higher values. Thirdly, with an airflow from both local (Korea) and Japan origins medium values are recorded. Fourthly, when an airflow of maritime origin arrives low values of atmospheric CH₄are observed at TAP.

유치 매복에 관한 증례보고

이제호,이종갑,최병재,전승준 大韓小兒齒科學會 1995 大韓小兒齒科學會誌 Vol.22 No.2

The term impaction is defined as a tooth has failed to erupt into normal position beyond the time usually expected for such appearance. Most of the cases of unerupted and impacted teeth reported in the literature are of permanent teeth. Impactions of mandibular primary second molars, however, are as numerous as all other primary impactions combined. Early detection of impaction is necessary during periodic oral examination and also radiographic examination and proper management is needed, because impaction of primary tooth may lead to obstruction of successive permanent tooth, space loss, and cystic change of tooth follicle. In these cases, 5 cases of primary teeth impaction are presented. Impaction teeth of each cases are maxillary primary incisor, maxillary and mandibular second primary molar, mandibular first primary molar. Following results were achieved by these cases; 1. In this cases, the cause of primary tooth impaction are abnormal eruption path, odontoma and fibrotic gingiva. 2. In this cases, impaction of primary tooth results in eruption problem of successive permanent tooth and failure of space maintenance. 3. Proper treatment plan should be established after through consideration of impacted tooth and it's relation with successive permanent tooth, and periodic examination and proper treatment about successive permanent tooth and eruptive condition is needed.

무증상의 후두개곡 낭종 환자에서 예기치 못한 어려운 기관내 삽관 1례

이상모,최준석,이철승,김원태,박천희 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1

Although vallecular cyst is often asymptomatic and harmless to the patient, discovery of large vallecular cyst after induction of anesthesia is a potentially life-threatening problem for thepatient and provides for the anesthesiologist a challenge in airway management. We describe a case of difficult intubation where the laryngeal inlet was obscured by a large vallecular cyst that was discovered during induction of general anesthesia. A 47-year-old man presented for elective laparoscopic colecystectomy due to GB polyp. He had normal mouth opening and neck extension; no mass or distortions of the tongue or neck were observed. Anesthesia and paralysis were induced with 80 ㎎ propofol, alfentanil 0.5 ㎎, midazolam 2.0 ㎎ and rocuromum 50 ㎎. It was noted that ventilation of the lungs via mask was difficult. Despite insertion of an oropharyngeal airway, ventilation proved to be more difficult. Intubation was attempted. Direct laryngoscopy (Macintosh 3 blade) revealed a 3-4 ㎝ tranlucent cyst arising from the left vallecula. The cyst completely obscured the view of epiglottis and vocal cords, preventing intubation despite multiple attempts by three anesthesiologists. StafF anesthesiologist was aspirated cyst using a 16-guage needle, syringe and 20 ㎖ of serous fluid were aspirated from cyst. The epiglottis and vocal cord were then exposed and tracheal intubation was performed easily with a size 7.0 cuffed oral tracheal tube. Anesthesia and the operation then proceeded uneventfully, following laparoscopic colecystectomy, an ENT surgeon removed the cyst.