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박화진,--,--,--,--,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.1
We have investigated the effects of hypha-water extracts (HWE), fruit body-water extracts (FWE) and cordycepin from Cordyceps militaris on serotonin release out of human platelets and human platelet aggregation. HWE and FWE inhibited the release of [^(3)H]-serotonin from human platelet stimulated by thrombin (2 U/ml) or collagen (20 ㎍/ml) in a dose-dependent manner. Furthermore, cordycepin, a major component of Cordyceps militaris, inhibited the human platelet aggregation induced by collagen (10 ㎍/ml) in a dose-dependent manner. These results suggest that cordycepin containing in HWE and FWE may inhibit the serotonin release by suppressing the collagen-induced human platelet aggregation. Accordingly, our data demonstrate that HWE and FWE containing much cordycepin might have antithrombotic and antimigrainous functions.
홍삼류의 섭취가 비만과 혈중 지질의 상호관계에 미치는 영향
박화진,이정희,이소진,함혜선,조현정,임창률,유영빈,박기현 대한의생명과학회 2000 Journal of biomedical laboratory sciences Vol.6 No.4
비만은 동맥경화의 위험인자로서 혈중에 triglyceride의 농도를 종가시키고, 상대적으로 HDL-Cholesterol의 농도를 감소시킴과 동시에 수축기 혈압을 상승시킨다. 본 연구에서 홍삼제품류를 4년 또는 5년 동안 복용해 온 건강한 사람 (ginseng군)과 홍삼제품을 복용하지 않은 건강한 사람 (control군)을 대상으로 하여 신체 계측치로부터 비만지수를 구하고 이것과 혈중의 triglyceride (TG)농도, TG/HDL-Cholesterol ratio 및 수축기 혈압과의 상호관계를 연구한 바, ginseng군에서는 대조군에 비해 혈중의 TG 농도가 일정하게 유지되었고, TG/HDL-Cholesterol ratio 및 수축기 혈압도 일정하게 유지되었다. 이러한 현상은 ginseng군에서 기호품으로 alcohol을 섭취하거나, 흡연을 한 경우에도 상관없이 일정하게 유지 되었다. 이 결과는 홍삼제품류를 장기 복용하면 비만의 저하 및 고혈압 또는 동맥경화의 위험인자가 억제될 수 있고, 결론적으로 비만, 고혈압 및 동맥경화를 예방할 수 있을 것으로 추정한다. Obesity is the risk fcactor of atherosclerosis and not only increases triglyceride concentration in blood but also decreases relatively the ratio of TG to HDL-Cholesterol in blood. In case of obesity, systolic blood pressure is also increased in responding the increase of TG in blood. Index of obesity in red ginseng-taking group (ginseng group) was lower as compared with non-red ginseng-taking group (control group). The TG concentration, the ratio of triglyceride to HDL-cholesterol in blood and systolic blood pressure were decreased in the subjects of ginseng group compared with that in control group. It is inferred that long-term intake of ginseng products may help to prevent the risk of atherosclerosis and obesity.
Ethylene 중합용 Pentamethylene Bridged Dinuclear Zirconocene 합성에 관한 연구
박융호,임선화 漢陽大學校 工學技術硏究所 2001 工學技術論文集 Vol.10 No.-
본 연구는 메탈로센 신촉매 공정 개발을 위하여 진행되었으며, 하나의 촉매에 두 개의 활성점을 갖는 pentamethylene bridged dinuclear zirconocene을 Noh 등의 protocol을 활용하여 합성하였고, 상업화시 가장 중요한 변수인 반응 수율을 향상시키기 위하여 각 합성 단계의 개선을 시도하였다. Biscyclopentadienyl pentane 합성시 silica gel chromatography column을 이용하여 순수한 ligand를 제조하였고, trimethyltin compound 합성시 용매 변환과 TEA 주입을 통하여 수율을 향상시켰다. 최종 메탈레이션 반응시에는 반응 온도의 변화를 통하여 촉매의 활성을 향상시킬 수 있었다. This study was done for the development of a new metallocene catalyst process. The pentamethylene bridged dinuclear zirconocene which have two active sites in one catalyst had been synthesized using Noh et al's protocol and each synthetic step was modified for the improvement of reaction yield which was the most important variable in commercialization. Pure biscyclopentadienylpentane was obtained by passing through silica gel chromatography column and the reaction yield of trimethyltin compound was improved by solvent change and TEA injection. A change in the reaction temperature during the final metallation process also improved the catalytic activity.
Intrauterine tamponade using Bakri balloon catheter during cesarean section for placenta previa
( Seon Hwa Lim ),( Jung Hwa Park ),( Ga Hyun Son ),( Baik Lee ),( Hee Young Cho ),( Young Han Kim ),( Yong Won Park ),( Ja Young Kwon ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-
Since 2009, our institute has been applying Bakri balloon for intrauterine balloon tamponade as a first choice to reduce undesired hysterectomy for postpartum bleeding. The aim of this study was to analyze the efficacy of intrauterine tamponade using Bakri balloon catheter during cesarean section for abnormal placentation. Retrospective review of the medical records of patients who had underwent elective cesarean section for abnormal placentation between Aug 2009 and July 2010 was performed. The surgery and insertion of the Bakri balloon catheter were performed by a single qualified operator (JYK). Bakri balloon was applied when a bleeding over 500 mL and tachycardia were noted during the surgery. A total of 72 patients (low-lying 18, previa partialis 10, previa totalis 44) underwent cesarean section for abnormal placentation during the study period. Forty patients (55.6 %) required intrauterine balloon tamponade during cesarean section due to postpartum bleeding from the low uterine segment, of which 72.7 % of cases was placenta previa totalis). And immediate hysterectomy was performed in 2 patients (2.8%) due to profuse bleeding. Of those who received the Bakri balloon uterine tamponade, 30.2 % (13/40) required additional treatment such as bilateral uterine artery embolization (11/40) or hysterectomy (2/40) to achieve complete bleeding control. No material mortality or balloon related complication was encountered. Intrauterine tamponade using Bakri balloon was efficient in managing postpartum bleeding following cesarean section for abnormal placentation to avoid hysterectomy.
Case Report : Primary omental yolk sac tumor
( Seon Hwa Lim ),( Yon Hee Kim ),( Ga Won Yim ),( Eun Ji Nam ),( Young Tae Kim ),( Sung Hoon Kim ) 대한산부인과학회 2013 Obstetrics & Gynecology Science Vol.56 No.6
Extra-ovarian yolk sac tumor arising in the omentum is extremely rare. As yolk sac tumor originated from the omentum has been rarely reported, its clinical information is very limited. The authors encountered a case of yolk sac tumor originated from the omentum, and reported the case herein. A 32-year-old woman was presented with developed low abdominal distension for a month. Magnetic resonance imaging findings were suggestive of ovarian malignancy with ascites and peritoneal seeding nodules. Explorative laparotomy was performed and then the findings from frozen biopsy of omentum were suggestive of poorly differentiated tumor though whether it was primary or metastatic was uncertain. Thus, staging laparotomy were performed. Histopathology confirmed that the tumor was a yolk sac tumor of omentum origin. Then, 6 cycles of postoperative adjuvant chemotherapy at intervals of 3 weeks were performed using bleomycin, etoposide, and cisplatin regimen. Four-year outpatient follow-up thereafter showed no relapse.
( Seon Hwa Lim ),( Yun Hae Lee ),( Hee Wan Kang ) 한국균학회 2013 Mycobiology Vol.41 No.4
This study was conducted in order to perform efficient extraction of lignocellulolytic enzymes amylase (EC 3.2.1.1), cellulase (EC 3.2.1.4), laccase (EC 1.10.3.2), and xylanase (EC 3.2.1.8) from spent mushroom compost (SMC) of Pleurotus ostreatus, P. eryngii, and P. cornucopiae. Optimal enzyme recovery was achieved when SMCs were extracted with 50 mM sodium citrate (pH 4.5) buffer at 4oC for 2 hr. Amylase, cellulase, and xylanase activities showed high values in extracts from P. ostreatus SMC, with 2.97 U/g, 1.67 U/g, and 91.56 U/g, respectively, whereas laccase activity and filter paper degradation ability were highest in extracts from P. eryngii SMC, with values of 9.01 U/g and 0.21 U/g, respectively. Enzymatic activities varied according to the SMCs released from different mushroom farms. The synthetic dyes remazol brilliant blue R and Congo red were decolorized completely by the SMC extract of P. eryngii within 120 min, and the decolorization ability of the extract was comparable to that of 0.3 U of commercial laccase. In addition, laccase activity of the SMC extract from P. eryngii was compared to that of commercial enzymes or its industrial application in decolorization.
보문 : 큰느타리(Pleurotus eryngii)의 수확 후 배지추출물을 이용한 다양한 염료의 탈색효과
임선화 ( Seon Hwa Lim ),곽아민 ( A Min Kwak ),민경진 ( Gyeong Jin Min ),김상수 ( Sang Su Kim ),이상엽 ( Sang Yeop Lee ),강희완 ( Hee Wan Kang ) 한국균학회 2014 韓國菌學會誌 Vol.42 No.3
Water extract from spent mushroom substrates (SMS) of Pleurotus eryngii was utilized in decolorization of eight synthetic dyes and wastewater from a textile factory. High laccase activity was detected in the extract of P. eryngii (SMSE). The SMSE showed that decolorization rate was 34~93% after 24 h incubation without any mediator on eight dyes including Rit-blue and Rit-red used in fiber dyeing. Dye decolorization rate more than 90% was observed on bromophenol blue and remazol brilliant blue R (RBBR). Dye in textile wastewater was decolorized at room temperature after three days by addition of P. eryngii SMSE. The results suggest that biological decolorization of dyes using the P. eryngii SMSE can be used as environmental friendly materials.
여성배우자의 시간가치 및 가족규모가 외식수요에 미치는 영향
임선화 ( Seon-hwa Lim ),유소이 ( So-ye You ),홍성훈 ( Seonghoon Hong ) 한국농업경제학회 2016 農業經濟硏究 Vol.57 No.4
This paper investigates the impact of household size and wife`s value of time on the demand for food away from home by using the sample of married households in Household Income and Expenditure Survey. The estimation results employing Tobit model with heteroscedasticity showed that per capita eating out expenditures decreased as 3.6 thousand Won while it increased the ratio of eating out expenditures relative to total food expenditures as 1.9%. These results imply that as household size increases, economies of scale effect in eating out consumption makes households reduce per capita food-away-from-home expenditures although eating out preferring effect due to the increase in total time spent on home meal production overpowers home meal preferring effect due to the economies of scale in it.