Multi‑tissue lipotoxicity caused by high‑fat diet feeding is attenuated by the supplementation of Korean red ginseng in mice

Seon‑A Jang,Seung Namkoong,이성률,Jin Woo Lee,Yuna Park,Gyeongseop So,Sung Hyeok Kim,Mi‑Ja Kim,Ki‑Hyo Jang,Alberto P. Avolio,Sumudu V. S. Gangoda,Hyun Jung Koo,Myung Kyum Kim,Se Chan Kang,Eun‑Hwa Sohn 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

Background Excessive intake of fat, one of the causes of obesity, is associated with low-grade infammation in various susceptible organs and eventually causes tissue toxicity. This study examines the multifaceted suppressive efects of Korean red ginseng extract (KRG) on high-fat diet (HFD)-induced lipotoxicity and infammatory responses in the aorta, liver, and brain. Methods Male C57BL/6 mice were fed HFD with or without KRG for 12 weeks. The improvement efect in KRG on lipotoxicity and infammatory potential was determined in the blood and the aorta, liver, and brain tissues. Results KRG signifcantly inhibited 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by >20% in vitro. KRG supplementation suppressed HFD-associated body weight gain, lipid profle changes, and excessive fat deposition in the liver and increased leptin, insulin, and ALT levels in the blood. Infammatory markers in the aorta, liver, and brain were also signifcantly reduced by KRG treatment. In microvascular endothelial cells, the 15% cyclic stretch-mediated upregulation of ICAM-1 and vascular cell adhesion protein-1 (VCAM-1) expression was signifcantly attenuated in the presence of KRG. Conclusion KRG supplementation attenuates HFD-mediated body weight gain, lipid profle changes, and multi-tissue infammatory responses.

대전문학사 서술의 현황과 전망

김화선(Kim, Hwa??Seon) 한국비평문학회 2013 批評文學 Vol.- No.50

본 논문은 지역문학의 정체성을 사유하고 한국문학사 속에서 대전문학이 갖는 의미를 고민하는 작업의 일환으로 대전문학사가 형성되는 그 기원의 지점을 탐색하고 있다. 이를 위해 기존의 지역문학 논의가 놓치고 있는 지역 문학사 기술과 관련된 다양한 담론들의 양상을 꼼꼼하게 점검하면서 해방공간을 중심으로 상이한 로컬 역사들이 서로 만나면서 충돌하고 있는 상황을 구체적으로 살펴보고 있다. 문학사는 엄격한 실증이 기초가 되어야 함에도 불구하고 그간의 대전문학사는 자료 수집의 곤란함이 야기한 실질적인 어려움과 연구자들의 실증적인 태도의 부재 등 여러 가지 이유로 인해 오류를 반복하고 재생산해왔다. 이 글은 지금까지 논의된 대전문학사 서술의 오류를 구체적 자료를 통해 점검하고 문학사 서술이 기억에 의존할 때 왜곡될 수밖에 없는 양상을 분석하여 다음의 결과를 도출하였다. 우선 대전문학사 서술에 있어 「향토」, 「동백」과 관련된 오류가 존재하고 있음을 확인하였다. 또한 기억과 망각이 맞물린 해방공간의 대전문학장이 이데올로기적 투쟁으로 얼룩져 좌익 성향의 잡지인 「현대」와 「신성」이 문학사에서 배제되어 왔음을 알 수 있었다. 「향토」?「동백」-「호서문학」으로 이어지는 순수문학의 흐름이 주된 경향으로 자리 잡은 기존의 대전문학사 서술에서 참여파 진보문인들의 목소리는 침묵당해 왔던 것이다. 대전문학사 서술의 오류를 지적하고, 해방기 진보적인 성향의 「현대」와 「신성」을 제외하고 만들어진 대전문학의 기원과 정체에 문제제기를 함으로써 소외되고 망각된 지역문학의 흐름을 복원해야 하는 필요성을 제시하고 있다는 점에서 본 논문의 의의를 찾을 수 있다. This paper aims to analyze the origin of the history of the local literature in Daejeon, especially focused on the liberation period for agonizing the meaning of Daejeon literature under the history of Korean literature. This paper examines diverse discourses about situations of the history of the local literature and different conditions of local history. Though the history of literature is based in the actual proof materials, the history of Daejeon literature has reproduced many errors because of troubles of data collection and non-positive attitudes of researchers. The results of this thesis are listed below. First, this paper found out description"s mistakes of the history of Daejeon literature specially in Hyangto(향토) and Dongback(동백). And the field of Daejeon literature on the liberation period was stained with an ideological conflict, therefore Hyundae(현대) and Sinsung(신성) which were left-wing literary magazines was totally excluded in the history of the local literature in Daejeon. Then the flow of history of Daejeon literature has become a tendency of pure literature in Hyangto(향토)-Dongback(동백)-Hosemunhak(호서문학). This paper has a literary significant meanings for finding errors in the history of Daejeon literature and raising the issue of identity and origin of it.

저강도 펄스형 초음파를 이용한 개의 슬개골 탈구 치료 효과

조성진,김남수,김화영,김선균,이성호,김병수 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

The effect of low-intensity ultrasonography on dislocation of the patella and fracture healing is controversial, and current management of that does not generally involve the use of ultrasound therapy. Nine patients with dislocation of the patella were treated with low-intensity ultrasonography(l5 mW/㎠, 1∼3.3 MHz) per 10-15 min/days, with an interval of 3 days during the last 3 weeks, at Family Animal Hospital(in Kunsan city). Ultrasound therapy may be beneficial to dislocation of the patella and healing. This finding is of considerable importance in that treatment with a low-intensity pulsed ultrasound signal may reduce healing time and could yield substantial cost savings and decreases in disability associated with delayed healing of dislocation of the patella.

급랭응고한 Mg-Zn-Ca-Si계 합금의 열안정성에 관한 연구

김태봉,김선화 순천향대학교 부설 산업기술연구소 2000 순천향 산업기술연구소논문집 Vol.6 No.1

Melt spinning process was used to prepare the rapidly solidified ribbons of Mg-6Zn-5Ca(wt%) alloys with 1, 2 wt% Si. In present work, SEM, EDS, XRD, and microhardness test were performed to investigate the characteristics of the ribbons. The microhardness of the ribbons according to Si content decreased slowly since the content of MgCaSi precipitates in air side of ribbons increased. The Mg-6Zn-5Ca-1Si melt-spin ribbon heat-treated at 150 ℃ and 1hr showed the maximum microhardness and then its microhardness decreased slowly above 150 ℃.For the ribbon of alloy with 2 wt% Si, its hardness increased up to 200℃ and then decreased rapidly. As the content of Si and the heat-treatment temperature increased, the content of MgCaSi formed initially in air side increased. The present result showed that the addition of Si to Mg-6Zn-5Ca alloys decreased the microhardness of the ribbons and did not improve them mechanically even after aging.

급랭응고된 Al-Fe계 합금의 열안정성에 관한 연구

김선화 순천향대학교 1992 논문집 Vol.15 No.3

The main purpose of this paper was to investigate the change of rapidly solidified microstructures and dispersoid behavior according to heat-treatment in Al-Fe-V-Si and Al-Fe- Cr-Y alloys. The rapidly solidified microstructure of the Al-Fe-V-Si alloy was microdendritic structure at wheel contact area and cell structure at air contact area. Subcell structure was observed in the Al-Fe-Cr-Y alloy. instead of tangled dislocation. (111) preferred orientation was formed at both alloys The main role of the other elements seems to alter the rapidly solidified microstructure and the kinetics of precipitataion in the aluminum alloys. Decomposition of the Al-Fe-V-Si alloy occurred at about 350℃. This alloy exhibited excellent thermal stability at elevated temperature. Thermal stability of the Al-Fe-Cr-Y alloy was less than that of the Al-Fe-Cr-Y alloy.

피질골 절제술을 응용한 구치의 원심직립 이동

김상철,강경화,오승환,이인성,김선영 대한치과교정학회 2004 대한치과교정학회지 Vol.34 No.5

빠르며 정확하고 안전한 치아이동을 목표로 삼고 있는 교정치료에서 새로운 패러다임이라고 여겨지는 피질골 절제술과 견인 골형성술을 응용한 구치의 원심직립이동에 대하여 알아보았다. 일반적인 방법으로는 어렵거나 치료 기간이 길어질 것으로 판단되는 구치의 원심직립 이동을 피질골 절제술과 견인 골형성술을 응용하여 도모하였다. 각각의 원심직립 증례를 통해 피질골 절제술과 견인 골형성술의 적용 술식, 견인장치 등을 논하고 그 효과를 파악하였다. 빠른 치아이동과 이에 따른 교정치료 기간의 단축이 가능하고 통상의 교정치료로는 이동에 한계가 있었던 치아이동을 구치의 정출이나 고정원의 상실 없이 도모할 수 있었다. Tooth movement facilitated by corticotomy and distraction osteogenesis, a new paradigm in orthodontics, was discussed. Molar uprighting was thought to be either difficult or nearly impossible. In this study, a section of cortical bone. which may act as resistance to tooth movement in alveolar bone, was removed. Active bone deposition was also made possible in the tension side. This forms the main concept of tooth movement facilitated by corticotomy and distraction osteogenesis. Molars in two cases were uprighted at such a speedy rate as we could not Imagine in conventional tooth movement, which lead to reduction of the total treatment period. And molar uprighting was possible without side effects, for example, supraversion of the tooth or anterior anchorage loss. These were the superior aspects to conventional orthodontics.

GC/NPD를 이용한 다성분 잔류농약의 동시분석

김우성,이선화,김상엽,정동윤,김재이,이영자,이홍재,정성욱,박흥재 한국환경과학회 2003 한국환경과학회지 Vol.12 No.10

Pesticides were extracted from samples with 70% acetone and methylene chloride in order, and then cleaned up via open-column chromatography apparatus packed with fiorisil, and finally analyzed simultaneously the organophosphorus pesticides using GC/NPD, Ultra-2 and Ultra-1 fused silica capillary columns were used to separate and identify the products. Recovery of most analytes from soybean sample, taken from pesticide residues well, was greater than(80%) for all except(6) analytes. This method can simultaneously determine multiple pesticides with a high degree of accuracy and precision.

Sputtering법으로 제조된 TiO_(2) 박막의 광촉매력에 관한 연구

김영민,김선화 순천향대학교 부설 산업기술연구소 2001 순천향 산업기술연구소논문집 Vol.7 No.1

TiO_(2) thin films as new bactericidal materials were prepared on Al substrate under the various conditions(oxygen partial pressure, working pressrue and D.C. power) by reactive sputtering process. This paper studied to the photocatalytic efficiency, the surface morphology and phases of the coated TiO_(2) films. TiO_(2) thin films were investigated using XRD, AFM and standard plate count method. The phase of TiO_(2) thin film was Anatase. The crystallinity of coated TiO_(2) thin films increased at low oxygen partial pressure, low working pressure and high D.C power. The surface morphology of TiO_(2) films was transformed from rounded-shaped crystal to square-shaped columnar structure under the same conditions. At Escherichia coli. experiment, The excellent crystallinity and the high roughness surface improved photocatalytic efficiency of TiO_(2) thin films. The highest efficiency on the bactericidal ability was 78% under UV radiation.

팔라디움 촉매하에서 산염화물과 유기주석의 커플링 반응

김두화,박정환,한도수,허선아,김성현,조성동 조선대학교 기초과학연구소 1992 自然科學硏究 Vol.15 No.1

The reaction of Asymmetrical organotins with acid chlorides in the presence of Benzylbis (triphenylphosphine) palladium(Ⅱ) chloride gave good yields of ketones in chloroform.

수평연속공정으로 주조된 회주물의 열처리 영향에 관한 연구

김기선,김선화 순천향대학교 부설 산업기술연구소 2001 순천향 산업기술연구소논문집 Vol.7 No.2

This study was based on the examination of the microstructure depending on the heat-treatment temperature and cooling rate of the gray cast ion produced of fabricated by the horizontal continuous casting method, The heat-treatment were performed at 900, 1,000, and 1,100℃. for 1 hour, respectively, The cross sectional microstructures of the as-cast and the treated specimens were observed by the optical microscope and the hardness numbers were measured by Rockwell hardness tester. The type A and type B graphites were observed on the center of the as-cast specimen. The matrix of the specimen was ferrite structure. The dendrite structures and the type D graphites were formed at the outside of the matrix. The pearlite and the nodular graghite in the matrix were formed by the dissolution of the graphites according to the heat treatment temperature increase. The martensite structure was observed in case of water cooling. The pearlite structure and the martensite structure were formed in case of heat-treatment at 1,100℃. The hardness number of treated specimens with the pearlite and martensite matrix increased.