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( Seon Ah Cha ),( Kyung Yoon Chang ),( Hoon Suk Park ),( Dong Chan Jin ),( Hyung Wook Kim ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
A 29-year-old woman with hypertension presented seizure and lower extremity weakness with severe hypokalemia. We found the presence of potassium depletion due to renal loss (transtubular potassium gradient was 14%) and high urine chloride metabolic alkalosis. Thyroid function test was normal. Hormone study showed elevated plasma aldosterone concentration (PAC), suppressed plasma renin activity (PRA), elevated PAC to PRA ratio, increased 24-hour urinary free cortisol excretion, and very low serum ACTH level. Cortisol secretion was not suppressed by administration of 1 mg, 2 mg, and 8 mg dexamethasone but the clinical features of Cushing syndrome were not found. Adrenal CT revealed 2.1×1.6 cm sized nodule in left adrenal gland (Fig 1A). We identified autonomous aldosterone and cortisol co-producing adenoma. We did preoperative management with spironolactone and the patient underwent a laparoscopic left adrenalectomy. Pathological examination of the resected specimens, including immunohistochemical staining, demonstrated that adrenal adenoma produced both aldosterone and cortisol (Fig 1E, 1F). We started steroid therapy just after surgery and then tapered spironolactone and steroid. This case report intends to emphasize that we should perform the screening test for Cushing syndrome in primary aldosteronism without clinical feature of Cushing syndrome.
Microalgal Oil Supplementation Has an Anti-Obesity Effect in C57BL/6J Mice Fed a High Fat Diet
Jin-Seon Yook,Kyung-Ah Kim,Jeong Eun Park,Seon-Hwa Lee,Youn-Soo Cha 한국식품영양과학회 2015 Preventive Nutrition and Food Science Vol.20 No.4
This study investigated the impact of microalgal oil (MO) on body weight management in C57BL/6J mice. Obesity was induced for 8 weeks and animals were orally supplemented with the following for 8 additional weeks: beef tallow (BT), corn oil, fish oil (FO), microalgal oil (MO), or none, as a high fat diet control group (HD). A normal control group was fed with a normal diet. After completing the experiment, the FO and MO groups showed significant decreases in body weight gain, epididymal fat pad weights, serum triglycerides, and total cholesterol levels compared to the HD and BT groups. A lower mRNA expression level of lipid anabolic gene and higher levels of lipid catabolic genes were observed in both FO and MO groups. Serum insulin and leptin concentrations were lower in the MO group. These results indicated that microalgal oil has an anti-obesity effect that can combat high fat diet-induced obesity in mice.
Prevalence of Listeria spp. over Commercial Frozen and Refrigerated Foods at the Supermarket Level
In-Ho Cha,Sung-Hyun Jin,Eun-Hee Park,Sung-Ah Park,Seon-Bong Kim,Hyeon-Cheol Cho,Young-Sook Lee,Young-Guen Lee 한국식품영양과학회 1998 Preventive Nutrition and Food Science Vol.3 No.2
As a part of investigation for listeriosis, we attempted isolation of Listeria spp. from commercial frozen and refrigerated foods at the supermarket level. Seven strains of Listeria spp. were isolated from 6 samples (7.1%) among 84 samples of frozen foods, and ten strains of Listeria spp. were also isolated from 8 samples (7.6%) among 105 samples of refrigerated foods at the supermarkets in Pusan area. From a total of 189 commercial foods, the number of isolated Listeria spp. and ratio were 6 strains (3.2%) of L. grayi, one strain (0.5%) of L. welshimeri, 6 strains (3.2%) of L. innocua and 4 strains (2.1%) of L. monocytogenes. Listeria spp. isolates except L. monocytogenes did not show β-hemolysis on blood agar and positive reaction in CAMP test with Staphyloccccus aureus. In the antibiotic susceptibility, most isolates of Listeria spp. were susceptible to 12 antibiotics such as ampicillin, cephalothin, penicillin, amikacin, gentamicin, erythromycin, kanamycin, vancomycin, tobramycin, carbenicillin, tetracycline and trimethoprim/sulfamethoxazole. Four strains of L. monocytogenes were susceptible to antibiotics used in this study except nitrofurantoin. The serotype of 3 strains and one strain of L. monocytogenes were classified into Listeria O serotype 1 and 4, respectively.
산전 초음파에서 발견된 태아 수신증을 가진 신생아의 출생 후 임상적 예후
김신아 ( Shin Ah Kim ),이정재 ( Jeong Jae Lee ),최규연 ( Ku Yeon Choi ),박선영 ( Seon Yeong Park ),차상헌 ( Sang Heon Cha ),정성윤 ( Seong Yun Jeong ),이임순 ( Im Soon Lee ),이권해 ( Kwon Hae Lee ) 대한주산의학회 2004 Perinatology Vol.15 No.3
목적 : 산전에 발견된 수신증의 출생 후 검사 및 치료와 예후에 대하여 알아보고, 이를 산전 상담에 참고하고자 한다. 방법 : 2000년 1월부터 2001년 12월까지 순천향대학교병원 산부인과에서 시행한 산전 초음파에서 발견되고 출생 후 확진된 수신증이 있는 20명을 대상으로 하였다. 산전에 수신증을 진단받은 신생아들은 출생 후에 지속적으로 초음파 및 요 검사를 받았고, 선택적으로 99mTc-DTPA 스캔, 경정맥신우조영술, 배뇨성 요도방광조영술을 시행하였다. 임신 30주 이후 신우의 전후 직경이 7 mm 이상일 때 수신증으로 정의하였고, 추적기간은 6~18개월로 평균 12개월이었다. 결과 : 13명은 일측성, 7명은 양측성 수신증을 보였다. 빈도는 4:1로 남아가 더 많았고, 좌측이 더 많이 이환되었다. 관해가 되지 않은 경우 생후 18개월까지 추적검사를 하였는데 11명이 자연 관해되었고, 모두 일측성이었다. 이 관해된 군의 산전 신우의 전후 직경 범위는 7~13 mm였고, 호전된 군은 9~14 mm였다. 신우성형술은 신기능의 저하가 있었던 2명의 일측성 수신증에서 시행되었다. 결론 : 산전에 신우의 전후직경이 적어도 14 mm 이하인 경우는 수신증이 더 이상 진행하지 않았다. 산전에 발견된 14 mm 이하의 수신증은 대부분 보존적 요법으로 경과를 관찰하여도 자연 관해를 보일 수 있으며, 소수에서 수술적 교정이 필요하다는 것을 산전 상담에서 충분히 고려해야 한다. 본 연구에서는 신우 전후 직경이 14 mm 이상인 환자군이 부족하였다는 아쉬운 점이 있어 앞으로 좀 더 많은 대상군의 연구가 필요하리라고 사료된다. Objective : To help prenatal counselling in fetal hydronephrosis by demonstrating the postnatal investigation, treatment and outcome of infants with hydronephrosis prenatally diagnosed. Methods : Between January 2000 and December 2001, we studied 20 infants who presented with fetal hydronephrosis confirmed by postnatal ultrasonography. In the postnatal follow-up period, the infants were followed with sequential ultrasonography and urinalysis. 99mTc-DTPA scan, intravenous pyelography and voiding cystourethrography were performed in selected cases. An anteroposterior renal pelvic diameter >7 mm after 30 weeks of pregnancy was defined as fetal hydronephrosis. Follow-up ranged from 6 to 18 months (mean, 12). Results : Unilateral hydronephrosis was diagnosed in 13 infants and bilateral in 7. A male predilection was found (4:1) and the left kidney was more commonly involved. If there was no resolution, ultrasonographic follow-up was done until 18 months. As a results, hydronephrosis resolved in 11, who were all in the unilateral hydronephrosis group. The range of the fetal renal pelvis on prenatal ultrasonography was 7~13 mm in the resolution group. Pyeloplasty was performed in two unilateral hydronephrosis infants. Conclusion : When the fetal renal pelvis was below 14 mm at least on prenatal ultrasonography, it didn`t progress. Fetal hydronephrosis below 14 mm may be safely observed, and surgical correction was performed only a few infants. So, we suppose that this outcome must be considered enough in prenatal counsellings and that the work-up for more many people is needed, because of the small number of the patients whose renal pelvic diameter is above 14 mm in this study.