자기동조 레귤레이터의 비선형성 보상을 위한 새로운 신경회로망 제어방식

엄기환,이용구,정성부,김진식 東國大學校 1996 東國論叢 Vol.35 No.-

In this paper, we propose a new controller design method that can get good control performance and reduce computation by loosing to small step size of conventional STR, owe to adding a neural network controller in STR with parallel for compensating for STR's nonlinearity. Through having tested the validity of the proposed controller by one link manipulator simulation and experiment, we compare with control performance for convention-al STR

콩 미이라병의 유전적 분리

엄상미,윤홍태,김용호 순천향대학교 기초과학연구소 2003 순천향자연과학연구 논문집 Vol.9 No.2

Phomopsis seed decay (PSD) is a major fungal disease found in most soybean production areas of the world. PSD significantly reduces soybean yield and seed quailty, particularly when soybean plants are exposed to high humidity and high temperature during maturation. To certificate genetic segregation ratio for PSD, PI 417479 line(resistant) and Hwaeomputkong(susceptible) were crossed and examined their inheritance mode. Experiment was conducted at glasshouse of Soonchunhyang Univ., in Korea. Different PSD seed infection levels were induced in soybean seeds by artificially infected plants exposing to above 95% relative humidity and 30˚C. A sample of seeds harvested from inoculated plants was analyzed to determine percent PSD incidence. The patterns of resistant response between Hwaeomputkong and PI 417479 were different in their seed and pod shape. The F₁plants of the resistance is governed by the two dominant genes. This results indicate that a resistance to PSD is controlled by complementary genes.

재식전 건조시에 따른 Emdogain^(R)의 적용이 치근흡수에 미치는 영향 : 조직학적, 3차원영상 분석

엄찬용,최영철,박재홍,최성철 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.4

완전탈구된 치아의 구강외 건조시간에 따른 Emdogain^(R)의 적용이 재식치의 치주조직의 치유반응에 미치는 효과를 관찰하기 위하여 체중 10-13 kg의 비글 3마리의 상하악 12개의 전치를 발거하여 재식하였다. 구강외 건조시간은 15(I 군), 30(II 군) 및 60분 (III 군)으로 분류한 후, 각 군은 Emdogain^(R)을 적용한 실험군과 적용하지 않은 대조군을 두었다. 건조시간에 따른 Emdogain^(R)의 적용이 치주조직치유에 미치는 효과를 비교, 평가하기 위하여 치과용 cone beam CT를 이용한 3차원적 영상과 조직학적 관찰을 통하여 다음과 같은 결론을 얻었다. 1. 대조군과 실험군 모두에서 건조 시간이 길어질수록 재식 후 염증성 흡수가 현저히 증가하였다(P<0.001). 2. Emdogain^(R)의 적용은 대조군에 비하여 염증 억제 효과가 있는 것으로 나타났으며, 특히 I 군과 III 군에서 Emdogain^(R)을 적용한 실험군에서 염증성 흡수의 감소가 나타났으며(P<0.01). II군에서는 차이가 없었다. 3. 치근의 흡수는 치근단 1/3 부위(절편 16, 15, 14순으로)에서 주로 발생하였으며(P<0.05, 0.001), 또한 치경부 1/3 부위(P<0.05)에서도 현저히 나타났다. 4. 치아의 장축에 직각인 절단면에서 관찰된 흡수는 주로 협설측 부위에 주로 발생하였다(P<0.01). This study three-dimensionally and histologically assessed the effect of Emdogain^(R) on periodontal healing in replanted teeth in three beagle dogs which were 1 to 2 years old. weighing from 10 to 13 kg. Twelve maxillary and mandibular incisors were intentionally extracted and replanted after 15(Group I). 30(Group II) and 60(Group III) minutes of air dry storage with and without the application of Emdogain^(R). The following conclusions could be drawn from the present investigation. 1. Increased incidence of inflammatory healing response in periodontal tissue was proportional to air dry time in Both control and experimental group(P<0.01). 2. Treatment Group showed lower inflammatory root resorption, especially there were statically significant in Group I, III(P<0.001, Group II : P=0.093). 3. Inflammatory root resorption were mainly occurred in apical third(14, 15-16 section)(P<0.05. 0.001), and cervical third(1 section)(P<0.05). 4. In view of horizontal section of long tooth axis. Main root resorption area were 1, 4, 5 line area(bucco-lingual area)(P<0.01).

사티오시아노코발트[Ⅱ]산 이온을 이용한 植物性鹽基成分의 確認 및 定量

嚴東玉,潘泰煥,韓相旭,申台容,都京三 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

A Coloring and spectrophotometric method using tetrathiocyanatocobaltate(Ⅱ) ion as a complexation reagent was developed for the identification of Coptidis Rhizoma and Phellodendri Cortex in herb medicine. Identification tests could be carried out coloring in test tube and ultraviolet-visible spectrophotometry. Coptidis Rhizoma and Phellodendri Cortex: with a solution of 1,2-dichloroethane in thst tube - yellowish green. The ultraviolet - visible spectrum of base components in 1,2-dichloroethane exgibits maxima at 270, 340, 442 and 624nm and was developed for the determination of berberine or palmatine in Coptidis Rhizoma and Phellodendri Cortex. Optimum conditions for good determination was determined: Maximum wavelength 442nm; Determination of berberine was possible to the range of 0.01mg/ml-0.10mg/ml in 1,2-dichloroethane. Calibration curve showed that the coefficient of variation was 0.999% for berberine. And determination of palmatine was possible to the range of 0.10mg/ml - 0.60mg/ml in 1,dichloroethane. The method was rapid, accurate. It was considered that spectrophotometry could be greatly applied to the analysis of base components in Coptidis Rhizoma and Phellodendri Cortex containing relatively small amount of gerb medicine extract.

成分檢出에 의한 오수유의 確認

엄동욱,김용성,신태용,도경삼 우석대학교 생명과학연구소 1998 생명과학연구소 논문집 Vol.2 No.-

Evodiamine and evocarpine are basic components to contain in Evodiae Fructus. After Evodiamine and evocarpine heve been isolated from the Evodiae fructus as the precipitate, they could be identifified and separated by coloured test, UV/Vis. absorption wavelength or TLC The presence of evodiamine and evocarpine are confirmed by its reaction with the TCR ion, [Co(SCN)_4]^2-, to produce the blue or yellowish blue precipitate, It is based on the formation of complex compounds by evodiamine and evocarpine with TCR reagent. The method has been found to be simple, convenient and suitable for routine identification of evodiamine and evocarpine, related basic constituents, the crude drug "Evodiae fructus" prepared from the Evodia officinalis Dode or Evodia rutaecarpa Bentham(Rutaceae).

최대밀도점 부근의 물 속에 잠겨있는 등온 수직 긴원기둥에 의한 자연대류의 실험적 연구

엄용균,권승혜 安東大學校 工業技術硏究所 1996 공업기술연구논문집 Vol.3 No.1

An experimental study of the free convection due to a isothermal vertical long cylinder immersed in water near its density extremum has been carried out. The surface temperature of the cylinder is 0℃, the aspect ratio is 4.8×10^(-2). Time-exposure photographs of the buoyancy-driven flow adjacent to a vertical cylinder in pure water are presented for adjacent water temperatures between 2.0 and 10℃. These conditions are of special interest since between 2.0 and 10℃ the buoyancy force distribution id locally bi-directional across the thermal transport region, Oweing to the density extremum at about 4℃. Resurts of the visualization show three distinct flow regions: upware flow for 2.0℃≤T_(∞)≤4.3℃, downward flow for 5.8℃≤T_(∞), dual flow for 5.6℃<T_(∞)<5.8℃ and unsteady atate flow for 4.3℃<T_(∞)≤5.6℃. The temperature range which the upward flow regions appeared is the same with those of short cylinder, but the temperature which the dualflow region and the downflow region occur is lower than those of short cylinder. Mean Nusselt numbers were smaller at unsteady state region than at the other regions. In the downward flow region, mean Nusselt number increase with increasing the surrounding temperature. In the upward flow region, mean Nusselt number increase and decrese with increasing the surrounding temperature, so there are maxmum Nusselt number at T_(∞)=3.0℃. Comparion of mean Nusselt number with past theoretical study shows good agreement

정향 수침액에 의한 아나필락시의 억제 효과

신태용,김상현,이석봉,엄동옥,임종필,이은희,김형민 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

The current study evaluates the capacity of Caryophylli Flos water extract(CFWE) to regulate immediate allergic reaction by control of histamine release. CFWE was found to exhibit a ingibitory activity on the compound 48/80-induced anaphylaxis. CFWE inhibited the serum histamine release induced in anaphylaxis by compound 48/80. CFWE was also showed a dose-depent activity on the conpound 40/80-induced histamine release from the highly purified population of Alcian Blue-positive peritoneal mast cells. This result suggest that CFWE may be useful for the prevention and treatment of allergy related disease.

요중 비소농도와 N-acetyl-β-D-glucosaminidase 농도와의 관련성 평가

이용찬,임동혁,엄상용,김용대,김헌 충북대학교 의과대학 충북대학교 의학연구소 2010 忠北醫大學術誌 Vol.20 No.1

Purposes: This study was performed to evaluate the possibility of impairment of renal tubular function by exposure to inorganic arsenic of low concentration. Materials and methods: Study subjects were 867 individuals (365 men and 502 women) who resided around abandoned mine areas in Chungbuk Province, Republic of Korea. Information about the life style, drinking water type, seafood intake, and mine working history was gathered, and urinary arsenic concentration and N-acetyl-β-d-glucosaminidase (NAG) activity were measured. The correlation between arsenic concentration and urinary NAG activity was tested in groups classified according to urinary NAG activity and seafood consumption prior to urine sampling. Results: No statistically significant difference in urinary arsenic concentrations was observed between different gender and age groups. The participants those who ate seafood within three days before the urinary sample showed a higher mean urinary arsenic concentration than those who did not. In a correlation analysis between natural logarithm of urinary arsenic concentrations and that of urinary NAG activities, no statistical significance was found in a total sample as well as within a gender group. In a group with the urinary arsenic concentrations higher than the geometric mean and the urinary NAG activities higher the geometric mean, the correlation coefficient between two variables was 0.182 and significant. (p-value<0.05) Conclusions: It is suggested that renal tubular damage could be induced by non-occupational exposure to low level inorganic arsenic. 연구목적 : 본 연구는 폐금속광산 주변지역 주민들을 대상으로, 저농도 비소노출에 의하여 신세뇨관 기능이상이 유발될 수 있는지를 평가하는 것을 목적으로 시행하였다. 대상 및 방법 : 충청북도에 소재하고 있는 폐금속광산의 주변에 거주하는 주민 867명을 대상으로 직접 면접조사를 실시하였다. 대상자의 소변을 채취하여 요중 비소농도와 요중 N-acetyl-β-D-glucosaminidase (NAG) 활성을 측정하였고, 조사대상자를 역학적 변수에 따라 구분하여 두 변수 사이의 상관관계를 분석하였다. 결과 : 소변시료를 채취하기전 3일 이내에 해산물을 섭취한 사람들의 요중 비소농도는 그 기간동안 해산물을 섭취하지 않은 사람들의 농도에 비하여 유의하게 높았다. 조사 대상자들의 요중 NAG 농도의 평균값은 남녀차이가 없었으나, 65세 미만 대상자와, 표본을 채취하기 전 3일 이내에 해산물을 섭취한 사람들의 요중 NAG 활성도의 평균값은 그렇지 않은 사람들에 비하여 유의하게 낮았다. 요중 비소농도가 기하평균 이상이고, 요중 NAG 활성이 기하평균 이상인 군에서 두 변수의 상관관계가 0.182 로 유의하였다. 결론 : 정상범위의 비소 노출이라도 요중 비소농도가 8.28 μg/g creatinine을 초과하는 경우에는 미세한 신장손상을 유발할 가능성이 있으며, 해산물을 섭취함으로써 체내에 흡수되는 비소는 이러한 신독성이 거의 없다.

진성 복압성 요실금 환자에서 복강경하 방광경부현수술의 유용성: 타술식과의 비교 연구

김용태,엄민식,이석영,신관희,서정원,윤석중,이상철,김원재 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.2

연구목적: 진성 복압성 요실금의 치료법으로서 복강경을 이용한 Burch 수술을 타수술법과 비교하여 그 유용성을 알아보고자 하였다. 대상 및 방법: 진성 복압성 요실금을 주소로 본원 비뇨기과에서 수술을 시행받은 44명의 환자를 수술법별로 분류하여 수술법에 따른 성공률, 수술 시간, 입원 기간 및 합병증의 빈도를 비교 분석 하였다. 결과: 전체 환자에서 수술 성공률은 86.4% 였으며 이들 중 복강경을 이용한 Burch 수술군에서는 성공률이 100% 이었다. 복강경을 이용한 Burch 수술군은 타수술군에 비하여 입원 기간이 짧았다. 복강경을 이용한 Burch 수술군은 합병증이 매우 경미하였으며 전체 환자의 31.8%에서 단기간의 배뇨곤란을 호소하였으나 장기간의 배뇨곤란은 없었으며 슬링 수술군에서는 3례(16.7%)에서 심한 절박성 요실금을 호소하였다. 결론: 복강경을 이용한 Burch 수술은 높은 치료 성공률과 낮은 합병증의 빈도를 나타내어 진성 복압성 요실금의 치료에서 매우 우수한 수술법으로 사료된다. Purpose: We performed this study to investigate the usefulness of laparoscopic Burch colposuspension as a treatment of genuine stress incontinence compare to other anti-incontinence operation. Materials and Methods : We analyzed success rate, operation time, admission day, and complication rate of various anti-incontinence operations in 44 genuine stress incontinence patients who have been received operation in our hospital. Results : Overall success rate was 86.4%, but laparoscopic Burch coposuspension showed 100% success rate. Laparoscopic Burch colposuspension required shorter admission day compared to other anti-incontinence oparations. Complication rate was lower in laparoscopic Burch colposuspension group. Short-term voiding problems were identified in 31.8% of total patients but 3 patients(16.7%) who have received sling operation complained severe urge incontinence. Conclusion : Laparoscopic Burch colposuspension is considered as an effective surgical method for genuine stress incontinence due to high success rate and low complication rate.

알데히드탈수소효소 2(ALDH2) 및 CYP2E1 유전자 다형성에 따른 요중 뮤콘산 농도와 요중 8-hydroxydeoxyguanosine과의 관련성

김용대,강종원,엄상용,장연위,김성훈,김은영,이철호,문재동,김헌 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.2