Robotic Distal Pancreatectomy with Celiac Axis Resection

( Rong Liu ),( Sai Chou ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Methods: woman in her 70s found lesion in pancreatic neck by ordinary physical examination and denied abdominal discomfort, vomiting, nausea, fever or backache. undergone a robotic distal pancreatectomy with celiac axis resection (Appleby). Surgeon: Rong Liu, Sai Chou Results: operation time94 mins blood loss: 50ml hospital stay: 5 days postoperative pathology: pancreatic adenocarcinoma R0 without lymph(-) No postoperative pancreas fistula

Multiple Acyl-CoA Dehydrogenase Deficiency Presenting as Rhabdomyolysis After Gastrointestinal Endoscopy

Rong-Rong Liu,Qiu Han,Li Ma 대한신경과학회 2023 Journal of Clinical Neurology Vol.19 No.4

지각동사 ‘보다’의 의미 연구

유영영(Liu, Rong-Rong) 한국언어학회 2014 언어 Vol.39 No.3

The purpose of this paper is to make a point that "poda" should be divided into ‘poda1’ which indicates activity and ‘poda2’ which indicates state. ‘poda1’ has the features of activity, intention and duration, while ‘poda2’ which expresses instantaneous visual contact has the features of fortuity, passivity and instantaneite. This semantic difference about ‘poda1’ and "poda2" has a effect on their aspect. We can prove the necessity of distinguishing "poda1" from "poda2" by the combination of ‘poda’ and some adverbs such as "ilbureo‘, ’kyesok‘, ’uyeonhi‘, temporal adverbs such as ‘T-tongan’, ‘T-mane’, endings such as ‘-ko issda’, ‘-eo issda’, imperative sentences, ‘-lyeogo hada’ or negative sentences. Especially, "poida‘ can also be used to indicate state besides ‘poda2", and form corresponding relation with ‘poda2’ only, but not ‘poda1’. Furthermore, according to the aspectual properties of ‘poda‘, ‘poda1‘ can be defined as an activity verb, while ‘poda2‘ can be defined as an achievement verb. Both the composition verbs including ‘poda’ as a component and the comparison with Chinese can also be helpful to proving the rationality of distinguishing ‘poda1’ and ‘poda2’.

Mechanical dragon

Liu Xiao Rong 한국콘텐츠학회 2018 한국콘텐츠학회 ICCC 논문집 Vol.2018 No.12

Mechanical dragon

Liu Xiao Rong 한국콘텐츠학회 2018 ICCC International Digital Design Invitation Exhib Vol.2018 No.12

Senescence as A Consequence of Ginsenoside Rg₁ Response on K562 Human Leukemia Cell Line

Liu, Jun,Cai, Shi-Zhong,Zhou, Yue,Zhang, Xian-Ping,Liu, Dian-Feng,Jiang, Rong,Wang, Ya-Ping Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

Aims and Background: Traditional chemotherapy strategies for human leukemia commonly use drugs based on cytotoxicity to eradicate cancer cells. One predicament is that substantial damage to normal tissues is likely to occur in the course of standard treatments. Obviously, it is urgent to explore therapies that can effectively eliminate malignant cells without affecting normal cells. Our previous studies indicated that ginsenoside $Rg_1$ ($Rg_1$), a major active pharmacological ingredient of ginseng, could delay normal hematopoietic stem cell senescence. However, whether $Rg_1$ can induce cancer cell senescence is still unclear. Methods: In the current study, human leukemia K562 cells were subjected to $Rg_1$ exposure. The optimal drug concentration and duration with K562 cells was obtained by MTT colorimetric test. Effects of $Rg_1$ on cell cycle were analyzed using flow cytometry and by SA-${\beta}$-Gal staining. Colony-forming ability was measured by colony-assay. Telomere lengths were assessed by Southern blotting and expression of senescence-associated proteins P21, P16 and RB by Western blotting. Ultrastructural morphology changes were observed by transmission electron microscopy. Results: K562 cells demonstrated a maximum proliferation inhibition rate with an $Rg_1$ concentration of $20{\mu}\;mol{\cdot}L^{-1}$ for 48h, the cells exhibiting dramatic morphological alterations including an enlarged and flat cellular morphology, larger mitochondria and increased number of lysosomes. Senescence associated-${\beta}$-galactosidase (SA-${\beta}$-Gal) activity was increased. K562 cells also had decreased ability for colony formation, and shortened telomere length as well as reduction of proliferating potential and arrestin $G_2$/M phase after $Rg_1$ interaction. The senescence associated proteins P21, P16 and RB were significantly up-regulated. Conclusion: Ginsenoside $Rg_1$ can induce a state of senescence in human leukemia K562 cells, which is associated with p21-Rb and p16-Rb pathways.

The effects of paeoniflorin injection on soluble triggering receptor expressed on myeloid-1 (sTREM-1) levels in severe septic rats

Liu, Xiao-Rong,Xu, Jie,Wang, Yi-Min,Ji, Ming-Suo,Liu, Fu-Shan The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.6

Paeoniflorin (PAE) is the most abundant compound in Xuebijing injection widely used to treat sepsis. We aimed to investigate effect of PAE on expression of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in a rat model of sepsis. Wistar rats were divided into Normal, Model, and PAE groups (n=20 each). Endotoxin was administrated at 5 mg/ml/kg in Model and PAE rats to establish rat sepsis model. 1 h after endotoxin administration, PAE was administrated at 4 ml/kg in PAE group once per day for 3 days. Routine blood tests and biochemical indexes were assessed, including aspartate aminotransferase (AST) and creatine kinase-MB (CK-MB). The plasma sTREM-1 level was measured using quantitative ELISA. At the end of experiment, the small intestine, liver, kidney and lung were subjected to pathological examinations. A rat model of sepsis-induced multiple organ dysfunction syndrome (MODS) was established successfully with endotoxin administration (5 mg/ml/kg), evidenced by histo-pathological examinations, routine blood tests and biochemical indexes: platelet count decreased and white blood cell count increased (p<0.05), CK-MB and AST increased (p<0.05). PAE treatment significantly reduced the plasma levels of AST, CK-MB, and sTREM-1, compared to Model group (p<0.05). Meanwhile, sepsis-induced damages in the liver, lung, stomach and intestinal mucosa were also markedly ameliorated by PAE treatment. PAE demonstrated a significantly protective effect in a rat model of sepsis by decreasing plasma sTREM-1 level, reducing inflammation, preventing MODS and protecting organ functions.

A Three-dimensional Biomechanical Model for Numerical Simulation of Dynamic Pressure Functional Performances of Graduated Compression Stocking (GCS)

Liu, Rong,Kwok, Yi-Lin,Li, Yi,Lao, Terence-T,Zhang, Xin,Dai, Xiao-Qun The Korean Fiber Society 2006 Fibers and polymers Vol.7 No.4

The beneficial effects of graduated compression stockings (GCS) in prophylaxis and treatment of venous disorders of human lower extremity have been recognized. However, their pressure functional performances are variable and unstable in practical applications, and the exact mechanisms of action remain controversial. Direct surface pressure measurements and indirect material properties testing are not enough for fully understanding the interaction between stocking and leg. A three dimensional (3D) biomechanical mathematical model for numerically simulating the interaction between leg and GCS in dynamic wear was developed based on the actual geometry of the female leg obtained from 3D reconstruction of MR images and the real size and mechanical properties of the compression stocking prototype. The biomechanical solid leg model consists of bones and soft tissues, and an orthotropic shell model is built for the stocking hose. The dynamic putting-on process is simulated by defining the contact of finite relative sliding between the two objects. The surface pressure magnitude and distribution along the different height levels of the leg and stress profiles of stockings were simulated. As well, their dynamic alterations with time processing were quantitatively analyzed. Through validation, the simulated results showed a reasonable agreement with the experimental measurements, and the simulated pressure gradient distribution from the ankle to the thigh (100:67:30) accorded with the advised criterion by the European committee for standardization. The developed model can be used to predict and visualize the dynamic pressure and stress performances exerted by compression stocking in wear, and to optimize the material mechanical properties in stocking design, thus, helping us understand mechanisms of compression action and improving medical functions of GCS.

25th anniversary exchange between China and Korea

Liu Xiao Rong 한국콘텐츠학회 2018 ICCC International Digital Design Invitation Exhib Vol.2018 No.7

Lack of Associations of the COMT Val158Met Polymorphism with Risk of Endometrial and Ovarian Cancer: a Pooled Analysis of Case-control Studies

Liu, Jin-Xin,Luo, Rong-Cheng,Li, Rong,Li, Xia,Guo, Yu-Wu,Ding, Da-Peng,Chen, Yi-Zhi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

This meta-analysis was conducted to examine whether the genotype status of Val158Met polymorphism in catechol-O-methyltransferase (COMT) is associated with endometrial and ovarian cancer risk. Eligible studies were identified by searching several databases for relevant reports published before January 1, 2014. Pooled odds ratios (ORs) were appropriately derived from fixed-effects or random-effects models. In total, 15 studies (1,293 cases and 2,647 controls for ovarian cancer and 2,174 cases and 2,699 controls for endometrial cancer) were included in the present meta-analysis. When all studies were pooled into the meta-analysis, there was no evidence for significant association between COMT Val158Met polymorphism and ovarian cancer risk (Val/Met versus Val/Val: OR=0.91, 95% CI=0.76-1.08; Met/Met versus Val/Val: OR=0.90, 95% CI=0.73-1.10; dominant model: OR=0.90, 95% CI=0.77-1.06; recessive model: OR=0.95, 95% CI=0.80-1.13). Similarly, no associations were found in all comparisons for endometrial cancer (Val/Met versus Val/Val: OR 0.97, 95% CI=0.77-1.21; Met/Met versus Val/Val: OR=1.02, 95% CI=0.73-1.42; dominant model: OR=0.98, 95% CI=0.77-1.25; recessive model: OR=1.02, 95% CI=0.87-1.20). In the subgroup analyses by source of control and ethnicity, no significant associations were found in any subgroup of population. This meta-analysis strongly suggests that COMT Val158Met polymorphism is not associated with increased endometrial and ovarian cancer risk.