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정상안에서 Pressure Eye Patch가 외안부에 미치는 영향
김재호,온영훈,신환호,정순국 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.1
Immobilizaiton of eyelids by pressure eye patch may relieve photophobia and some ocular pain. Although many ophthalmologists prefer pressure eye patch after operation and ocular trauma, it was not considered that eye patch may induce some ocular symptoms. We therefore studied the effects of pressure eye patch in normal eyes of healthy young adults. Thirty two medical students and doctors participated in this study. The pressure eye patch in normal eyes of healthy young adults. Thirty two medical students and doctors participated in this study. The pressure eye patch was applied for 14 hours on one eye of participants. Both eyes of all participants were examined twice, before and after patching. The examination included opthalmic examination and questionnaire of subject symptoms. Each symptom and sign was graded on a scale from 0 to 3. The scores were statistically evaluated by using the the Wilcoxon signed-rank test. In group 1 (patched eyes), 30 of 32 participants had clinical symptoms and signs. In comparison between group 1 (patched eyes) and group 2 (unpatched eyes), participants in the group 1 had more symptoms and signs such as discomfort (P<0.01), itching (P<0.01), congestion (P<0.01) and irregular astigmatism (P<0.01). Thus we concluded that complicaitons of varialbe severity and shape were induced by eye patch in normal eyes. So we considered that Eye Patch ater operation and trauma may contribute the above mentioned complicaitons and we must doing this procedure cautously.
KIM, OHN SOON,SEO, CHANG-SEOB,KIM, YEJI,SHIN, HYEUN-KYOO,HA, HYEKYUNG SPANDIDOS PUBLICATIONS 2015 MOLECULAR MEDICINE REPORTS Vol.12 No.1
<P>Traditional herbal formulas made from Scutellariae Radix (SR), the root of Scutellaria baicalensis, have previously been used in the treatment of inflammatory diseases, such as atherosclerosis. The aim of the present study was to investigate the effects of SR on low-density lipoprotein (LDL) oxidation and inflammation in macrophages, which are early events in the development of atherosclerosis. High-performance liquid chromatography photo-diode array analysis was used to obtain a three-dimensional chromatogram of SR. The antioxidative effects of SR were evaluated by determining its scavenging activities against ABTS and DPPH radicals. The inhibitory effect of SR on LDL oxidation was examined using a thiobarbituric acid-reactive substance assay and a relative electrophoretic mobility assay. In addition, the anti-inflammatory effects of SR were evaluated in lipopolysaccharide (LPS)-induced RAW264.7 murine macrophage cells. The results showed that SR exhibited radical-scavenging activities in a dose-dependent manner; in addition, SR attenuated the Cu2+-induced oxidation of LDL as well as significantly inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) expression in LPS-induced RAW264.7 cells. Furthermore, SR induced the protein expression of heme oxygenase-1 (HO-1) in RAW264.7 cells. In conclusion, the results of the present study demonstrated that SR decreased the oxidation of LDL and suppressed inflammatory responses in macrophages, which occurred at least in part via the induction of HO?1. These results therefore suggested that SR may be a potential therapeutic agent for the treatment of atherosclerosis.</P>
김정현,Ohn Soon Kim,김찬식,Eunjin Sohn,Kyuhyung Jo,JinSookKim 생화학분자생물학회 2012 Experimental and molecular medicine Vol.44 No.2
The formation of advanced glycation end products (AGEs) has been considered to be a potential causative factor of injury to lens epithelial cells (LECs). Damage of LECs is believed to contribute to cataract formation. The purpose of this study was to investigate the cytotoxic effect of AGEs on LECs both in vitro and in vivo. We examined the accumulation of argpyrimidine, a methylglyoxal-derived AGE, and the expression of apoptosis-related molecules including nuclear factor-kappaB (NF-κB), Bax, and Bcl-2 in the human LEC line HLE-B3 and in cataractous lenses of Zucker diabetic fatty (ZDF) rats, an animal model of type 2diabetes. In cataractous lenses from twenty-oneweek-old ZDF rats, LEC apoptosis was markedly increased,and the accumulation of argpyrimidine as well as subsequent activation of NF-κB in LECs were significantly enhanced. The ratio of Bax to Bcl-2 protein levels was also increased. In addition, the accumulation of argpyrimidine triggered apoptosis in methylglyoxal-treated HLE-B3 cells. However, the presence of pyridoxamine (an AGEs inhibitor) and pyrrolidine dithiocarbamate (a NF-κB inhibitor) prevented apoptosis in HLE-B3 cells through the inhibition of argpyrimidine formation and the blockage of NF-κB nuclear translocalization, respectively. These results suggest that the cellular accumulation of argpyrimidine in LECs is NF-κB-dependent and pro-apoptotic.
( Yun Mi Lee ),( Ohn Soon Kim ) 한국운동영양학회 2017 Physical Activity and Nutrition (Phys Act Nutr) Vol.21 No.1
[Purpose] Jaeumganghwa-Tang (JGT), a traditional herbal formula composed of 12 medicinal herbs, is used for the treatment of age-related diseases. In the present study, we investigated the effects of JGT on muscle mass and function in aged mice. [Methods] Young (5-month-old) and old (19-month-old) male C57BL/6 mice were divided into two groups each; one group received JGT (75 mg/d) and the other group received the vehicle for 6 weeks. At the end of the experimental period, muscle strength was examined using the wire hang test, and the tibialis anterior and gastrocnemius muscles were weighed. Muscle samples were further used for histological analysis to assess muscle damage, and the expression of transforming growth factor-beta was investigated via western blotting and immunohistochemistry. [Results] Our results showed that treatment of old mice with JGT improved muscle strength, increased skeletal muscle mass, alleviated muscle damage, and suppressed intramuscular expression of transforming growth factor-beta. [Conclusion] In conclusion, JGT has beneficial effects on age-related loss of muscle mass and function. Thus, it might serve as a potential therapeutic agent for sarcopenia.
김온순,서창섭,김예지,신현규,Kim, Ohn Soon,Seo, Chang-Seob,Kim, Yeji,Shin, Hyeun-Kyoo 대한한의학방제학회 2012 大韓韓醫學方劑學會誌 Vol.20 No.2
Objectives : The purpose of this study was to investigate the differences of chemical composition or biological activities between decoction and commercial herbal medicines of Samchulkunbi-tang (Shenzhujianpi-tang, SKT). Methods : The extracts of SKT from decoction (SKT1) and two different commercial extractive granules (SKT2 and SKT3) were prepared. The index components of SKTs were analyzed with HPLC. The antioxidant activities of SKTs were studied by measuring free radical scavenging activities on ABTS and DPPH. The anti-inflammatory effects were determined by measuring NO, $PGE_2$ and IL-6 in LPS-stimulated RAW 264.7 cells. Results : The contents of 7 components were 1.40-6.08 mg/g in SKT1, not detected-4.75 mg/g in SKT2, 0.03-1.46 mg/g in SKT3. The scavenging activities on ABTS and DPPH of herbal formulas were increased in dose-dependent manner (SKT1>SKT2>SKT3). SKT1 significantly inhibited $PGE_2$ and IL-6 production and SKT3 slightly inhibited $PGE_2$ production in LPS-stimulated RAW264.7 cells. SKT2 showed no inhibitory effects on production of inflammatory mediators such as $PGE_2$ and IL-6. Conclusions : These results demonstrate that the decoction of SKT has more strong anti-oxidant and anti-inflammatory effects than that of commercial herbal medicines consistent with the contents of index components.